| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nan Xu, Ang-Di Li, Li-Li Ji, Yao Ye, Zhen-Yu Wang, Lei Ton. miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q. European journal of histochemistry : EJH. vol 63. issue 2. 2019-05-28. PMID:31060348. |
cognitive impairment in alzheimer's disease (ad) is usually accompanied by synaptic loss in both the hippocampus and neocortex. |
2019-05-28 |
2023-08-13 |
mouse |
| Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V Kamath, George A Carlson, Israel Nelken, Bradley T Hyma. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559471. |
the coexistence of amyloid-β (aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in alzheimer's disease. |
2019-05-21 |
2023-08-13 |
Not clear |
| Yuek Ling Chai, Joyce R Chong, Jiaju Weng, David Howlett, Andrea Halsey, Jasinda H Lee, Johannes Attems, Dag Aarsland, Paul T Francis, Christopher P Chen, Mitchell K P La. Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration. Brain pathology (Zurich, Switzerland). vol 29. issue 1. 2019-05-20. PMID:30051532. |
lysosomal cathepsin d is upregulated in alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration. |
2019-05-20 |
2023-08-13 |
Not clear |
| Andrew S P Lim, Hans-Ulrich Klein, Lei Yu, Lori B Chibnik, Sanam Ali, Jishu Xu, David A Bennett, Philip L De Jage. Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease. Nature communications. vol 8. 2018-11-09. PMID:28368004. |
diurnal and seasonal molecular rhythms in human neocortex and their relation to alzheimer's disease. |
2018-11-09 |
2023-08-13 |
human |
| Aileen I Pogue, Walter J Luki. Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD). Cellular and molecular neurobiology. vol 38. issue 5. 2018-10-05. PMID:29302837. |
alzheimer's disease (ad) of the brain neocortex and age-related macular degeneration (amd) of the retina are two complex neurodegenerative disorders, which (i) involve the progressive dysregulation and deterioration of multiple neurobiological signaling pathways, (ii) exhibit the temporal accumulation of pro-inflammatory lesions including the amyloid beta (aβ) peptide-containing senile plaques of ad and the drusen of amd, and (iii) culminate in an insidious inflammatory neurodegeneration ending, respectively, in neural cell atrophy and death and progressive loss of cognition and central visual function. |
2018-10-05 |
2023-08-13 |
Not clear |
| Jeffrey S Phillips, Fulvio Da Re, Laynie Dratch, Sharon X Xie, David J Irwin, Corey T McMillan, Sanjeev N Vaishnavi, Carlo Ferrarese, Edward B Lee, Leslie M Shaw, John Q Trojanowski, David A Wolk, Murray Grossma. Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of aging. vol 63. 2018-09-26. PMID:29223682. |
amnestic alzheimer's disease (ad) is characterized by early atrophy of the hippocampus and medial temporal lobes before spreading to the neocortex. |
2018-09-26 |
2023-08-13 |
Not clear |
| b' Sara van Duijn, Marjolein Bulk, Sjoerd G van Duinen, Rob J A Nabuurs, Mark A van Buchem, Louise van der Weerd, Remco Natt\\xc3\\xa. Cortical Iron Reflects Severity of\\xc2\\xa0Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 60. issue 4. 2018-07-23. PMID:29081415.' |
abnormal iron distribution in the isocortex is increasingly recognized as an in vivo marker for alzheimer's disease (ad). |
2018-07-23 |
2023-08-13 |
human |
| Florence Clavaguera, Markus Tolnay, Michel Goeder. The Prion-Like Behavior of Assembled Tau in Transgenic Mice. Cold Spring Harbor perspectives in medicine. vol 7. issue 10. 2018-06-07. PMID:27940600. |
the pattern of tau deposition in alzheimer's disease follows a stereotypical progression, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2018-06-07 |
2023-08-13 |
mouse |
| Manon Thierry, Serge Marty, Susana Boluda, Charles Duyckaert. Alzheimer's senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28386671. |
samples of neocortex, hippocampus and striatum were taken from formalin-fixed brains (one control case; three cases with severe alzheimer disease). |
2018-03-20 |
2023-08-13 |
Not clear |
| Alejandro Antón-Fernández, Guillermo Aparicio-Torres, Silvia Tapia, Javier DeFelipe, Alberto Muño. Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation. Neurobiology of disease. vol 97. issue Pt A. 2018-02-21. PMID:27793637. |
in the present study, we have analyzed the possible alterations of ga in neurons from the temporal neocortex and hippocampus of alzheimer's disease (ad) patients, using double immunofluorescence techniques, confocal microscopy and 3d quantification techniques. |
2018-02-21 |
2023-08-13 |
Not clear |
| Joyce R Chong, Yuek Ling Chai, Jasinda H Lee, David Howlett, Johannes Attems, Clive G Ballard, Dag Aarsland, Paul T Francis, Christopher P Chen, Mitchell K P La. Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load. Journal of Alzheimer's disease : JAD. vol 56. issue 1. 2018-02-21. PMID:27911312. |
increased transforming growth factor β2 in the neocortex of alzheimer's disease and dementia with lewy bodies is correlated with disease severity and soluble aβ42 load. |
2018-02-21 |
2023-08-13 |
Not clear |
| Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. |
dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. |
2018-02-20 |
2023-08-13 |
rat |
| Tiina Laiterä, Jussi Paananen, Seppo Helisalmi, Timo Sarajärvi, Joel Huovinen, Marjo Laitinen, Tuomas Rauramaa, Irina Alafuzoff, Anne M Remes, Hilkka Soininen, Annakaisa Haapasalo, Juha E Jääskeläinen, Ville Leinonen, Mikko Hiltune. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-β Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27802227. |
in alzheimer's disease (ad) patients, diffuse aggregates of amyloid-β (aβ) and neurofibrillary hyperphosphorylated tau are detected in the neocortex of the brain, while similar accumulation of aβ is also detected in inph. |
2018-02-20 |
2023-08-13 |
Not clear |
| Stefan J Kempf, Athanasios Metaxas, María Ibáñez-Vea, Sultan Darvesh, Bente Finsen, Martin R Larse. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model. Oncotarget. vol 7. issue 23. 2018-01-17. PMID:27144524. |
the aim of this study was to elucidate the molecular signature of alzheimer's disease-associated amyloid pathology.we used the double appswe/ps1Δe9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated n-linked glycosylation patterns, pathway-focused transcriptome and neurological disease-associated mirnaome with age-matched controls in neocortex, hippocampus, olfactory bulb and brainstem. |
2018-01-17 |
2023-08-13 |
mouse |
| A A Thaker, B D Weinberg, W P Dillon, C P Hess, H J Cabral, D A Fleischman, S E Leurgans, D A Bennett, B T Hyman, M S Albert, R J Killiany, B Fischl, A M Dale, R S Desika. Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology. AJNR. American journal of neuroradiology. vol 38. issue 5. 2018-01-02. PMID:28279988. |
the entorhinal cortex, a critical gateway between the neocortex and hippocampus, is one of the earliest regions affected by alzheimer disease-associated neurofibrillary tangle pathology. |
2018-01-02 |
2023-08-13 |
Not clear |
| Zhuang Song, Ian M McDonough, Peiying Liu, Hanzhang Lu, Denise C Par. Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408792. |
yet, in the earliest preclinical phase of alzheimer's disease (ad), amyloid-beta (aβ) plaques deposit primarily in the neocortex, not in the medial temporal lobe. |
2017-11-17 |
2023-08-13 |
human |
| Huayang Xing, Yun-An Lim, Joyce R Chong, Jasinda H Lee, Dag Aarsland, Clive G Ballard, Paul T Francis, Christopher P Chen, Mitchell K P La. Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias. Molecular brain. vol 9. issue 1. 2017-11-06. PMID:27609071. |
hence, we measured crmp2 phosphorylation at thr509, thr514 and ser522, as well as markers of β-amyloid (aβ), tau-phosphorylation, α-synuclein and synaptic function in the postmortem neocortex of a longitudinally assessed cohort of lbd patients characterized by low (parkinson's disease dementia, pdd) and high (dementia with lewy bodies, dlb) burden of alzheimer type pathology. |
2017-11-06 |
2023-08-13 |
Not clear |
| Michael Schöll, Rik Ossenkoppele, Olof Strandberg, Sebastian Palmqvist, Jonas Jögi, Tomas Ohlsson, Ruben Smith, Oskar Hansso. Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 9. 2017-10-30. PMID:29050382. |
comparing patients with early-onset alzheimer's disease with controls resulted in significantly higher 18f-av-1451 retention throughout the neocortex, while comparing healthy controls with late-onset alzheimer's disease patients yielded a distinct pattern of higher 18f-av-1451 retention, predominantly confined to temporal lobe regions. |
2017-10-30 |
2023-08-13 |
Not clear |
| Nasrin Hosseini, Hojjatollah Alaei, Parham Reisi, Maryam Radahmad. The effects of NBM- lesion on synaptic plasticity in rats. Brain research. vol 1655. 2017-08-08. PMID:27867034. |
the nucleus basalis magnocellularis (nbm) is a major source of cholinergic projections to the neocortex that is vulnerable to degeneration in alzheimer's disease. |
2017-08-08 |
2023-08-13 |
rat |
| Brian Spencer, Paula A Desplats, Cassia R Overk, Elvira Valera-Martin, Robert A Rissman, Chengbiao Wu, Michael Mante, Anthony Adame, Jazmin Florio, Edward Rockenstein, Eliezer Maslia. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466341. |
alzheimer's disease (ad) is characterized by the progressive accumulation of amyloid β (aβ) and microtubule associate protein tau, leading to the selective degeneration of neurons in the neocortex, limbic system, and nucleus basalis, among others. |
2017-07-10 |
2023-08-13 |
mouse |