| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica M Posimo, Amanda M Titler, Hailey J H Choi, Ajay S Unnithan, Rehana K Lea. Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo. PloS one. vol 8. issue 3. 2013-12-27. PMID:23536801. |
in parkinson's and alzheimer's diseases, the allocortex accumulates aggregated proteins such as synuclein and tau well before neocortex. |
2013-12-27 |
2023-08-12 |
rat |
| D R Crapper McLachlan, W J Lukiw, T P Kruc. Aluminum, altered transcription, and the pathogenesis of Alzheimer's disease. Environmental geochemistry and health. vol 12. issue 1-2. 2013-11-11. PMID:24202576. |
reduced transcription may account for many disorders in cellular metabolic processes including the regulation of phosphorylation, calcium homeostasis, free radical metabolism, proteolysis and neurotransmitter metabolism.the experimental evidence indicates that one important toxic action of aluminum in alzheimer's disease neocortex is to increase the binding of histones, particularly hl(o), to dna which results in increased compaction of chromatin and reduced transcription. |
2013-11-11 |
2023-08-12 |
human |
| D R Crapper McLachlan, W J Lukiw, T P Kruc. Aluminum, altered transcription, and the pathogenesis of Alzheimer's disease. Environmental geochemistry and health. vol 12. issue 1-2. 2013-11-11. PMID:24202576. |
the supporting evidence includes: (1) a statistically reliable correlation between the aluminum to dna ratio on intermediate euchromatin and the amount of highly condensed heterochromatin found in a given preparation from alzheimer affected neocortex (crapperet al., 1980). |
2013-11-11 |
2023-08-12 |
human |
| D R Crapper McLachlan, W J Lukiw, T P Kruc. Aluminum, altered transcription, and the pathogenesis of Alzheimer's disease. Environmental geochemistry and health. vol 12. issue 1-2. 2013-11-11. PMID:24202576. |
compared to age matched control dinucleosomes, the alzheimer affected dinucleosomes contain an increased abundance of the linker histone hl(o) and an increased proportion of dna containing the promoter region of the gene coding for nf-l. (3) a reduction in abundance to 14% of control mrna coding for nf-l in alzheimer affected neocortex (crapper mclachlanet al., 1988). |
2013-11-11 |
2023-08-12 |
human |
| Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolna. "Prion-like" templated misfolding in tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 3. 2013-10-28. PMID:23587140. |
in alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2013-10-28 |
2023-08-12 |
Not clear |
| Csaba Szigeti, Norbert Bencsik, Aurel Janos Simonka, Adam Legradi, Peter Kasa, Karoly Guly. Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: a model for Alzheimer's disease. Brain research bulletin. vol 94. 2013-10-17. PMID:23357177. |
alzheimer's disease is associated with a significant decrease in the cholinergic input to the neocortex. |
2013-10-17 |
2023-08-12 |
rat |
| Sébastien S Hébert, Wang-Xia Wang, Qi Zhu, Peter T Nelso. A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. Journal of Alzheimer's disease : JAD. vol 35. issue 2. 2013-10-17. PMID:23403535. |
a study of small rnas from cerebral neocortex of pathology-verified alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. |
2013-10-17 |
2023-08-12 |
human |
| José Julio Rodríguez, Harun N Noristani, Alexei Verkhratsk. The serotonergic system in ageing and Alzheimer's disease. Progress in neurobiology. vol 99. issue 1. 2013-07-10. PMID:22766041. |
alzheimer's disease (ad) is one of the major neurodegenerative diseases that deteriorates cognitive functions and primarily affects associated brain regions involved in learning and memory, such as the neocortex and the hippocampus. |
2013-07-10 |
2023-08-12 |
Not clear |
| Elina M Sutinen, Tuula Pirttilä, George Anderson, Antero Salminen, Johanna O Ojal. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22898493. |
alzheimer's disease (ad) involves increased accumulation of amyloid-β (aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex. |
2013-06-17 |
2023-08-12 |
human |
| Kiren Ubhi, Edward Rockenstein, Ruben Vazquez-Roque, Michael Mante, Chandra Inglis, Christina Patrick, Anthony Adame, Margaret Fahnestock, Edith Doppler, Philip Novak, Herbert Moessler, Eliezer Maslia. Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease. Journal of neuroscience research. vol 91. issue 2. 2013-05-30. PMID:23152192. |
alzheimer's disease (ad) is characterized by degeneration of neocortex, limbic system, and basal forebrain, accompanied by accumulation of amyloid-β and tangle formation. |
2013-05-30 |
2023-08-12 |
mouse |
| Virawudh Soontornniyomkij, Benchawanna Soontornniyomkij, David J Moore, Ben Gouaux, Eliezer Masliah, Spencer Tung, Harry V Vinters, Igor Grant, Cristian L Achi. Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22450766. |
we studied sestrin-2 immunoreactivity in 42 isocortex sections from hiv-1-infected subjects compared to 18 age-matched non-hiv controls and 19 advanced alzheimer's disease (ad) cases. |
2013-04-10 |
2023-08-12 |
human |
| Enrica Boda, Eriola Hoxha, Alessandro Pini, Francesca Montarolo, Filippo Tempi. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21912965. |
in addition, we measured the levels of kv3.1 and kv3.4 messenger rnas (mrnas) and proteins in neocortex and hippocampus of appps1 mice, a transgenic model of alzheimer's disease. |
2013-02-25 |
2023-08-12 |
mouse |
| Enrica Boda, Eriola Hoxha, Alessandro Pini, Francesca Montarolo, Filippo Tempi. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21912965. |
in contrast, in the neocortex of aged appps1 mice, kv3.1 mrna and protein levels were significantly lower compared to wild type, suggesting that a decrease in kv3 currents could play a role in the cognitive symptoms of alzheimer's disease. |
2013-02-25 |
2023-08-12 |
mouse |
| Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, Bradley T Hyma. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22867711. |
in alzheimer disease (ad), deposition of neurofibrillary tangles and loss of synapses in the neocortex and limbic system each correlate strongly with cognitive impairment. |
2013-02-06 |
2023-08-12 |
human |
| Peter N Alexandrov, Prerna Dua, James M Hill, Surjyadipta Bhattacharjee, Yuhai Zhao, Walter J Luki. microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). International journal of biochemistry and molecular biology. vol 3. issue 4. 2013-01-10. PMID:23301201. |
in these experiments we analyzed amyloid beta (aβ) peptide and micro rna (mirna) abundance in csf and in short post-mortem interval (pmi <2.1 hr) brain tissue-derived extracellular fluid (ecf) from alzheimer's disease (ad) and age-matched control neocortex. |
2013-01-10 |
2023-08-12 |
human |
| Alessandro Martorana, Giulia M Sancesario, Zaira Esposito, Marzia Nuccetelli, Roberto Sorge, Amanda Formosa, Vincenzo Dinallo, Giorgio Bernardi, Sergio Bernardini, Giuseppe Sancesari. Plasmin system of Alzheimer's disease patients: CSF analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 7. 2012-11-06. PMID:22415062. |
alzheimer's disease (ad) is a multifactorial neurodegenerative disorder characterized by the extracellular deposit of amyloid beta (aβ), mainly of the amyloid beta(1-42) (aβ(1-42)) peptide in the hippocampus and neocortex leading to progressive cognitive decline and dementia. |
2012-11-06 |
2023-08-12 |
Not clear |
| Walter J Lukiw, Bhattacharjee Surjyadipta, Prerna Dua, Peter N Alexandro. Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). International journal of biochemistry and molecular biology. vol 3. issue 1. 2012-10-02. PMID:22509485. |
alzheimer's disease (ad) and age-related macular degeneration (amd) are complex and progressive inflammatory degenerations of the human neocortex and retina. |
2012-10-02 |
2023-08-12 |
human |
| Paul M Thompson, Harry V Vinter. Pathologic lesions in neurodegenerative diseases. Progress in molecular biology and translational science. vol 107. 2012-08-02. PMID:22482446. |
as alzheimer disease progresses over time, there is progressive atrophy of the hippocampus and neocortex--this can be quantified and regional accentuation of the atrophy can be evaluated using quantitative mri scanning. |
2012-08-02 |
2023-08-12 |
Not clear |
| Tamar Gefen, Katherine Gasho, Alfred Rademaker, Mona Lalehzari, Sandra Weintraub, Emily Rogalski, Christina Wieneke, Eileen Bigio, Changiz Geula, M-Marsel Mesula. Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain : a journal of neurology. vol 135. issue Pt 5. 2012-06-25. PMID:22522938. |
identification of alzheimer pathology in these aphasic patients is puzzling since tangles and related neuronal loss in alzheimer's disease typically emerge in memory-related structures such as entorhinal cortex and spread to language-related neocortex later in the disease. |
2012-06-25 |
2023-08-12 |
Not clear |
| Khanh vinh quoc Lu'o'ng, Lan Thi Hoang Nguye. Role of thiamine in Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 26. issue 8. 2012-06-12. PMID:22218733. |
alzheimer's disease (ad) is the most common form of dementia in elderly individuals and is associated with progressive neurodegeneration of the human neocortex. |
2012-06-12 |
2023-08-12 |
human |