| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leslie Crews, Edward Rockenstein, Eliezer Maslia. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain structure & function. vol 214. issue 2-3. 2010-06-15. PMID:20091183. |
alzheimer's disease (ad) is characterized by cognitive impairment, progressive degeneration of neuronal populations in the neocortex and limbic system, and formation of amyloid plaques and neurofibrillary tangles. |
2010-06-15 |
2023-08-12 |
Not clear |
| Maï Panchal, Jacqueline Loeper, Jack-Christophe Cossec, Claire Perruchini, Adina Lazar, Denis Pompon, Charles Duyckaert. Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry. Journal of lipid research. vol 51. issue 3. 2010-05-07. PMID:19779135. |
senile plaques were microdissected from sections of the isocortex in three braak vi alzheimer's disease cases and compared with a similar number of samples from the adjoining neuropil, free of amyloid-beta peptide (a beta) deposit. |
2010-05-07 |
2023-08-12 |
Not clear |
| Charmian Cher, Marie-Helene Tremblay, Jack R Barber, Shi Chung Ng, Bin Zhan. Identification of chaulmoogric acid as a small molecule activator of protein phosphatase 5. Applied biochemistry and biotechnology. vol 160. issue 5. 2010-05-03. PMID:19404779. |
recent studies showed that pp5 activity in the neocortex from patients with alzheimer's disease (ad) is decreased significantly, suggesting that small molecule pp5 activator may have therapeutic potential for ad. |
2010-05-03 |
2023-08-12 |
Not clear |
| Thomas Fraser, Hannah Tayler, Seth Lov. Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19904605. |
fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in alzheimer's disease. |
2010-04-30 |
2023-08-12 |
mouse |
| Diego Mastroeni, Ann McKee, Andrew Grover, Joseph Rogers, Paul D Colema. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PloS one. vol 4. issue 8. 2010-01-19. PMID:19672297. |
in a rare set of monozygotic twins discordant for alzheimer's disease (ad), significantly reduced levels of dna methylation were observed in temporal neocortex neuronal nuclei of the ad twin. |
2010-01-19 |
2023-08-12 |
Not clear |
| Evelin L Schaeffer, Barbara A Novaes, Emanuelle R da Silva, Heni D Skaf, Alvaro G Mendes-Net. Strategies to promote differentiation of newborn neurons into mature functional cells in Alzheimer brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19596396. |
alzheimer disease (ad) is characterized by neuron loss in the hippocampus (dg and ca1 field), entorhinal cortex, and association neocortex, which underlies the learning and memory deficits. |
2009-11-17 |
2023-08-12 |
Not clear |
| Prerna Sethi, Walter J Luki. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neuroscience letters. vol 459. issue 2. 2009-09-14. PMID:19406203. |
micro-rna abundance and stability in human brain: specific alterations in alzheimer's disease temporal lobe neocortex. |
2009-09-14 |
2023-08-12 |
human |
| Prerna Sethi, Walter J Luki. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neuroscience letters. vol 459. issue 2. 2009-09-14. PMID:19406203. |
in short pmi alzheimer's disease (ad)-affected temporal lobe neocortex, mirna-9, mirna-125b and mirna-146a were found to be significantly up-regulated, an effect that was not seen in several related neurological disorders. |
2009-09-14 |
2023-08-12 |
human |
| A Rocchi, D Orsucci, G Tognoni, R Ceravolo, G Sicilian. The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects. Current Alzheimer research. vol 6. issue 3. 2009-08-19. PMID:19519304. |
alzheimer's disease (ad) is a late-onset progressive neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus. |
2009-08-19 |
2023-08-12 |
Not clear |
| Jianmin Chen, Karl Herru. Selective vulnerability of neurons in primary cultures and in neurodegenerative diseases. Reviews in the neurosciences. vol 19. issue 4-5. 2009-04-09. PMID:19145987. |
the findings recapitulate selective vulnerability in the neocortex of alzheimer's disease. |
2009-04-09 |
2023-08-12 |
human |
| E Tessa Hedley-Whyte, James E Goldman, Maiken Nedergaard, Alan Friedman, Xiaoning Han, Robert E Schmidt, James M Power. Hyaline protoplasmic astrocytopathy of neocortex. Journal of neuropathology and experimental neurology. vol 68. issue 2. 2009-04-09. PMID:19151628. |
eosinophilic inclusions in the cytoplasm of protoplasmic astrocytes of the neocortex, usually in the clinical setting of epilepsy and/or psychomotor retardation, were first recognized and illustrated by alois alzheimer in 1910. |
2009-04-09 |
2023-08-12 |
Not clear |
| Yoko Uchida, Hiroshi Takahash. Rapid detection of Abeta deposits in APP transgenic mice by Hoechst 33342. Neuroscience letters. vol 448. issue 3. 2009-02-24. PMID:18955112. |
the accumulation of beta-amyloid (abeta) is the earliest event seen in the neocortex and hippocampus of alzheimer's disease (ad) patients. |
2009-02-24 |
2023-08-12 |
mouse |
| Vahram Haroutunian, Michal Schnaider-Beeri, James Schmeidler, Michael Wysocki, Dushyant P Purohit, Daniel P Perl, Leslie S Libow, Gerson T Lesser, Maria Maroukian, Hillel T Grossma. Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Archives of neurology. vol 65. issue 9. 2008-09-29. PMID:18779425. |
neuritic plaques (nps) and neurofibrillary tangles (nfts) in the brain, especially in the hippocampus, entorhinal cortex, and isocortex, are hallmark lesions of alzheimer disease and dementia in the elderly. |
2008-09-29 |
2023-08-12 |
Not clear |
| J A P van de Nes, R Nafe, W Schlot. Non-tau based neuronal degeneration in Alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex. Brain research. vol 1213. 2008-09-19. PMID:18455153. |
non-tau based neuronal degeneration in alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex. |
2008-09-19 |
2023-08-12 |
human |
| Denis Vallei. [The Alzheimer's disease or the fall of the neocortical empire at the age of nonsense]. Morphologie : bulletin de l'Association des anatomistes. vol 91. issue 295. 2008-05-21. PMID:18243029. |
if we observe the evolution of the alzheimer's disease of a premature entorhinal stage at an evolved stage of the neocortex, the succession of the confusions of the simple mnesic complaint in the aphasia, praxia, gnosia, visual, psychological and comportemental difficulties testify of the extension of the lesions in the neocortical structures. |
2008-05-21 |
2023-08-12 |
Not clear |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
we report a post mortem biochemical analysis of amyloid-beta (abeta) (elisa) and tau (western immunoblots) in the temporo-parietal neocortex of subjects with a clinical diagnosis of mild cognitive impairment (mci, n=12), alzheimer's disease (ad, n=12) or no cognitive impairment (nci, n=12). |
2008-03-25 |
2023-08-12 |
human |
| Yoko Uchida, Shun-ichirou Nakano, Fujiya Gomi, Hiroshi Takahash. Differential regulation of basic helix-loop-helix factors Mash1 and Olig2 by beta-amyloid accelerates both differentiation and death of cultured neural stem/progenitor cells. The Journal of biological chemistry. vol 282. issue 27. 2007-09-17. PMID:17488716. |
despite increased neurogenic differentiation markers in the hippocampal ca1 in alzheimer disease, neurons are not replaced in ca1 and the neocortex in the disease. |
2007-09-17 |
2023-08-12 |
mouse |
| Jian-Guo Cui, James M Hill, Yuhai Zhao, Walter J Luki. Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's disease. Neuroreport. vol 18. issue 2. 2007-04-10. PMID:17301674. |
in this study, using dna arrays and western immunoassay, gene expression patterns were examined in the thalamus and primary visual cortex of moderate-stage and late-stage alzheimer's disease and age-matched controls using a set of proinflammatory genes known to be upregulated in the temporal lobe neocortex and hippocampus of moderate-stage alzheimer's disease. |
2007-04-10 |
2023-08-12 |
Not clear |
| Daniel J Payette, Jun Xie, Qing Gu. Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain research. vol 1135. issue 1. 2007-04-05. PMID:17196556. |
since human neocortex has recently been shown to possess intrinsic cholinergic innervation, our results indicate that alterations in cht1-mediated high affinity choline uptake in cortical neurons may contribute to alzheimer's dementia. |
2007-04-05 |
2023-08-12 |
mouse |
| Ganesh M Shankar, Brenda L Bloodgood, Matthew Townsend, Dominic M Walsh, Dennis J Selkoe, Bernardo L Sabatin. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360908. |
alzheimer's disease (ad) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment. |
2007-04-05 |
2023-08-12 |
human |