| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Lalonde, C Straziell. Brain regions and genes affecting limb-clasping responses. Brain research reviews. vol 67. issue 1-2. 2012-05-30. PMID:21356243. |
these phenotypes are observed in mice with lesions in cerebellum, basal ganglia, and neocortex, as well as transgenic models of alzheimer's disease. |
2012-05-30 |
2023-08-12 |
mouse |
| Khanh Vinh Quôc Lu'o'ng, Lan Thi Hoàng Nguyê. The beneficial role of vitamin D in Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 26. issue 7. 2012-04-25. PMID:22202127. |
alzheimer's disease (ad) is the most common form of dementia in the elderly individuals and is associated with progressive neurodegeneration of the human neocortex. |
2012-04-25 |
2023-08-12 |
human |
| Stanley I Rapoport, Peter T Nelso. Biomarkers and evolution in Alzheimer disease. Progress in neurobiology. vol 95. issue 4. 2012-04-09. PMID:21801803. |
biomarkers such as reduced glucose metabolism in association neocortex, defects in long white matter tracts, rna neurochemical changes, and high csf levels of total and phosphorylated tau protein, which are helpful to identify mci and preclinical alzheimer disease patients, may also provide insights into what brain changes led to this disease being introduced during hominid evolution. |
2012-04-09 |
2023-08-12 |
Not clear |
| Christy M Kelley, Sylvia E Perez, Cassia R Overk, David Wynick, Elliott J Mufso. Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. Journal of Alzheimer's disease : JAD. vol 25. issue 3. 2011-11-15. PMID:21471639. |
amyloid-β (aβ) plaques occur in close apposition to thickened or swollen cholinergic and galaninergic neurites within the neocortex and hippocampus in alzheimer's disease (ad). |
2011-11-15 |
2023-08-12 |
mouse |
| Daniel Varon, David A Loewenstein, Elizabeth Potter, Maria T Greig, Joscelyn Agron, Qian Shen, Weizhao Zhao, Maria Celeste Ramirez, Isael Santos, Warren Barker, Huntington Potter, Ranjan Duar. Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment. Dementia and geriatric cognitive disorders. vol 31. issue 4. 2011-09-01. PMID:21494034. |
in alzheimer's disease, neurodegenerative atrophy progresses from the entorhinal cortex (erc) to the hippocampus (hp), limbic system and neocortex. |
2011-09-01 |
2023-08-12 |
human |
| Doris Culpan, Patrick G Kehoe, Seth Lov. Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro. International journal of molecular epidemiology and genetics. vol 2. issue 2. 2011-07-14. PMID:21686130. |
tumour necrosis factor-α (tnf-α) and mirna expression in frontal and temporal neocortex in alzheimer's disease and the effect of tnf-α on mirna expression in vitro. |
2011-07-14 |
2023-08-12 |
Not clear |
| Anna Fiorentini, Maria Cristina Rosi, Cristina Grossi, Ilaria Luccarini, Fiorella Casament. Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187954. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions, extracellular β-amyloid (aβ) plaques and intracellular neurofibrillary tangles within neocortex and hippocampus. |
2011-07-05 |
2023-08-12 |
mouse |
| Gaël Chételat, Victor L Villemagne, Kerryn E Pike, Kathryn A Ellis, Pierrick Bourgeat, Gareth Jones, Graeme J O'Keefe, Olivier Salvado, Cassandra Szoeke, Ralph N Martins, David Ames, Colin L Masters, Christopher C Row. Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 3. 2011-04-15. PMID:21310725. |
in the pre-dementia stage of alzheimer's disease, subtle episodic memory impairment is related to β-amyloid deposition, especially in the temporal neocortex, and independently from hippocampal atrophy, suggesting that both factors should be independently targeted in therapeutic trials aimed at reducing cognitive decline. |
2011-04-15 |
2023-08-12 |
Not clear |
| Y Y Li, J G Cui, J M Hill, S Bhattacharjee, Y Zhao, W J Luki. Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. Neuroscience letters. vol 487. issue 1. 2011-03-09. PMID:20934487. |
in this study we examined mirna-146a levels in early-, moderate- and late-stage alzheimer's disease (ad) neocortex and hippocampus, in several human primary brain and retinal cell lines, and in 5 different transgenic mouse models of ad including tg2576, tgcrnd8, psapp, 3xtg-ad and 5xfad. |
2011-03-09 |
2023-08-12 |
mouse |
| Odete A B da Cruz e Silva, Ana Gabriela Henriques, Sara Catarina Timóteo Santos Domingues, Edgar F da Cruz e Silv. Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942790. |
individuals with alzheimer's disease (ad) exhibit extracellular senile plaques (sps) of aggregated a beta and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein (nfts), and also an extensive loss in basal forebrain cholinergic neurons that innervate the hippocampus and neocortex. |
2011-02-28 |
2023-08-12 |
mouse |
| Rahul S Desikan, Mert R Sabuncu, Nicholas J Schmansky, Martin Reuter, Howard J Cabral, Christopher P Hess, Michael W Weiner, Alessandro Biffi, Christopher D Anderson, Jonathan Rosand, David H Salat, Thomas L Kemper, Anders M Dale, Reisa A Sperling, Bruce Fisch. Selective disruption of the cerebral neocortex in Alzheimer's disease. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886094. |
selective disruption of the cerebral neocortex in alzheimer's disease. |
2011-02-18 |
2023-08-12 |
Not clear |
| Rahul S Desikan, Mert R Sabuncu, Nicholas J Schmansky, Martin Reuter, Howard J Cabral, Christopher P Hess, Michael W Weiner, Alessandro Biffi, Christopher D Anderson, Jonathan Rosand, David H Salat, Thomas L Kemper, Anders M Dale, Reisa A Sperling, Bruce Fisch. Selective disruption of the cerebral neocortex in Alzheimer's disease. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886094. |
alzheimer's disease (ad) and its transitional state mild cognitive impairment (mci) are characterized by amyloid plaque and tau neurofibrillary tangle (nft) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. |
2011-02-18 |
2023-08-12 |
Not clear |
| Jian Guo Cui, Yuan Yuan Li, Yuhai Zhao, Surjyadipta Bhattacharjee, Walter J Luki. Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20937840. |
here we extend those observations to the hippocampus and neocortex of alzheimer disease (ad) brain and to stressed human astroglial (hag) cells in primary culture. |
2011-01-10 |
2023-08-12 |
human |
| Nicolas Villain, Gaël Chételat, Béatrice Desgranges, Francis Eustach. [Neuroimaging in Alzheimer's disease: a synthesis and a contribution to the understanding of physiopathological mechanisms]. Biologie aujourd'hui. vol 204. issue 2. 2010-11-16. PMID:20950559. |
these techniques have thus provided morphological and functional brain alterations mapping of alzheimer's disease: on one hand grey matter atrophy first concerns the medial temporal lobe before extending to the temporal neocortex and then other neocortical areas; on the other hand, metabolic alterations are first located within the posterior cingulate cortex and then reach the temporo-parietal area as well as the prefrontal cortex, especially in its medial part. |
2010-11-16 |
2023-08-12 |
Not clear |
| Andrew King, Fiona Sweeney, Istvan Bodi, Claire Troakes, Satomi Maekawa, Safa Al-Sarra. Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 30. issue 4. 2010-11-12. PMID:20102526. |
abnormal tdp-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of alzheimer's disease. |
2010-11-12 |
2023-08-12 |
Not clear |
| Peter T Nelson, Wang-Xia Wan. MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20413881. |
mir-107 is reduced in alzheimer's disease brain neocortex: validation study. |
2010-11-02 |
2023-08-12 |
human |
| Emiley Pham, Leslie Crews, Kiren Ubhi, Lawrence Hansen, Anthony Adame, Anna Cartier, David Salmon, Douglas Galasko, Sarah Michael, Jeffrey N Savas, John R Yates, Charles Glabe, Eliezer Maslia. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. The FEBS journal. vol 277. issue 14. 2010-08-26. PMID:20573181. |
the cognitive impairment in patients with alzheimer's disease is closely associated with synaptic loss in the neocortex and limbic system. |
2010-08-26 |
2023-08-12 |
mouse |
| Michelangelo Mancuso, Daniele Orsucci, Annalisa LoGerfo, Valeria Calsolaro, Gabriele Sicilian. Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA. Advances in experimental medicine and biology. vol 685. 2010-08-20. PMID:20687493. |
alzheimer's disease (ad) is a neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus. |
2010-08-20 |
2023-08-12 |
Not clear |
| Michelle G Tan, Wei-Ting Chua, Margaret M Esiri, A David Smith, Harry V Vinters, Mitchell K La. Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. Journal of neuroscience research. vol 88. issue 6. 2010-06-22. PMID:19937809. |
genome wide profiling of altered gene expression in the neocortex of alzheimer's disease. |
2010-06-22 |
2023-08-12 |
Not clear |
| Michelle G Tan, Wei-Ting Chua, Margaret M Esiri, A David Smith, Harry V Vinters, Mitchell K La. Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. Journal of neuroscience research. vol 88. issue 6. 2010-06-22. PMID:19937809. |
alzheimer's disease (ad) is characterized by a complex neurodegenerative process affecting multiple genes and proteins in the neocortex, many of which have not been well-studied. |
2010-06-22 |
2023-08-12 |
Not clear |