| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Gyu Jo, Joo-Yong Lee, Yeon-Mi Hong, Sungmin Song, Inhee Mook-Jung, Jae-Young Koh, Yong-Keun Jun. Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. Journal of neurochemistry. vol 88. issue 3. 2004-02-24. PMID:14720210. |
calsenilin levels were elevated in the cortex region of alzheimer's patient brains and in the neocortex and the hippocampus of swedish mutant beta-amyloid precursor protein transgenic mice brains. |
2004-02-24 |
2023-08-12 |
mouse |
| N Girardot, B Allinquant, D Langui, A Laquerrière, B Dubois, J-J Hauw, C Duyckaert. Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease. Neuropathology and applied neurobiology. vol 29. issue 5. 2003-11-28. PMID:14507337. |
we compared flotillin-1 immunoreactivity in the hippocampus, amygdala and isocortex (brodmann area 22) of six controls and 13 alzheimer's disease (ad) cases (10 sporadic and three familial). |
2003-11-28 |
2023-08-12 |
Not clear |
| Pascale Piolino, Béatrice Desgranges, Serge Belliard, Vanessa Matuszewski, Catherine Lalevée, Vincent De la Sayette, Francis Eustach. Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases. Brain : a journal of neurology. vol 126. issue Pt 10. 2003-11-06. PMID:12821510. |
in order to test these models, we studied three groups of patients with a neurodegenerative disease predominantly affecting different cerebral structures namely the mtl (13 patients in the early stages of alzheimer's disease) and the neocortex involving either the anterior temporal lobe (10 patients with semantic dementia) or the frontal lobe (15 patients with the frontal variant of frontotemporal dementia, fv-ftd). |
2003-11-06 |
2023-08-12 |
human |
| M K Lai, S W Tsang, P T Francis, M M Esiri, T Hope, O F Lai, I Spence, C P Che. [3H]GR113808 binding to serotonin 5-HT(4) receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 7. 2003-10-14. PMID:12811638. |
[3h]gr113808 binding to serotonin 5-ht(4) receptors in the postmortem neocortex of alzheimer disease: a clinicopathological study. |
2003-10-14 |
2023-08-12 |
human |
| Shirley W Y Tsang, Mitchell K P Lai, Paul T Francis, Peter T-H Wong, Ian Spence, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. Neuroreport. vol 14. issue 10. 2003-09-26. PMID:12876460. |
serotonin transporters are preserved in the neocortex of anxious alzheimer's disease patients. |
2003-09-26 |
2023-08-12 |
human |
| Shirley W Y Tsang, Mitchell K P Lai, Paul T Francis, Peter T-H Wong, Ian Spence, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. Neuroreport. vol 14. issue 10. 2003-09-26. PMID:12876460. |
densities of serotonin transporters (5-htt) in the postmortem neocortex of behaviorally assessed alzheimer's disease (ad) patients and aged controls were measured by radioligand binding with [3h]citalopram. |
2003-09-26 |
2023-08-12 |
human |
| Ofer Zohar, Sebastiano Cavallaro, Velia D'Agata, Daniel L Alko. Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain. Brain research. Molecular brain research. vol 115. issue 1. 2003-09-05. PMID:12824056. |
in alzheimer's disease (ad) patients, the enzymatic activity and protein levels of bace are increased in the neocortex, suggesting their differential expression may have a role in abeta plaque formation. |
2003-09-05 |
2023-08-12 |
human |
| N Radenahmad, J W Neal, G Wilcock, R C A Pearso. A neurofilament antibody recognizes a subset of pyramidal cells in the human neocortex that are preserved in Alzheimer's disease. Neuropathology and applied neurobiology. vol 29. issue 3. 2003-07-31. PMID:12787329. |
a neurofilament antibody recognizes a subset of pyramidal cells in the human neocortex that are preserved in alzheimer's disease. |
2003-07-31 |
2023-08-12 |
human |
| Ashley I Bus. The metallobiology of Alzheimer's disease. Trends in neurosciences. vol 26. issue 4. 2003-05-29. PMID:12689772. |
the cause of alzheimer's disease (ad) is closely related to the aggregation of a normal protein, beta-amyloid (abeta), within the neocortex. |
2003-05-29 |
2023-08-12 |
mouse |
| J A Colombo, B Quinn, V Puissan. Disruption of astroglial interlaminar processes in Alzheimer's disease. Brain research bulletin. vol 58. issue 2. 2002-11-06. PMID:12127023. |
in the present study, this distinctive cytoarchitectonic feature was analyzed in tissue deriving from the neocortex of cases affected by alzheimer's disease (n=14) and age-matched control cases (n=10). |
2002-11-06 |
2023-08-12 |
Not clear |
| J A Colombo, B Quinn, V Puissan. Disruption of astroglial interlaminar processes in Alzheimer's disease. Brain research bulletin. vol 58. issue 2. 2002-11-06. PMID:12127023. |
in addition, our data indicate that different types of neocortical astrocytes (namely intralaminar and interlaminar astrocytes) respond differently to the pathobiology of alzheimer's disease in the neocortex, inasmuch as interlaminar processes tend to disappear while intralaminar processes become reactive. |
2002-11-06 |
2023-08-12 |
Not clear |
| Hiroaki Fukumoto, Bonnie S Cheung, Bradley T Hyman, Michael C Irizarr. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Archives of neurology. vol 59. issue 9. 2002-10-07. PMID:12223024. |
beta-secretase protein and activity are increased in the neocortex in alzheimer disease. |
2002-10-07 |
2023-08-12 |
Not clear |
| Yuko Saito, Kenichi Nakahara, Hiroshi Yamanouchi, Shigeo Murayam. Severe involvement of ambient gyrus in dementia with grains. Journal of neuropathology and experimental neurology. vol 61. issue 9. 2002-09-23. PMID:12230325. |
the temporal neocortex and hippocampus were relatively spared in dg, in contrast to alzheimer disease. |
2002-09-23 |
2023-08-12 |
Not clear |
| John H Morrison, Patrick R Ho. Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Progress in brain research. vol 136. 2002-09-19. PMID:12143403. |
alzheimer's disease (ad), a classic neurodegenerative disorder, is characterized by extensive yet selective neuron death in the neocortex and hippocampus that leads to dramatic decline in cognitive abilities and memory. |
2002-09-19 |
2023-08-12 |
monkey |
| Béatrice Desgranges, Jean-Claude Baron, Catherine Lalevée, Bénédicte Giffard, Fausto Viader, Vincent de La Sayette, Francis Eustach. The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration. Brain : a journal of neurology. vol 125. issue Pt 5. 2002-06-17. PMID:11960900. |
however, the subgroup analysis disclosed that, in the less severe subgroup, all significant correlations (p < 0.005, uncorrected) were restricted to the parahippocampal gyrus and retrosplenial cortex, in accordance with both the distribution of changes in tau in early alzheimer's disease and the known involvement of this network in normal and impaired memory function, while in the more severe subgroup they mainly involved the left temporal neocortex, which is known to be implicated in semantic memory. |
2002-06-17 |
2023-08-12 |
Not clear |
| Patrick R Hof, Huiling Duan, Tanya L Page, Michael Einstein, Bridget Wicinski, Yong He, Joseph M Erwin, John H Morriso. Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys. Brain research. vol 928. issue 1-2. 2002-05-23. PMID:11844485. |
a distinct subpopulation of neurons forming long corticocortical projections in the association neocortex is highly vulnerable to the degenerative process in alzheimer's disease. |
2002-05-23 |
2023-08-12 |
monkey |
| Anastazija Gnjec, Justin A Fonte, Craig Atwood, Ralph N Martin. Transition metal chelator therapy--a potential treatment for Alzheimer's disease? Frontiers in bioscience : a journal and virtual library. vol 7. 2002-04-15. PMID:11897554. |
a defining feature of alzheimer's disease (ad) pathology is the presence of amyloid beta known as a-beta (abeta) within neuritic plaques of the hippocampus and neocortex of the brain. |
2002-04-15 |
2023-08-12 |
mouse |
| David L King, Gary W Arendas. Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment. Brain research. vol 926. issue 1-2. 2002-04-04. PMID:11814407. |
regional loss of synapses, particularly within the neocortex and hippocampus, is characteristic of alzheimer's disease (ad) and strongly correlated with extent of cognitive impairment. |
2002-04-04 |
2023-08-12 |
mouse |
| Luca Bondolfi, Michael Calhoun, Florian Ermini, H Georg Kuhn, Karl-Heinz Wiederhold, Lary Walker, Matthias Staufenbiel, Mathias Jucke. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784797. |
app23 transgenic mice express mutant human amyloid precursor protein and develop amyloid plaques predominantly in neocortex and hippocampus progressively with age, similar to alzheimer's disease. |
2002-01-30 |
2023-08-12 |
mouse |
| F Amenta, L Parnetti, V Gallai, A Walli. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589920. |
the observations of the loss of cholinergic function in neocortex and hippocampus in alzheimer's disease (ad) developed the hypothesis that replacement of cholinergic function may be of therapeutic benefit to ad patients. |
2001-12-31 |
2023-08-12 |
Not clear |