| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tharick A Pascoal, Andrea L Benedet, Nicholas J Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas K Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Net. Microglial activation and tau propagate jointly across Braak stages. Nature medicine. vol 27. issue 9. 2021-10-08. PMID:34446931. |
compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in alzheimer's disease (ad). |
2021-10-08 |
2023-08-13 |
human |
| Mariska Reinartz, Silvy Gabel, Jolien Schaeverbeke, Karen Meersmans, Katarzyna Adamczuk, Emma Susanne Luckett, Steffi De Meyer, Koen Van Laere, Stefan Sunaert, Patrick Dupont, Rik Vandenbergh. Changes in the language system as amyloid-β accumulates. Brain : a journal of neurology. 2021-09-17. PMID:34534284. |
our findings confirm the central role of the neocortex surrounding the posterior superior temporal sulcus as the area of predilection within the language network in the earliest stages of alzheimer's disease. |
2021-09-17 |
2023-08-13 |
human |
| Pauline Olivieri, Lorraine Hamelin, Julien Lagarde, Valérie Hahn, Elodie Guichart-Gomez, Carole Roué-Jagot, Marie Sarazi. Characterization of the initial complaint and care pathways prior to diagnosis in very young sporadic Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33926533. |
very-early-onset alzheimer's disease (young-ad) differentiates from late-onset ad (old-ad) by a predominant involvement of the parietal neocortex leading to atypical presentations. |
2021-06-24 |
2023-08-13 |
Not clear |
| Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 2. 2021-03-25. PMID:33219003. |
studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of β-amyloid (aβ) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
these elements are the extent of involvement (spread) by cerebral aβ based on the progression model defined by the thal aβ phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. |
2021-03-09 |
2023-08-13 |
Not clear |
| Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049030. |
alzheimer's disease (ad) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. |
2021-03-08 |
2023-08-13 |
mouse |
| Camille Pernègre, Antoine Duquette, Nicole Lecler. Tau Secretion: Good and Bad for Neurons. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293374. |
in alzheimer's disease (ad), neurofibrillary tangles (nfts), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuhai Zhao, Vivian R Jaber, Ayrian LeBeauf, Nathan M Sharfman, Walter J Luki. microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD). Frontiers in neurology. vol 10. 2020-09-29. PMID:30792687. |
integrating a combination of bioinformatics, microrna microfluidic arrays, elisa analysis, led northern, and transfection-luciferase reporter assay data using human neuronal-glial (hng) cells in primary culture we have discovered a set of up-regulated micrornas (mirnas) linked to a small family of down-regulated messenger rnas (mrnas) within the superior temporal lobe neocortex (brodmann a22) of sporadic alzheimer's disease (ad) brain. |
2020-09-29 |
2023-08-13 |
human |
| Matthias L Schroeter, Franziska Albrecht, Tommaso Ballarini, Dominique Leuthold, Angela Legler, Simone Hartwig, Solveig Tiepolt, Arno Villringe. Capgras Delusion in Posterior Cortical Atrophy-A Quantitative Multimodal Imaging Single Case Study. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32547387. |
amyloid accumulation as assessed by pet with f18-florbetaben was found in the gray matter of the neocortex indicating underlying alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sushma, Amal Chandra Monda. Role of GPCR signaling and calcium dysregulation in Alzheimer's disease. Molecular and cellular neurosciences. vol 101. 2020-05-05. PMID:31655116. |
alzheimer's disease (ad), a late onset neurodegenerative disorder is characterized by the loss of memory, disordered cognitive function, caused by accumulation of amyloid-β (aβ) peptide and neurofibrillary tangles (nfts) in the neocortex and hippocampal brain area. |
2020-05-05 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096045. |
in sporadic alzheimer's disease (sad), tau pathology gradually but relentlessly progresses from the transentorhinal region of the temporal lobe into both the allocortex and temporal high order association areas of the neocortex. |
2020-04-08 |
2023-08-13 |
Not clear |
| Brendan P Lucey, Austin McCullough, Eric C Landsness, Cristina D Toedebusch, Jennifer S McLeland, Aiad M Zaza, Anne M Fagan, Lena McCue, Chengjie Xiong, John C Morris, Tammie L S Benzinger, David M Holtzma. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Science translational medicine. vol 11. issue 474. 2020-02-21. PMID:30626715. |
in alzheimer's disease (ad), deposition of insoluble amyloid-β (aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. |
2020-02-21 |
2023-08-13 |
human |
| Yu Yamazaki, Mitsuru Shinohara, Motoko Shinohara, Akari Yamazaki, Melissa E Murray, Amanda M Liesinger, Michael G Heckman, Elizabeth R Lesser, Joseph E Parisi, Ronald C Petersen, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770921. |
collectively, these results indicate that loss of tight junction proteins occurs predominantly in the neocortex during alzheimer's disease progression. |
2019-12-10 |
2023-08-13 |
human |
| Marcon, Giaccone, Tagliavini, Bugian. Diagnosis of Alzheimer's disease. Advances in clinical pathology : the official journal of Adriatic Society of Pathology. vol 1. issue 4. 2019-11-20. PMID:10352487. |
for the postmortem diagnosis of alzheimer's disease, both b-protein immunoreactivity and hyperphosphorylated t-protein immunoreactivity have to be found in the neocortex. |
2019-11-20 |
2023-08-12 |
Not clear |
| Marcon, Giaccone, Tagliavini, Bugian. Diagnosis of Alzheimer's disease. Advances in clinical pathology : the official journal of Adriatic Society of Pathology. vol 1. issue 4. 2019-11-20. PMID:10352487. |
the cooccurrence of these lesions in the neocortex of alzheimer patients is likely the result of the abnormal vulnerability of selected nerve cell populations to b-protein. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jerzy Wegiel, Maciej Bobinski, Michal Tarnawski, Jerzy Dziewiatkowski, Eirene Popovitch, Margaret Bobinski, Boleslaw Lach, Barry Reisberg, Douglas C. Miller, Susan De Santi, Mony J. De Leo. Shift from fibrillar to nonfibrillar Abeta deposits in the neocortex of subjects with Alzheimer disease. Journal of Alzheimer's disease : JAD. vol 3. issue 1. 2019-11-20. PMID:12214072. |
shift from fibrillar to nonfibrillar abeta deposits in the neocortex of subjects with alzheimer disease. |
2019-11-20 |
2023-08-12 |
human |
| Jerzy Wegiel, Maciej Bobinski, Michal Tarnawski, Jerzy Dziewiatkowski, Eirene Popovitch, Margaret Bobinski, Boleslaw Lach, Barry Reisberg, Douglas C. Miller, Susan De Santi, Mony J. De Leo. Shift from fibrillar to nonfibrillar Abeta deposits in the neocortex of subjects with Alzheimer disease. Journal of Alzheimer's disease : JAD. vol 3. issue 1. 2019-11-20. PMID:12214072. |
a morphometric study of amyloid-beta-positive plaques in the neocortex of eight non-demented people from 68 to 82 years of age and 17 subjects with late-stage alzheimer disease (gds stage 7/fast stages 7a-f) from 73 to 93 years of age shows a shift from prevalence of fibrillar plaques to prevalence of nonfibrillar plaques. |
2019-11-20 |
2023-08-12 |
human |
| Laurent Lescaudron, Donald G. Stei. Differences in memory impairment and response to GM1 ganglioside treatment following electrolytic or ibotenic acid lesions of the nucleus basalis magnocellularis. Restorative neurology and neuroscience. vol 15. issue 1. 2019-11-20. PMID:12671241. |
alzheimer's disease is a progressive dementia associated with cholinergic cell loss in the nucleus of meynert that induces deficiencies in cholinergic neurotransmission in the neocortex. |
2019-11-20 |
2023-08-12 |
Not clear |
| Nancy R Stallings, Melissa A O'Neal, Jie Hu, Ege T Kavalali, Ilya Bezprozvanny, James S Malte. Pin1 mediates Aβ Science signaling. vol 11. issue 522. 2019-09-16. PMID:29559586. |
pin1 mediates aβ early-stage alzheimer's disease is characterized by the loss of dendritic spines in the neocortex of the brain. |
2019-09-16 |
2023-08-13 |
Not clear |
| Jes Buster Madsen, Jonas Folke, Bente Pakkenber. Stereological Quantification of Plaques and Tangles in Neocortex from Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29914026. |
stereological quantification of plaques and tangles in neocortex from alzheimer's disease patients. |
2019-07-15 |
2023-08-13 |
human |