| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Delaère, C Duyckaerts, C Masters, K Beyreuther, F Piette, J J Hau. Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neuroscience letters. vol 116. issue 1-2. 1991-01-28. PMID:2259457. |
in addition, determination of beta a4 level in the neocortex is not sufficient for the diagnosis of dementia of alzheimer type. |
1991-01-28 |
2023-08-11 |
Not clear |
| H Braak, E Braa. Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia. Acta neuropathologica. vol 80. issue 5. 1991-01-17. PMID:2251904. |
neither ammon's horn nor isocortex revealed sufficiently large numbers of tangles to permit the diagnosis of fully developed alzheimer's disease. |
1991-01-17 |
2023-08-11 |
Not clear |
| M O Kristense. [Neurotransmitters in Alzheimer's disease]. Ugeskrift for laeger. vol 152. issue 30. 1990-10-16. PMID:1975961. |
alzheimer's disease is characterized by markedly reduced concentration of acetylcholine in hippocampus and neocortex, caused by degeneration of cholinergic neurons. |
1990-10-16 |
2023-08-11 |
Not clear |
| I N Ferrier, A Leak. Peptides in the neocortex in Alzheimer's disease and ageing. Psychoneuroendocrinology. vol 15. issue 2. 1990-08-02. PMID:1972799. |
peptides in the neocortex in alzheimer's disease and ageing. |
1990-08-02 |
2023-08-11 |
Not clear |
| H Braak, E Braa. Cognitive impairment in Parkinson's disease: amyloid plaques, neurofibrillary tangles, and neuropil threads in the cerebral cortex. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 1. 1990-08-02. PMID:2357270. |
neither the ammon's horn nor the isocortex revealed a sufficiently large number of tangles to permit the diagnosis of a coexisting fully developed alzheimer's disease. |
1990-08-02 |
2023-08-11 |
Not clear |
| A M Iacopino, S Christako. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 11. 1990-07-12. PMID:2140897. |
comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mrna in the substantia nigra (parkinson disease), in the corpus striatum (huntington disease), in the nucleus basalis (alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (parkinson, huntington, and alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus. |
1990-07-12 |
2023-08-11 |
human |
| A M Cataldo, R A Nixo. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 10. 1990-06-21. PMID:1692625. |
similar structures were abundant in degenerating neurons of alzheimer neocortex, and cathepsin-laden neuronal perikarya in various stages of disintegration could be seen within some senile plaques. |
1990-06-21 |
2023-08-11 |
Not clear |
| P Cervera, C Duyckaerts, M Ruberg, E Hirsch, G Ransmayr, J J Hauw, Y Agi. Tyrosine hydroxylase-like immunoreactivity in senile plaques is not related to the density of tyrosine hydroxylase-positive fibers in patients with Alzheimer's disease. Neuroscience letters. vol 110. issue 1-2. 1990-05-24. PMID:1970142. |
the numbers of silver-stained senile plaques and plaques containing tyrosine hydroxylase (th)-like immunoreactivity were counted in the neocortex, amygdala and hippocampus of control subjects and patients with alzheimer's disease, and compared with the density of th-positive nerve fibers. |
1990-05-24 |
2023-08-11 |
human |
| D W Dickson, A Wertkin, L A Mattiace, E Fier, Y Kress, P Davies, S H Ye. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta neuropathologica. vol 79. issue 5. 1990-05-24. PMID:2158201. |
they differ from some of the neurites in senile plaques in the neocortex in alzheimer's disease by the absence of paired helical filaments. |
1990-05-24 |
2023-08-11 |
human |
| C Duyckaerts, E Llamas, P Delaère, P Miele, J J Hau. Neuronal loss and neuronal atrophy. Computer simulation in connection with Alzheimer's disease. Brain research. vol 504. issue 1. 1990-02-06. PMID:2598020. |
a decrease in the number of neuronal profiles in the isocortex of man may be observed on microscopic sections in aging and in degenerative diseases such as alzheimer's disease. |
1990-02-06 |
2023-08-11 |
Not clear |
| D M Mann, A Brown, D P Wilks, C A Davie. Immunocytochemical and lectin histochemical studies of plaques and tangles in Down's syndrome patients at different ages. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2532371. |
the presence of numerous senile plaques (sp) and neurofibrillary tangles (nft) within association areas of the neocortex and within the hippocampus and amygdala, is generally regarded as providing the histopathological hallmarks of alzheimer's disease (ad) (mann, 1985). |
1990-01-31 |
2023-08-11 |
Not clear |
| S Flament, A Delacourte, B Hémon, A Défosse. Characterization of two pathological tau protein, variants in Alzheimer brain cortices. Journal of the neurological sciences. vol 92. issue 2-3. 1989-12-01. PMID:2509637. |
moreover, in association areas of neocortex from alzheimer brains, the antisera detected 2 additional tau variants of 64 and 69 kda. |
1989-12-01 |
2023-08-11 |
Not clear |
| R N Kalaria, S I Hari. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2769254. |
we studied the hexose transporter protein of the frontal and temporal neocortex, hippocampus, putamen, cerebellum, and cerebral microvessels (which constitute the blood-brain barrier) in alzheimer disease and control subjects by reversible and covalent binding with [3h]cytochalasin b and by immunological reactivity. |
1989-10-12 |
2023-08-11 |
human |
| R N Kalaria, S I Hari. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2769254. |
in alzheimer disease subjects, we found a marked decrease in the hexose transporter in brain microvessels and in the cerebral neocortex and hippocampus, regions that are most affected in alzheimer disease, but there were no abnormalities in the putamen or cerebellum. |
1989-10-12 |
2023-08-11 |
human |
| D E Grigoriadis, R G Struble, D L Price, E B De Souz. Normal pattern of labeling of cerebral cortical corticotropin-releasing factor (CRF) receptors in Alzheimer's disease: evidence from chemical cross-linking studies. Neuropharmacology. vol 28. issue 7. 1989-09-11. PMID:2548115. |
in order to determine whether the increases in crf receptors in alzheimer's disease were due to altered molecular composition of the binding protein, we compared the labeling pattern of 125i-tyr0-ovine crf in temporal neocortex of alzheimer's patients and age-matched controls using chemical cross-linking techniques. |
1989-09-11 |
2023-08-11 |
Not clear |
| H Akiyama, P L McGeer, S Itagaki, E G McGeer, T Kanek. Loss of glutaminase-positive cortical neurons in Alzheimer's disease. Neurochemical research. vol 14. issue 4. 1989-09-08. PMID:2761669. |
phosphate activated glutaminase (pag) was evaluated in the neocortex of alzheimer and control cases. |
1989-09-08 |
2023-08-11 |
rat |
| P Delaère, C Duyckaerts, J P Brion, V Poulain, J J Hau. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta neuropathologica. vol 77. issue 6. 1989-08-25. PMID:2501966. |
tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of alzheimer type. |
1989-08-25 |
2023-08-11 |
Not clear |
| P Delaère, C Duyckaerts, J P Brion, V Poulain, J J Hau. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta neuropathologica. vol 77. issue 6. 1989-08-25. PMID:2501966. |
tau immunoreactivity was studied in temporal neocortex, area 22, in 15 cases with graded intellectual status and compared with the immunoreactivity observed with an antiserum against paired helical filaments (phf) and with the density of amyloid revealed by thioflavin s. samples came from women over 75 years either intellectually normal or affected by senile dementia of the alzheimer type at various degrees of severity. |
1989-08-25 |
2023-08-11 |
Not clear |
| C Duyckaerts, H Kawasaki, P Delaère, C Rainsard, J J Hau. Fibre disorganization in the neocortex of patients with senile dementia of the Alzheimer type. Neuropathology and applied neurobiology. vol 15. issue 3. 1989-08-15. PMID:2747844. |
fibre disorganization in the neocortex of patients with senile dementia of the alzheimer type. |
1989-08-15 |
2023-08-11 |
Not clear |
| C Duyckaerts, H Kawasaki, P Delaère, C Rainsard, J J Hau. Fibre disorganization in the neocortex of patients with senile dementia of the Alzheimer type. Neuropathology and applied neurobiology. vol 15. issue 3. 1989-08-15. PMID:2747844. |
the loss of neurons, which is thought to occur during senile dementia of the alzheimer type, could alter the fibre organization of the neocortex. |
1989-08-15 |
2023-08-11 |
Not clear |