| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Stern, L Otvos, J Q Trojanowski, V M Le. Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. The American journal of pathology. vol 134. issue 5. 1989-06-20. PMID:2524164. |
using rabbit and mouse antisera, and 7 mabs, sections of neocortex, hippocampus, cerebellum, and spinal cord from alzheimer's disease (ad), down's syndrome (ds), and control cases were probed. |
1989-06-20 |
2023-08-11 |
mouse |
| H Braak, E Braak, P Kalu. Alzheimer's disease: areal and laminar pathology in the occipital isocortex. Acta neuropathologica. vol 77. issue 5. 1989-06-15. PMID:2566255. |
alzheimer's disease: areal and laminar pathology in the occipital isocortex. |
1989-06-15 |
2023-08-11 |
Not clear |
| H Braak, E Braak, P Kalu. Alzheimer's disease: areal and laminar pathology in the occipital isocortex. Acta neuropathologica. vol 77. issue 5. 1989-06-15. PMID:2566255. |
sensitive and specific silver methods for demonstration of (1) amyloid and/or precursors of amyloid and (2) neurofibrillary changes were applied to examine the pathology revealed by the occipital isocortex in cases of alzheimer's disease and age-matched controls. |
1989-06-15 |
2023-08-11 |
Not clear |
| N W Kowall, M F Bea. Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease. Neuroscience letters. vol 98. issue 1. 1989-05-26. PMID:2469045. |
galanin-immunoreactive neurites were found in a small number of senile plaques in the hippocampus and temporal isocortex of alzheimer's disease patients. |
1989-05-26 |
2023-08-11 |
human |
| T Yamamoto, Y Iwasaki, Y Sato, H Yamamoto, H Konn. Astrocytic pathology of methionine sulfoximine-induced encephalopathy. Acta neuropathologica. vol 77. issue 4. 1989-05-26. PMID:2565645. |
prolonged mso-loading (every 12 h up to three times, 100-150 mg/kg body weight) brought about the appearance of astrocytes with swollen, watery nuclei reminiscent of alzheimer ii glia chiefly in the neocortex, hippocampus and lateral thalamus after 24 h. concomitantly, profound accumulation of glycogen ensued in the superficial three layers of the neocortex, hippocampus and pyriform cortex. |
1989-05-26 |
2023-08-11 |
rat |
| R M Zweig, K M Schegg, J H Peacock, D Melarke. A case of Alzheimer's disease and hippocampal sclerosis with normal cholinergic activity in basal forebrain, neocortex, and hippocampus. Neurology. vol 39. issue 2 Pt 1. 1989-03-23. PMID:2915803. |
a case of alzheimer's disease and hippocampal sclerosis with normal cholinergic activity in basal forebrain, neocortex, and hippocampus. |
1989-03-23 |
2023-08-11 |
Not clear |
| R M Zweig, K M Schegg, J H Peacock, D Melarke. A case of Alzheimer's disease and hippocampal sclerosis with normal cholinergic activity in basal forebrain, neocortex, and hippocampus. Neurology. vol 39. issue 2 Pt 1. 1989-03-23. PMID:2915803. |
a 76-year-old man without apparent dementia met pathologic criteria at autopsy for alzheimer's disease, which included a maximum senile plaque density greater than 15 per square millimeter of neocortex. |
1989-03-23 |
2023-08-11 |
Not clear |
| M M Mesulam, C Geul. Acetylcholinesterase-rich pyramidal neurons in the human neocortex and hippocampus: absence at birth, development during the life span, and dissolution in Alzheimer's disease. Annals of neurology. vol 24. issue 6. 1989-02-07. PMID:3207359. |
acetylcholinesterase-rich pyramidal neurons in the human neocortex and hippocampus: absence at birth, development during the life span, and dissolution in alzheimer's disease. |
1989-02-07 |
2023-08-11 |
human |
| Y Ihar. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain research. vol 459. issue 1. 1988-11-21. PMID:3139259. |
in addition to neurofibrillary tangles and senile plaques, antibodies to human tau revealed extensive tau-immunoreactive meshworks in layers iii and v of the neocortex affected with alzheimer's disease. |
1988-11-21 |
2023-08-11 |
human |
| P Duffy, R Mayeux, W Kupsk. Familial Alzheimer's disease with myoclonus and 'spongy change'. Archives of neurology. vol 45. issue 10. 1988-11-04. PMID:3178530. |
"spongy change," or vacuolar change, was observed in the neocortex of temporal and frontal lobes in four of 27 patients with clinical and pathologic characteristics of alzheimer's disease. |
1988-11-04 |
2023-08-11 |
Not clear |
| D R McLachlan, W J Lukiw, L Wong, C Bergeron, N T Bech-Hanse. Selective messenger RNA reduction in Alzheimer's disease. Brain research. vol 427. issue 3. 1988-09-22. PMID:3401702. |
the relative abundance of 7 messenger rnas extracted from alzheimer and control neocortex were examined by northern and quantitative dot blot analysis. |
1988-09-22 |
2023-08-11 |
Not clear |
| D M Mann, B Marcyniuk, P O Yates, D Neary, J S Snowde. The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathology and applied neurobiology. vol 14. issue 3. 1988-09-15. PMID:3405392. |
the progression of the pathological changes of alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. |
1988-09-15 |
2023-08-11 |
Not clear |
| D A Lewis, G A Higgins, W G Young, D Goldgaber, D C Gajdusek, M C Wilson, J H Morriso. Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 5. 1988-04-01. PMID:3278324. |
we used in situ hybridization techniques to map the anatomical distribution of precursor amyloid-beta-protein mrna in the neocortex of brains from three subjects with no known neurologic disease and from five patients with alzheimer disease. |
1988-04-01 |
2023-08-11 |
human |
| S Nakamura, T Kawamata, I Akiguchi, M Kameyama, H Kimur. [Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]. Rinsho shinkeigaku = Clinical neurology. vol 27. issue 8. 1988-02-16. PMID:3690919. |
[reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with alzheimer type dementia and aged controls]. |
1988-02-16 |
2023-08-11 |
Not clear |
| G F Hohmann, G L Wenk, P Lowenstein, M E Brown, J T Coyl. Age-related recurrence of basal forebrain lesion-induced cholinergic deficits. Neuroscience letters. vol 82. issue 3. 1988-01-28. PMID:3696497. |
lesions of basal forebrain cholinergic nuclei projecting in neocortex have recently been employed as an animal model for the cholinergic deficits in alzheimer's disease. |
1988-01-28 |
2023-08-11 |
rat |
| R C Pearson, T P Powel. Anterograde vs. retrograde degeneration of the nucleus basalis medialis in Alzheimer's disease. Journal of neural transmission. Supplementum. vol 24. 1988-01-19. PMID:3119773. |
the neuroanatomical distribution of the pathological changes typical of alzheimer's disease in the neocortex suggests a progression of the disease process, from the medial temporal cortex and amygdala out into the parieto-temporal association areas. |
1988-01-19 |
2023-08-11 |
Not clear |
| W R Gibb, M M Esiri, A J Lee. Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia). Brain : a journal of neurology. vol 110 ( Pt 5). 1988-01-12. PMID:2823957. |
three cases also had severe neurofibrillary tangle change or senile plaques in the neocortex, compatible with alzheimer's disease, but the cortical tangle distribution did not always match that of the lewy bodies. |
1988-01-12 |
2023-08-11 |
Not clear |
| E C Hirsch, A M Graybiel, C Duyckaerts, F Javoy-Agi. Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. Proceedings of the National Academy of Sciences of the United States of America. vol 84. issue 16. 1987-09-18. PMID:3475716. |
the basal forebrain cholinergic cell groups, which innervate widespread areas of the neocortex, undergo degeneration in alzheimer disease and also in parkinsonism associated with dementia. |
1987-09-18 |
2023-08-11 |
Not clear |
| P H Gibso. Ultrastructural abnormalities in the cerebral neocortex and hippocampus associated with Alzheimer's disease and aging. Acta neuropathologica. vol 73. issue 1. 1987-07-24. PMID:3604576. |
ultrastructural abnormalities in the cerebral neocortex and hippocampus associated with alzheimer's disease and aging. |
1987-07-24 |
2023-08-11 |
Not clear |
| N R Sims, J P Blass, C Murphy, D M Bowen, D Near. Phosphofructokinase activity in the brain in Alzheimer's disease. Annals of neurology. vol 21. issue 5. 1987-07-14. PMID:2954507. |
the activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with alzheimer's disease. |
1987-07-14 |
2023-08-11 |
Not clear |