| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C H Lee, J H Chun. The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11390408. |
in humans, ataxia telangiectasia-mutated (atm) and ataxia-telangiectasia and rad3-related kinases activate hcds1 by phosphorylating thr(68) . |
2001-09-06 |
2023-08-12 |
Not clear |
| X Cortes-Bratti, C Karlsson, T Lagergård, M Thelestam, T Frisa. The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11076947. |
in the ataxia telangiectasia-mutated gene (atm)-deficient lymphoblastoid cell lines, intoxication was significantly delayed compared with atm wild type cells, and was associated with a slower kinetic of p53 stabilization, suggesting that the early response to hdcdt is atm-dependent. |
2001-06-28 |
2023-08-12 |
Not clear |
| J Doostzadeh-Cizeron, N H Terry, D W Goodric. The nuclear death domain protein p84N5 activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. The Journal of biological chemistry. vol 276. issue 2. 2001-04-05. PMID:11050087. |
we conclude that p84n5 induces an ataxia telangiectasia-mutated kinase (atm)-independent, caffeine-sensitive g(2)/m cell cycle arrest prior to the onset of apoptosis. |
2001-04-05 |
2023-08-12 |
Not clear |
| K C Drumea, E Levine, J Bernstein, B Shank, S Green, E Kaplan, L Mandell, J Cropley, J Obropta, I Braccia, A Krupnik, B S Rosenstei. ATM heterozygosity and breast cancer: screening of 37 breast cancer patients for ATM mutations using a non-isotopic RNase cleavage-based assay. Breast cancer research and treatment. vol 61. issue 1. 2001-01-18. PMID:10930092. |
based upon the results of several epidemiologic studies, it has been suggested that women who are carriers for a mutation in the ataxia telangiectasia-mutated (atm) gene are susceptible for the development of breast cancer. |
2001-01-18 |
2023-08-12 |
Not clear |
| M A Johnson, P E Bryant, N J Jone. Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887218. |
hamster xrcc8 mutants show phenotypic similarities to cultured cells from ataxia telangiectasia and nijmegen break syndrome (nbs) patients and are likely to be defective in the same pathway in which the atm (ataxia telangiectasia-mutated) and the nbs genes operate. |
2000-11-03 |
2023-08-12 |
Not clear |
| S Matsuoka, G Rotman, A Ogawa, Y Shiloh, K Tamai, S J Elledg. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 19. 2000-10-12. PMID:10973490. |
phosphorylation and activation of chk2 are ataxia telangiectasia-mutated (atm) dependent in response to ir, whereas chk2 phosphorylation is atm-independent when cells are exposed to uv or hu. |
2000-10-12 |
2023-08-12 |
Not clear |
| D Delia, S Mizutani, S Panigone, E Tagliabue, E Fontanella, M Asada, T Yamada, Y Taya, S Prudente, S Saviozzi, L Frati, M A Pierotti, L Chess. ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes. British journal of cancer. vol 82. issue 12. 2000-07-10. PMID:10864201. |
of two ataxia without telangiectasia [a-(t)] cases, one expressed 20% and the other approximately 70% of the normal atm levels. |
2000-07-10 |
2023-08-12 |
Not clear |
| J Guan, S DiBiase, G Iliaki. The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication. Nucleic acids research. vol 28. issue 5. 2000-04-24. PMID:10666461. |
in mammalian cells, inhibition of replicon initiation requires the ataxia telagiectasia mutated ( atm ) gene, a member of the phosphatidyl inositol kinase-like (pikl) family of protein kinases. |
2000-04-24 |
2023-08-12 |
human |
| S Hassin-Baer, A Bar-Shira, S Gilad, Y Galanty, R Khosravi, A Lossos, N Giladi, R Weitz, B Ben-Zeev, Y Goldhammer, Y Shilo. Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia. Journal of neurology. vol 246. issue 8. 1999-10-19. PMID:10460451. |
in order to define the clinical phenotype of patients homozygous (or compound heterozygotes) for other, milder mutations, we decided to search for atm mutations in patients with either sporadic or familial idiopathic ataxia. |
1999-10-19 |
2023-08-12 |
Not clear |
| C Iftode, Y Daniely, J A Borowie. Replication protein A (RPA): the eukaryotic SSB. Critical reviews in biochemistry and molecular biology. vol 34. issue 3. 1999-10-12. PMID:10473346. |
rpa is a phosphorylation target for dna-dependent protein kinase (dna-pk) and likely the ataxia telangiectasia-mutated gene (atm) protein kinase, and recent observations are described that suggest that rpa phosphorylation plays a significant modulatory role in the cellular response to dna damage. |
1999-10-12 |
2023-08-12 |
Not clear |
| R Araki, R Fukumura, A Fujimori, Y Taya, Y Shiloh, A Kurimasa, S Burma, G C Li, D J Chen, K Sato, Y Hoki, K Tatsumi, M Ab. Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer research. vol 59. issue 15. 1999-09-07. PMID:10446957. |
our observation clearly indicates that dna-pk catalytic subunit does not phosphorylate p53 ser-18 in vivo or control the transactivation of p53 in response to dna damage, and these results further emphasize the different pathways in which ataxia telangiectasia-mutated (atm) and dna-pk operate following radiation damage. |
1999-09-07 |
2023-08-12 |
mouse |
| W C Liao, A Haimovitz-Friedman, R S Persaud, M McLoughlin, D Ehleiter, N Zhang, M Gatei, M Lavin, R Kolesnick, Z Fuk. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364237. |
stable transfection of wild type atm cdna reversed these events, whereas antisense inactivation of ataxia telangiectasia-mutated gene product in normal b cells conferred the ataxia telangiectasia phenotype. |
1999-07-15 |
2023-08-12 |
Not clear |
| F Teyssier, J O Bay, C Dionet, P Verrell. [Cell cycle regulation after exposure to ionizing radiation]. Bulletin du cancer. vol 86. issue 4. 1999-06-07. PMID:10341340. |
the ataxia telangectasia mutant (atm) protein and/or the dna-dependent protein kinase (dna-pk), that are both activated by dna damage, may initiate cell cycle arrest by activating the p53 tumor suppressor protein. |
1999-06-07 |
2023-08-12 |
human |
| D P Gately, J C Hittle, G K Chan, T J Ye. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Molecular biology of the cell. vol 9. issue 9. 1999-03-22. PMID:9725899. |
ataxia telangiectasia-mutated gene (atm) is a 350-kda protein whose function is defective in the autosomal recessive disorder ataxia telangiectasia (at). |
1999-03-22 |
2023-08-12 |
human |
| R Eilam, Y Peter, A Elson, G Rotman, Y Shiloh, Y Groner, M Sega. Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 21. 1998-11-12. PMID:9770541. |
surprisingly, mice in which the atm gene has been inactivated lack distinct behavioral ataxia or pronounced cerebellar degeneration, the hallmarks of the human disease. |
1998-11-12 |
2023-08-12 |
mouse |
| Y Fujiwar. [The mechanisms of aging and perspective for elimination of deleterious effects]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 33. issue 7. 1996-12-24. PMID:8890601. |
mutations in the cockayne syndrome genes (the csa and csb genes acting for preferential repair of active genes by interacting with transcription factor tfiih) and in the ataxia telangictasia gene atm (homologous with pi-3 kinase for signal transduction) have been disclosed. |
1996-12-24 |
2023-08-12 |
human |