| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung-Jung Mu, Yi Wang, Hao Luo, Mei Leng, Jinglan Zhang, Tao Yang, Dario Besusso, Sung Yun Jung, Jun Qi. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. The Journal of biological chemistry. vol 282. issue 24. 2007-09-25. PMID:17478428. |
atm (ataxia telangiectasia-mutated) and atr (atm-rad3-related) are proximal checkpoint kinases that regulate dna damage response (ddr). |
2007-09-25 |
2023-08-12 |
Not clear |
| Naval P Shanware, Anthony T Trinh, Leah M Williams, Randal S Tibbett. Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. The Journal of biological chemistry. vol 282. issue 9. 2007-06-18. PMID:17209043. |
we previously demonstrated that the interaction between creb and cbp is inhibited by dna-damaging stimuli through a mechanism whereby creb is phosphorylated by the ataxia telangiectasia-mutated (atm) protein kinase. |
2007-06-18 |
2023-08-12 |
Not clear |
| Kristof De Schutter, Jérôme Joubès, Toon Cools, Aurine Verkest, Florence Corellou, Elena Babiychuk, Els Van Der Schueren, Tom Beeckman, Sergeï Kushnir, Dirk Inzé, Lieven De Veylde. Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint. The Plant cell. vol 19. issue 1. 2007-06-18. PMID:17209125. |
upon the incidence of dna stress, the ataxia telangiectasia-mutated (atm) and rad3-related (atr) signaling kinases activate a transient cell cycle arrest that allows cells to repair dna before proceeding into mitosis. |
2007-06-18 |
2023-08-12 |
Not clear |
| Nozomi Tomimatsu, Candice G T Tahimic, Akihiro Otsuki, Sandeep Burma, Akiko Fukuhara, Kenzo Sato, Goshi Shiota, Mitsuo Oshimura, David J Chen, Akihiro Kurimas. Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. The Journal of biological chemistry. vol 282. issue 14. 2007-06-06. PMID:17272272. |
double strand break (dsb) recognition is the first step in the dsb damage response and involves activation of ataxia telangiectasia-mutated (atm) and phosphorylation of targets such as p53 to trigger cell cycle arrest, dna repair, or apoptosis. |
2007-06-06 |
2023-08-12 |
Not clear |
| Yuling Shi, Gerald E Dodson, Partha S Mukhopadhyay, Naval P Shanware, Anthony T Trinh, Randal S Tibbett. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. The Journal of biological chemistry. vol 282. issue 12. 2007-05-02. PMID:17244605. |
the functionally related atm (ataxia telangiectasia-mutated) and atr (atm-rad3-related) protein kinases are critical regulators of dna damage responses in mammalian cells. |
2007-05-02 |
2023-08-12 |
human |
| Young-Joo Jang, Jae-Hoon Ji, Young-Chul Choi, Chun Jeih Ryu, Seon-Yle K. Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. The Journal of biological chemistry. vol 282. issue 4. 2007-04-09. PMID:17121863. |
normally, ataxia telangiectasia-mutated kinase (atm) is a key enzyme involved in g2 phase cell cycle arrest following dna damage, and inhibition of plk1 by dna damage during g2 occurs in a atm/atr-dependent manner. |
2007-04-09 |
2023-08-12 |
Not clear |
| Amanda Dutton, Ciaran B Woodman, Marilyn B Chukwuma, James I K Last, Wenbin Wei, Martina Vockerodt, Karl R N Baumforth, Joanne R Flavell, Martin Rowe, A Malcolm R Taylor, Lawrence S Young, Paul G Murra. Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells. Blood. vol 109. issue 6. 2007-04-02. PMID:17148591. |
we show here that bmi-1 and lmp1 down-regulate the ataxia telangiectasia-mutated (atm) tumor suppressor and conclude that bmi-1 contributes to lmp1-induced oncogenesis in hl. |
2007-04-02 |
2023-08-12 |
mouse |
| Keisuke Ito, Keiyo Takubo, Fumio Arai, Hitoshi Satoh, Sahoko Matsuoka, Masako Ohmura, Kazuhito Naka, Masaki Azuma, Kana Miyamoto, Kentaro Hosokawa, Yasuo Ikeda, Tak W Mak, Toshio Suda, Atsushi Hira. Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 1. 2007-03-06. PMID:17182545. |
the ataxia telangiectasia-mutated (atm) gene plays a pivotal role in the maintenance of genomic stability. |
2007-03-06 |
2023-08-12 |
mouse |
| Noriyuki Miyoshi, Koji Uchida, Toshihiko Osawa, Yoshimasa Nakamur. Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells. International journal of cancer. vol 120. issue 3. 2007-02-05. PMID:17096346. |
we also observed ataxia telangiectasia-mutated (atm) phosphorylation in the quiescent cells. |
2007-02-05 |
2023-08-12 |
human |
| Giacomo Buscemi, Luigi Carlessi, Laura Zannini, Sofia Lisanti, Enrico Fontanella, Silvana Canevari, Domenico Deli. DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Molecular and cellular biology. vol 26. issue 21. 2007-01-30. PMID:16940182. |
phosphorylation of chk2 in vivo by ataxia telangiectasia-mutated (atm) on threonine 68 (t68) initiates a phosphorylation cascade that promotes the full activity of chk2. |
2007-01-30 |
2023-08-12 |
Not clear |
| Keiyo Takubo, Atsushi Hirao, Masako Ohmura, Masaki Azuma, Fumio Arai, Go Nagamatsu, Toshio Sud. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis. Biochemical and biophysical research communications. vol 351. issue 4. 2007-01-23. PMID:17097049. |
it has been shown that ataxia telangiectasia-mutated (atm) is required for meiotic division of the seminiferous tubules. |
2007-01-23 |
2023-08-12 |
mouse |
| Shutong Yang, Jae-Hoon Jeong, Alexandra L Brown, Chang-Hun Lee, Pier Paolo Pandolfi, Jay H Chung, Myung K Ki. Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. The Journal of biological chemistry. vol 281. issue 36. 2006-12-18. PMID:16835227. |
we demonstrate that pml interacts with chk2 and activates chk2 by mediating its autophosphorylation step, an essential step for chk2 activity that occurs after phosphorylation by the upstream kinase atm (ataxia telangiectasia-mutated). |
2006-12-18 |
2023-08-12 |
Not clear |
| W Li, W Jian, X Xiaoping, L Yingfeng, X Tao, X Xiaoya. Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16. issue 4. 2006-12-05. PMID:16884376. |
the ataxia telangiectasia-mutated (atm) protein, which is mutated in the inherited disease ataxia telangiectasia (at), is a key activator of cell cycle checkpoint, initiating cell response to dna damage and ensuring genomic stability. |
2006-12-05 |
2023-08-12 |
human |
| Cagri G Besirli, Eugene M Johnso. The activation loop phosphorylation of protein kinase D is an early marker of neuronal DNA damage. Journal of neurochemistry. vol 99. issue 1. 2006-11-14. PMID:16911582. |
phosphorylation of the pkd-activation domain could be detected within 15 min of genotoxic stress and was concurrent with ataxia telangiectasia-mutated (atm) activation. |
2006-11-14 |
2023-08-12 |
rat |
| Francine Durocher, Yvan Labrie, Penny Soucy, Olga Sinilnikova, Damian Labuda, Paul Bessette, Jocelyne Chiquette, Rachel Laframboise, Jean Lépine, Bernard Lespérance, Geneviève Ouellette, Roxane Pichette, Marie Plante, Sean V Tavtigian, Jacques Simar. Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families. BMC cancer. vol 6. 2006-11-08. PMID:17010193. |
ataxia telangiectasia-mutated and rad3-related (atr) is a member of the pik-related family which plays, along with atm, a central role in cell-cycle regulation. |
2006-11-08 |
2023-08-12 |
Not clear |
| Jaejoon Won, Mina Kim, Nuri Kim, Jin Hee Ahn, Woo Gil Lee, Sung Soo Kim, Ki-Young Chang, Yong-Weon Yi, Tae Kook Ki. Small molecule-based reversible reprogramming of cellular lifespan. Nature chemical biology. vol 2. issue 7. 2006-08-09. PMID:16767085. |
here we show that the intrinsic 'senescence clock' can be reset in a reversible manner by selective modulation of the ataxia telangiectasia-mutated (atm) protein and atm- and rad3-related (atr) protein with a small molecule, cgk733. |
2006-08-09 |
2023-08-12 |
human |
| Aude Dupré, Louise Boyer-Chatenet, Jean Gautie. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nature structural & molecular biology. vol 13. issue 5. 2006-07-12. PMID:16622404. |
this model clarifies the mechanism of atm activation in normal cells and explains the phenotype of cells from patients with ataxia telangiectasia-like disorder and nijmegen breakage syndrome. |
2006-07-12 |
2023-08-12 |
Not clear |
| Steven Bergink, Florian A Salomons, Deborah Hoogstraten, Tom A M Groothuis, Harm de Waard, Junxin Wu, Li Yuan, Elisabetta Citterio, Adriaan B Houtsmuller, Jacques Neefjes, Jan H J Hoeijmakers, Wim Vermeulen, Nico P Dantum. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes & development. vol 20. issue 10. 2006-07-05. PMID:16702407. |
uv-induced ubiquitylation of h2a is dependent on the dna damage signaling kinase atr (atm- and rad3-related) but not the related kinase atm (ataxia telangiectasia-mutated). |
2006-07-05 |
2023-08-12 |
Not clear |
| O Igoucheva, V Alexeev, K Yoo. Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene therapy. vol 13. issue 3. 2006-06-29. PMID:16177821. |
in addition, the presented data indicate that the presence of exogenous dsdna triggered a dna damage response by activation of atr (ataxia telangiectasia-rad3-related) but not atm (ataxia telangiectasia mutated) pathway. |
2006-06-29 |
2023-08-12 |
Not clear |
| Simon Bekker-Jensen, Claudia Lukas, Risa Kitagawa, Fredrik Melander, Michael B Kastan, Jiri Bartek, Jiri Luka. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. The Journal of cell biology. vol 173. issue 2. 2006-06-09. PMID:16618811. |
chromatin marked by gamma-h2ax is occupied by ataxia telangiectasia-mutated (atm) kinase, mdc1, and 53bp1. |
2006-06-09 |
2023-08-12 |
Not clear |