| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chung-Yi Chen, Ya-Ling Hsu, Yu-Chieh Tsai, Po-Lin Ku. Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 7. 2008-08-05. PMID:18511169. |
blockade of cell cycle was associated with increased the activation of ataxia telangiectasia-mutated (atm). |
2008-08-05 |
2023-08-12 |
human |
| Ali Jazayeri, Alessia Balestrini, Elizabeth Garner, James E Haber, Vincenzo Costanz. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. The EMBO journal. vol 27. issue 14. 2008-07-30. PMID:18596698. |
dna double-strand breaks (dsbs) can be processed by the mre11-rad50-nbs1 (mrn) complex, which is essential to promote ataxia telangiectasia-mutated (atm) activation. |
2008-07-30 |
2023-08-12 |
human |
| Xiaorong Zhao, Ramiro J Madden-Fuentes, Becky X Lou, James M Pipas, Jeannine Gerhardt, Christopher J Rigell, Ellen Fannin. Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. Journal of virology. vol 82. issue 11. 2008-06-11. PMID:18353955. |
we show here that in sv40-infected primate cells, the activated ataxia telangiectasia-mutated (atm) damage-signaling kinase, gamma-h2ax, and mre11-rad50-nbs1 (mrn) assemble with t antigen and other viral dna replication proteins in large nuclear foci. |
2008-06-11 |
2023-08-12 |
Not clear |
| Dashnamoorthy Ravi, Harish Muniyappa, Kumuda C Da. Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17932622. |
in the present study, we show that uv-induced nf-kappab activation is mediated by the activation of ataxia telangiecia mutated (atm) and protein kinase c (pkc). |
2008-06-10 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Arubala P Redd. Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18182058. |
pivotal changes in apoptosis and cell cycle pathways included twofold or greater increases in sod1, ikappabalpha, fas apoptotic inhibitory molecule, fibroblast growth factor-receptor 2 (fgfr2), neurotrophic tyrosine kinase receptor 2 (ntrk2), phosphoinositide-3-kinase (p85 subunit), cyclic amp dependent protein kinase (pka) (catalytic subunit), calpain 2, and ataxia telangectasia mutated (atm). |
2008-06-06 |
2023-08-12 |
monkey |
| John P Alao, Per Sunnerhage. Rad3 and Sty1 function in Schizosaccharomyces pombe: an integrated response to DNA damage and environmental stress? Molecular microbiology. vol 68. issue 2. 2008-05-23. PMID:18366437. |
in schizosaccharomyces pombe, the ataxia telangiectasia-mutated (atm)/atm and rad 3 related (atr) homologue rad3 is an essential regulator of the response to dna damage and stalled replication forks. |
2008-05-23 |
2023-08-12 |
Not clear |
| Alexander Roesch, Bernd Becker, Stefan Bentink, Rainer Spang, Annegret Vogl, Ilja Hagen, Michael Landthaler, Thomas Vog. Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 16. issue 11. 2008-05-16. PMID:18006941. |
of these transcripts, three were selected for immunohistochemical confirmation: tissue inhibitor of metalloproteinase-2, tumor protein d52, and ataxia telangiectasia-mutated gene (atm). |
2008-05-16 |
2023-08-12 |
human |
| D Watling, C R Carmo, I M Kerr, A P Costa-Pereir. Multiple kinases in the interferon-gamma response. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 16. 2008-05-12. PMID:18417454. |
as one example, inhibition of the ifn-gamma response by sirna to ataxia telangiectasia-mutated (atm) differentially affects a spectrum of ifn-gamma-stimulated mrnas, with inhibitions being seen as early as 1 h after ifn-gamma stimulation. |
2008-05-12 |
2023-08-12 |
Not clear |
| Johanna A Smith, Feng-Xiang Wang, Hui Zhang, Kou-Juey Wu, Kevin Jon Williams, René Danie. Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair. Virology journal. vol 5. 2008-04-22. PMID:18211700. |
in the current study, we found that the nijmegen breakage syndrome 1 protein (nbs1), an early sensor of dsbs, associates with hiv-1 dna, recruits the ataxia telangiectasia-mutated (atm) kinase, promotes stable retroviral transduction, mediates efficient integration of viral dna and blocks integrase-dependent apoptosis that can arise from unrepaired viral-host dna linkages. |
2008-04-22 |
2023-08-12 |
Not clear |
| L N Kwong, K R Weiss, K M Haigis, W F Dov. Atm is a negative regulator of intestinal neoplasia. Oncogene. vol 27. issue 7. 2008-03-04. PMID:17700532. |
the ataxia telangiectasia-mutated (atm) gene has been implicated as an early barrier to the growth and progression of incipient solid tumors. |
2008-03-04 |
2023-08-12 |
mouse |
| Hiroyuki Takai, Richard C Wang, Kaori K Takai, Haijuan Yang, Titia de Lang. Tel2 regulates the stability of PI3K-related protein kinases. Cell. vol 131. issue 7. 2008-02-07. PMID:18160036. |
the effects of tel2 deletion correlated with significantly reduced protein levels for the pi3k-related kinases ataxia telangiectasia mutated (atm), atm and rad3 related (atr), dna-dependent protein kinase catalytic subunit ataxia (dna-pkcs). |
2008-02-07 |
2023-08-12 |
mouse |
| Verónica Rodríguez-Bravo, Sandra Guaita-Esteruelas, Noelia Salvador, Oriol Bachs, Neus Agel. Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089794. |
here, we present clear insights in the different responses of tumor and non-transformed cells to the inhibition of dna replication with hydroxyurea in combination with checkpoint abrogation via inhibition of ataxia telangiectasia-mutated- (atm) and rad3-related/atm (atr/atm) and chk1 kinases. |
2008-01-15 |
2023-08-12 |
Not clear |
| Heather L Armata, David S Garlick, Hayla K Slus. The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089799. |
one of these phosphorylation sites (mouse ser(18) and human ser(15)) is a substrate for the ataxia telangiectasia-mutated (atm) and atm-related (atr) protein kinases. |
2008-01-15 |
2023-08-12 |
mouse |
| Christian R Loehberg, Tiia Thompson, Michael B Kastan, Kirsteen H Maclean, Dean G Edwards, Frances S Kittrell, Daniel Medina, Orla M Conneely, Bert W O'Malle. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089834. |
p53 activation occurs at a posttranslational level via chloroquine-dependent phosphorylation of the checkpoint protein kinase, ataxia telangiectasia-mutated (atm), leading to atm-dependent phosphorylation of p53. |
2008-01-15 |
2023-08-12 |
mouse |
| Matthew P Stokes, John Rush, Joan Macneill, Jian Min Ren, Kam Sprott, Julie Nardone, Vicky Yang, Sean A Beausoleil, Steven P Gygi, Mark Livingstone, Hui Zhang, Roberto D Polakiewicz, Michael J Com. Profiling of UV-induced ATM/ATR signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 50. 2008-01-11. PMID:18077418. |
the serine/threonine kinases ataxia telangiectasia-mutated (atm) and atm and rad3-related (atr) activate checkpoint signaling by phosphorylating substrate proteins at sq/tq motifs. |
2008-01-11 |
2023-08-12 |
Not clear |
| F Merolla, F Pentimalli, R Pacelli, G Vecchio, A Fusco, M Grieco, A Celett. Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17420723. |
the kinase ataxia telangectasia mutated (atm) phosphorylates a limited number of downstream protein targets in response to dna damage. |
2007-10-24 |
2023-08-12 |
Not clear |
| Michael W Lee, Wan-Ju Kim, Dillon I Beardsley, Kevin D Brow. N-methyl-N'-nitro-N-nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts. DNA and cell biology. vol 26. issue 9. 2007-10-23. PMID:17678437. |
in this study we examined the response of human fibroblasts, either proficient or deficient for the damage-activated protein kinase ataxia telangiectasia-mutated (atm), to the alkylating agent n-methyl-n'-nitro-n-nitrosoguanidine (mnng). |
2007-10-23 |
2023-08-12 |
human |
| Elke H Heiss, Yvonne D C Schilder, Verena M Dirsc. Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17626009. |
chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (atm)-dependent senescence in p53-positive cancer cells. |
2007-10-19 |
2023-08-12 |
Not clear |
| Satoko Iwahori, Noriko Shirata, Yasushi Kawaguchi, Sandra K Weller, Yoshitaka Sato, Ayumi Kudoh, Sanae Nakayama, Hiroki Isomura, Tatsuya Tsurum. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. Journal of virology. vol 81. issue 18. 2007-10-17. PMID:17609267. |
the ataxia telangiectasia-mutated (atm) protein, a member of the related phosphatidylinositol 3-like kinase family encoded by a gene responsible for the human genetic disorder ataxia telangiectasia, regulates cellular responses to dna damage and viral infection. |
2007-10-17 |
2023-08-12 |
human |
| Jung-Jung Mu, Yi Wang, Hao Luo, Mei Leng, Jinglan Zhang, Tao Yang, Dario Besusso, Sung Yun Jung, Jun Qi. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. The Journal of biological chemistry. vol 282. issue 24. 2007-09-25. PMID:17478428. |
a proteomic analysis of ataxia telangiectasia-mutated (atm)/atm-rad3-related (atr) substrates identifies the ubiquitin-proteasome system as a regulator for dna damage checkpoints. |
2007-09-25 |
2023-08-12 |
Not clear |