| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shan Zha, Chunguang Guo, Cristian Boboila, Valentyn Oksenych, Hwei-Ling Cheng, Yu Zhang, Duane R Wesemann, Grace Yuen, Harin Patel, Peter H Goff, Richard L Dubois, Frederick W Al. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. vol 469. issue 7329. 2011-02-11. PMID:21160472. |
the ataxia telangiectasia-mutated protein (atm) detects dsbs and activates dsb responses by phosphorylating substrates including histone h2ax. |
2011-02-11 |
2023-08-12 |
mouse |
| Yong Luo, Aaron Yun Chen, Jianming Qi. Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death. Journal of virology. vol 85. issue 1. 2011-01-20. PMID:21047968. |
we discovered that both atm (ataxia telangiectasia-mutated kinase) and atr (atm- and rad3-related kinase) were phosphorylated in mvc-infected wrd cells and confirmed that atm activation was responsible for the phosphorylation of h2ax, whereas atr activation was required for the phosphorylation of rpa32. |
2011-01-20 |
2023-08-12 |
Not clear |
| Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang, Lin Zhan. The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. Journal of experimental & clinical cancer research : CR. vol 29. 2010-12-28. PMID:20799949. |
emerging evidence suggests that ataxia telangiectasia-mutated (atm) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. |
2010-12-28 |
2023-08-12 |
Not clear |
| Neera Tewari-Singh, Mallikarjuna Gu, Chapla Agarwal, Carl W White, Rajesh Agarwa. Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chemical research in toxicology. vol 23. issue 6. 2010-10-04. PMID:20469912. |
mechanistic studies showed phosphorylation of dna damage sensors and checkpoint kinases, ataxia telangiectasia-mutated (atm) at ser1981 and ataxia telangiectasia-rad3-related (atr) at ser428 within 30 min of cees exposure, and modulation of s and g2-m phase-associated cell cycle regulatory proteins, which are downstream targets of atm and atr kinases. |
2010-10-04 |
2023-08-12 |
mouse |
| Daniela Volonte, Ferruccio Galbiat. Caveolin-1, cellular senescence and pulmonary emphysema. Aging. vol 1. issue 9. 2010-09-16. PMID:20157570. |
mechanistically, we uncovered that premature senescence of lung fibroblasts induced by oxidative stress occurred through activation of an ataxia telangiectasia-mutated (atm)/p53-depedent pathway following sequestration of the catalytic subunit of protein phosphatase 2a (pp2a-c), an inhibitor of atm, by caveolin-1 into caveolar membranes. |
2010-09-16 |
2023-08-12 |
mouse |
| Kristen E Hurov, Cecilia Cotta-Ramusino, Stephen J Elledg. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes & development. vol 24. issue 17. 2010-09-14. PMID:20810650. |
tti1 and tti2 exist in multiple complexes, including a 2-mda complex with tel2 (telomere maintenance 2), called the triple t complex, and phosphoinositide-3-kinase-related protein kinases (pikks) such as ataxia telangiectasia-mutated (atm). |
2010-09-14 |
2023-08-12 |
Not clear |
| Narisorn Kongruttanachok, Chutipa Phuangphairoj, Araya Thongnak, Wanpen Ponyeam, Prakasit Rattanatanyong, Wichai Pornthanakasem, Apiwat Mutirangur. Replication independent DNA double-strand break retention may prevent genomic instability. Molecular cancer. vol 9. 2010-07-30. PMID:20356374. |
during g0, most dsbs are repaired by non-homologous end-joining repair (nhej), mediated by at least two distinct pathways; the ku-mediated and the ataxia telangiectasia-mutated (atm)-mediated. |
2010-07-30 |
2023-08-12 |
Not clear |
| Deborah A Greer Card, Megan L Sierant, Scott Dave. Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. The Journal of biological chemistry. vol 285. issue 20. 2010-06-14. PMID:20305300. |
examination of ataxia telangectasia (a-t) cells demonstrates that atr does not compensate for atm loss, suggesting that phosphorylation of rad9a and chk2 by atm plays an additional role in response to topo ii inhibition than checkpoint function alone. |
2010-06-14 |
2023-08-12 |
Not clear |
| C Nam, K Doi, H Nakayam. Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway. Histology and histopathology. vol 25. issue 4. 2010-05-13. PMID:20183801. |
phosphorylation of ataxia telangiectasia-mutated kinase (atm) at ser1981 and gammah2ax after vp-16 treatment showed dna damage. |
2010-05-13 |
2023-08-12 |
mouse |
| Igor Landais, Sanne Hiddingh, Matthew McCarroll, Chao Yang, Aiming Sun, Mitchell S Turker, James P Snyder, Maureen E Hoatli. Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors. Molecular cancer. vol 8. 2010-04-29. PMID:20043851. |
the fa pathway displays synthetic lethal relationship with certain dna repair genes such as atm (ataxia telangectasia mutated) that are frequently mutated in tumors. |
2010-04-29 |
2023-08-12 |
Not clear |
| Yun Wu, Virginia A Zakia. Identity crisis when telomeres left unprotected. Journal of molecular cell biology. vol 2. issue 1. 2010-03-29. PMID:19805416. |
in a recent nature paper, chang and colleagues reported that the dna repair protein mre11 contributes to multiple events at the uncapped telomere, including ataxia telangiectasia-mutated (atm)-dependent signaling, processing of the telomeric g-tail and homologous recombination (hr). |
2010-03-29 |
2023-08-12 |
Not clear |
| Andrea Riccardo Filippi, Pierfrancesco Franco, Marco Galliano, Umberto Ricard. Peripheral blood complete remission after splenic irradiation in mantle-cell lymphoma with 11q22-23 deletion and ATM inactivation. Radiation oncology (London, England). vol 1. 2010-03-22. PMID:16956411. |
in this context, among nhls, mcl subtype has the highest rate of atm (ataxia teleangiectasia mutated) inactivation. |
2010-03-22 |
2023-08-12 |
Not clear |
| Ulrich Bork, Wing-Kee Lee, Anna Kuchler, Thomas Dittmar, Frank Théveno. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells. American journal of physiology. Renal physiology. vol 298. issue 2. 2010-03-09. PMID:19923412. |
the data indicate that in p53-inactivated pt cells cd(2+)-induced ros formation and dna damage trigger signaling of checkpoint activating kinases ataxia telangiectasia-mutated kinase (atm) and ataxia telangiectasia and rad3-related kinase (atr) to cause g(2)/m arrest. |
2010-03-09 |
2023-08-12 |
Not clear |
| Ya-Ling Hsu, Yih-Huei Uen, Yi Chen, Hsin-Lin Liang, Po-Lin Ku. Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. Journal of agricultural and food chemistry. vol 57. issue 18. 2010-01-28. PMID:19705844. |
cell cycle blockade is associated with increased activation of ataxia telangiectasia-mutated (atm). |
2010-01-28 |
2023-08-12 |
human |
| Hong Zhu, Ze-Hong Miao, Min Huang, Jian-Ming Feng, Zhi-Xiang Zhang, Jin-Jian Lu, Yu-Jun Cai, Lin-Jiang Tong, Yu-Fang Xu, Xu-Hong Qian, Jian Din. Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. Neoplasia (New York, N.Y.). vol 11. issue 11. 2010-01-08. PMID:19881958. |
then, r16 and amonafide were revealed to induce phosphorylation of the dna damage sensor ataxia telangiectasia-mutated (atm) responding to dna double-strand breaks (dsbs). |
2010-01-08 |
2023-08-12 |
human |
| Michael Stilmann, Michael Hinz, Seda Cöl Arslan, Anja Zimmer, Valérie Schreiber, Claus Scheiderei. A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Molecular cell. vol 36. issue 3. 2010-01-06. PMID:19917246. |
the sumo-1 ligase piasy and the kinase ataxia talengiectasia mutated (atm) have been implicated to sumoylate and phosphorylate nuclear ikkgamma (nemo) in a consecutive mode of action, which in turn results in activation of cytoplasmic ikk holocomplexes. |
2010-01-06 |
2023-08-12 |
Not clear |
| Lian Xue, Dong Yu, Yoshiya Furusawa, Ryuichi Okayasu, Jian Tong, Jianping Cao, Saijun Fa. Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation. Mutation research. vol 670. issue 1-2. 2010-01-05. PMID:19583974. |
the novel function of ataxia telangiectasia-mutated (atm) protein is its involvement in the dsb repair of slow kinetics for "dirty" breaks rejoining by nhej, this suggests that atm may play a more important role in high let radiation-induced dna damage. |
2010-01-05 |
2023-08-12 |
human |
| Ali Entezam, Karen Usdi. ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice. Nucleic acids research. vol 37. issue 19. 2009-12-21. PMID:19710035. |
by crossing the fx premutation mice to ataxia telangiectasia-mutated (atm) mutant mice, we show here that atm also prevents repeat expansion. |
2009-12-21 |
2023-08-12 |
mouse |
| Ya-Ling Hsu, Chun-Chieh Chia, Ping-Jye Chen, Su-Er Huang, Soon-Cen Huang, Po-Lin Ku. Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. Molecular nutrition & food research. vol 53. issue 7. 2009-10-22. PMID:19536869. |
blockade of cell cycle is associated with increased activation of ataxia telangiectasia-mutated (atm). |
2009-10-22 |
2023-08-12 |
human |
| Yongjiang Li, Emma Bolderson, Rakesh Kumar, Parameswary A Muniandy, Yutong Xue, Derek J Richard, Michael Seidman, Tej K Pandita, Kum Kum Khanna, Weidong Wan. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. The Journal of biological chemistry. vol 284. issue 35. 2009-10-19. PMID:19605351. |
hssb1 (human single strand dna-binding protein 1) has been shown to participate in homologous recombination (hr)-dependent repair of dna double strand breaks (dsbs) and ataxia telangiectasia-mutated (atm)-mediated checkpoint pathways. |
2009-10-19 |
2023-08-12 |
human |