| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vicky L Brandt, Susannah L Hewitt, Jane A Sko. It takes two: communication between homologous alleles preserves genomic stability during V(D)J recombination. Nucleus (Austin, Tex.). vol 1. issue 1. 2012-06-29. PMID:21327101. |
this relocation to pch requires the dna damage sensor atm (ataxia telengiectasia mutated). |
2012-06-29 |
2023-08-12 |
Not clear |
| Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koik. Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions. Proteomics. vol 12. issue 2. 2012-05-07. PMID:22121028. |
in contrast, shifts in the mobility of various phosphorylated species of a high-molecular-mass protein, ataxia telangiectasia-mutated kinase (atm, 350 kda), could only be detected in the tris-acoh system with a 3% w/v polyacrylamide gel strengthened with 0.5% w/v agarose. |
2012-05-07 |
2023-08-12 |
Not clear |
| Valentyn Oksenych, Frederick W Alt, Vipul Kumar, Bjoern Schwer, Duane R Wesemann, Erica Hansen, Harin Patel, Arthur Su, Chunguang Gu. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 7. 2012-04-20. PMID:22308489. |
mutations in the xlf c-nhej factor or ataxia telangiectasia-mutated (atm) dsb response protein cause radiosensitivity and immunodeficiency in humans. |
2012-04-20 |
2023-08-12 |
mouse |
| Idoia Martín-Guerrero, Anna Enjuanes, Julia Richter, Ole Ammerpohl, Dolors Colomer, Maite Ardanaz, Fernando Marco, Antonio Salas, Elias Campo, Reiner Siebert, Africa García-Ora. A putative "hepitype" in the ATM gene associated with chronic lymphocytic leukemia risk. Genes, chromosomes & cancer. vol 50. issue 11. 2012-03-15. PMID:21910157. |
the atm (ataxia telangiectasia-mutated) protein is the principal integrator of cellular responses to dsbs. |
2012-03-15 |
2023-08-12 |
Not clear |
| Meta Volcic, Sabine Karl, Bernd Baumann, Daniela Salles, Peter Daniel, Simone Fulda, Lisa Wiesmülle. NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes. Nucleic acids research. vol 40. issue 1. 2012-02-27. PMID:21908405. |
even though nf-κb can be activated by dna damage via ataxia telangiectasia-mutated (atm) signalling, little was known about an involvement in dna repair. |
2012-02-27 |
2023-08-12 |
Not clear |
| Tibor Pastor, Franco Pagan. Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858080. |
we have previously identified an alu-derived intronic splicing enhancer (ise) in the ataxia teleangectasia mutated gene (atm) that facilitates intron pre-mrna processing and leads to the inclusion of a cryptic exon in the final mrna transcript. |
2012-02-15 |
2023-08-12 |
Not clear |
| Dana L Madison, Daniel Stauffer, James R Lundbla. The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. DNA repair. vol 10. issue 10. 2012-01-30. PMID:21840268. |
parp1 interacts with the cell cycle checkpoint proteins ataxia telangectasia mutated (atm) and atm and rad3-related (atr) and therefore may influence growth arrest cascades. |
2012-01-30 |
2023-08-12 |
Not clear |
| Eric F Joyce, Michael Pedersen, Stanley Tiong, Sanese K White-Brown, Anshu Paul, Shelagh D Campbell, Kim S McKi. Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. The Journal of cell biology. vol 195. issue 3. 2012-01-12. PMID:22024169. |
ataxia telangiectasia-mutated (atm) and ataxia telangiectasia-related (atr) kinases are conserved regulators of cellular responses to double strand breaks (dsbs). |
2012-01-12 |
2023-08-12 |
drosophila_melanogaster |
| Bunsyo Shiotani, Lee Zo. A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases. Methods in molecular biology (Clifton, N.J.). vol 782. 2012-01-09. PMID:21870292. |
the ataxia telangiectasia-mutated (atm) and the atm-rad3-related (atr) kinases are master regulators of the dna damage-signaling pathways that respond to a wide variety of dna damage. |
2012-01-09 |
2023-08-12 |
human |
| Gudrun Böhmdorfer, Alexander Schleiffer, Reinhard Brunmeir, Stefan Ferscha, Viktoria Nizhynska, Jaroslav Kozák, Karel J Angelis, David P Kreil, Dieter Schweize. GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis. The Plant journal : for cell and molecular biology. vol 67. issue 3. 2011-11-07. PMID:21481027. |
the induction of gmi1 by γ-irradiation depends on the signalling kinase ataxia telangiectasia-mutated (atm) but not on atm and rad3-related (atr). |
2011-11-07 |
2023-08-12 |
Not clear |
| Kathleen A Wilson, Sierra A Colavito, Vincent Schulz, Patricia Heffernan Wakefield, William Sessa, David Tuck, David F Ster. NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Molecular cancer research : MCR. vol 9. issue 6. 2011-10-21. PMID:21551225. |
nfbd1 binds to the chromatin component γh2ax at sites of dna damage, causing amplification of ataxia telangiectasia-mutated gene (atm) pathway signaling and recruitment of dna repair factors. |
2011-10-21 |
2023-08-12 |
Not clear |
| Edward A Nam, Runxiang Zhao, Gloria G Glick, Carol E Bansbach, David B Friedman, David Corte. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21705319. |
the dna damage response kinases ataxia telangiectasia-mutated (atm), dna-dependent protein kinase (dna-pk), and ataxia telangiectasia-mutated and rad3-related (atr) signal through multiple pathways to promote genome maintenance. |
2011-10-19 |
2023-08-12 |
Not clear |
| E M Goetz, B Shankar, Y Zou, J C Morales, X Luo, S Araki, R Bachoo, L D Mayo, D A Boothma. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene. vol 30. issue 35. 2011-10-14. PMID:21460853. |
here, we show that activation of ataxia telangiectasia-mutated kinase (atm) by endogenous or exogenous forms of dna damage was required to relieve basal repression of igf-1 transcription by the p53/nf-ya complex, leading to sclu expression. |
2011-10-14 |
2023-08-12 |
Not clear |
| Jacquelyn J Bower, Yingchun Zhou, Tong Zhou, Dennis A Simpson, Sonnet J Arlander, Richard S Paules, Marila Cordeiro-Stone, William K Kaufman. Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM. Cell cycle (Georgetown, Tex.). vol 9. issue 8. 2011-09-09. PMID:20372057. |
previous studies indicated that the atm- and rad3-related (atr) checkpoint kinase, but not the ataxia telangiectasia-mutated (atm) kinase, was required for decatenation g2 checkpoint function. |
2011-09-09 |
2023-08-12 |
human |
| Chunlan Yan, Jing Lu, Guanglin Zhang, Tieer Gan, Qunli Zeng, Zhengping Shao, Penelope J Duerksen-Hughes, Jun Yan. Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 1. 2011-05-17. PMID:20888899. |
h2ax is phosphorylated (γh2ax) by members of the phosphatidylinositol 3-kinase (pi3k) family, including ataxia telangiectasia-mutated (atm), atm- and rad3-related (atr) and dna-pk in response to dna damage. |
2011-05-17 |
2023-08-12 |
mouse |
| Ming Yang, Li Zhang, Nan Bi, Wei Ji, Wen Tan, Lujun Zhao, Dianke Yu, Chen Wu, Luhua Wang, Dongxin Li. Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. International journal of radiation oncology, biology, physics. vol 79. issue 5. 2011-05-12. PMID:20729006. |
accumulating evidence indicates that p53 and the ataxia telangiectasia-mutated protein (atm)-dependent signaling response cascade play a crucial role in radiation-induced diseases. |
2011-05-12 |
2023-08-12 |
Not clear |
| D H'mida-Ben Brahim, A M'zahem, M Assoum, Y Bouhlal, F Fattori, M Anheim, L Ali-Pacha, F Ferrat, M Chaouch, C Lagier-Tourenne, N Drouot, C Thibaut, T Benhassine, Y Sifi, D Stoppa-Lyonnet, K N'Guyen, J Poujet, A Hamri, F Hentati, R Amouri, F M Santorelli, M Tazir, M Koeni. Molecular diagnosis of known recessive ataxias by homozygosity mapping with SNP arrays. Journal of neurology. vol 258. issue 1. 2011-04-25. PMID:20798953. |
we identified six families homozygous for regions containing the autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs) gene, two families homozygous for the ataxia-telangiectasia gene (atm), two families homozygous for the ataxia with oculomotor apraxia type 1 (aoa1) gene, and one family homozygous for the aoa type 2 (aoa2) gene. |
2011-04-25 |
2023-08-12 |
Not clear |
| Zirui Zheng, Junyan Li, Jing Sun, Ting Song, Congwen Wei, Yanhong Zhang, Guirong Rao, Guangming Chen, DeChao Li, Gongming Yang, Bao Han, Shi Wei, Cheng Cao, Hui Zhon. Inhibition of HBV replication by theophylline. Antiviral research. vol 89. issue 2. 2011-04-25. PMID:21167867. |
in this study, we show that one of the clinically used compounds of atr and ataxia telangiectasia-mutated (atm) kinases inhibitor, theophylline (tp), significantly reduced the yield of hbv dna, hbsag and hbeag in hepg2215 cell culture system, furthermore, tp could also suppress serum hbv dna and hbsag levels in the hbv-transgenic mice. |
2011-04-25 |
2023-08-12 |
mouse |
| Shan Zha, Wenxia Jiang, Yuko Fujiwara, Harin Patel, Peter H Goff, James W Brush, Richard L Dubois, Frederick W Al. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 5. 2011-03-23. PMID:21245310. |
dna-pkcs and the ataxia telangiectasia-mutated (atm) kinase are members of the same family, and they share common substrates in the dna damage response. |
2011-03-23 |
2023-08-12 |
Not clear |
| Tracey A Dobbs, John A Tainer, Susan P Lees-Mille. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA repair. vol 9. issue 12. 2011-03-02. PMID:21030321. |
more generally, they provide prototypic information for the phosphatidylinositol-3 kinase-like (pikk) family of serine/threonine protein kinases that includes ataxia telangiectasia-mutated (atm) and atm-, rad3-related (atr) as well as dna-pkcs. |
2011-03-02 |
2023-08-12 |
Not clear |