| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karen S Hathcock, Steven Bowen, Ferenc Livak, Richard J Hode. ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire. PloS one. vol 8. issue 4. 2013-11-26. PMID:23626787. |
the present report investigates the requirement for ataxia telangiectasia-mutated (atm) kinase, a component of dna double-strand break repair, during tcrβ recombination and in subsequent tcrβ-dependent repertoire generation and thymocyte development. |
2013-11-26 |
2023-08-12 |
mouse |
| Jia Guo, Philip C Hanawalt, Graciela Spiva. Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells. Nucleic acids research. vol 41. issue 16. 2013-11-05. PMID:23775797. |
to validate our method, we have documented transcription-coupled repair of cyclobutane pyrimidine dimers in the ataxia telangiectasia-mutated (atm) gene in human fibroblasts irradiated with 254 nm ultraviolet at 0.1 j/m2, a dose ∼100-fold lower than those typically used. |
2013-11-05 |
2023-08-12 |
human |
| Stela S Palii, Yuxia Cui, Cynthia L Innes, Richard S Paule. Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit. Cell cycle (Georgetown, Tex.). vol 12. issue 7. 2013-10-21. PMID:23462183. |
the phosphoinositide 3-kinase-related kinases (pikks) ataxia telangiectasia-mutated (atm), atm and rad 3-related kinase (atr) and dna-dependent protein kinase (dna-pk) are crucial for sensing lesions and signal transduction. |
2013-10-21 |
2023-08-12 |
Not clear |
| Ye Xu, Chang Xu, Brendan D Pric. Mechanistic links between ATM and histone methylation codes during DNA repair. Progress in molecular biology and translational science. vol 110. 2013-09-30. PMID:22749149. |
the ataxia telangiectasia-mutated (atm) protein kinase is the master regulator of the dna double-strand break (dsb) repair pathway. |
2013-09-30 |
2023-08-12 |
human |
| Houda Mokrani-Benhelli, Laetitia Gaillard, Patricia Biasutto, Tangui Le Guen, Fabien Touzot, Nadia Vasquez, Jun Komatsu, Emmanuel Conseiller, Capucine Pïcard, Eliane Gluckman, Christine Francannet, Alain Fischer, Anne Durandy, Jean Soulier, Jean-Pierre de Villartay, Marina Cavazzana-Calvo, Patrick Rev. Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations. Human mutation. vol 34. issue 2. 2013-07-26. PMID:23111928. |
ataxia telangiectasia-mutated (atm) and ataxia telangiectasia and rad3-related (atr) kinases are two key regulators of dna-damage responses (ddr) that are mainly activated in response to dna double-strand breaks and single-stranded dna damages, respectively. |
2013-07-26 |
2023-08-12 |
human |
| Carla Hajj, Adriana Haimovitz-Friedma. Sphingolipids' role in radiotherapy for prostate cancer. Handbook of experimental pharmacology. issue 216. 2013-07-24. PMID:23563654. |
j biol chem 283:5677-5684, 2008).this de novo ceramide synthesis has been observed in irradiated cells through a pathway normally suppressed by ataxia telangiectasia-mutated (atm) protein, a key component of the cellular response to dna double-strand breaks (liao et al. |
2013-07-24 |
2023-08-12 |
human |
| Ji-Hoon Lee, Michael R Mand, Rajashree A Deshpande, Eri Kinoshita, Soo-Hyun Yang, Claire Wyman, Tanya T Paul. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. The Journal of biological chemistry. vol 288. issue 18. 2013-07-12. PMID:23525106. |
ataxia telangiectasia-mutated (atm) kinase activity is regulated by atp-driven conformational changes in the mre11/rad50/nbs1 (mrn) complex. |
2013-07-12 |
2023-08-12 |
Not clear |
| Ji-Hoon Lee, Michael R Mand, Rajashree A Deshpande, Eri Kinoshita, Soo-Hyun Yang, Claire Wyman, Tanya T Paul. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. The Journal of biological chemistry. vol 288. issue 18. 2013-07-12. PMID:23525106. |
the ataxia telangiectasia-mutated (atm) protein kinase is recruited to sites of double-strand dna breaks by the mre11/rad50/nbs1 (mrn) complex, which also facilitates atm monomerization and activation. |
2013-07-12 |
2023-08-12 |
Not clear |
| Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, Domenico Deli. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22735644. |
here, we report that, in human cell lines, dna damage triggered the phosphorylation of dbc1 on thr454 by atm (ataxia telangiectasia-mutated) and atr (ataxia telangiectasia and rad3-related) kinases. |
2013-06-21 |
2023-08-12 |
human |
| L Lundholm, P Hååg, D Zong, T Juntti, B Mörk, R Lewensohn, K Viktorsso. Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. Cell death & disease. vol 4. 2013-06-17. PMID:23370278. |
indeed, we found that tics exhibited increased basal γh2ax (h2a histone family, member x) expression and diminished dna damage-induced phosphorylation of dna-dependent protein kinase (dna-pk), ataxia telangiectasia-mutated (atm), krüppel-associated protein 1 (kap1) and monoubiquitination of fanconi anemia, complementation group d2 (fancd2). |
2013-06-17 |
2023-08-12 |
mouse |
| Elizabeth M Kass, Hildur R Helgadottir, Chun-Chin Chen, Maria Barbera, Raymond Wang, Ulrica K Westermark, Thomas Ludwig, Mary Ellen Moynahan, Maria Jasi. Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 14. 2013-06-11. PMID:23509290. |
consistent with an hdr defect, brca1 mutant mice are highly sensitive to the cross-linking agent mitomycin c. by contrast, loss of the dsb signaling ataxia telangiectasia-mutated (atm) kinase did not significantly alter hdr levels, indicating that atm is dispensable for hdr. |
2013-06-11 |
2023-08-12 |
mouse |
| Yong Luo, Xuefeng Deng, Fang Cheng, Yi Li, Jianming Qi. SMC1-mediated intra-S-phase arrest facilitates bocavirus DNA replication. Journal of virology. vol 87. issue 7. 2013-05-02. PMID:23365434. |
the intra-s-phase arrest is regulated by atm (ataxia telangiectasia-mutated kinase) signaling in a p53-independent manner. |
2013-05-02 |
2023-08-12 |
Not clear |
| Rebeka Sultana, Tarek Abdel-Fatah, Rachel Abbotts, Claire Hawkes, Nada Albarakati, Claire Seedhouse, Graham Ball, Stephen Chan, Emad A Rakha, Ian O Ellis, Srinivasan Madhusuda. Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer research. vol 73. issue 5. 2013-04-26. PMID:23253910. |
preclinically, we evaluated xrcc1-deficient and -proficient chinese hamster and human cancer cells for synthetic lethality application using double-strand break (dsb) repair inhibitors [ku55933 (ataxia telangectasia-mutated; atm inhibitor) and nu7441 (dna-pkcs inhibitor)]. |
2013-04-26 |
2023-08-12 |
human |
| Prashanthi Javvadi, Haruhiko Makino, Amit K Das, Yu-Fen Lin, David J Chen, Benjamin P Chen, Chaitanya S Nirod. Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Molecular cancer research : MCR. vol 10. issue 10. 2013-04-24. PMID:22923485. |
the data reveal that both the kinase activity of dna-pkcs and radiation-induced phosphorylation of dna-pkcs by the ataxia telangiectasia-mutated (atm) kinase are critical prerequisites for egfr-mediated radioresponse. |
2013-04-24 |
2023-08-12 |
human |
| Michele Menotta, Sara Biagiotti, Marzia Bianchi, Luciana Chessa, Mauro Magnan. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23055520. |
dexamethasone partially rescues ataxia telangiectasia-mutated (atm) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. |
2013-02-07 |
2023-08-12 |
Not clear |
| Michele Menotta, Sara Biagiotti, Marzia Bianchi, Luciana Chessa, Mauro Magnan. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23055520. |
ataxia telangiectasia (at) is a rare genetic disease, still incurable, resulting from biallelic mutations in the ataxia telangiectasia-mutated (atm) gene. |
2013-02-07 |
2023-08-12 |
Not clear |
| Franziska Hoche, Kay Seidel, Marius Theis, Stefan Vlaho, Ralf Schubert, Stefan Zielen, Matthias Kieslic. Neurodegeneration in ataxia telangiectasia: what is new? What is evident? Neuropediatrics. vol 43. issue 3. 2012-11-06. PMID:22614068. |
neurodegeneration in at is closely related to the absence or partial lack of the ataxia telangiectasia-mutated (atm) kinase. |
2012-11-06 |
2023-08-12 |
Not clear |
| Emma Bolderson, Kienan I Savage, Robert Mahen, Venkat Pisupati, Mark E Graham, Derek J Richard, Phillip J Robinson, Ashok R Venkitaraman, Kum Kum Khann. Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin. The Journal of biological chemistry. vol 287. issue 33. 2012-11-05. PMID:22715096. |
recent studies have shown that the repair of transcriptionally inactive chromatin, named heterochromatin, is dependent upon the phosphorylation of the co-repressor, krüppel-associated box (krab) domain-associated protein (kap-1), by the ataxia telangiectasia-mutated (atm) kinase. |
2012-11-05 |
2023-08-12 |
Not clear |
| Hui-Chun Wang, Alan Yueh-Luen Lee, Wen-Cheng Chou, Chin-Chung Wu, Chao-Neng Tseng, Kevin Yen-Ting Liu, Wen-Lien Lin, Fang-Rong Chang, Da-Wei Chuang, Attila Hunyadi, Yang-Chang W. Inhibition of ATR-dependent signaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22532598. |
dna damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (atm) and atm and rad3-related (atr)-dependent phosphorylation of chk2 and chk1 kinases, which are hallmarks of the dna damage response (ddr). |
2012-10-31 |
2023-08-12 |
Not clear |
| Junna Ye, Yan Qi, Weiqing Wang, Fukang Sun, Qin Wei, Tingwei Su, Weiwei Zhou, Yiran Jiang, Wenqi Yuan, Jianfei Cai, Bin Cui, Guang Nin. Lower expression of ATM and gene deletion is more frequent in adrenocortical carcinomas than adrenocortical adenomas. Endocrine. vol 41. issue 3. 2012-09-13. PMID:22311173. |
there was a significant difference in the number of aberration copies of the ataxia telangiectasia-mutated (atm) gene located on chromosome 11q22-q23 between accs and acas. |
2012-09-13 |
2023-08-12 |
Not clear |