| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ravichandran Panchanathan, Hongzhu Liu, Divaker Choube. Activation of p53 in Human and Murine Cells by DNA-Damaging Agents Differentially Regulates Aryl Hydrocarbon Receptor Levels. International journal of toxicology. vol 34. issue 3. 2016-03-01. PMID:25878193. |
because dox in cells activates a dna damage response involving ataxia telangiectasia-mutated (atm)-mediated activation of p53, we investigated whether the activation of the p53 in cells by dna-damaging agents such as dox or bleomycin could regulate the ahr levels. |
2016-03-01 |
2023-08-13 |
human |
| Elisabeth Roitinger, Manuel Hofer, Thomas Köcher, Peter Pichler, Maria Novatchkova, Jianhua Yang, Peter Schlögelhofer, Karl Mechtle. Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana. Molecular & cellular proteomics : MCP. vol 14. issue 3. 2015-12-03. PMID:25561503. |
quantitative phosphoproteomics of the ataxia telangiectasia-mutated (atm) and ataxia telangiectasia-mutated and rad3-related (atr) dependent dna damage response in arabidopsis thaliana. |
2015-12-03 |
2023-08-13 |
Not clear |
| Elisabeth Roitinger, Manuel Hofer, Thomas Köcher, Peter Pichler, Maria Novatchkova, Jianhua Yang, Peter Schlögelhofer, Karl Mechtle. Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana. Molecular & cellular proteomics : MCP. vol 14. issue 3. 2015-12-03. PMID:25561503. |
the two serine/threonine protein kinases ataxia telangiectasia-mutated (atm) and ataxia telangiectasia-mutated and rad3-related (atr) are key factors in this process, each specific for different kinds of dna lesions. |
2015-12-03 |
2023-08-13 |
Not clear |
| Szu-Ying Wu, Shiow-Lin Pan, Zhi-Yan Xiao, Jui-Ling Hsu, Mei-Chuan Chen, Kuo-Hsiung Lee, Che-Ming Ten. NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells. PloS one. vol 9. issue 11. 2015-11-25. PMID:25372714. |
nprl-z-1 induced ataxia telangiectasia-mutated (atm) protein kinase phosphorylation at serine 1981, leading to the activation of dna damage signaling pathways, including chk2, histone h2ax, and p53/p21. |
2015-11-25 |
2023-08-13 |
human |
| Daniel L Menezes, Jenny Holt, Yan Tang, Jiajia Feng, Paul Barsanti, Yue Pan, Majid Ghoddusi, Wei Zhang, George Thomas, Jocelyn Holash, Emma Lees, Lorena Tarican. A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25232030. |
not surprisingly, disruption of key dna damage response pathway factors, such as ataxia telangiectasia-mutated (atm)/ataxia telangiectasia and rad3-related (atr) results in loss of genomic integrity. |
2015-09-16 |
2023-08-13 |
Not clear |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
these steps include physical interaction with bcl2 and attenuation of akt-dependent inhibition of foxo3a functions, such as transcriptional induction of bim and phosphorylation of ataxia telangiectasia-mutated (atm) after dna damage. |
2015-09-11 |
2023-08-13 |
human |
| Suprawee Tepsuporn, Jiazhi Hu, Monica Gostissa, Frederick W Al. Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer immunology research. vol 2. issue 9. 2015-08-31. PMID:24913718. |
the ataxia telangiectasia-mutated (atm) kinase senses dna double-strand breaks (dsb) and facilitates their repair. |
2015-08-31 |
2023-08-13 |
mouse |
| K Yamamoto, B J Lee, C Li, R L Dubois, E Hobeika, G Bhagat, S Zh. Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice. Leukemia. vol 29. issue 6. 2015-08-25. PMID:25676421. |
ataxia telangiectasia-mutated (atm) kinase is a master regulator of the dna damage response. |
2015-08-25 |
2023-08-13 |
mouse |
| W-T Wang, J W F Catto, M Meut. Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene. vol 34. issue 22. 2015-08-24. PMID:25043304. |
the primary signalling cascade responding to replication stress in malignant cells (ataxia telangiectasia-mutated (atm) and rad3-related-checkpoint kinase 1 (atr-chk1)) is not activated in htert-nhu cells after treatment with a replication inhibitor and these cells do not depend upon chk1 for protection from apoptosis during replication stress. |
2015-08-24 |
2023-08-13 |
human |
| Cui-Cui Sun, Hui-Min Xu, Yi Yuan, Zu-Hua Gao, Hong-Xiang Lou, Xian-Jun Q. Riccardin D, a macrocyclic bisbibenzy, inhibits human breast cancer growth through the suppression of telomerase activity. Basic & clinical pharmacology & toxicology. vol 115. issue 6. 2015-07-28. PMID:24836118. |
telomerase inhibition and telomere dysfunction could activate the canonical ataxia telangiectasia-mutated (atm) kinase-mediated dna damage response, as shown by elevated expression of γ-h2 ax, p-atm and p-chk2. |
2015-07-28 |
2023-08-13 |
mouse |
| Liang Liu, Weiying Zhou, Chun-Ting Cheng, Xiubao Ren, George Somlo, Miranda Y Fong, Andrew R Chin, Hui Li, Yang Yu, Yang Xu, Sean Timothy Francis O'Connor, Timothy R O'Connor, David K Ann, Jeremy M Stark, Shizhen Emily Wan. TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. Molecular cancer research : MCR. vol 12. issue 11. 2015-07-22. PMID:25103497. |
previously, it was reported that tgfβ downregulates the expression of ataxia telangiectasia-mutated (atm) and muts homolog 2 (msh2) in breast cancer cells through an mirna-mediated mechanism. |
2015-07-22 |
2023-08-13 |
human |
| Y Yan, A L Hein, P M Greer, Z Wang, R H Kolb, S K Batra, K H Cowa. A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation. Oncogene. vol 34. issue 17. 2015-06-29. PMID:24909175. |
g2 checkpoint activation involves activation of ataxia telangiectasia-mutated (atm)/atm- and rad3-related (atr) signalings, which leads to the inhibition of cdc2 kinase and subsequent g2/m cell cycle arrest. |
2015-06-29 |
2023-08-13 |
human |
| Rui Gao, Yongping Liu, Anabela Silva-Fernandes, Xiang Fang, Adriana Paulucci-Holthauzen, Arpita Chatterjee, Hang L Zhang, Tohru Matsuura, Sanjeev Choudhary, Tetsuo Ashizawa, Arnulf H Koeppen, Patricia Maciel, Tapas K Hazra, Partha S Sarka. Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS genetics. vol 11. issue 1. 2015-06-29. PMID:25590633. |
in the present study, we show that the essential dna strand break repair enzyme pnkp (polynucleotide kinase 3'-phosphatase) interacts with, and is inactivated by, the mutant atxn3, resulting in inefficient dna repair, persistent accumulation of dna damage/strand breaks, and subsequent chronic activation of the dna damage-response ataxia telangiectasia-mutated (atm) signaling pathway in sca3. |
2015-06-29 |
2023-08-13 |
Not clear |
| Yuan He, Qian-ming Chen, Lan-yan Wu, Bing-qi L. [Role of ataxia telangiectasis mutated in the oncogenesis of oral squamous cell carcinoma]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. vol 26. issue 1. 2015-06-06. PMID:18357894. |
to investigate the role of ataxia telangiectasis mutated (atm) gene in the oncogenesis and progression of oral squamous cell carcinoma (oscc). |
2015-06-06 |
2023-08-12 |
Not clear |
| Lihua Dong, Jingkun Cui, Fengjiao Tang, Xiaofeng Cong, Fujun Ha. Ataxia telangiectasia-mutated gene polymorphisms and acute normal tissue injuries in cancer patients after radiation therapy: a systematic review and meta-analysis. International journal of radiation oncology, biology, physics. vol 91. issue 5. 2015-06-03. PMID:25832699. |
studies of the association between ataxia telangiectasia-mutated (atm) gene polymorphisms and acute radiation injuries are often small in sample size, and the results are inconsistent. |
2015-06-03 |
2023-08-13 |
Not clear |
| Bo Wang, Lisha Zhang, Fuman Qiu, Wenxiang Fang, Jieqiong Deng, Yifeng Zhou, Jiachun Lu, Lei Yan. A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese. PloS one. vol 9. issue 9. 2015-05-28. PMID:25198518. |
mediator of dna damage checkpoint protein 1 (mdc1) plays an early and core role in double-strand break repair (ddr) and ataxia telangiectasia-mutated (atm) mediated response to dna double-strand breaks (dsbs), and thus involves the pathogenesis of several dna damage-related diseases such as cancer. |
2015-05-28 |
2023-08-13 |
Not clear |
| Mohammad Abu-Odeh, Zaidoun Salah, Christoph Herbel, Thomas G Hofmann, Rami I Aqeila. WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 44. 2015-04-14. PMID:25331887. |
we show that wwox deficiency results in reduced activation of the ataxia telangiectasia-mutated (atm) checkpoint kinase, inefficient induction and maintenance of γ-h2ax foci, and impaired dna repair. |
2015-04-14 |
2023-08-13 |
Not clear |
| Ryan T Y Wu, Lei Cao, Benjamin P C Chen, Wen-Hsing Chen. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25336634. |
oxidative stress and persistent dna damage response contribute to cellular senescence, a degeneration process critically involving ataxia telangiectasia-mutated (atm) and p53. |
2015-03-03 |
2023-08-13 |
human |
| b' Barbora \\xc5\\xa0alovsk\\xc3\\xa1, Ivo Fabrik, Kamila \\xc4\\x8euri\\xc5\\xa1ov\\xc3\\xa1, Marek Link, Ji\\xc5\\x99ina V\\xc3\\xa1vrov\\xc3\\xa1, Martina \\xc5\\x98ez\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa1, Ale\\xc5\\xa1 Tich\\xc3\\xb. Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. International journal of molecular sciences. vol 15. issue 7. 2015-02-24. PMID:25003641.' |
dna damage response (ddr)-triggered by radiation-induced double strand breaks-is orchestrated mainly by three phosphatidylinositol 3-kinase-related kinases (pikks): ataxia teleangiectasia mutated (atm), dna-dependent protein kinase (dna-pk) and atm and rad3-related kinase (atr). |
2015-02-24 |
2023-08-13 |
human |
| Zhong Guo, Jin Zhao, Lei Song, Jian-Xiu Ma, Chen-Jing Wang, Shu-Yan Pei, Chao Jiang, Shang-Biao L. Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family. Cancer cell international. vol 14. issue 1. 2014-12-22. PMID:25530717. |
h2ax is phosphorylated (γh2ax) by members of the phosphatidylinositol 3-kinase (pi3k) family, including ataxia telangiectasia-mutated (atm), atm- and rad3-related (atr) and dna-pk in response to dna damage. |
2014-12-22 |
2023-08-13 |
human |