| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Zhang, Fanfan Zhang, Xinjie Cheng, Kangwei Liu, Jiaqi Tang, Yafei Li, Ding Tang, Zhukuan Cheng, Hengxiu Y. OsATM Safeguards Accurate Repair of Meiotic Double-Strand Breaks in Rice. Plant physiology. vol 183. issue 3. 2021-03-19. PMID:32404412. |
ataxia telangiectasia-mutated (atm) protein has been well studied for its roles in the dna damage response. |
2021-03-19 |
2023-08-13 |
Not clear |
| b' Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Baril\\xc3\\xa. ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence? Frontiers in cell and developmental biology. vol 8. 2021-01-26. PMID:33490066.' |
ataxia-telangiectasia mutated kinase (atm) is the product of a gene that is lost in ataxia-telangiectasia (a-t), a rare genetic disorder characterized by ataxia and cerebellar neurodegeneration, defects in the immune response, higher incidence of lymphoma development, and premature aging. |
2021-01-26 |
2023-08-13 |
Not clear |
| Md Kawsar Mustofa, Yuki Tanoue, Chie Tateishi, Cyrus Vaziri, Satoshi Tateish. Roles of Chk2/CHEK2 in guarding against environmentally induced DNA damage and replication-stress. Environmental and molecular mutagenesis. vol 61. issue 7. 2020-12-14. PMID:32578892. |
persistently stalled and unresolved dna replication forks can "collapse" to generate dsbs that induce signaling via chk2 and its upstream activator the ataxia telangiectasia-mutated (atm) protein kinase. |
2020-12-14 |
2023-08-13 |
human |
| Peng Wang, Chun Wang, Chunying Li. Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration. Oncology letters. vol 21. issue 1. 2020-12-08. PMID:33281970. |
investigations into the mechanism revealed that the expression levels of phosphorylated ataxia telangiectasia-mutated (atm) were considerably activated by dioscin, which significantly upregulated the expression levels of p53 to activate mitochondrial apoptosis signaling. |
2020-12-08 |
2023-08-13 |
human |
| Masaya Inoue, Yoshio Honma, Takeshi Urano, Junji Suzumiy. Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693235. |
as ataxia telangiectasia mutated (atm) and ataxia telangiectasia- and rad3-related (atr) kinases are key mediators of the dna damage response, the effects of the combination of bendamustine and atm/atr inhibitors (ku-60019 and ve-821) on lymphoma cells were investigated. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ana Belén Herrero, Norma Carmen Gutiérre. Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival. Frontiers in oncology. vol 7. 2020-09-29. PMID:28580318. |
the absence of atr was partially compensated by ataxia telangiectasia-mutated protein (atm), since chemical inhibition of both kinases using ve-821 and ku-55933 significantly increased the death of mm cells with dna damage. |
2020-09-29 |
2023-08-13 |
human |
| Eirini Terpsi Vitti, Andrzej Kacperek, Jason L Parson. Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. Cancers. vol 12. issue 6. 2020-09-28. PMID:32517381. |
the impact of targeting the major protein kinases involved in the signaling of dna double-strand break (dsb) repair, namely ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), and the catalytic subunit of dna-dependent protein kinase (dna-pkcs), on the radiosensitisation of hnscc cells was examined. |
2020-09-28 |
2023-08-13 |
human |
| Sherry S Agabiti, Jin Li, Willie Dong, Michael M Poe, Andrew J Wieme. Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. Cell death & disease. vol 10. issue 10. 2020-09-23. PMID:31570763. |
ggdps inhibition increases phosphorylation of histone h2a.x, and inhibitors of ataxia telangiectasia-mutated kinase (atm) mitigate ggdps inhibitor-induced apoptosis. |
2020-09-23 |
2023-08-13 |
Not clear |
| T Maiuri, C E Suart, C L K Hung, K J Graham, C A Barba Bazan, R Truan. DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 4. 2020-08-24. PMID:31364066. |
potential targets for therapy that may prove beneficial across many of these diseases are also identified, defining nodes in the ataxia telangiectasia-mutated (atm) complex, mismatch repair, and poly adp-ribose polymerases (parps). |
2020-08-24 |
2023-08-13 |
human |
| Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun, Chan Din. ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells. PLoS pathogens. vol 16. issue 6. 2020-08-11. PMID:32479542. |
the activation of ataxia telangiectasia-mutated (atm) kinase is central to dna double-strand break (dsb) for maintaining host-genome integrity in mammalian cells. |
2020-08-11 |
2023-08-13 |
Not clear |
| Jusik Kim, Keeeun Kim, Jung-Soon Mo, Youngsoo Le. Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation. Nucleic acids research. vol 48. issue 7. 2020-07-06. PMID:32123907. |
however, dual inactivation of polb and atm resulted in ataxia without significant neuropathological defects in the cerebellum. |
2020-07-06 |
2023-08-13 |
mouse |
| Qing Sun, Yige Guo, Xiaohong Liu, Frank Czauderna, Michael I Carr, Frank T Zenke, Andree Blaukat, Lyubomir T Vassile. Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. Molecular cancer research : MCR. vol 17. issue 12. 2020-06-22. PMID:31551253. |
in p53 wild-type cells, ataxia telangiectasia-mutated (atm) and its targets, p53 and checkpoint kinase 2 (chk2), were more strongly activated by combination treatment with m3814 and radiation than by radiation alone, leading to a complete p53-dependent cell-cycle block and premature cell senescence. |
2020-06-22 |
2023-08-13 |
Not clear |
| Xin Zhang, Yao Qin, Zhaohai Pan, Minjing Li, Xiaona Liu, Xiaoyu Chen, Guiwu Qu, Ling Zhou, Maolei Xu, Qiusheng Zheng, Defang L. Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. vol 9. issue 8. 2020-05-08. PMID:31349651. |
further investigation showed that cbd significantly upregulated ataxia telangiectasia-mutated gene (atm) and p53 protein expression and downregulated p21 protein expression in sgc-7901 cells, which subsequently inhibited the levels of cdk2 and cyclin e, thereby resulting in cell cycle arrest at the g0-g1 phase. |
2020-05-08 |
2023-08-13 |
human |
| Christopher J Bakkenist, R Kenneth Czambel, Yan Lin, Nathan A Yates, Xuemei Zeng, Jeffery Shogan, John C Schmit. Quantitative analysis of ATM phosphorylation in lymphocytes. DNA repair. vol 80. 2020-04-13. PMID:31176958. |
ataxia telangiectasia-mutated (atm) kinase is the principal regulator of cellular responses to dna double-strand breaks (dsbs). |
2020-04-13 |
2023-08-13 |
human |
| Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, Grant Wishart, Kim L Matthews, Sarah L Martin, Helen C Cox, George McAllister, Stephen D Penrose, Huw Vater, William Esmieu, Amanda Van de Poël, Rhea Van de Bospoort, Annelieke Strijbosch, Marieke Lamers, Philip Leonard, Rebecca E Jarvis, Wesley Blackaby, Karen Barnes, Maria Eznarriaga, Simon Dowler, Graham D Smith, David F Fischer, Ovadia Lazari, Dawn Yates, Mark Rose, Sung-Wook Jang, Ignacio Muñoz-Sanjuan, Celia Domingue. Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models. Journal of medicinal chemistry. vol 62. issue 6. 2020-03-03. PMID:30840447. |
genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (atm) kinase activity can ameliorate mutant huntingtin (mhtt) toxicity in cellular and animal models of huntington's disease (hd), suggesting that selective inhibition of atm could provide a novel clinical intervention to treat hd. |
2020-03-03 |
2023-08-13 |
mouse |
| Rui Gao, Anirban Chakraborty, Charlene Geater, Subrata Pradhan, Kara L Gordon, Jeffrey Snowden, Subo Yuan, Audrey S Dickey, Sanjeev Choudhary, Tetsuo Ashizawa, Lisa M Ellerby, Albert R La Spada, Leslie M Thompson, Tapas K Hazra, Partha S Sarka. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. eLife. vol 8. 2020-02-28. PMID:30994454. |
abrogated pnkp activity results in persistent dna break accumulation, preferentially in actively transcribed genes, and aberrant activation of dna damage-response ataxia telangiectasia-mutated (atm) signaling in hd transgenic mouse and cell models. |
2020-02-28 |
2023-08-13 |
mouse |
| Shujuan Zhou, Bo Xu, Liang Qi, Dongqin Zhu, Baorui Liu, Jia We. Next-generation sequencing reveals mutational accordance between cell-free DNA from plasma, malignant pleural effusion and ascites and directs targeted therapy in a gastric cancer patient. Cancer biology & therapy. vol 20. issue 1. 2020-02-26. PMID:30118648. |
in all three samples, we detected an amplification in the cellular-mesenchymal to epithelial transition factor (met) gene, a truncation mutation in smad3 (p.r368x), and four ataxia telangiectasia-mutated gene (atm) variants, including a missense mutation (p.e2351a), an in-frame deletion (p.npavim2353delinsk), a frame-shift deletion (p.d1758fs) and an atm- bpi fold containing family b member 1 (bpifb1) gene fusion. |
2020-02-26 |
2023-08-13 |
Not clear |
| Himadri Biswas, Greicy Goto, Weibin Wang, Patrick Sung, Katsunori Sugimot. Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts. PLoS genetics. vol 15. issue 8. 2020-01-07. PMID:31369547. |
the dna damage checkpoint response is controlled by the phosphatidylinositol 3-kinase-related kinases (pikk), including ataxia telangiectasia-mutated (atm) and atm and rad3-related (atr). |
2020-01-07 |
2023-08-13 |
Not clear |
| Vaughn Thada, David Corte. Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation. The Journal of biological chemistry. vol 294. issue 21. 2019-12-09. PMID:30940728. |
dna damage response ser/thr kinases, including ataxia telangiectasia-mutated (atm) and rad3-related (atr), control cell cycle progression, dna repair, and apoptosis. |
2019-12-09 |
2023-08-13 |
Not clear |
| Chunrong Zhang, Feng Jiang, Chuan Su, Pengfei Xie, Lin X. Upregulation of long noncoding RNA SNHG20 promotes cell growth and metastasis in esophageal squamous cell carcinoma via modulating ATM-JAK-PD-L1 pathway. Journal of cellular biochemistry. 2019-11-20. PMID:30767270. |
moreover, we uncover that snhg20 modulates the expression of ataxia telangiectasia-mutated kinase (p-atm), p-jak1/2, and programmed cell death 1 ligand 1 (pd-l1) in escc cells and atm upregulation restores the suppressive effect of snhg20 inhibition on escc progression. |
2019-11-20 |
2023-08-13 |
Not clear |