| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Xiong, Fuzhou Hua, Yao Dong, Yue Lin, Jun Ying, Jie Liu, Xifeng Wang, Lieliang Zhang, Jing Zhan. DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology. Frontiers in aging neuroscience. vol 14. 2022-09-30. PMID:36177479. |
dna damage response (ddr) can activate ataxia telangiectasia-mutated serine/threonine kinase (atm) and rad3-related serine/threonine kinase (atr), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. |
2022-09-30 |
2023-08-14 |
Not clear |
| Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Ada Esteban-Sánchez, Víctor Lorca, Inés Llinares-Burguet, Jamie Allen, Alicia García-Álvarez, Pedro Pérez-Segura, Mercedes Durán, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco-Sampedr. Minigene-based splicing analysis and ACMG/AMP-based tentative classification of 56 ATM variants. The Journal of pathology. 2022-06-18. PMID:35716007. |
the ataxia telangiectasia-mutated (atm) protein is a major coordinator of the dna damage response pathway. |
2022-06-18 |
2023-08-14 |
human |
| Yu Ma, Siwen Li, Shuzi Ye, Die Hu, Lai Wei, Fang Xia. Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response. Ecotoxicology and environmental safety. vol 239. 2022-05-19. PMID:35588622. |
continuous cr(vi) stimulation led to dna damaged in hepatocytes, and dna damage response (ddr) signals were transmitted by ataxia telangiectasia-mutated gene (atm)/ataxia telangiectasia and rad-3-related protein (atr), resulting in zinc finger transcription factor gata4 escaping p62-mediated selective autophagy, thereby regulating nuclear factor kappa-b (nf-κb) to induce premature senescence in hepatocytes. |
2022-05-19 |
2023-08-13 |
Not clear |
| Paulina Ramirez, Mary Wingard, Paige Shook, Suman Dalal, Mahipal Singh, Krishna Sing. Deficiency of Ataxia Telangiectasia-mutated Kinase (ATM) Preserves Heart Function by Affecting Cardiac Remodeling in Response to Western-type Diet in Female Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553125. |
deficiency of ataxia telangiectasia-mutated kinase (atm) preserves heart function by affecting cardiac remodeling in response to western-type diet in female mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Alexandra N Nail, Lakynkalina M McCaffrey, Mayukh Banerjee, Ana P Ferragut Cardoso, J Christopher State. Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes. Toxicology and applied pharmacology. 2022-05-05. PMID:35513056. |
here, we report that phosphorylation of ataxia telengectasia mutated (atm) protein at a critical site (pser1981) important for ddr signaling, and downstream chek2 activation, are significantly reduced in two human keratinocyte lines as a result of chronic ias exposure. |
2022-05-05 |
2023-08-13 |
human |
| Pan Yang, Xiaoping Li, Qinghui Wen, Xiaan Zha. Quercetin attenuates the proliferation of arsenic-related lung cancer cells via a caspase-dependent DNA damage signaling. Molecular carcinogenesis. 2022-04-18. PMID:35436022. |
the flow cytometry-based cell cycle analysis showed that the antiproliferative function of quercetin was mediated by s-phase cell cycle arrest, which was associated with upregulation of the ataxia telangiectasia-mutated (atm), but not atm and rad3-related. |
2022-04-18 |
2023-08-13 |
Not clear |
| Nicolás Romero, Herman W Favoree. Pseudorabies Virus Infection Triggers NF-κB Activation via the DNA Damage Response but Actively Inhibits NF-κB-Dependent Gene Expression. Journal of virology. vol 95. issue 24. 2021-12-08. PMID:34613805. |
we show that prv triggers the dna damage response (ddr) and that this ddr response drives nf-κb activation since inhibition of the nuclear ataxia telangiectasia-mutated (atm) kinase, a chief controller of ddr, abolished prv-induced nf-κb activation. |
2021-12-08 |
2023-08-13 |
Not clear |
| Anna Tessari, Shimaa H A Soliman, Arturo Orlacchio, Marina Capece, Joseph M Amann, Rosa Visone, David P Carbone, Dario Palmieri, Vincenzo Coppol. RANBP9 as potential therapeutic target in non-small cell lung cancer. Journal of cancer metastasis and treatment. vol 6. 2021-11-26. PMID:34778565. |
ranbp9 knockout cells are more sensitive than controls to the inhibition of the ataxia and telangiectasia-related (atr) kinase but not to atm inhibition. |
2021-11-26 |
2023-08-13 |
Not clear |
| K Stakyte, M Rotheneder, K Lammens, J D Bartho, U Grädler, T Fuchß, U Pehl, A Alt, E van de Logt, K P Hopfne. Molecular basis of human ATM kinase inhibition. Nature structural & molecular biology. vol 28. issue 10. 2021-11-22. PMID:34556870. |
human checkpoint kinase ataxia telangiectasia-mutated (atm) plays a key role in initiation of the dna damage response following dna double-strand breaks. |
2021-11-22 |
2023-08-13 |
human |
| Emma St Martin, Alejandro Ferrer, Abhishek A Mangaonkar, Shakila P Khan, Mira A Kohorst, Avni Y Joshi, William J Hogan, Horatiu Olteanu, Ann M Moyer, Aref Al-Kali, Ayalew Tefferi, Dong Chen, Kitsada Wudhikarn, Ronald Go, David Viswanatha, Rong He, Rhett Ketterling, Phuong L Nguyen, Jennifer L Oliveira, Naseema Gangat, Terra Lasho, Mrinal M Patnai. Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes. American journal of hematology. vol 96. issue 11. 2021-11-15. PMID:34390506. |
seventy-two (50%) patients had ibmfs (telomere biology disorders-32,fanconi anemia-18, diamond blackfan anemia - 11, congenital neutropenia-5, schwachman-diamond syndrome-5 and bloom syndrome-1), 27 (19%) had gps with antecedent thrombocytopenia (runx1-fpd-15, ankrd26-6, etv6-2, gata1-1, mpl-3), 28 (19%) had gps without antecedent thrombocytopenia (gata2 haploinsufficiency-16, ddx41-10, cbl-1 and cebpa-1) and 17 (12%) had general cancer predisposition syndromes (ataxia telangiectasia-7, heterozygous atm variants-3, chek2-2, tp53-2, cdk2na-1, nf1-1 and nijmegen breakage syndrome-1). |
2021-11-15 |
2023-08-13 |
Not clear |
| Shuang Qiao, Wenhua Lu, Christophe Glorieux, Jiangjiang Li, Peiting Zeng, Ning Meng, Huiqin Zhang, Shijun Wen, Peng Huan. Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer. Oncogene. vol 40. issue 39. 2021-10-01. PMID:34349242. |
genetic abrogation of idh2 in crc cells leads to reactive oxygen species (ros)-mediated dna damage and an accumulation of 8-oxoguanine with dna strand breaks, which activates dna damage response (ddr) with elevated γh2ax and phosphorylation of ataxia telangiectasia-mutated (atm) protein, leading to a partial cell cycle arrest and eventually cell senescence. |
2021-10-01 |
2023-08-13 |
Not clear |
| Natalie Y L Ngoi, Melissa M Pham, David S P Tan, Timothy A Ya. Targeting the replication stress response through synthetic lethal strategies in cancer medicine. Trends in cancer. vol 7. issue 10. 2021-09-24. PMID:34215565. |
the replication stress response (rsr) involves a downstream kinase cascade comprising ataxia telangiectasia-mutated (atm), atm and rad3-related (atr), checkpoint kinases 1 and 2 (chk1/2), and wee1-like protein kinase (wee1), which cooperate to arrest the cell cycle, protect stalled forks, and allow time for replication fork repair. |
2021-09-24 |
2023-08-13 |
Not clear |
| Natalie Yl Ngoi, Vignesh Sundararajan, David Sp Ta. Exploiting replicative stress in gynecological cancers as a therapeutic strategy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 30. issue 8. 2021-09-09. PMID:32571890. |
small molecule inhibitors designed to target the dna damage sensors, such as inhibitors of ataxia telangiectasia-mutated (atm), atr, chk1 and wee1, impair smooth cell cycle modulation and disrupt efficient dna repair, or a combination of the above, have demonstrated interesting monotherapy and combinatorial activity, including the potential to reverse drug resistance and have entered developmental pipelines. |
2021-09-09 |
2023-08-13 |
Not clear |
| Shu-Ting Pan, Gan Huang, Qiaohong Wang, Jia-Xuan Qi. Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM. Journal of oncology. vol 2021. 2021-09-07. PMID:34484337. |
rt-pcr was used to examine the gene expression level of ataxia telangiegatasiata muted (atm) and nuclear factor kappa beta (nf-κb) after various treatment groups. |
2021-09-07 |
2023-08-13 |
Not clear |
| Chibin Cheng, Daniel Seen, Chunwen Zheng, Ruijie Zeng, Enmin L. Role of Small GTPase RhoA in DNA Damage Response. Biomolecules. vol 11. issue 2. 2021-07-19. PMID:33546351. |
in ddr, 2 key components of dna repair, ataxia telangiectasia-mutated (atm) and flap structure-specific endonuclease 1 (fen1), along with intracellular reactive oxygen species (ros) have been shown to regulate rhoa activation. |
2021-07-19 |
2023-08-13 |
Not clear |
| May Yung Tiet, Rita Horvath, Anke E Hensie. Ataxia telangiectasia: what the neurologist needs to know. Practical neurology. vol 20. issue 5. 2021-07-09. PMID:32958592. |
patients with variant ataxia telangiectasia-with some preserved ataxia telangiectasia-mutated (atm) kinase activity-have a milder and often atypical phenotype, which can lead to long delays in diagnosis. |
2021-07-09 |
2023-08-13 |
Not clear |
| Amanda Van de Poël, Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, Grant Wishart, Kim L Matthews, Sarah L Martin, Marcus Peacock, Amy Barnard, Helen C Cox, Graham Jones, George McAllister, Huw Vater, William Esmieu, Cole Clissold, Marieke Lamers, Philip Leonard, Rebecca E Jarvis, Wesley Blackaby, Maria Eznarriaga, Ovadia Lazari, Dawn Yates, Mark Rose, Sung-Wook Jang, Ignacio Muñoz-Sanjuan, Celia Domingue. Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease. Journal of medicinal chemistry. vol 64. issue 8. 2021-06-14. PMID:33783225. |
our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (atm) kinase inhibitors may have potential as novel therapeutics for the treatment of huntington's disease (hd). |
2021-06-14 |
2023-08-13 |
Not clear |
| Hatice Mutlu-Albayrak, Emre Kırat, Gürkan Gürbü. Childhood-onset autosomal recessive ataxias: a cross-sectional study from Turkey. Neurogenetics. vol 21. issue 1. 2021-05-28. PMID:31741144. |
atm gene analysis should be performed foremost on children presenting early-onset ataxia from southeastern anatolia. |
2021-05-28 |
2023-08-13 |
Not clear |
| Masoumeh Moslemi, Yousef Moradi, Hojat Dehghanbanadaki, Hamed Afkhami, Mansoor Khaledi, Najmeh Sedighimehr, Javad Fathi, Ehsan Sohrab. The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis. BMC cancer. vol 21. issue 1. 2021-05-14. PMID:33402103. |
ataxia telangiectasia-mutated (atm) gene contributes to repair damaged dna and to regulate cell cycle; therefore, atm variants seem to increase breast cancer risk; however, the results are controversial. |
2021-05-14 |
2023-08-13 |
Not clear |
| Agata Patel, Elena Seraia, Daniel Ebner, Anderson Joseph Rya. Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity. International journal of cancer. vol 147. issue 5. 2021-04-02. PMID:32159854. |
ataxia telangiectasia-mutated (atm) and rad3-related (atr) signalling, a dna damage repair (ddr) pathway, is activated by regions of single-stranded dna (ssdna) that can arise during replication stress. |
2021-04-02 |
2023-08-13 |
Not clear |