| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine Schon, Nienke J H van Os, Nicholas Oscroft, Helen Baxendale, Daniel Scoffings, Julian Ray, Mohnish Suri, William P Whitehouse, Puja R Mehta, Natasha Everett, Leonardo Bottolo, Bart P van de Warrenburg, Philip J Byrd, Corry Weemaes, Michel A Willemsen, Marc Tischkowitz, A Malcolm Taylor, Anke E Hensie. Genotype, extrapyramidal features, and severity of variant ataxia-telangiectasia. Annals of neurology. vol 85. issue 2. 2019-11-19. PMID:30549301. |
variant ataxia-telangiectasia is caused by mutations that allow some retained ataxia telangiectasia-mutated (atm) kinase activity. |
2019-11-19 |
2023-08-13 |
Not clear |
| Watson P Folk, Alpana Kumari, Tetsushi Iwasaki, Slovénie Pyndiah, Joanna C Johnson, Erica K Cassimere, Amy L Abdulovic-Cui, Daitoku Sakamur. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin. The Journal of biological chemistry. vol 294. issue 14. 2019-10-16. PMID:30733337. |
here, we report that bin1 inactivates ataxia telangiectasia-mutated (atm) serine/threonine kinase, particularly when bin1 binds e2f1. |
2019-10-16 |
2023-08-13 |
Not clear |
| Júlia Canet-Pons, Ralf Schubert, Ruth Pia Duecker, Roland Schrewe, Sandra Wölke, Matthias Kieslich, Martina Schnölzer, Andreas Chiocchetti, Georg Auburger, Stefan Zielen, Uwe Warnke. Ataxia telangiectasia alters the ApoB and reelin pathway. Neurogenetics. vol 19. issue 4. 2019-09-25. PMID:30343341. |
a-t is caused by inactivating mutations in the ataxia telangiectasiamutated (atm) gene, a serine-threonine protein kinase involved in dna damage response and excitatory neurotransmission. |
2019-09-25 |
2023-08-13 |
mouse |
| Xiaoxu Zhao, Yanying Rao, Jie Liang, Shoukai Lin, Xiumei Wang, Zhangliang Li, Jianhui Huan. Silver Nanoparticle-Induced Phosphorylation of Histone H3 at Serine 10 Involves MAPK Pathways. Biomolecules. vol 9. issue 2. 2019-08-30. PMID:30813344. |
on the other hand, p-h3s10 formation was not due to dna damage induced by agnps, or the activation of the kinases ataxia telangiectasia-mutated (atm) and atm-rad3-related (atr). |
2019-08-30 |
2023-08-13 |
Not clear |
| Constantinos Savva, Karen De Souza, Reem Ali, Emad A Rakha, Andrew R Green, Srinivasan Madhusuda. Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers. Breast cancer research and treatment. vol 175. issue 1. 2019-08-20. PMID:30746633. |
clinicopathological significance of ataxia telangiectasia-mutated (atm) kinase and ataxia telangiectasia-mutated and rad3-related (atr) kinase in myc overexpressed breast cancers. |
2019-08-20 |
2023-08-13 |
Not clear |
| Ziguo Yang, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Juan Zhang, Yuntao Xi. Prevalence and characterization of ATM germline mutations in Chinese BRCA1/2-negative breast cancer patients. Breast cancer research and treatment. vol 174. issue 3. 2019-07-16. PMID:30607632. |
the ataxia telangiectasia-mutated (atm) gene is a moderate susceptibility gene for breast cancer. |
2019-07-16 |
2023-08-13 |
Not clear |
| Shiyuan Hong, Junfen Xu, Yan Li, Jorge Andrade, Paul Hoover, Paul J Kaminski, Laimonis A Laimin. Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation. Oncogene. vol 38. issue 17. 2019-05-21. PMID:30631149. |
high-risk human papillomaviruses (hpvs) constitutively activate ataxia telangiectasia mutated (atm) and ataxia telangiectasia- and rad3-related (atr) dna damage repair pathways for viral genome amplification. |
2019-05-21 |
2023-08-13 |
human |
| Teresa Frisan, Noemi Nagy, Dimitrios Chioureas, Marie Terol, Francesca Grasso, Maria G Masucc. A bacterial genotoxin causes virus reactivation and genomic instability in Epstein-Barr virus infected epithelial cells pointing to a role of co-infection in viral oncogenesis. International journal of cancer. vol 144. issue 1. 2019-04-15. PMID:29978480. |
using isogenic aa strains that differ in the production of the cytolethal distending toxin (cdt) and purified catalytically active or inactive toxin, we found that the cdt acts via induction of dna double strand breaks and activation of the ataxia telangectasia mutated (atm) kinase. |
2019-04-15 |
2023-08-13 |
human |
| Althaf Shaik, Rashmi Bhakuni, Sivapriya Kirubakara. Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors. Molecules (Basel, Switzerland). vol 23. issue 5. 2018-09-18. PMID:29695073. |
the key mediators involved in this pathway are ataxia telangiectasia-mutated kinase (atm) and ataxia telangiectasia-mutated, rad3-related kinase (atr). |
2018-09-18 |
2023-08-13 |
Not clear |
| Rohit A Panchakshari, Xuefei Zhang, Vipul Kumar, Zhou Du, Pei-Chi Wei, Jennifer Kao, Junchao Dong, Frederick W Al. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 4. 2018-07-18. PMID:29311308. |
deficiency for dsb response (dsbr) factors, including ataxia telangiectasia-mutated (atm) and 53bp1, variably impair csr end-joining, with 53bp1 deficiency having the greatest impact. |
2018-07-18 |
2023-08-13 |
mouse |
| Li Wei, Shanshan Zhu, Jing Wang, Rong Quan, Xu Yan, Zixue Li, Lei Hou, Naidong Wang, Yi Yang, Haijun Jiang, Jue Li. Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses. Scientific reports. vol 6. 2018-06-19. PMID:27982097. |
the response requires active viral replication, and all the atm (ataxia telangiectasia-mutated kinase), atr (atm- and rad3-related kinase), and dna-pk (dna-dependent protein kinase) are the transducers of the ddr signaling events in the pcv2-infected cells as demonstrated by the phosphorylation of atm, atr, and dna-pk signalings as well as reductions in their activations after treatment with specific kinase inhibitors. |
2018-06-19 |
2023-08-13 |
Not clear |
| Xueyan Gu, Yongmei Qi, Zengxiu Feng, Lin Ma, Ke Gao, Yingmei Zhan. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicology letters. vol 291. 2018-05-23. PMID:29660402. |
however, whether ataxia telangiectasis mutated (atm) which is reported to be linked with pten-induced putative kinase 1 (pink1)/parkin pathway (a well-characterized mitophagic pathway) participates in the regulation of pb-induced mitophagy and its exact role remains enigmatic. |
2018-05-23 |
2023-08-13 |
mouse |
| Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D'Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnan. ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T. Orphanet journal of rare diseases. vol 12. issue 1. 2018-04-17. PMID:28679388. |
atm splicing variants as biomarkers for low dose dexamethasone treatment of a-t. ataxia telangiectasia (at) is a rare incurable genetic disease, caused by biallelic mutations in the ataxia telangiectasia-mutated (atm) gene. |
2018-04-17 |
2023-08-13 |
Not clear |
| Vincent Picco, Isabelle Coste, Marie-Josèphe Giraud-Panis, Toufic Renno, Eric Gilson, Gilles Pagè. ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2. Oncotarget. vol 7. issue 29. 2018-02-02. PMID:27366950. |
within this complex, telomeric repeat binding factor 2 (trf2) plays an essential role by blocking the ataxia telangiectasia-mutated protein (atm) signaling pathway at telomeres and preventing chromosome end fusion. |
2018-02-02 |
2023-08-13 |
human |
| Vipul Kumar, Frederick W Alt, Richard L Froc. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 38. 2018-01-25. PMID:27601633. |
the xrcc4-like-factor (xlf) c-nhej protein is dispensable for v(d)j recombination in normal cells, but because of functional redundancy, it is absolutely required for this process in cells deficient for the ataxia telangiectasia-mutated (atm) dsb response factor. |
2018-01-25 |
2023-08-13 |
mouse |
| Chelsey C Spriggs, Laimonis A Laimin. Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication. Viruses. vol 9. issue 8. 2018-01-25. PMID:28820495. |
high-risk hpvs activate the ataxia telangiectasia-mutated (atm) and atm and rad3-related (atr) dna damage repair pathways, which are essential for viral replication (particularly differentiation-dependent genome amplification). |
2018-01-25 |
2023-08-13 |
human |
| Cecilia Marelli, Claire Guissart, Cecile Hubsch, Mathilde Renaud, Jean-Philippe Villemin, Lise Larrieu, Perrine Charles, Xavier Ayrignac, Sabrina Sacconi, Patrick Collignon, Danielle Cuntz-Shadfar, Laurine Perrin, Anelia Benarrosh, Adrian Degardin, Ouhaïd Lagha-Boukbiza, Eugenie Mutez, Bertrand Carlander, Raul Juntas Morales, Victoria Gonzalez, Clarisse Carra-Dalliere, Souhayla Azakri, Claude Mignard, Elisabeth Ollagnon, Nicolas Pageot, Dominique Chretien, Christian Geny, Jean-Philippe Azulay, Christine Tranchant, Mireille Claustres, Pierre Labauge, Mathieu Anheim, Cyril Goizet, Patrick Calvas, Michel Koeni. Mini-Exome Coupled to Read-Depth Based Copy Number Variation Analysis in Patients with Inherited Ataxias. Human mutation. vol 37. issue 12. 2017-11-07. PMID:27528516. |
we identified both atypical presentation of known ataxia genes (atm, npc1) and mutations in genes very rarely associated with ataxia (ercc4, hsd17b4). |
2017-11-07 |
2023-08-13 |
Not clear |
| Michael G Kem. DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH). The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28592488. |
the role of the dna damage response protein kinase ataxia telangiectasia-mutated (atm)- and rad-3-related (atr) in the cellular response to dna damage during the replicative phase of the cell cycle has been extensively studied. |
2017-09-26 |
2023-08-13 |
human |
| Chelsey C Spriggs, Laimonis A Laimin. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. mBio. vol 8. issue 1. 2017-07-21. PMID:28196964. |
replication of high-risk hpvs requires the activation of the ataxia telangiectasia-mutated (atm) and atm and rad3-related (atr) dna repair pathways. |
2017-07-21 |
2023-08-13 |
human |
| Andrea Sau, Rosanna Lau, Miguel A Cabrita, Emma Nolan, Peter A Crooks, Jane E Visvader, M A Christine Prat. Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage. Cell stem cell. vol 19. issue 1. 2017-07-19. PMID:27292187. |
hormone-independent luminal progenitor colony formation required nf-κb, ataxia telangiectasia-mutated (atm), and the inhibitor of kappab kinase, ikkα. |
2017-07-19 |
2023-08-13 |
mouse |