| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalie C Steinel, Megan R Fisher, Katherine S Yang-Iott, Craig H Bassin. The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusion. Journal of immunology (Baltimore, Md. : 1950). vol 193. issue 6. 2014-11-25. PMID:25127855. |
the ataxia telangietasia mutated (atm) protein kinase promotes dna repair and activates checkpoints to suppress aberrant ig and tcr rearrangements. |
2014-11-25 |
2023-08-13 |
mouse |
| Daniel C Anacker, Dipendra Gautam, Kenric A Gillespie, William H Chappell, Cary A Mood. Productive replication of human papillomavirus 31 requires DNA repair factor Nbs1. Journal of virology. vol 88. issue 15. 2014-10-01. PMID:24850735. |
activation of the atm (ataxia telangiectasia-mutated kinase)-dependent dna damage response (ddr) is necessary for productive replication of human papillomavirus 31 (hpv31). |
2014-10-01 |
2023-08-13 |
human |
| Jiazhi Hu, Suprawee Tepsuporn, Robin M Meyers, Monica Gostissa, Frederick W Al. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 28. 2014-09-19. PMID:24982162. |
mature igm(+) b-cell lymphomas that arise in certain ataxia telangiectasia-mutated (atm)-deficient compound mutant mice harbor translocations that fuse v(d)j recombination-initiated igh double-strand breaks (dsbs) on chromosome 12 to sequences downstream of c-myc on chromosome 15, generating dicentric chromosomes and c-myc amplification via a breakage-fusion-bridge mechanism. |
2014-09-19 |
2023-08-13 |
mouse |
| Ching-Shyi Wu, Jian Ouyang, Eiichiro Mori, Hai Dang Nguyen, Alexandre Maréchal, Alexander Hallet, David J Chen, Lee Zo. SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes & development. vol 28. issue 13. 2014-09-02. PMID:24990965. |
the atr (atm [ataxia telangiectasia-mutated]- and rad3-related) checkpoint is a crucial dna damage signaling pathway. |
2014-09-02 |
2023-08-13 |
Not clear |
| M D Wallace, T L Southard, K J Schimenti, J C Schiment. Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene. vol 33. issue 28. 2014-09-01. PMID:23975433. |
we found that animals doubly mutant for chaos3 and components of the ataxia telangiectasia-mutated (atm) double-strand break response pathway (atm, p21/cdkn1a and chk2/chek2) had decreased tumor latency and/or increased tumor susceptibility. |
2014-09-01 |
2023-08-12 |
mouse |
| Marina K Ayrapetov, Ozge Gursoy-Yuzugullu, Chang Xu, Ye Xu, Brendan D Pric. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 25. 2014-08-18. PMID:24927542. |
these domains of h3k9me3 function to activate the tip60 acetyltransferase, allowing tip60 to acetylate both ataxia telangiectasia-mutated (atm) kinase and histone h4. |
2014-08-18 |
2023-08-13 |
Not clear |
| R C Bueno, R A Canevari, R A R Villacis, M A C Domingues, J R F Caldeira, R M Rocha, S A Drigo, S R Rogatt. ATM down-regulation is associated with poor prognosis in sporadic breast carcinomas. Annals of oncology : official journal of the European Society for Medical Oncology. vol 25. issue 1. 2014-08-11. PMID:24285016. |
ataxia telangiectasia-mutated (atm) gene downexpression has been reported in sporadic breast carcinomas (bc); however, the prognostic value and mechanisms of atm deregulation remain unclear. |
2014-08-11 |
2023-08-12 |
Not clear |
| Yuko Ibuki, Tatsushi Toyooka, Xiaoxu Zhao, Ikuma Yoshid. Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes. Carcinogenesis. vol 35. issue 6. 2014-08-04. PMID:24398671. |
these pathways were different from that of the css-induced phosphorylation of histone h2ax (γ-h2ax) mediated by ataxia telangiectasia-mutated (atm) and atm-rad3-related (atr) protein kinases. |
2014-08-04 |
2023-08-12 |
human |
| Kotoka Nakamura, Francesca Fike, Sara Haghayegh, Rachel Saunders-Pullman, Angelika J Dawson, Thilo Dörk, Richard A Gatt. A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity. Molecular genetics & genomic medicine. vol 2. issue 4. 2014-07-31. PMID:25077176. |
the presence of at least trace amounts of atm kinase activity on some immunoblots may account for the late-onset, mild ataxia of these patients. |
2014-07-31 |
2023-08-13 |
Not clear |
| Sung-Tae Hong, Kwang-Wook Cho. TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster. Nature communications. vol 4. 2014-07-06. PMID:24352200. |
recently, human tctp has been suggested to play a role in the dna damage response by forming a complex with ataxia telangiectasia-mutated (atm) kinase . |
2014-07-06 |
2023-08-12 |
human |
| Stefania Staibano, Gennaro Ilardi, Vincenza Leone, Chiara Luise, Francesco Merolla, Francesco Esposito, Francesco Morra, Maria Siano, Renato Franco, Alfredo Fusco, Paolo Chieffi, Angela Celett. Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors. BMC cancer. vol 13. 2014-06-23. PMID:24059746. |
ccdc6 is a pro-apoptotic phosphoprotein substrate of the kinase ataxia telangectasia mutated (atm) able to sustain dna damage checkpoint in response to genotoxic stress and is commonly rearranged in malignancies upon fusion with different partners. |
2014-06-23 |
2023-08-12 |
human |
| Liwen Zhang, Dennis A Simpson, Cynthia L Innes, Jeff Chou, Pierre R Bushel, Richard S Paules, William K Kaufmann, Tong Zho. Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals. Physiological genomics. vol 45. issue 19. 2014-06-11. PMID:23943852. |
ataxia telangiectasia (at) is a rare autosomal recessive disease caused by mutations in the ataxia telangiectasia-mutated gene (atm). |
2014-06-11 |
2023-08-12 |
human |
| Jinfeng Cui, Jing Liu, Sha Wu, Yuan Wang, Haitao Shen, Lingxiao Xing, Junling Wang, Xia Yan, Xianghong Zhan. Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro. Archives of toxicology. vol 87. issue 10. 2014-05-06. PMID:23515941. |
oxidative dna damage is involved in ochratoxin a-induced g2 arrest through ataxia telangiectasia-mutated (atm) pathways in human gastric epithelium ges-1 cells in vitro. |
2014-05-06 |
2023-08-12 |
human |
| Jinfeng Cui, Jing Liu, Sha Wu, Yuan Wang, Haitao Shen, Lingxiao Xing, Junling Wang, Xia Yan, Xianghong Zhan. Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro. Archives of toxicology. vol 87. issue 10. 2014-05-06. PMID:23515941. |
to explore the putative roles of oxidative dna damage and the ataxia telangiectasia-mutated (atm) pathways on the ota-induced g2 arrest, the current study systematically evaluated the roles of reactive oxygen species (ros) production, dna damage, and atm-dependent pathway activation on the ota-induced g2 phase arrest in ges-1 cells. |
2014-05-06 |
2023-08-12 |
human |
| Bianca Schröder-Heurich, Britta Wieland, Martin F Lavin, Detlev Schindler, Thilo Dör. Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 3. 2014-05-01. PMID:24344331. |
ionizing radiation led to an ∼4-fold increase in the rate of chromatin bridges in an ataxia telangiectatica mutated (atm)-dependent manner in human rad50-proficient fibroblasts but not in rad50-deficient cells. |
2014-05-01 |
2023-08-12 |
human |
| Julie Chaumeil, Mariann Micsinai, Panagiotis Ntziachristos, David B Roth, Iannis Aifantis, Yuval Kluger, Ludovic Deriano, Jane A Sko. The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage. Nature communications. vol 4. 2014-02-27. PMID:23900513. |
nonetheless, mistakes can happen, leading to the generation of aberrant rearrangements, such as tcra/d-igh inter-locus translocations that are a hallmark of ataxia telangiectasia-mutated (atm) deficiency. |
2014-02-27 |
2023-08-12 |
Not clear |
| Yi Zhou, Tanya T Paul. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). The Journal of biological chemistry. vol 288. issue 52. 2014-02-21. PMID:24220101. |
dna-dependent protein kinase regulates dna end resection in concert with mre11-rad50-nbs1 (mrn) and ataxia telangiectasia-mutated (atm). |
2014-02-21 |
2023-08-12 |
human |
| Gregory A Sowd, Nancy Yan Li, Ellen Fannin. ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication. PLoS pathogens. vol 9. issue 4. 2014-01-10. PMID:23592994. |
mutation of dna damage checkpoint signaling kinases ataxia telangiectasia-mutated (atm) or atm- and rad3-related (atr) results in genomic instability disorders. |
2014-01-10 |
2023-08-12 |
Not clear |
| Lorenzo Nanetti, Simona Cavalieri, Viviana Pensato, Alessandra Erbetta, Davide Pareyson, Marta Panzeri, Giovanna Zorzi, Carlo Antozzi, Isabella Moroni, Cinzia Gellera, Alfredo Brusco, Caterina Mariott. SETX mutations are a frequent genetic cause of juvenile and adult onset cerebellar ataxia with neuropathy and elevated serum alpha-fetoprotein. Orphanet journal of rare diseases. vol 8. 2014-01-02. PMID:23941260. |
ataxia with oculomotor apraxia defines a group of genetically distinct recessive ataxias including ataxia-telangectasia (a-t, atm gene), ataxia with oculomotor apraxia type 1 (aoa1, aptx gene) and type 2 (aoa2, setx gene). |
2014-01-02 |
2023-08-12 |
Not clear |
| Donghui Zhang, Yu Cui, Haitao Shen, Lingxiao Xing, Jinfeng Cui, Juan Wang, Xianghong Zhan. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PloS one. vol 8. issue 5. 2013-12-30. PMID:23705030. |
to further explore the molecular mechanism through which st induces g2 arrest, the current study was designed to precisely dissect the role of dna damage and the dna damage sensor ataxia telangiectasia-mutated (atm)/p53-dependent pathway in the st-induced g2 arrest in ges-1 cells. |
2013-12-30 |
2023-08-12 |
human |