| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth Keramaris, Atsushi Hirao, Ruth S Slack, Tak W Mak, David S Par. Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12857758. |
instead, we show that p53 phosphorylation, stability, as well as neuronal death is regulated, in part, by the ataxia telangiectasia-mutated (atm) protein. |
2003-11-17 |
2023-08-12 |
Not clear |
| Isaac A Manke, Drew M Lowery, Anhco Nguyen, Michael B Yaff. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (New York, N.Y.). vol 302. issue 5645. 2003-11-10. PMID:14576432. |
using a library of partially degenerate phosphopeptides, we identified tandem brct (brca1 carboxyl-terminal) domains in ptip (pax transactivation domain-interacting protein) and in brca1 as phosphoserine- or phosphothreonine-specific binding modules that recognize substrates phosphorylated by the kinases atm (ataxia telangiectasia-mutated) and atr (ataxia telangiectasia- and rad3-related) in response to gamma-irradiation. |
2003-11-10 |
2023-08-12 |
Not clear |
| Deborah A Greer, Blair D A Besley, Katherine B Kennedy, Scott Dave. hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941802. |
this localization is independent of the damage repair kinase ataxia telangiectasia-mutated kinase (atm), because hrad9/gamma h2ax colocalization still occurs in atm(-/-) fibroblasts. |
2003-09-24 |
2023-08-12 |
Not clear |
| Eugenia M Yazlovitskaya, Diane L Person. Inhibition of cisplatin-induced ATR activity and enhanced sensitivity to cisplatin. Anticancer research. vol 23. issue 3B. 2003-08-28. PMID:12894503. |
ataxia teleangiectasia mutated (atm) kinase, atm-rad3-related (atr) kinase and dna-protein kinase (dna-pk) belong to a subgroup of protein kinases which play a role in the dna damage response. |
2003-08-28 |
2023-08-12 |
Not clear |
| Haiming Ding, Wenrui Duan, Wei-Guo Zhu, Rong Ju, Kanur Srinivasan, Gregory A Otterson, Miguel A Villalona-Caler. P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells. Biochemical and biophysical research communications. vol 305. issue 4. 2003-07-24. PMID:12767922. |
caffeine, an ataxia telangiectasia-mutated (atm), and atm- and rad3-related kinase (atr) inhibitor, abrogated genistein-induced p21(waf1/cip1) and largely blocked etoposide-induced p21(waf1/cip1) expression. |
2003-07-24 |
2023-08-12 |
human |
| Irene M Ward, Kay Minn, Jan van Deursen, Junjie Che. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Molecular and cellular biology. vol 23. issue 7. 2003-04-04. PMID:12640136. |
it relocates to the sites of dna strand breaks in response to dna damage and is a putative substrate of the ataxia telangiectasia-mutated (atm) kinase. |
2003-04-04 |
2023-08-12 |
mouse |
| Yi Tan. [ATM and Cancer]. Zhongguo shi yan xue ye xue za zhi. vol 10. issue 1. 2003-02-03. PMID:12513844. |
the mutation of at gene (atm) leads to the at disease (ataxia telangiectasis), the cancer incidence of at patients and its carriers are significantly higher than the normal persons. |
2003-02-03 |
2023-08-12 |
human |
| Gopal P Sapkota, Maria Deak, Agnieszka Kieloch, Nick Morrice, Aaron A Goodarzi, Carl Smythe, Yosef Shiloh, Susan P Lees-Miller, Dario R Aless. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical journal. vol 368. issue Pt 2. 2003-01-17. PMID:12234250. |
thr-366 lies in an optimal phosphorylation motif for the phosphoinositide 3-kinase-like kinases dna-dependent protein kinase (dna-pk), ataxia telangiectasia mutated kinase (atm) and ataxia telangiectasia-related kinase (atr), which function as sensors for dna damage in cells and mediate cellular responses to dna damage. |
2003-01-17 |
2023-08-12 |
xenopus_laevis |
| Richard A DiTullio, Tamara A Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek, Thanos D Halazoneti. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature cell biology. vol 4. issue 12. 2003-01-09. PMID:12447382. |
53bp1 is required for at least a subset of ataxia telangiectasia-mutated (atm)-dependent phosphorylation events at sites of dna breaks and for cell cycle arrest at the g2-m interphase after exposure to irradiation. |
2003-01-09 |
2023-08-12 |
human |
| Pia Roos-Mattjus, Benjamin T Vroman, Matthew A Burtelow, Matthew Rauen, Alex K Eapen, Larry M Karnit. Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12228248. |
although we found that rad9 undergoes an additional phosphatidylinositol 3-kinase-related kinase (pikk)-dependent posttranslational modification, we also show that genotoxin-triggered 9-1-1 chromatin binding does not depend on the catalytic activity of the pikks ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), or dna-pk. |
2003-01-02 |
2023-08-12 |
human |
| Ying Liu, David M Virshup, Raymond L White, Lih-Ching Hs. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer research. vol 62. issue 22. 2002-12-17. PMID:12438214. |
kinases known to phosphorylate brca1 include cyclin-dependent kinase 2, as well as ataxia telangiectasia-mutated (atm) and atm and rad3-related kinase (atr), which function in g2 checkpoint control. |
2002-12-17 |
2023-08-12 |
Not clear |
| Ke-jie Yin, Shang-Der Chen, Jin-Moo Lee, Jan Xu, Chung Y Hs. ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells. Stroke. vol 33. issue 10. 2002-11-25. PMID:12364740. |
cells lacking the atm (ataxia telangectasia mutated) gene are hypersensitive to dna damage caused by a variety of insults. |
2002-11-25 |
2023-08-12 |
mouse |
| El Mustapha Bahassi, Christopher W Conn, David L Myer, Robert F Hennigan, Clare H McGowan, Yolanda Sanchez, Peter J Stambroo. Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. Oncogene. vol 21. issue 43. 2002-10-10. PMID:12242661. |
phosphorylation enhances its kinase activity and is dependent upon ataxia telangiectasia-mutated (atm) in the former case but not the latter. |
2002-10-10 |
2023-08-12 |
Not clear |
| Xinjiang Wang, Dan Michael, Gilbert de Murcia, Moshe Ore. p53 Activation by nitric oxide involves down-regulation of Mdm2. The Journal of biological chemistry. vol 277. issue 18. 2002-07-02. PMID:11867628. |
we report here that no induces the accumulation of transcriptionally active p53 in a variety of cell types and that no signaling to p53 does not require ataxia telangiectasia-mutated (atm), poly(adp-ribose) polymerase 1, or the arf tumor suppressor protein. |
2002-07-02 |
2023-08-12 |
mouse |
| Chang Y Guo, David L Brautigan, James M Larne. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. The Journal of biological chemistry. vol 277. issue 7. 2002-03-21. PMID:11723136. |
in ataxia telangiectasia-mutated (atm)-deficient cells the amount of nuclear pp2a heterotrimer relative to heterodimer was not reduced by radiation, but the radiation response was restored by transfection of these cells with plasmids encoding atm. |
2002-03-21 |
2023-08-12 |
Not clear |
| S Tavor, S Takeuchi, K Tsukasaki, C W Miller, W K Hofmann, T Ikezoe, J W Said, H P Koeffle. Analysis of the CHK2 gene in lymphoid malignancies. Leukemia & lymphoma. vol 42. issue 3. 2002-01-16. PMID:11699418. |
chk2 acts downstream of ataxia teleangiecstasia mutated (atm), modulates the function of p53 and may help mediate cell cycle arrest at g2/m by phosphorylation of cdc25c. |
2002-01-16 |
2023-08-12 |
human |
| H Wang, J Guan, H Wang, A R Perrault, Y Wang, G Iliaki. Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. Cancer research. vol 61. issue 23. 2002-01-03. PMID:11731442. |
although ataxia telangiectasia-mutated (atm) and dna-dependent protein kinase (dna-pk) phosphorylate rpa2 in vitro, their role in vivo remains uncertain, and contradictory results have been reported. |
2002-01-03 |
2023-08-12 |
human |
| J Xu, S Xin, W D. Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS letters. vol 508. issue 3. 2001-12-26. PMID:11728459. |
chk2 is a major target of ataxia telangiectasia-mutated (atm) and atm- and rad3-related (atr). |
2001-12-26 |
2023-08-12 |
drosophila_melanogaster |
| Y Morita, D V Maravei, L Bergeron, S Wang, G I Perez, O Tsutsumi, Y Taketani, M Asano, R Horai, S J Korsmeyer, Y Iwakura, J Yuan, J L Till. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell death and differentiation. vol 8. issue 6. 2001-11-01. PMID:11536012. |
caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (atm) gene function. |
2001-11-01 |
2023-08-12 |
mouse |
| Y Morita, D V Maravei, L Bergeron, S Wang, G I Perez, O Tsutsumi, Y Taketani, M Asano, R Horai, S J Korsmeyer, Y Iwakura, J Yuan, J L Till. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell death and differentiation. vol 8. issue 6. 2001-11-01. PMID:11536012. |
however, caspase-2 deficiency cannot overcome gametogenic failure resulting from meiotic recombination defects in ataxia telangiectasia-mutated (atm) null female mice. |
2001-11-01 |
2023-08-12 |
mouse |