| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peisu Zhang, Katsutoshi Furukawa, Patricia L Opresko, Xiangru Xu, Vilhelm A Bohr, Mark P Mattso. TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. Journal of neurochemistry. vol 97. issue 2. 2006-06-08. PMID:16539655. |
the telomere-associated protein trf2 (telomeric repeat binding factor 2) is critical for the control of telomere structure and function; trf2 dysfunction results in the exposure of the telomere ends and activation of atm (ataxia telangiectasin mutated)-mediated dna damage response. |
2006-06-08 |
2023-08-12 |
Not clear |
| Amanda S Coutts, Nicholas La Thangu. The p53 response during DNA damage: impact of transcriptional cofactors. Biochemical Society symposium. issue 73. 2006-05-25. PMID:16626298. |
dna damage induces the activity of p53, via damage sensors such as atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia-related), which leads to the transcriptional regulation of a variety of genes involved in cell cycle control and apoptosis. |
2006-05-25 |
2023-08-12 |
Not clear |
| Laura Carrassa, Massimo Broggini, Eugenio Erba, Giovanna Dami. Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. Cell cycle (Georgetown, Tex.). vol 3. issue 9. 2006-04-14. PMID:15326376. |
they are activated by upstream kinases (ataxia telangectasia mutated gene and atm and rad 3 related gene) and interfere with the activity of the cdc2/cyclinb1 complex, necessary for the g(2)-m transition, through the inactivation of the cdc25 phosphatases (cdc25a and cdc25c). |
2006-04-14 |
2023-08-12 |
Not clear |
| Young C Shin, Hiroyuki Nakamura, Xiaozhen Liang, Pinghui Feng, Heesoon Chang, Timothy F Kowalik, Jae U Jun. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. Journal of virology. vol 80. issue 5. 2006-03-17. PMID:16474133. |
infected cells recognize viral replication as a dna damage stress and elicit the ataxia telangiectasia-mutated (atm)/p53-mediated dna damage response signal transduction pathway as part of the host surveillance mechanisms, which ultimately induces the irreversible cell cycle arrest and apoptosis. |
2006-03-17 |
2023-08-12 |
Not clear |
| Christine T Brew, Ida Aronchik, Jocelyn C Hsu, Joon-Ho Sheen, Robert B Dickson, Leonard F Bjeldanes, Gary L Fireston. Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. International journal of cancer. vol 118. issue 4. 2006-02-28. PMID:16152627. |
with i3c treatment, phosphatidyl-inositol-3-kinase family member ataxia telangiectasia-mutated (atm) was phosphorylated, as were its substrates p53, chk2 and brca1. |
2006-02-28 |
2023-08-12 |
human |
| Alpna Tyagi, Rana P Singh, Chapla Agarwal, Sunitha Siriwardana, Robert A Sclafani, Rajesh Agarwa. Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis. vol 26. issue 11. 2005-12-13. PMID:15975956. |
further upstream, we observed that resveratrol causes phosphorylation of cell division cycle 25c (cdc25c) tyrosine phosphatase via the activation of checkpoint kinases chk1 and chk2, which in turn were activated via atm (ataxia telangiectasia mutated)/atr (ataxia telangiectasia-rad3-related) kinase in response to dna damage, as resveratrol also increased phospho-h2a.x (ser139), which is known to be phosphorylated by atm/atr in response to dna damage. |
2005-12-13 |
2023-08-12 |
human |
| M Meier, M L den Boer, A G Hall, J A E Irving, M Passier, L Minto, E R van Wering, G E Janka-Schaub, R Pieter. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia. Leukemia. vol 19. issue 11. 2005-11-15. PMID:16167060. |
relation between genetic variants of the ataxia telangiectasia-mutated (atm) gene, drug resistance, clinical outcome and predisposition to childhood t-lineage acute lymphoblastic leukaemia. |
2005-11-15 |
2023-08-12 |
Not clear |
| Markus Löbrich, Penny A Jegg. Harmonising the response to DSBs: a new string in the ATM bow. DNA repair. vol 4. issue 7. 2005-10-03. PMID:15978533. |
ataxia telangiestasia mutated protein (atm) is the major kinase that initiates the dna damage signal transduction response following exposure to ionising radiation (ir) in mammalian cells. |
2005-10-03 |
2023-08-12 |
Not clear |
| Zheng Zhang, Joan D Ferraris, Carlos E Irarrazabal, Natalia I Dmitrieva, Jong-Hwan Park, Maurice B Bur. Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP. American journal of physiology. Renal physiology. vol 289. issue 3. 2005-09-27. PMID:15840767. |
high nacl also damages dna, and dna damage activates ataxia telangiectasia-mutated (atm) kinase through autophosphorylation on serine 1981. |
2005-09-27 |
2023-08-12 |
Not clear |
| J L Andersen, E S Zimmerman, J L DeHart, S Murala, O Ardon, J Blackett, J Chen, V Planelle. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell death and differentiation. vol 12. issue 4. 2005-09-07. PMID:15650754. |
in a previous study, we identified the ataxia telangiectasia-mutated (atm) and rad3-related protein (atr) as a cellular factor that mediates vpr-induced cell cycle arrest. |
2005-09-07 |
2023-08-12 |
human |
| Hui-Ju Ch'ang, Jerzy G Maj, François Paris, H Rosie Xing, Jianjun Zhang, Jean-Philip Truman, Carlos Cardon-Cardo, Adriana Haimovitz-Friedman, Richard Kolesnick, Zvi Fuk. ATM regulates target switching to escalating doses of radiation in the intestines. Nature medicine. vol 11. issue 5. 2005-07-12. PMID:15864314. |
whereas ataxia telangiectasia-mutated (atm) kinase normally represses ceramide synthase, its derepression in atm(-/-) mice increased crypt stem cell radiosensitivity 3.7-fold without sensitizing the microvascular response. |
2005-07-12 |
2023-08-12 |
mouse |
| Natalia I Dmitrieva, Maurice B Burg, Joan D Ferrari. DNA damage and osmotic regulation in the kidney. American journal of physiology. Renal physiology. vol 289. issue 1. 2005-07-11. PMID:15951478. |
the inhibition of dna repair is associated with suppressed activity of some dna damage-response proteins like mre11, chk1, and h2ax but not that of others, like gadd45, p53, ataxia telangiectasia-mutated kinase (atm), and ku86. |
2005-07-11 |
2023-08-12 |
Not clear |
| Julie K Horton, Donna F Stefanick, Jana M Naron, Padmini S Kedar, Samuel H Wilso. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. The Journal of biological chemistry. vol 280. issue 16. 2005-06-23. PMID:15701627. |
caffeine, an inhibitor of the upstream checkpoint kinases atm (ataxia telangiectasia-mutated) and atr (atm and rad3-related), has no effect on the early inhibition of dna synthesis, but cells are no longer able to maintain the block after 8 h. instead, the addition of caffeine leads to arrest of cells in g(2)/m rather than s-phase after 24 h. analysis of signaling pathways in cell extracts reveals an activation of chk1 after treatment with mms and 4-an, which can be suppressed by caffeine. |
2005-06-23 |
2023-08-12 |
mouse |
| Ayumi Kudoh, Masatoshi Fujita, Lumin Zhang, Noriko Shirata, Tohru Daikoku, Yutaka Sugaya, Hiroki Isomura, Yukihiro Nishiyama, Tatsuya Tsurum. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611093. |
induction of the epstein-barr virus (ebv) lytic program elicited a cellular dna damage response, with activation of the ataxia telangiectasia-mutated (atm) signal transduction pathway. |
2005-04-07 |
2023-08-12 |
Not clear |
| Paul A Jowsey, Aidan J Doherty, John Rous. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. The Journal of biological chemistry. vol 279. issue 53. 2005-02-25. PMID:15456759. |
human ptip (hptip) was recently isolated in a screen for proteins, translated from cdna pools, capable of interacting with peptides phosphorylated by the atm (ataxia telangiectasia-mutated)/atr (ataxia telangiectasia-related) protein kinases. |
2005-02-25 |
2023-08-12 |
mouse |
| Joanne M Lumsden, Thomas McCarty, Lisa K Petiniot, Rhuna Shen, Carrolee Barlow, Thomas A Wynn, Herbert C Morse, Patricia J Gearhart, Anthony Wynshaw-Boris, Edward E Max, Richard J Hode. Immunoglobulin class switch recombination is impaired in Atm-deficient mice. The Journal of experimental medicine. vol 200. issue 9. 2005-01-18. PMID:15504820. |
because the protein kinase ataxia telengiectasia (at) mutated (atm) plays a critical role in dsb repair and at patients show abnormalities of ig isotype expression, we assessed the role of atm in csr by examining atm-deficient mice. |
2005-01-18 |
2023-08-12 |
mouse |
| A Carter, K Lin, P D Sherrington, A R Pettit. Detection of p53 dysfunction by flow cytometry in chronic lymphocytic leukaemia. British journal of haematology. vol 127. issue 4. 2004-12-17. PMID:15521919. |
the type b defect is characterized by impaired ir-induced p53 up-regulation and is associated with inactivation of the ataxia telangiectasia-mutated gene (atm). |
2004-12-17 |
2023-08-12 |
Not clear |
| D Alwyn Dart, Kate E Adams, Ildem Akerman, Nicholas D Laki. Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. The Journal of biological chemistry. vol 279. issue 16. 2004-07-22. PMID:14871897. |
the ataxia telangiectasia-mutated (atm) and rad3-related kinase (atr) is a central component of the cell cycle checkpoint machinery required to induce cell cycle arrest in response to dna damage. |
2004-07-22 |
2023-08-12 |
Not clear |
| Shutong Yang, Christin Kuo, John E Bisi, Myung K Ki. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nature cell biology. vol 4. issue 11. 2004-04-14. PMID:12402044. |
here, we report that hcds1/chk2 mediates gamma irradiation-induced apoptosis in a p53-independent manner through an ataxia telangiectasia-mutated (atm)-hcds1/chk2-pml pathway. |
2004-04-14 |
2023-08-12 |
Not clear |
| Kumuda C Das, Ravi Dashnamoorth. Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 1. 2004-02-06. PMID:12959929. |
although h2o2 and other peroxides have been shown to induce ataxia telangiectasia-mutated (atm)-dependent p53 phosphorylation in response to dna damage, the signal transduction mechanisms in response to hyperoxia are currently unknown. |
2004-02-06 |
2023-08-12 |
Not clear |