| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
pathological changes in the tau protein, at the gene and protein level due to cerebral ischemia, can lead to the development of alzheimer's disease-type neuropathology and dementia. |
2021-11-19 |
2023-08-13 |
Not clear |
| Brian Spencer, Robert A Rissman, Cassia Overk, Eliezer Maslia. Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer's Disease and Related Dementias. Methods in molecular biology (Clifton, N.J.). vol 2383. 2021-11-19. PMID:34766306. |
these single chain antibodies are modified by the addition of a fragment of the apob protein to facilitate trafficking into the brain, once in the cns these antibody fragments recognize tau with potential value for the treatment of ad and related dementias. |
2021-11-19 |
2023-08-13 |
Not clear |
| Emma Gerrits, Nieske Brouwer, Susanne M Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, Jan Mulder, Markus Kummer, Thomas Möller, Knut Biber, Wilfred F A den Dunnen, Peter P De Deyn, Bart J L Eggen, Erik W G M Boddek. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33609158. |
alzheimer's disease (ad) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads. |
2021-11-16 |
2023-08-13 |
mouse |
| Izabela Winkel, Natalia Ermann, Agnieszka Żelwetro, Bożydar Sambor, Barbara Mroczko, Johannes Kornhuber, Bogusław Paradowski, Piotr Lewczu. Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 6. 2021-11-16. PMID:34036433. |
αsyn and the four neurochemical dementia diagnostics (ndd) csf biomarkers, (aβ1-42, aβ42/40, tau, and ptau181), interpreted according to the erlangen score algorithm, were measured in patients with positive ndd results and presence of extrapyramidal symptoms (ndd + / ep+; n = 26), in patients with positive ndd results and absence of extrapyramidal symptoms (ndd+ / ep-; n = 54), and in subjects with negative ndd results (ndd-; n = 34). |
2021-11-16 |
2023-08-13 |
human |
| Joseph Therriault, Tharick A Pascoal, Marcus Sefranek, Sulantha Mathotaarachchi, Andrea L Benedet, Mira Chamoun, Firoza Z Lussier, Cécile Tissot, Bruna Bellaver, Pamela S Lukasewicz, Eduardo R Zimmer, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Net. Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia. Annals of clinical and translational neurology. vol 8. issue 10. 2021-11-16. PMID:34617688. |
amyloid-dependent and amyloid-independent effects of tau in individuals without dementia. |
2021-11-16 |
2023-08-13 |
Not clear |
| Joseph Therriault, Tharick A Pascoal, Marcus Sefranek, Sulantha Mathotaarachchi, Andrea L Benedet, Mira Chamoun, Firoza Z Lussier, Cécile Tissot, Bruna Bellaver, Pamela S Lukasewicz, Eduardo R Zimmer, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Net. Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia. Annals of clinical and translational neurology. vol 8. issue 10. 2021-11-16. PMID:34617688. |
to investigate the relationship between the topography of amyloid-β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. |
2021-11-16 |
2023-08-13 |
Not clear |
| Fabian Kreilaus, Rebecca Masanetz, Georgia Watt, Magdalena Przybyla, Arne Ittner, Lars Ittner, Tim Kar. The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. vol 397. 2021-11-15. PMID:33017638. |
the tau58/2 transgenic mouse model expresses mutant human tau (p301s mutation) and exhibits behavioural abnormalities relevant to dementia in early adulthood. |
2021-11-15 |
2023-08-13 |
mouse |
| Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-13. PMID:34607969. |
frontotemporal lobar dementia mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism. |
2021-11-13 |
2023-08-13 |
rat |
| Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-13. PMID:34607969. |
inherited mutations in tau cause early onset frontotemporal lobar dementias (ftld-tau) and are commonly used to model mechanisms of tau toxicity in tauopathies. |
2021-11-13 |
2023-08-13 |
rat |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
alzheimer's disease is the most common form of dementia characterized by intracellular aggregates of hyperphosphorylated tau protein and extracellular accumulation of amyloid β (aβ) peptides. |
2021-11-11 |
2023-08-13 |
mouse |
| Jessica E Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q Trojanowski, Dheeraj Malhotra, Daniel H Geschwin. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell reports. vol 33. issue 7. 2021-11-08. PMID:33207193. |
tau pathology drives dementia risk-associated gene networks toward chronic inflammatory states and immunosuppression. |
2021-11-08 |
2023-08-13 |
mouse |
| Pradeep K Singh, Ana Badimon, Zu-Lin Chen, Sidney Strickland, Erin H Norri. The contact activation system and vascular factors as alternative targets for Alzheimer's disease therapy. Research and practice in thrombosis and haemostasis. vol 5. issue 4. 2021-11-06. PMID:33977208. |
however, approaches to slow or stop ad progression and dementia by reducing aβ production, neutralizing toxic aβ aggregates, or inhibiting tau aggregation have been largely unsuccessful in clinical trials. |
2021-11-06 |
2023-08-13 |
Not clear |
| Tammaryn Lashley, Maria-Armineh Tossounian, Neve Costello Heaven, Samantha Wallworth, Sew Peak-Chew, Aaron Bradshaw, J Mark Cooper, Rohan de Silva, Surjit Kaila Srai, Oksana Malanchuk, Valeriy Filonenko, Margreet B Koopman, Stefan G D Rüdiger, Mark Skehel, Ivan Gou. Extensive Anti-CoA Immunostaining in Alzheimer's Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A. Frontiers in cellular neuroscience. vol 15. 2021-11-02. PMID:34720880. |
extensive anti-coa immunostaining in alzheimer's disease and covalent modification of tau by a key cellular metabolite coenzyme a. alzheimer's disease (ad) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. |
2021-11-02 |
2023-08-13 |
human |
| Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of disease. vol 147. 2021-11-01. PMID:33184027. |
aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like alzheimer's disease. |
2021-11-01 |
2023-08-13 |
mouse |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:34426645. |
alzheimer's disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. |
2021-11-01 |
2023-08-13 |
Not clear |
| Jiajun Han, Yaohua Fan, Peipei Wu, Zifeng Huang, Xinrong Li, Lijun Zhao, Yichun Ji, Meiling Zh. Parkinson's Disease Dementia: Synergistic Effects of Alpha-Synuclein, Tau, Beta-Amyloid, and Iron. Frontiers in aging neuroscience. vol 13. 2021-10-30. PMID:34707492. |
parkinson's disease dementia: synergistic effects of alpha-synuclein, tau, beta-amyloid, and iron. |
2021-10-30 |
2023-08-13 |
Not clear |
| Maggie E Amer, Azza I Othamn, Mohamed A El-Missir. Melatonin ameliorates diabetes-induced brain injury in rats. Acta histochemica. vol 123. issue 2. 2021-10-29. PMID:33401187. |
mlt also prevented increase in homocysteine, amyloid-β42 and tau levels in diabetic rats, and this suggests that it can reduce the risk of dementia. |
2021-10-29 |
2023-08-13 |
rat |
| D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32643143. |
second, studies at early time points show that pathology begins decades before the onset of dementia and indicate different anatomical locations for initiation of aβ and tau accumulation. |
2021-10-28 |
2023-08-13 |
human |
| Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowi. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cells. vol 10. issue 7. 2021-10-28. PMID:34209408. |
tau pathology correlates not only with progressive dementia but also with microglia-mediated inflammation in ad. |
2021-10-28 |
2023-08-13 |
human |
| Ayman A Soubh, Amira A El-Gazar, Eman A Mohamed, Azza S Awad, Hanan S El-Abha. Further insights for the role of Morin in mRTBI: Implication of non-canonical Wnt/PKC-α and JAK-2/STAT-3 signaling pathways. International immunopharmacology. vol 100. 2021-10-27. PMID:34560511. |
the results obtained has shown that all the chosen regimens opposed the upregulated dementia markers (aβ1-40,p(thr231)tau) and inflammatory protein contents/expression of p(ser53s6)nf-κbp65, tnf-α, il-6,and il-1β and the elevated gfap in immune stained cortex sections. |
2021-10-27 |
2023-08-13 |
Not clear |