| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
abnormal accumulation of tau protein is closely associated with neurodegeneration and cognitive impairment and it is a biomarker of neurodegeneration in the dementia field, especially in alzheimer's disease (ad); therefore, it is crucial to be able to assess the tau deposits in vivo. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
in recent years, several first-generation tau pet tracers have been developed and applied in the dementia field. |
2021-12-10 |
2023-08-13 |
Not clear |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
we also describe the distribution patterns of tau tracers in ad, in atypical ad, and further neurodegenerative diseases in the dementia field. |
2021-12-10 |
2023-08-13 |
Not clear |
| Jian-Hong Wang, Lei Guo, Su Wang, Neng-Wei Yu, Fu-Qiang Gu. The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions. Current opinion in pharmacology. vol 62. 2021-12-10. PMID:34891124. |
β-hydroxybutyl acid (βohb), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially alzheimer's dementia (ad), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of aβ and tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. |
2021-12-10 |
2023-08-13 |
human |
| Joana B Pereira, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Danielle van Westen, Jeffrey L Dage, Niklas Mattsson-Carlgren, Oskar Hansso. Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34077494. |
to achieve this, plasma amyloid-β 42/40 (aβ42/40), phosphorylated-tau181, phosphorylated-tau217 and neurofilament light were determined in 159 non-demented individuals, 123 patients with alzheimer's disease dementia and 35 patients with a non-alzheimer's dementia from the swedish biofinder-2 study, who underwent longitudinal amyloid (18f-flutemetamol) and tau (18f-ro948) pet, structural mri (t1-weighted) and cognitive testing. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
dementia with lewy bodies (dlb) is neuropathologically defined by the presence of α-synuclein aggregates, but many dlb cases show concurrent alzheimer's disease pathology in the form of amyloid-β plaques and tau neurofibrillary tangles. |
2021-12-09 |
2023-08-13 |
human |
| Paul A Yushkevich, Mónica Muñoz López, María Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R Das, Emilio Artacho-Pérula, Marı'a Del Mar Arroyo Jiménez, Marı'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward B Lee, John Q Trojanowski, Daniel T Ohm, Laura E M Wisse, David A Wolk, David J Irwin, Ricardo Insaust. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34259858. |
tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in alzheimer's disease and related dementias. |
2021-12-09 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
a next generation of tau pet tracers for the imaging of alzheimer's disease and other dementias has recently been developed. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
we characterized the binding of the tau tracers pi2620, ro948, mk6240 and jnj067 in human post-mortem brain tissue from a cohort of 25 dementia cases and age-matched controls using quantitative phosphorimaging with tritium-labelled radiotracers in conjunction with phospho-tau specific immunohistochemistry. |
2021-12-08 |
2023-08-13 |
human |
| Rebecca M Parodi-Rullán, Sabzali Javadov, Silvia Fossat. Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Cells. vol 10. issue 11. 2021-12-08. PMID:34831125. |
alzheimer's disease (ad) is the most prevalent cause of dementia and is pathologically characterized by the presence of parenchymal senile plaques composed of amyloid β (aβ) and intraneuronal neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-12-08 |
2023-08-13 |
Not clear |
| Ali Ezzati, Ahmed Abdulkadir, Clifford R Jack, Paul M Thompson, Danielle J Harvey, Monica Truelove-Hill, Lasya P Sreepada, Christos Davatzikos, Richard B Lipto. Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer's disease dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 11. 2021-12-08. PMID:34870371. |
we aimed to evaluate the value of atn biomarker classification system (amyloid beta [a], pathologic tau [t], and neurodegeneration [n]) for predicting conversion from mild cognitive impairment (mci) to dementia. |
2021-12-08 |
2023-08-13 |
Not clear |
| Michelle R Campbell, Susan Ashrafzadeh-Kian, Ronald C Petersen, Michelle M Mielke, Jeremy A Syrjanen, Argonde C van Harten, Val J Lowe, Clifford R Jack, Joshua A Bornhorst, Alicia Algeciras-Schimnic. P-tau/Aβ42 and Aβ42/40 ratios in CSF are equally predictive of amyloid PET status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-12-01. PMID:34027020. |
measurement of amyloid beta (aβ40 and aβ42) and tau (phosphorylated tau [p-tau] and total tau [t-tau]) in cerebrospinal fluid (csf) can be utilized to differentiate clinical and preclinical alzheimer's disease dementia (ad) from other neurodegenerative processes. |
2021-12-01 |
2023-08-13 |
Not clear |
| Elijah Mak, Nicolas Nicastro, Maura Malpetti, George Savulich, Ajenthan Surendranathan, Negin Holland, Luca Passamonti, P Simon Jones, Stephen F Carter, Li Su, Young T Hong, Tim D Fryer, Guy B Williams, Franklin Aigbirhio, James B Rowe, John T O'Brie. Imaging tau burden in dementia with Lewy bodies using [ Neurobiology of aging. vol 101. 2021-11-30. PMID:33631469. |
imaging tau burden in dementia with lewy bodies using [ alzheimer's disease (ad) pathology is frequently observed as a comorbidity in people with dementia with lewy bodies (dlb). |
2021-11-30 |
2023-08-13 |
Not clear |
| Sheelakumari Raghavan, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Jonathan Graff-Radford, Christopher G Schwarz, David S Knopman, Michelle M Mielke, Mary M Machulda, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition. Brain communications. vol 3. issue 2. 2021-11-30. PMID:34136811. |
three hundred and twenty-eight participants (264 cognitively unimpaired, 57 mild cognitive impairment and 7 dementia with a mean age of 68.3 ± 13.1 years) from the mayo clinic study of aging with multi-shell diffusion imaging, fluid attenuated inversion recovery mri as well as amyloid and tau pet scans were included in this study. |
2021-11-30 |
2023-08-13 |
human |
| Sumire Matsumoto, Tomomi Tsunemats. Association between Sleep, Alzheimer's, and Parkinson's Disease. Biology. vol 10. issue 11. 2021-11-30. PMID:34827122. |
alzheimer's disease (ad) is a type of dementia that slowly affects memory and cognitive function, and is characterized by the aggregation of the β-amyloid protein and tau neurofibrillary tangles in the brain. |
2021-11-30 |
2023-08-13 |
Not clear |
| Heiko Kroth, Felix Oden, Andreia Monica Serra, Jerome Molette, Andre Mueller, Mathias Berndt, Francesca Capotosti, Emanuele Gabellieri, Heribert Schmitt-Willich, David Hickman, Andrea Pfeifer, Ludger Dinkelborg, Andrew Stephen. Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core. Bioorganic & medicinal chemistry. vol 52. 2021-11-30. PMID:34839158. |
tau aggregates represent a critical pathology in alzheimer's disease (ad) and other forms of dementia. |
2021-11-30 |
2023-08-13 |
human |
| Nastaran Samimi, Govinda Sharma, Taeko Kimura, Tomoyasu Matsubara, Anni Huo, Kurumi Chiba, Yuko Saito, Shigeo Murayama, Hiroyasu Akatsu, Yoshio Hashizume, Masato Hasegawa, Mojtaba Farjam, Koorosh Shahpasand, Kanae Ando, Shin-Ichi Hisanag. Distinct phosphorylation profiles of tau in brains of patients with different tauopathies. Neurobiology of aging. vol 108. 2021-11-24. PMID:34536819. |
here, we investigated the phosphorylation states of tau in several tauopathies, including corticobasal degeneration, pick's disease, progressive supranuclear palsy (psp), argyrophilic grain dementia (agd) and alzheimer's disease (ad). |
2021-11-24 |
2023-08-13 |
Not clear |
| James R Hall, Melissa Petersen, Leigh Johnson, Sid E O'Bryan. Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults. Frontiers in psychology. vol 12. 2021-11-23. PMID:34803857. |
tau pathology is a key feature of a number of dementias. |
2021-11-23 |
2023-08-13 |
human |
| Tun-Wei Hsu, Jong-Ling Fuh, Da-Wei Wang, Li-Fen Chen, Chia-Jung Chang, Wen-Sheng Huang, Hsiu-Mei Wu, Wan-Yuo Gu. Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686089. |
disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from dementia is related to the cellular accumulation of β-amyloid plaques, tau aggregates, or α-synuclein aggregates, or to neurotransmitter deficiencies in the dopaminergic and cholinergic pathways. |
2021-11-22 |
2023-08-13 |
human |
| Charles Arber, Argyro Alatza, Claire A Leckey, Ross W Paterson, Henrik Zetterberg, Selina Wra. Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia. Journal of neurochemistry. vol 159. issue 2. 2021-11-19. PMID:33539581. |
mass spectrometry analysis of tau and amyloid-beta in ipsc-derived models of alzheimer's disease and dementia. |
2021-11-19 |
2023-08-13 |
human |