| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Gómez-Isla, Matthew P Frosc. Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes. Nature reviews. Neurology. 2022-03-25. PMID:35332316. |
in this review, we begin by considering the heterogeneity of clinical manifestations associated with the presence of plaques and tangles, and then focus on insights derived from the rare yet informative individuals who display high amounts of amyloid and tau deposition in their brains (observed directly at autopsy) without manifesting dementia during life. |
2022-03-25 |
2023-08-13 |
Not clear |
| Niels Hansen, Aaron Levin Juhl, Insa Maria Grenzer, Sina Hirschel, Bianca Teegen, Dirk Fitzner, Claudia Bartels, Charles Timäus, Jens Wiltfang, Berend Malcho. Cerebrospinal Fluid Total Tau Protein Correlates With Longitudinal, Progressing Cognitive Dysfunction in Anti-Neural Autoantibody-Associated Dementia and Alzheimer's Dementia: A Case-Control Study. Frontiers in immunology. vol 13. 2022-03-21. PMID:35309366. |
cerebrospinal fluid total tau protein correlates with longitudinal, progressing cognitive dysfunction in anti-neural autoantibody-associated dementia and alzheimer's dementia: a case-control study. |
2022-03-21 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Frédérique K Kok, Suzanne L van Leerdam, Elizabeth C M de Lang. Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. 2022-03-11. PMID:35275527. |
alzheimer's disease (ad) is the most common form of dementia and typically characterized by the accumulation amyloid-β plaques and tau tangles. |
2022-03-11 |
2023-08-13 |
human |
| Tyler C Hammond, Xin Xing, Lucy M Yanckello, Arnold Stromberg, Ya-Hsuan Chang, Peter T Nelson, Ai-Ling Li. Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer's Disease. Journal of cellular immunology. vol 3. issue 6. 2022-03-10. PMID:35265943. |
alzheimer's disease (ad) is the most common form of dementia with hallmarks of β-amyloid (aβ) plaques, tau tangles, and neurodegeneration. |
2022-03-10 |
2023-08-13 |
human |
| Qin Chen, Scott A Przybelski, Matthew L Senjem, Christopher G Schwarz, Timothy G Lesnick, Hugo Botha, David S Knopman, Jonathan Graff-Radford, Rodolfo Savica, David T Jones, Julie A Fields, Manoj K Jain, Neill R Graff-Radford, Tanis J Ferman, Walter K Kremers, Clifford R Jack, Ronald C Petersen, Bradley F Boeve, Val J Lowe, Kejal Kantarc. Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies. Movement disorders : official journal of the Movement Disorder Society. 2022-03-09. PMID:35261094. |
longitudinal tau positron emission tomography in dementia with lewy bodies. |
2022-03-09 |
2023-08-13 |
Not clear |
| Heidi G Standke, Allison Krau. Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. Cell and tissue research. 2022-03-08. PMID:35258712. |
first shown for prp prions and prion diseases, it is now recognized that self-propagating misfolded proteins occur broadly in neurodegenerative diseases and include amyloid-β (aβ) and tau in alzheimer's disease (ad), tau in chronic traumatic encephalopathy (cte), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), and α-synuclein (α-syn) in parkinson's disease (pd) and lewy body dementias (lbd). |
2022-03-08 |
2023-08-13 |
Not clear |
| Hao Hu, Jun-Ting Fu, Yan-Lin Bi, Ya-Hui Ma, Yu-Yuan Huang, Xin Wang, Lan Tan, Jin-Tai Y. Tau Pathologies Mediate the Association of Cigarette Smoking with Cognitive Impairment in Older Adults Without Dementia: The CABLE Study. Journal of Alzheimer's disease : JAD. 2022-03-07. PMID:35253762. |
tau pathologies mediate the association of cigarette smoking with cognitive impairment in older adults without dementia: the cable study. |
2022-03-07 |
2023-08-13 |
Not clear |
| Jéssica Abdo Gonçalves Tosatti, Adriana Fialho da Silva Fontes, Paulo Caramelli, Karina Braga Gome. Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials. Drugs & aging. 2022-02-21. PMID:35187615. |
alzheimer's disease (ad) comprises 60-70% of diagnosed dementia cases, and is characterized by the deposition of β-amyloid peptide and the formation of neurofibrillary tangles of tau protein. |
2022-02-21 |
2023-08-13 |
Not clear |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
thanks to recent technological advances, total and phosphorylated tau can now be quantified also on peripheral blood, and accumulating evidence shows that measurement of plasma phosphorylated tau species (p-tau181, p-tau217, and p-tau231) has high performances in discriminating ad patients from cognitively unimpaired subjects but also from patients with other dementias. |
2022-02-17 |
2023-08-13 |
human |
| Carolyn N Mann, Shamulailatpam Shreedarshanee Devi, Corey T Kersting, Amber V Bleem, Celeste M Karch, David M Holtzman, Gilbert Gallard. Astrocytic α2-Na Science translational medicine. vol 14. issue 632. 2022-02-16. PMID:35171651. |
astrocytic α2-na alzheimer's disease (ad) is the most dominant form of dementia characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tau tangles (nfts). |
2022-02-16 |
2023-08-13 |
Not clear |
| Elena Pizzo, Jennifer Wenborn, Jane Burgess, Jacqueline Mundy, Martin Orrell, Michael King, Rumana Omar, Stephen Morri. Cost-utility analysis of community occupational therapy in dementia (COTiD-UK) versus usual care: Results from VALID, a multi-site randomised controlled trial in the UK. PloS one. vol 17. issue 2. 2022-02-11. PMID:35148329. |
a community-based occupational therapy intervention for people with mild to moderate dementia and their family carers: the community occupational therapy in dementia-uk version (cotid-uk); and treatment as usual (tau) were randomly assigned to 468 pairs (each comprising a person with dementia and a family carer) in the valuing active life in dementia (valid) randomised controlled trial (rct). |
2022-02-11 |
2023-08-13 |
Not clear |
| Sheelakumari Raghavan, Scott A Przybelski, Robert I Reid, Timothy G Lesnick, Vijay K Ramanan, Hugo Botha, Billie J Matchett, Melissa E Murray, R Ross Reichard, David S Knopman, Jonathan Graff-Radford, David T Jones, Val J Lowe, Michelle M Mielke, Mary M Machulda, Ronald C Petersen, Kejal Kantarci, Jennifer L Whitwell, Keith A Josephs, Clifford R Jack, Prashanthi Vemur. White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition. Acta neuropathologica communications. vol 10. issue 1. 2022-02-06. PMID:35123591. |
we identified two independent cohorts with multi-shell diffusion mri, amyloid and tau pet, and cognitive assessments: specifically, a population-based cohort of 347 elderly randomly sampled from the olmsted county, minnesota, population and a clinical research-based cohort of 61 amyloid positive alzheimer's dementia participants. |
2022-02-06 |
2023-08-13 |
human |
| Rebecca L Kow, Aristide H Black, Aleen D Saxton, Nicole F Liachko, Brian C Kraeme. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. GeroScience. 2022-02-05. PMID:35122183. |
neurodegenerative diseases with tau pathology, or tauopathies, include alzheimer's disease and related dementia disorders. |
2022-02-05 |
2023-08-13 |
mouse |
| Rik Ossenkoppele, Colin Groo. Associations between the APOE-ε2 and APOE-ε4 alleles with resistance and resilience against Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108977. |
to examine associations between the apoe-ε2 and apoe-ε4 alleles and core alzheimer's disease (ad) pathological hallmarks as measured by amyloid-β (aβ) and tau pet in older individuals without dementia. |
2022-02-03 |
2023-08-13 |
Not clear |
| Laura Vegas-Gomez, George A Edwards, Omar Hasan, Nazaret Gamez Ruiz, Jonathan Schulz, Claudio Soto, Paul E Schulz, Ines Moreno-Gonzale. Correlation between 18F-THK5351 tau PET imaging and the progression of neuropathology and clinical signs in a mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109088. |
positron emission tomography (pet) imaging is a promising avenue that may identify tau aggregates in vivo cross-sectionally and longitudinally in various dementia conditions. |
2022-02-03 |
2023-08-13 |
mouse |
| Miguel Minaya, Rita Martinez, William W Seeley, Abdallah M Eteleeb, Carlos Cruchaga, Oscar Harari, Celeste M Karc. Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient-derived pluripotent cell models. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109104. |
mutations in the microtubule-associated protein tau (mapt) cause heterogeneous forms of frontotemporal lobar dementia with tau inclusions (ftld-tau). |
2022-02-03 |
2023-08-13 |
Not clear |
| Grant Kauwe, Kristeen Pareja-Navarro, Jackson Chen, Yaqiao Li, David Le, Yungui Zhou, Li Gan, Tara E Trac. Effect of KIBRA on tau-mediated synaptic and memory deficits. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109173. |
previous work showed that aberrant acetylation of k274 and k281 on tau in postmortem human ad brains is linked to dementia. |
2022-02-03 |
2023-08-13 |
mouse |
| Timothy Wu, Caiwei Guo, Joshua M Shulma. Elucidating cellular contributions to tau-mediated neurodegeneration using drosophila and single-cell transcriptomics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109262. |
alzheimer's dementia (ad) is neuropathologically defined by aggregations of amyloid-beta plaques and tau neurofibrillary tangles in the brain, with tau pathology being most strongly correlated with cognitive decline. |
2022-02-03 |
2023-08-13 |
human |
| Pamela V Martino Adami, Adelina Orellana, Pablo García, Luca Kleineidam, Emilio Alarcón-Martín, Laura Montrreal, Nuria Aguilera, Ana Espinosa, Carla Abdelnour, Maitee Rosende-Roca, Juan Pablo Tartari, Liliana Vargas, Ana Mauleón, Ester Esteban-De Antonio, Rogelio López-Cuevas, Maria Carolina Dalmasso, Rafael Campos Martin, Kayenat Parveen, Victor M Andrade Fuentes, Najaf Amin, Shahzad Ahmad, M Arfan Ikram, Piotr Lewczuk, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Eckart Rüther, Jens Wiltfang, Lluis Tarraga, Merce Boada, Wolfgang Maier, Itziar de Rojas, Amanda Cano, Angela Sanabria, Montserrat Alegret, Isabel Hernández, Marta Marquié, Sergi Valero, Cornelia M van Duijn, Michael Wagner, Frank Jessen, Anja Schneider, María Eugenia Sáez Goñi, Antonio González Pérez, Agustín Ruiz, Alfredo Ramíre. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type. Brain : a journal of neurology. 2022-01-28. PMID:35088840. |
our findings support the use of csf matrix metalloproteinase 10 as a prognostic marker for dementia of the alzheimer's type and its inclusion to the [a/t/(n)] scheme to incorporate pathologic aspects beyond amyloid and tau. |
2022-01-28 |
2023-08-13 |
human |