| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A Wolk, John Q Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbol. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-02. PMID:35655068. |
in this work, we measured asyn and tau aggregate concentrations of 237 cerebrospinal fluid (csf) samples from five cohorts: parkinson's disease (pd), dementia with lewy bodies (dlb), alzheimer's disease (ad), progressive supranuclear palsy (psp), and a neurologically-normal control group. |
2022-06-02 |
2023-08-14 |
human |
| Yutaka Nakagawa, Shizuo Yamad. The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications. Cellular and molecular neurobiology. 2022-05-31. PMID:35635600. |
in early alzheimer's and parkinson's diseases, metal dyshomeostasis and mitochondrial dysfunction likely induce locus coeruleus hyperactivation, pathological tau or α-synuclein formation, and neurodegeneration, while reduction of glymphatic and cerebrospinal fluid flow might be responsible for β-amyloid aggregation in the olfactory regions before the onset of dementia. |
2022-05-31 |
2023-08-13 |
Not clear |
| Zhen Zhao, Berislav V Zlokovi. Acetylated tau: A missing link between head injury and dementia. Med (New York, N.Y.). vol 2. issue 6. 2022-05-19. PMID:35590136. |
acetylated tau: a missing link between head injury and dementia. |
2022-05-19 |
2023-08-13 |
Not clear |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
ad is the main cause of progressive dementia characterized by the deposition of amyloid-β (aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. |
2022-05-14 |
2023-08-13 |
mouse |
| Bryson P Arnett, Tara Hawkinson, Lyndsay Young, Harrison Clarke, Michael Buoncristiani, Matthew Gentry, Ramon Su. Longitudinal profiling of the Plasma Glycome from Normal and Alzheimer's Disease individuals. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554486. |
alzheimer's disease (ad) is an incurable dementia known for its neurodegenerative pathologies including amyloid beta plaques, hyperphosphorylated neurofibrillary tau tangles, and brain glucose hypometabolism. |
2022-05-13 |
2023-08-13 |
human |
| Andrew N McCorkindale, Ellis Patrick, James A Duce, Boris Guennewig, Greg T Sutherlan. The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology. Frontiers in aging neuroscience. vol 14. 2022-05-13. PMID:35557837. |
alzheimer's disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to precipitate tau pathology, neurodegeneration, and dementia. |
2022-05-13 |
2023-08-13 |
Not clear |
| Yuan Cheng, Jun-Rong Ren, Jie-Ming Jian, Chen-Yang He, Man-Yu Xu, Gui-Hua Zeng, Cheng-Rong Tan, Ying-Ying Shen, Wang-Sheng Jin, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Yuan Zhang, Xian-Le Bu, Yan-Jiang Wan. Associations of plasma angiostatin and amyloid-β and tau levels in Alzheimer's disease. Translational psychiatry. vol 12. issue 1. 2022-05-10. PMID:35538065. |
plasma angiostatin levels were negatively correlated with plasma aβ42 and aβ40 levels in ad dementia patients and positively correlated with csf total tau (t-tau) levels and t-tau/aβ42 in ad dementia patients with apoe-ε4. |
2022-05-10 |
2023-08-13 |
human |
| Peng Zeng, Hong-Fei Su, Chao-Yuan Ye, Shuo-Wen Qiu, Anbing Shi, Jian-Zhi Wang, Xin-Wen Zhou, Qing Tia. A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Frontiers in pharmacology. vol 13. 2022-05-09. PMID:35529440. |
a tau pathogenesis-based network pharmacology approach for exploring the protections of alzheimer's disease (ad) is the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide. |
2022-05-09 |
2023-08-13 |
Not clear |
| Amy R Nelso. Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-05-06. PMID:35517047. |
the concept that pathogenic germs cause infections generating an innate immune response (e.g., aβ and tau produced by peripheral organs) that is associated with incident dementia is worthwhile considering in the context of sporadic ad with an unknown root cause. |
2022-05-06 |
2023-08-13 |
Not clear |
| Christian LoBue, Brendan J Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C Munro Cullum, Matthew E Peters, Peter M Dougla. Mild Traumatic Brain Injury is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491792. |
mild traumatic brain injury is related to elevated cerebrospinal fluid tau in alzheimer's disease dementia. |
2022-05-02 |
2023-08-13 |
Not clear |
| Christian LoBue, Brendan J Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C Munro Cullum, Matthew E Peters, Peter M Dougla. Mild Traumatic Brain Injury is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491792. |
for this reason, we compared an ad dementia group with an mtbi history (n = 10) to a matched ad control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. |
2022-05-02 |
2023-08-13 |
Not clear |
| Mingchao Shi, Fengna Chu, Feiqi Zhu, Jie Zh. Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab. Frontiers in aging neuroscience. vol 14. 2022-05-02. PMID:35493943. |
alzheimer's disease (ad) is the most prevalent form of age-related dementia in the world, and its main pathological features consist of amyloid-β (aβ) plaque deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. |
2022-05-02 |
2023-08-13 |
Not clear |
| Qiang Xie, Ming Ni, Feng Gao, Lin-Bin Dai, Xin-Yi Lv, Yi-Fan Zhang, Qin Shi, Xing-Xing Zhu, Ji-Kui Xie, Yong Shen, Shi-Cun Wan. Correlation between Cerebrospinal Fluid Core Alzheimer's Disease Biomarkers and β-Amyloid PET in Chinese Dementia Population. ACS chemical neuroscience. 2022-04-27. PMID:35476397. |
the current diagnoses of alzheimer's disease (ad) mainly rely on such measures as amyloid-β (aβ) and tau neuropathology biomarkers in vivo via cerebrospinal fluid (csf) and positron emission tomography (pet) imaging, which had been systematically studied in caucasian individuals, whereas diagnostic performances of these approaches in chinese dementia population still remain unclear. |
2022-04-27 |
2023-08-13 |
Not clear |
| Sophie Schmidt, Max Holzer, Thomas Arendt, Mandy Sonntag, Markus Morawsk. Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L- Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454094. |
tau protein modulates perineuronal extracellular matrix expression in the taup301l- tau mutations promote the formation of tau oligomers and filaments, which are neuropathological signs of several tau-associated dementias. |
2022-04-23 |
2023-08-13 |
Not clear |
| Giuseppe Barisano, Axel Montagne, Kassandra Kisler, Julie A Schneider, Joanna M Wardlaw, Berislav V Zlokovi. Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease. Nature cardiovascular research. vol 1. issue 2. 2022-04-22. PMID:35450117. |
therefore, better understanding of how vascular dysfunction caused by bbb breakdown interacts with amyloid-β and tau ad biomarkers to confer cognitive impairment may lead to new ways of thinking about pathogenesis, and possibly treatment and prevention of early cognitive impairment, dementia and ad, for which we still do not have effective therapies. |
2022-04-22 |
2023-08-13 |
human |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
aggregation of specific proteins are histopathological hallmarks of several neurodegenerative diseases, such as, amyloid β (aβ) plaques and tau neurofibrillary tangles in alzheimer's disease (ad); morphologically different inclusions of ratiometric 3 repeat (3r) and 4 repeat (4r) tau isoforms in progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid); α-synuclein (α-syn) containing lewy bodies (lbs) and dystrophic lewy neurites (lns) in parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-04-21 |
2023-08-13 |
Not clear |
| Harun Muayad Said, Derya Kaya, Idil Yavuz, Fatma Sena Dost, Zekiye Sultan Altun, Ahmet Turan Isi. A Comparison of Cerebrospinal Fluid Beta-Amyloid and Tau in Idiopathic Normal Pressure Hydrocephalus and Neurodegenerative Dementias. Clinical interventions in aging. vol 17. 2022-04-18. PMID:35431542. |
a comparison of cerebrospinal fluid beta-amyloid and tau in idiopathic normal pressure hydrocephalus and neurodegenerative dementias. |
2022-04-18 |
2023-08-13 |
Not clear |
| Akram A Hosseini, Thomas Brown, Luca Mannino, Bruno Gran, Kehinde Junaid, Elizabeta B Mukaetova-Ladinsk. Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. Journal of Alzheimer's disease : JAD. 2022-04-11. PMID:35404281. |
clinical utility of cerebrospinal fluid aβ42 and tau measures in diagnosing mild cognitive impairment in early onset dementia. |
2022-04-11 |
2023-08-13 |
Not clear |
| Edmarie Guzmán-Vélez, Ibai Diez, Dorothee Schoemaker, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T Fox-Fuller, Ana Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Jorge Sepulcre, Yakeel T Quiro. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-05. PMID:35380901. |
using high-resolution network analyses and positron emission tomography, we showed that greater tau burden was related to functional dysconnectivity of regions associated with memory function and increased connectivity of structures that are important for integrating information in cognitively unimpaired presenilin-1 e280a carriers, who will develop early-onset ad dementia. |
2022-04-05 |
2023-08-13 |
Not clear |
| Laetitia Miguel, Anne Rovelet-Lecrux, Pascal Chambon, Géraldine Joly-Helas, Stéphane Rousseau, David Wallon, Stéphane Epelbaum, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtoi. Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies. Stem cell research. vol 61. 2022-03-31. PMID:35358831. |
tau accumulates in patients' brain in several neurodegenerative diseases, including fronto-temporal dementia and alzheimer's disease. |
2022-03-31 |
2023-08-13 |
Not clear |