| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
moreover, tocilizumab could alleviate the "inflammatory storm" and impaired hippocampal synaptic plasticity in lps-challenged depression rats, inhibiting the hyperactivation of astrocyte and microglia, decreasing the peripheral and central abundance of il-6, crp, and tnf-α, and balancing the hippocampal expression levels of synaptic plasticity-associated proteins and key molecular in wnt/β-catenin signaling pathway. |
2023-09-17 |
2023-10-07 |
human |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
these results indicated a predictive role of il-6 in discriminating depression from controls, and demonstrated an antidepressant effect of tocilizumab in lps-challenged rats, targeting at the inflammatory storm and the subsequent impairments of hippocampal synaptic plasticity. |
2023-09-17 |
2023-10-07 |
human |
| Ruisi Liu, Yueling Gong, Chenyi Xia, Yemin Cao, Cheng Zhao, Mingmei Zho. Itaconate: A promising precursor for treatment of neuroinflammation associated depression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-17. PMID:37717531. |
neuroinflammation triggers the production of inflammatory factors, influences neuron generation and synaptic plasticity, thus playing an important role in the pathogenesis of depression and becoming an important direction of depression prevention and treatment. |
2023-09-17 |
2023-10-07 |
Not clear |
| Xu-Ben Yu, Kai-Long Zhong, Chuang Chen, Jing Fu, Fang Chen, Hong-Min Zhou, Xiu-Hua Zhang, Kwonseop Kim, Jing-Ye Pa. Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor. Psychopharmacology. 2023-09-15. PMID:37715015. |
given the role of synaptic impairment in depression development, we investigate the effect of simvastatin on synaptic plasticity in depression and the related mechanisms. |
2023-09-15 |
2023-10-07 |
mouse |
| Anika Heinze, Marco B Rus. Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity. European journal of cell biology. vol 102. issue 4. 2023-08-27. PMID:37634312. |
morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (ltp) or depression (ltd). |
2023-08-27 |
2023-09-07 |
mouse |
| Lv-Ping Zhuang, Wei-Jie Gao, Liu-Lv Fang, Gui-Rong Zeng, Qin-Yong Ye, Xiao-Man Dai, Jing Zhang, Xiao-Chun Che. HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice. Neurochemistry international. 2023-08-05. PMID:37543308. |
available literature indicates that it can regulate dendritic spine density through the extracellular signal-regulating kinase (erk) - brain-derived neurotrophic factor (bdnf) pathway, which is crucial to retain the synaptic plasticity in patients with major depressive disorder (mdd) and mouse depression models. |
2023-08-05 |
2023-08-14 |
mouse |
| Sophia Esalatmanesh, Ladan Kashani, Shahin Akhondzade. Effects of Antidepressant Medication on Brain-derived Neurotrophic Factor Concentration and Neuroplasticity in Depression: A Review of Preclinical and Clinical Studies. Avicenna journal of medical biotechnology. vol 15. issue 3. 2023-08-04. PMID:37538241. |
depression is associated with altered synaptic plasticity and neurogenesis. |
2023-08-04 |
2023-08-14 |
Not clear |
| Ning Sun, Wen-Qiang Cui, Xiao-Man Min, Guang-Ming Zhang, Jia-Zheng Liu, Hong-Yun W. A new perspective on hippocampal synaptic plasticity and post-stroke depression. The European journal of neuroscience. 2023-07-31. PMID:37518943. |
a new perspective on hippocampal synaptic plasticity and post-stroke depression. |
2023-07-31 |
2023-08-14 |
Not clear |
| Ning Sun, Wen-Qiang Cui, Xiao-Man Min, Guang-Ming Zhang, Jia-Zheng Liu, Hong-Yun W. A new perspective on hippocampal synaptic plasticity and post-stroke depression. The European journal of neuroscience. 2023-07-31. PMID:37518943. |
hippocampal synaptic plasticity is one of the key factors leading to post-stroke depression; however, the precise molecular mechanisms remain unclear. |
2023-07-31 |
2023-08-14 |
Not clear |
| Ning Sun, Wen-Qiang Cui, Xiao-Man Min, Guang-Ming Zhang, Jia-Zheng Liu, Hong-Yun W. A new perspective on hippocampal synaptic plasticity and post-stroke depression. The European journal of neuroscience. 2023-07-31. PMID:37518943. |
this review further elaborates on the role of hippocampal synaptic plasticity in post-stroke depression by summarizing recent research and analysing possible molecular mechanisms. |
2023-07-31 |
2023-08-14 |
Not clear |
| Tao Tong, Yiping Chen, Chonyao Hao, Junliang Shen, Wenjie Chen, Wenjing Cheng, Simin Yan, Jianguo Li, Yuhan Li, Tuergong Gulizhaerkezi, Xianjun Men. The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats. Behavioural brain research. 2023-05-27. PMID:37244435. |
as a non-invasive alternative, acupuncture (ap) has been widely used to treat depression in clinic, yet few basic studies have been focused on the effects and mechanism of acupuncture on synaptic plasticity in lhb. |
2023-05-27 |
2023-08-14 |
rat |
| Yaling Fu, Xiangfei Guo, Rui Yang, Hao Feng, Xueyong Yin, Shuang Wang, Li Song, Xi Wang, Penghui Zhao, Sheng Wang, Yun Shi, Haishui Sh. Hippocampal BAIAP2 prevents chronic mild stress-induced depression-like behaviors in mice. Frontiers in psychiatry. vol 14. 2023-05-26. PMID:37234209. |
the pathogenesis of depression is closely related to changes in hippocampal synaptic plasticity; however, the underlying mechanism is still unclear. |
2023-05-26 |
2023-08-14 |
mouse |
| Yue-Ming Zhang, Ru-Meng Wei, Xue-Yan Li, Yi-Zhou Feng, Kai-Xuan Zhang, Yi-Jun Ge, Xiao-Yi Kong, Xue-Chun Liu, Gui-Hai Che. Long-term environmental enrichment overcomes depression, learning, and memory impairment in elderly CD-1 mice with maternal sleep deprivation exposure. Frontiers in aging neuroscience. vol 15. 2023-05-11. PMID:37168717. |
the aim of this study was to explore the effects of msd on depression and cognition in elderly offspring cd-1 mice and to determine whether long-term environmental enrichment could alleviate these effects by improving neuroinflammation and synaptic plasticity. |
2023-05-11 |
2023-08-14 |
mouse |
| Zhengyang Quan, Hui Li, Zhenzhen Quan, Hong Qin. Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108261. |
these elements aggravate or alleviate depression by regulating a series of physiological processes, including the transmission of neural signals, inflammation, oxidative stress, neurogenesis, and synaptic plasticity, which thus affect the expression or activity of physiological components such as neurotransmitters, neurotrophic factors, receptors, cytokines, and ion-binding proteins in the body. |
2023-04-28 |
2023-08-14 |
Not clear |
| Matthew E Larsen, Olivia R Buonarati, Hai Qian, Johannes W Hell, K Ulrich Baye. Stimulating β-adrenergic receptors promotes synaptic potentiation by switching CaMKII movement from LTD to LTP mode. The Journal of biological chemistry. 2023-04-15. PMID:37061000. |
learning, memory and cognition are thought to require synaptic plasticity, specifically including hippocampal long-term potentiation and depression (ltp and ltd). |
2023-04-15 |
2023-08-14 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a Common Thread Linking Different Classes of Antidepressants. Research square. 2023-04-10. PMID:37034599. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis). |
2023-04-10 |
2023-08-14 |
mouse |
| Gonzalo Valdivia, Alvaro O Ardiles, Abimbola Idowu, Claudia Salazar, Hey-Kyoung Lee, Michela Gallagher, Adrian G Palacios, Alfredo Kirkwoo. mGluR-dependent plasticity in rodent models of Alzheimer's disease. Frontiers in synaptic neuroscience. vol 15. 2023-03-20. PMID:36937569. |
long-term potentiation (ltp) and depression (ltd) are currently the most comprehensive models of synaptic plasticity models to subserve learning and memory. |
2023-03-20 |
2023-08-14 |
mouse |
| Ana Salomé Correia, Armando Cardoso, Nuno Val. Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity. Antioxidants (Basel, Switzerland). vol 12. issue 2. 2023-02-25. PMID:36830028. |
oxidative stress in depression: the link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity. |
2023-02-25 |
2023-08-14 |
Not clear |
| Ana Salomé Correia, Armando Cardoso, Nuno Val. Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity. Antioxidants (Basel, Switzerland). vol 12. issue 2. 2023-02-25. PMID:36830028. |
keeping in mind the importance of a detailed study about cellular and molecular mechanisms that are present in depression, this review focuses on the link between oxidative stress and the stress response, neuroinflammation, serotonergic pathways, neurogenesis, and synaptic plasticity's imbalances present in depression. |
2023-02-25 |
2023-08-14 |
Not clear |
| Darlene Mae D Ortiz, Mikyung Kim, Hyun Jun Lee, Chrislean Jun Botanas, Raly James Perez Custodio, Leandro Val Sayson, Nicole Bon Campomayor, Chaeyeon Lee, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Ki. 4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism. Biomolecules & therapeutics. 2023-02-15. PMID:36789738. |
furthermore, treatment with 4-f-pcp rescued the decreased expression of proteins most likely involved in depression and synaptic plasticity. |
2023-02-15 |
2023-08-14 |
mouse |