| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damiana Scuteri, Maria Tiziana Corasaniti, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagett. New trends in pharmacological control of neuropsychiatric symptoms of dementia. Current opinion in pharmacology. vol 61. 2021-12-09. PMID:34634603. |
psychedelics in microdosing afford promotion of neurogenesis and synaptic plasticity and, recently, have been considered a revolution for the management of depression endowed with faster action and an improved side effect profile than antidepressants. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yuan-Jian Yang, Chun-Nuan Chen, Jin-Qiong Zhan, Qiao-Sheng Liu, Yun Liu, Shu-Zhen Jiang, Bo We. Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder. Frontiers in psychiatry. vol 12. 2021-12-04. PMID:34858235. |
accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. |
2021-12-04 |
2023-08-13 |
Not clear |
| Kun Zhang, Ran Liu, Jingruo Zhang, Xifang Wei, Yuan Gao, Wen Ma, Yijing Li, Wa Cai, Weidong She. Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-27. PMID:34777532. |
hippocampal synaptic plasticity during the pathological process of depression has received increasing attention. |
2021-11-27 |
2023-08-13 |
rat |
| Youssif Ben Zablah, Haiwang Zhang, Radu Gugustea, Zhengping Ji. LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases. Cells. vol 10. issue 8. 2021-11-17. PMID:34440848. |
in this paper, we will review studies on the roles and underlying mechanisms of limks in the regulation of long-term potentiation (ltp) and depression (ltd), the most extensively studied forms of long-lasting synaptic plasticity widely regarded as cellular mechanisms underlying learning and memory. |
2021-11-17 |
2023-08-13 |
Not clear |
| Shao-Tsu Chen, Chung-Pin Hsieh, Mei-Yi Lee, Liao-Chen Chen, Chien-Min Huang, Hwei-Hsien Chen, Ming-Huan Cha. Betaine prevents and reverses the behavioral deficits and synaptic dysfunction induced by repeated ketamine exposure in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34715446. |
these results demonstrated that both co-treatment and post-treatment with betaine could effectively prevent and reverse the adverse behavioral manifestations and hippocampal synaptic plasticity after repeated ketamine use, suggesting that betaine can be used as a novel adjunct therapy with ketamine for treatment-resistant depression and provide benefits for ketamine use disorders. |
2021-11-17 |
2023-08-13 |
mouse |
| Takaaki Fujii, Akira Sakurai, J Troy Littleton, Motojiro Yoshihar. Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33603074. |
synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission. |
2021-11-15 |
2023-08-13 |
Not clear |
| Takaaki Fujii, Akira Sakurai, J Troy Littleton, Motojiro Yoshihar. Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33603074. |
short-term synaptic plasticity is a fast and robust modification in neuronal presynaptic output that can enhance release strength to drive facilitation or diminish it to promote depression. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yanning Li, Yitong He, Haoliang Fan, Zhuo Wang, Jian Huang, Gehua Wen, Xiaohan Wang, Qiqian Xie, Pingming Qi. Brain-derived neurotrophic factor upregulates synaptic GluA1 in the amygdala to promote depression in response to psychological stress. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34419429. |
thus, activation of the creb/bdnf pathway in the amygdala following psychological stress upregulates synaptic glua1 via mtor signaling, which dysregulates synaptic plasticity of the amygdala, eventually promoting depression. |
2021-11-15 |
2023-08-13 |
mouse |
| Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zho. Microglia regulation of synaptic plasticity and learning and memory. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472455. |
these molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging, alzheimer's disease, traumatic brain injury, hiv-associated neurocognitive disorder, and other neurological or mental disorders such as autism, depression and post-traumatic stress disorder. |
2021-11-10 |
2023-08-13 |
Not clear |
| Ya-Ting Wang, Xiao-Le Wang, Si-Tong Feng, Nai-Hong Chen, Zhen-Zhen Wang, Yi Zhan. Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression. Pharmacological research. vol 171. 2021-11-09. PMID:34242798. |
novel rapid-acting glutamatergic modulators: targeting the synaptic plasticity in depression. |
2021-11-09 |
2023-08-13 |
Not clear |
| Katarzyna Głombik, Jan Detka, Bogusława Budziszewsk. Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism. Cells. vol 10. issue 6. 2021-11-01. PMID:34198731. |
venlafaxine and l-thyroxine treatment combination: impact on metabolic and synaptic plasticity changes in an animal model of coexisting depression and hypothyroidism. |
2021-11-01 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Bogusława Budziszewsk. Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism. Cells. vol 10. issue 6. 2021-11-01. PMID:34198731. |
we determined the effects of venlafaxine and/or l-thyroxine on metabolic parameters and markers involved in the regulation of synaptic plasticity and cell damage in an animal model of coexisting depression and hypothyroidism, namely, wistar kyoto rats treated with propylthiouracil. |
2021-11-01 |
2023-08-13 |
rat |
| Juliette Giacobbe, Carmine M Pariante, Alessandra Borsin. The innate immune system and neurogenesis as modulating mechanisms of electroconvulsive therapy in pre-clinical studies. Journal of psychopharmacology (Oxford, England). vol 34. issue 10. 2021-10-28. PMID:32648795. |
the impact of ect on several pathophysiological mechanisms of depression has been investigated, with a focus which has largely been on cellular and synaptic plasticity. |
2021-10-28 |
2023-08-13 |
Not clear |
| Cristiano Chiamulera, Alessandro Piva, Wickliffe C Abraha. Glutamate receptors and metaplasticity in addiction. Current opinion in pharmacology. vol 56. 2021-10-25. PMID:33128937. |
long-lasting effects of drugs of abuse rely on their ability to hijack glutamate receptor activity and long-term synaptic plasticity processes like long-term potentiation and depression. |
2021-10-25 |
2023-08-13 |
Not clear |
| Yan-Hui Cui, Ao Fu, Xue-Qin Wang, Bo-Xuan Tu, Kang-Zhi Chen, Yi-Kai Wang, Qiong-Gui Hu, Lai-Fa Wang, Zhao-Lan Hu, Pin-Hua Pan, Fang Li, Fang-Fang Bi, Chang-Qi L. Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress. Neuropharmacology. vol 184. 2021-10-22. PMID:33242526. |
substantial evidence has revealed that abnormalities in synaptic plasticity play important roles during the process of depression. |
2021-10-22 |
2023-08-13 |
mouse |
| Qinghua Han, Jianwei Jiang, Yue Yuan, Bo Tang, Jianjun Zhan. Bicaudal-C protein, a potential antidepressant target. Neuroreport. vol 32. issue 16. 2021-10-07. PMID:34554934. |
the decrease of synaptic plasticity plays a part in depression. |
2021-10-07 |
2023-08-13 |
Not clear |
| Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewsk. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562494. |
contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression. |
2021-09-06 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewsk. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562494. |
the role that thyroid hormone deficiency plays in depression and synaptic plasticity in adults has only begun to be elucidated. |
2021-09-06 |
2023-08-13 |
rat |
| Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gasse. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature communications. vol 12. issue 1. 2021-08-17. PMID:34330919. |
bdnf is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. |
2021-08-17 |
2023-08-13 |
Not clear |
| Radu Gugustea, Zhengping Ji. Genetic manipulations of AMPA glutamate receptors in hippocampal synaptic plasticity. Neuropharmacology. vol 194. 2021-07-28. PMID:34089730. |
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampars) are the principal mediators of fast excitatory synaptic transmission and they are required for various forms of synaptic plasticity, including long-term potentiation (ltp) and depression (ltd), which are key mechanisms of learning and memory. |
2021-07-28 |
2023-08-13 |
mouse |