| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuan Huang, Ju-Tao Che. Chronic retinoic acid treatment induces affective disorders by impairing the synaptic plasticity of the hippocampus. Journal of affective disorders. vol 274. 2021-02-15. PMID:32664002. |
animal experiments and clinical studies have demonstrated that retinoids are essential components in hippocampal synaptic plasticity, and they have a close relationship with depression. |
2021-02-15 |
2023-08-13 |
Not clear |
| Feifei Ren, Rongjuan Gu. Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity. Neuropsychiatric disease and treatment. vol 17. 2021-02-02. PMID:33519203. |
based on this concept, we will show how we understand the balance between the synaptic microenvironment and the synaptic plasticity network in depression. |
2021-02-02 |
2023-08-13 |
Not clear |
| Rodrigo Bainy Leal, Mark William Lopes, Douglas Affonso Formolo, Cristiane Ribeiro de Carvalho, Alexandre Ademar Hoeller, Alexandra Latini, Daniel Santos Sousa, Peter Wolf, Rui Daniel Prediger, Zuner Assis Bortolotto, Marcelo Neves Linhares, Kátia Lin, Roger Wal. Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. Molecular psychiatry. vol 25. issue 3. 2021-01-14. PMID:29880883. |
synaptic transmission efficacy can be bi-directionally modified through potentiation (long-term potentiation (ltp)) or depression (long-term depression (ltd)) as well as the phosphorylation state of ser831 and ser845 sites at the glua1 subunit of the glutamate ampa receptors, which has been characterized as a critical event for this synaptic plasticity. |
2021-01-14 |
2023-08-13 |
human |
| Xin-Ya Qin, Hui Fang, Qing-Hong Shan, Cong-Cong Qi, Jiang-Ning Zho. All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes International journal of molecular sciences. vol 21. issue 8. 2021-01-05. PMID:32290523. |
the hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. |
2021-01-05 |
2023-08-13 |
Not clear |
| Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang, Shuang Y. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction of BDNF expression in developmental stages. Biochemical and biophysical research communications. vol 527. issue 1. 2020-12-21. PMID:32446386. |
brain-derived neurotrophic factor (bdnf), which regulates the neuronal survival, differentiation and synaptic plasticity, has been proved to play a critical role in the pathology and treatment of several psychiatric disorders including depression. |
2020-12-21 |
2023-08-13 |
Not clear |
| Nicolas Deperrois, Michael Graupne. Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity. PLoS computational biology. vol 16. issue 9. 2020-12-15. PMID:32976516. |
short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity. |
2020-12-15 |
2023-08-13 |
Not clear |
| Jie Kang, Youhua Wang, Di Wan. Endurance and resistance training mitigate the negative consequences of depression on synaptic plasticity through different molecular mechanisms. The International journal of neuroscience. vol 130. issue 6. 2020-12-08. PMID:31847639. |
endurance and resistance training mitigate the negative consequences of depression on synaptic plasticity through different molecular mechanisms. |
2020-12-08 |
2023-08-13 |
Not clear |
| Mamoru Fukuch. Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons. Biochemical and biophysical research communications. vol 524. issue 4. 2020-10-26. PMID:32059848. |
low levels of brain-derived neurotrophic factor (bdnf), a key regulator of synaptic plasticity, are associated with neurological diseases, including depression and alzheimer's disease. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yu Kawaishi, Naoki Matsumoto, Toshiya Nishiwaki, Tatsuro Hiran. Postactivation depression of soleus H-reflex increase with recovery of lower extremities motor functions in patients with subacute stroke. Journal of physical therapy science. vol 29. issue 9. 2020-10-01. PMID:28931983. |
[conclusion] the results demonstrated that postactivation depression is partially normalized after rehabilitation in patients with subacute stroke, and suggested that the recovery in lower extremity function after stroke particularly standing stability is affected by spinal synaptic plasticity. |
2020-10-01 |
2023-08-13 |
human |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
timosaponin b-iii exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, bndf signaling and synaptic plasticity. |
2020-10-01 |
2023-08-13 |
mouse |
| Elham Bayat Mokhtari, J Josh Lawrence, Emily F Ston. Data Driven Models of Short-Term Synaptic Plasticity. Frontiers in computational neuroscience. vol 12. 2020-10-01. PMID:29872388. |
simple models of short term synaptic plasticity that incorporate facilitation and/or depression have been created in abundance for different synapse types and circumstances. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yin-Xiu Han, Chen Tao, Xin-Ran Gao, Le-le Wang, Fu-Hao Jiang, Chong Wang, Ke Fang, Xing-Xing Chen, Zheng Chen, Jin-Fang G. BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30429764. |
considering the increasing evidence regarding the role of copine 6 in the regulation of synaptic plasticity, the aim of the present study is to investigate copine 6 expression in the hippocampus and the prefrontal cortex (pfc) in a stress-induced depression rat model. |
2020-10-01 |
2023-08-13 |
rat |
| Pan Meng, Yuanshan Han, Qin Yang, Hui Yang, Qing Zhu, Xiaoyuan Lin, Xiuli Zhang, Hongqing Zhao, Zhuo Liu, Jian Liu, Lin Tang, Weixu Luo, Yuhong Wan. Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30581482. |
xiaoyao kangai jieyu fang, a chinese herbal formulation, ameliorates cancer-related depression concurrent with breast cancer in mice via promoting hippocampal synaptic plasticity. |
2020-10-01 |
2023-08-13 |
mouse |
| Natalia de M Lyra E Silva, Minh P Lam, Claudio N Soares, Douglas P Munoz, Roumen Milev, Fernanda G De Felic. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:30837902. |
in this article, we briefly review possible molecular mechanisms associating defective brain insulin signaling with reward system, neurogenesis, synaptic plasticity and hypothalamic-pituitary-adrenal (hpa) stress axis in depression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ke Ma, Hongxiu Zhang, Guohui Wei, Zhenfei Dong, Haijun Zhao, Xiaochun Han, Xiaobin Song, Huiling Zhang, Xin Zong, Zulqarnain Baloch, Shijun Wan. Identification of key genes, pathways, and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis. Neuropsychiatric disease and treatment. vol 15. 2020-10-01. PMID:30936699. |
stress-induced dysfunction in the subtype of neuronal cells and the change of synaptic plasticity and structural plasticity of nucleus accumbens (nac) are implicated in depression symptomology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shashikanta Tarai, Rupsha Mukherjee, Sharda Gupta, Albert A Rizvanov, Andras Palotás, V S Chandrasekhar Pammi, Arindam Bi. Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders. Cognitive neurodynamics. vol 13. issue 3. 2020-10-01. PMID:31168328. |
pharmacological enhancement of ketamine and scopolamine regulates depression at the molecular level, increasing synaptic plasticity in prefrontal regions. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shashikanta Tarai, Rupsha Mukherjee, Sharda Gupta, Albert A Rizvanov, Andras Palotás, V S Chandrasekhar Pammi, Arindam Bi. Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders. Cognitive neurodynamics. vol 13. issue 3. 2020-10-01. PMID:31168328. |
for the first time, the current review contributes to the literature of synaptic plasticity representing the role of epigenetic mechanisms and glucocorticoid receptors to predict depression and anxiety in clinical conditions. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bin Min, Douglas Zhou, David Ca. Effects of Firing Variability on Network Structures with Spike-Timing-Dependent Plasticity. Frontiers in computational neuroscience. vol 12. 2020-09-29. PMID:29410621. |
one of the most widespread forms of synaptic plasticity, spike-timing-dependent plasticity (stdp), uses the spike timing information of presynaptic and postsynaptic neurons to induce synaptic potentiation or depression. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yea-Hyun Leem, Sang-Sun Yoon, Sangmee Ahn J. Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice. Biomolecules & therapeutics. vol 28. issue 3. 2020-09-28. PMID:32028757. |
previous studies have shown disrupted synaptic plasticity and neural activity in depression. |
2020-09-28 |
2023-08-13 |
mouse |
| Yongfei Cui, Kerun Cao, Huiyuan Lin, Sainan Cui, Chongkun Shen, Wenhao Wen, Haixin Mo, Zhaoyang Dong, Shasha Bai, Lei Yang, Yafei Shi, Rong Zhan. Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32174832. |
people under early-life stress (els) are reportedly vulnerable to depression in their adulthood, and synaptic plasticity can be the molecular mechanism underlying such depression. |
2020-09-28 |
2023-08-13 |
rat |