| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Turovskaya, S G Gaidin, M V Vedunova, A A Babaev, E A Turovsk. BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia, Promoting Survival of GABAergic Neurons. Neuroscience bulletin. vol 36. issue 7. 2021-07-19. PMID:32219700. |
hypoxia causes depression of synaptic plasticity, hyperexcitation of neuronal networks, and the death of specific populations of neurons. |
2021-07-19 |
2023-08-13 |
Not clear |
| Wei Guo, Zi-Yang Tang, Zhen-Yu Cai, Wen-E Zhao, Jin Yang, Xi-Peng Wang, Juan Ji, Xin-Xin Huang, Xiu-Lan Su. Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33871072. |
synaptic plasticity damages play a crucial role in the onset and development of depression, especially in the hippocampus, which is more susceptible to stress and the most frequently studied brain region in depression. |
2021-07-19 |
2023-08-13 |
mouse |
| Jessica E Malberg, René Hen, Torsten M Madse. Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later. Biological psychiatry. vol 90. issue 2. 2021-07-16. PMID:33771348. |
this novel discovery and his decades of continued research in the field led to a new hypothesis about the mechanism of action of antidepressants, providing a critical step in our understanding of the neurotrophic hypothesis of depression and synaptic plasticity. |
2021-07-16 |
2023-08-13 |
human |
| Vasiliy V Reshetnikov, Natalia P Bonda. The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility. Biochemistry. Biokhimiia. vol 86. issue 6. 2021-07-15. PMID:34225586. |
stress negatively affects processes of synaptic plasticity and is a major risk factor of various psychopathologies such as depression and anxiety. |
2021-07-15 |
2023-08-13 |
human |
| Lily R Aleksandrova, Yu Tian Wang, Anthony G Phillip. Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32546197. |
accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. |
2021-07-08 |
2023-08-13 |
rat |
| Lily R Aleksandrova, Yu Tian Wang, Anthony G Phillip. Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32546197. |
we investigated ketamine's effects on in vivo dorsal hippocampal (dhpc) synaptic plasticity and their role in mediating aspects of antidepressant activity in the wistar-kyoto (wky) model of depression. |
2021-07-08 |
2023-08-13 |
rat |
| Hideyuki Matsumoto, Yoshikazu Ugaw. Quadripulse stimulation (QPS). Experimental brain research. vol 238. issue 7-8. 2021-06-29. PMID:32211927. |
in this mini-review, we briefly introduce qps: (i) principle and cortical plasticity (stimulators and protocols, synaptic plasticity, underlying mechanisms, meta-plasticity, axonal plasticity, and drug effects), (ii) robust and strong neural plasticity induction (variability, influence of phasic muscle contraction, independency of bdnf polymorphism, sensory cortical plasticity, neural plasticity in the contralateral hemisphere, on-line effects on the brain networks, studies of normal brain physiology, and visuomotor sequence learning), (iii) therapeutic applications to neurological and psychiatric disorders (parkinson's disease, epilepsy, cerebrovascular disease, and major depression), (iv) safety, and (v) future issues. |
2021-06-29 |
2023-08-13 |
Not clear |
| Xiao-Qing Wang, Lei Zhang, Zhong-Yuan Xia, Jia-Yin Chen, Yiru Fang, Yu-Qiang Din. PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33771972. |
our results indicate that pten serves as a key mediator in chronic stress-induced neuron atrophy as well as depression-like behaviors, providing molecular evidence supporting the synaptic plasticity theory of depression. |
2021-06-28 |
2023-08-13 |
mouse |
| Adam Hockley, Joel I Berger, Paul A Smith, Alan R Palmer, Mark N Wallac. Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus. The European journal of neuroscience. vol 51. issue 4. 2021-06-21. PMID:31494975. |
the gaseous free radical, nitric oxide (no) acts as a ubiquitous neuromodulator, contributing to synaptic plasticity in a complex way that can involve either long term potentiation or depression. |
2021-06-21 |
2023-08-13 |
Not clear |
| Lukas Frase, Lydia Mertens, Arno Krahl, Kriti Bhatia, Bernd Feige, Sven P Heinrich, Stefan Vestring, Christoph Nissen, Katharina Domschke, Michael Bach, Claus Norman. Transcranial direct current stimulation induces long-term potentiation-like plasticity in the human visual cortex. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33414402. |
the results demonstrate that tdcs can directly induce ltp-like plasticity in the human cortex and suggest a mechanism of action of tdcs relying on the restoration of dysregulated synaptic plasticity in psychiatric disorders such as depression and schizophrenia. |
2021-06-18 |
2023-08-13 |
human |
| Bin Wu, Yuanyuan Guo, Jie Deng, Qibin Chen, Su Mi. Reduced Synaptic Plasticity Contributes to Resistance Against Constant-Stimulus Electroconvulsive Treatment in a Rat Model of Stress-Induced Depression. Neuropsychiatric disease and treatment. vol 17. 2021-05-20. PMID:34007181. |
reduced synaptic plasticity contributes to resistance against constant-stimulus electroconvulsive treatment in a rat model of stress-induced depression. |
2021-05-20 |
2023-08-13 |
rat |
| Mitsuo Kawato, Shogo Ohmae, Huu Hoang, Terry Sange. 50 Years Since the Marr, Ito, and Albus Models of the Cerebellum. Neuroscience. vol 462. 2021-05-14. PMID:32599123. |
however, they differ in several important respects, including holistic versus complementary roles of the cerebellum, pattern recognition versus control as computational objectives, potentiation versus depression of synaptic plasticity, teaching signals versus error signals transmitted by climbing-fibers, sparse expansion coding by granule cells, and cerebellar internal models. |
2021-05-14 |
2023-08-13 |
Not clear |
| Zubaer I Mannan, Hyongsuk Kim, Leon Chu. Implementation of Neuro-Memristive Synapse for Long-and Short-Term Bio-Synaptic Plasticity. Sensors (Basel, Switzerland). vol 21. issue 2. 2021-04-14. PMID:33477650. |
specifically, the proposed neuromorphic synapse efficiently imitates the synaptic plasticity, especially long-term potentiation (ltp) and depression (ltd), and short-term facilitation (stf) and depression (std), phenomena of a biological synapse. |
2021-04-14 |
2023-08-13 |
Not clear |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
[effect of baihe dihuang decoction on synaptic plasticity of hippocampus in rats with anxious depression]. |
2021-04-02 |
2023-08-13 |
rat |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
to explore the effect of baihe dihuang decoction on the synaptic plasticity of hippocampal neurons in rats with anxious depression. |
2021-04-02 |
2023-08-13 |
rat |
| Hong-Qing Zhao, Jian Liu, Pan Meng, Hui Yang, Xiao-Yuan Lin, Hong-Ping Long, Xi-Ming Yu, Yu-Hong Wan. [Effect of Baihe Dihuang Decoction on synaptic plasticity of hippocampus in rats with anxious depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 5. 2021-04-02. PMID:33787116. |
therefore, we believe that baihe dihuang decoction can improve anxiety and depression behaviors by regulating the synaptic plasticity of hippocampal neurons. |
2021-04-02 |
2023-08-13 |
rat |
| Baomei Xia, Xiaoyan Huang, Guangda Sun, Weiwei Ta. Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling. Journal of ethnopharmacology. vol 268. 2021-03-08. PMID:33307051. |
iridoids from gardeniae fructus ameliorates depression by enhancing synaptic plasticity via ampa receptor-mtor signaling. |
2021-03-08 |
2023-08-13 |
Not clear |
| Ipsit Srivastava, Erika Vazquez-Juarez, Lukas Henning, Marta Gómez-Galán, Maria Lindsko. Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression. Cells. vol 9. issue 7. 2021-03-05. PMID:32708718. |
blocking astrocytic gaba restores synaptic plasticity in prefrontal cortex of rat model of depression. |
2021-03-05 |
2023-08-13 |
rat |
| Ipsit Srivastava, Erika Vazquez-Juarez, Lukas Henning, Marta Gómez-Galán, Maria Lindsko. Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression. Cells. vol 9. issue 7. 2021-03-05. PMID:32708718. |
a decrease in synaptic plasticity and/or a change in excitation/inhibition balance have been suggested as mechanisms underlying major depression disorder. |
2021-03-05 |
2023-08-13 |
rat |
| Joongkyu Par. Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity. Proteomes. vol 6. issue 4. 2021-02-18. PMID:30297624. |
an increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (ltp), and depression (ltd). |
2021-02-18 |
2023-08-13 |
Not clear |