| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kensuke Yoshida, Taro Toyoizum. Information maximization explains state-dependent synaptic plasticity and memory reorganization during non-rapid eye movement sleep. PNAS nexus. vol 2. issue 1. 2023-01-30. PMID:36712943. |
the model indicates that the optimal synaptic plasticity is biased toward depression as the baseline firing rate increases. |
2023-01-30 |
2023-08-14 |
Not clear |
| Soojung Yoon, Hamid Iqbal, Sun Mi Kim, Mirim Ji. Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder. Biomolecules & therapeutics. 2023-01-25. PMID:36694423. |
in this review, we describe the alterations in synaptic plasticity as underlying pathological mechanisms for depression in animal models and humans. |
2023-01-25 |
2023-08-14 |
Not clear |
| Soojung Yoon, Hamid Iqbal, Sun Mi Kim, Mirim Ji. Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder. Biomolecules & therapeutics. 2023-01-25. PMID:36694423. |
thus, intake of phytochemicals with safe and active effects on synaptic plasticity may be a strategy for preventing neuronal damage and alleviating depression in a stressful life. |
2023-01-25 |
2023-08-14 |
Not clear |
| Akihiro Goto, Yasunori Hayash. Offline neuronal activity and synaptic plasticity during sleep and memory consolidation. Neuroscience research. 2022-12-30. PMID:36584924. |
two forms of synaptic plasticity, potentiation and depression of synaptic transmission, are induced in parallel during sleep and is termed "offline synaptic plasticity", as opposed to the "online synaptic plasticity" that occurs immediately following a memory event. |
2022-12-30 |
2023-08-14 |
Not clear |
| Rainer Rupprecht, Arpit Kumar Pradhan, Marco Kufner, Lisa Marie Brunner, Caroline Nothdurfter, Simon Wein, Jens Schwarzbach, Xenia Puig, Christian Rupprecht, Gerhard Ramme. Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options. European archives of psychiatry and clinical neuroscience. 2022-12-27. PMID:36574032. |
neurosteroids and translocator protein 18 kda (tspo) in depression: implications for synaptic plasticity, cognition, and treatment options. |
2022-12-27 |
2023-08-14 |
Not clear |
| Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zh. The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3β pathway in depressive rats. Journal of affective disorders. 2022-11-13. PMID:36372121. |
the mechanism by which synaptic plasticity mediates the occurrence of depression is unknown. |
2022-11-13 |
2023-08-14 |
rat |
| Masud Ehsani, Jürgen Jos. Self-organized criticality in a mesoscopic model of excitatory-inhibitory neuronal populations by short-term and long-term synaptic plasticity. Frontiers in computational neuroscience. vol 16. 2022-10-27. PMID:36299476. |
we show how the network tunes itself through local long-term synaptic plasticity by stdp and short-term synaptic depression to be close to this bifurcation point. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ping Hu, Ying Lu, Bing-Xing Pan, Wen-Hua Zhan. New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232376. |
in this review, we first summarized the recent progress from both animal and human studies toward understanding the causal link between stress-induced inflammation and depression and anxiety disorders, with particular emphasis on findings showing the effect of inflammation on the functional changes in neurons in the amygdala, at levels ranging from molecular signaling, cellular function, synaptic plasticity, and the neural circuit to behavior, as well as their contributions to the pathology of inflammation-related depression and anxiety disorders. |
2022-10-14 |
2023-08-14 |
human |
| Shvetank Bhatt, Thangaraj Devadoss, Niraj Kumar Jha, Moushumi Baidya, Gaurav Gupta, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Du. Targeting inflammation: a potential approach for the treatment of depression. Metabolic brain disease. 2022-10-14. PMID:36239867. |
antidepressant treatment may attenuate depression via modulation of pathways of inflammation, transformation in structure of brain, and synaptic plasticity. |
2022-10-14 |
2023-08-14 |
Not clear |
| Kangyu Jin, Shiyi Zhang, Chaonan Jiang, Ripeng Liu, Bing Chen, Haoyang Zhao, Qin Zhang, Zhe Shen, Pengfeng Xu, Xiaohan Hu, Jianping Jiao, Jing Lu, Manli Huan. The role of reelin in the pathological mechanism of depression from clinical to rodents. Psychiatry research. vol 317. 2022-09-14. PMID:36103758. |
previous studies have suggested that synaptic plasticity in the hippocampus plays an important role in depression pathogenesis. |
2022-09-14 |
2023-08-14 |
rat |
| Kangyu Jin, Shiyi Zhang, Chaonan Jiang, Ripeng Liu, Bing Chen, Haoyang Zhao, Qin Zhang, Zhe Shen, Pengfeng Xu, Xiaohan Hu, Jianping Jiao, Jing Lu, Manli Huan. The role of reelin in the pathological mechanism of depression from clinical to rodents. Psychiatry research. vol 317. 2022-09-14. PMID:36103758. |
subsequent experiments confirmed that the reelin-apoer2-nr2a /nr2b pathway regulates hippocampal synaptic plasticity and may be involved in depression or antidepressant responses. |
2022-09-14 |
2023-08-14 |
rat |
| Xiao-Xu Fan, Wen-Yan Sun, Yu Li, Qin Tang, Li-Na Li, Xue Yu, Shu-Yan Wang, Ang-Ran Fan, Xiang-Qing Xu, Hong-Sheng Chan. Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation. Frontiers in pharmacology. vol 13. 2022-09-12. PMID:36091747. |
increasing evidence indicates that the pathogenesis of depression is closely linked to impairments in neuronal synaptic plasticity. |
2022-09-12 |
2023-08-14 |
rat |
| David W Jia, Tim P Vogels, Rui Ponte Cost. Developmental depression-to-facilitation shift controls excitation-inhibition balance. Communications biology. vol 5. issue 1. 2022-08-25. PMID:36008708. |
we introduce a model of the commonly observed developmental shift from depression to facilitation and show that neural activity remains stable throughout development, while inhibitory synaptic plasticity slowly balances excitation, consistent with experimental observations. |
2022-08-25 |
2023-08-14 |
Not clear |
| Yuan Cheng, Xiaoxuan Wang, Yinghua Yu, Jingxue Gu, Maofang Zhao, Qian Fu, Yilin Song, Yi Li. Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin. Neurochemical research. 2022-08-17. PMID:35978229. |
studies have shown that noise can lead to neuroinflammation, damage to synaptic plasticity and altered levels of neurotransmitters that may result in depression. |
2022-08-17 |
2023-08-14 |
mouse |
| Yanyan Feng, Guihua Zhu, Ruiming Chen, Guoao Shi, Min Peng, Yifu Zhou, Wenbin Fu, Peng Zho. Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression. Biochemical and biophysical research communications. vol 626. 2022-08-15. PMID:35970043. |
electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression. |
2022-08-15 |
2023-08-14 |
mouse |
| Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewsk. Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism. Pharmacological reports : PR. 2022-08-11. PMID:35951260. |
moreover, the identified changes in the levels of snap-25, glp-1r and glp-2r pointed to disturbances in synaptic plasticity and neuroprotection mechanisms in the examined brain structures.in conclusion, a reduction in cholesterol synthesis in the hippocampus in the model of depression may be the reason for the reduction of synaptic plasticity, whereas a lower level of ldl-r occurring in the frontal cortex in rats from the model of depression and hypothyroidism coexistence could be the reason of anxiogenic and depression-like behaviors. |
2022-08-11 |
2023-08-14 |
rat |
| Zi-Rong Li, De-Guo Liu, Sheng Xie, Yu-Hong Wang, Yuan-Shan Han, Chun-Yan Li, Man-Shu Zou, Hai-Xing Jian. Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. European journal of pharmacology. 2022-07-25. PMID:35878808. |
although depression and insomnia impair hippocampal synaptic plasticity, the mechanism by which this happens remains a mystery. |
2022-07-25 |
2023-08-14 |
rat |
| Zi-Rong Li, De-Guo Liu, Sheng Xie, Yu-Hong Wang, Yuan-Shan Han, Chun-Yan Li, Man-Shu Zou, Hai-Xing Jian. Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. European journal of pharmacology. 2022-07-25. PMID:35878808. |
this study aimed to investigate the pathogenesis of insomnia comorbidity in depression and the regulatory effect of venlafaxine combined with melatonin on hippocampal synaptic plasticity in chronic unpredictable mild stress (cums) with sleep deprivation (sd) rats. |
2022-07-25 |
2023-08-14 |
rat |
| Qi Li, Yao Gao, Hong Li, Hongmei Liu, Dan Wang, Weixing Pan, Sha Liu, Yong X. Brain structure and synaptic related protein expression alterations after antidepressant treatment in a Wistar-Kyoto rat model of depression. Journal of affective disorders. 2022-07-25. PMID:35878834. |
while synaptic plasticity has been previously proposed as the potential underlying mechanism of mri findings at a cellular and molecular scale, there is still insufficient evidence to link the mri findings and synaptic plasticity mechanisms in depression pathology. |
2022-07-25 |
2023-08-14 |
rat |
| Riley A Williams, Kenneth W Johnson, Francis S Lee, Hugh C Hemmings, Jimcy Plathol. A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures. Frontiers in molecular neuroscience. vol 15. 2022-07-11. PMID:35813074. |
here, we show that brain-derived neurotrophic factor (bdnf), a growth factor implicated in synaptic plasticity and dysfunction, enhances glutamate synaptic vesicle exocytosis, and that attenuation of vesicular bdnf release by isoflurane contributes to transient depression of excitatory synaptic transmission in mice. |
2022-07-11 |
2023-08-14 |
mouse |