| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megan Dutton, Amanda Boyes, Adem T Can, Abdalla Z Mohamed, Maryam Hajishafiee, Zack Y Shan, Jim Lagopoulos, Daniel F Hermen. Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality. Journal of psychiatric research. vol 169. 2023-12-02. PMID:38042058. |
ongoing stress results in hippocampal neuro-structural alterations which produce pathological consequences, including depression and suicidality. |
2023-12-02 |
2023-12-10 |
human |
| Sen Zhou, Yang Liu, Binbin Xue, Peigen Yua. Low-dose Esketamine suppresses NLRP3-mediated apoptotic and pyroptotic cell death in microglial cells to ameliorate LPS-induced depression via ablating GSK-3β. Behavioural brain research. vol 459. 2023-11-30. PMID:38029844. |
then, the following experiments verified that low-dose esketamine treatment decreased the expression levels of il-6, tnf-α and il-18 to restrain cellular inflammation, downregulated nlrp3, cleaved caspase-1, il-1β and gsdmd-n to hamper pyroptotic cell death, and inhibited cleaved caspase-3 and bax, but upregulated bcl-2 to restrict apoptotic cell death in the lps-treated mice hippocampus tissues and mouse microglial cells, leading to the suppression of depression development. |
2023-11-30 |
2023-12-10 |
mouse |
| Anbiao Wu, Jiyan Zhan. Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis. Journal of neuroinflammation. vol 20. issue 1. 2023-11-28. PMID:38012702. |
neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis. |
2023-11-28 |
2023-11-29 |
Not clear |
| Jennifer Monereo-Sánchez, Jacobus F A Jansen, Martin P J van Boxtel, Walter H Backes, Sebastian Köhler, Coen D A Stehouwer, David E J Linden, Miranda T Schra. Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study. The British journal of psychiatry : the journal of mental science. 2023-11-23. PMID:37993980. |
late-life depression has been associated with volume changes of the hippocampus. |
2023-11-23 |
2023-11-29 |
Not clear |
| Yuki Hirose, Yasunori Oda, Kouhei Yoshino, Fumiaki Yano, Makoto Kimura, Hiroshi Kimura, Masaomi Iyo, Yukihiko Shirayam. Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1 and CA-3 regions of a learned helplessness model of depression. Pharmacology, biochemistry, and behavior. 2023-11-22. PMID:37992974. |
reduction of claudin-5 and aquaporin-4 in the rat hippocampal ca-1 and ca-3 regions of a learned helplessness model of depression. |
2023-11-22 |
2023-11-29 |
rat |
| Bingran Chen, Cheng Zhao, Haojie Zhu, Xu Lu, Huijun Liu, Qun Lu, Tao Zhu, Chao Huan. β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus. European journal of pharmacology. 2023-11-08. PMID:37939990. |
a decline in microglia in the dentate gyrus of the hippocampus has recently been described as an important mechanism for the progression of depression. |
2023-11-08 |
2023-11-20 |
mouse |
| Santino Gaudio, Gull Rukh, Vincenzo Di Ciommo, Samuel Berkins, Lyle Wiemerslage, Helgi B Schiöt. Higher fresh fruit intake relates to larger grey matter volumes in areas involved in dementia and depression: A UK Biobank study. NeuroImage. vol 283. 2023-11-02. PMID:37918179. |
in particular, fresh fruit intake may have a protective role in specific cortical areas such as the hippocampus, areas robustly involved in the pathophysiology of dementia and depression. |
2023-11-02 |
2023-11-08 |
human |
| Hui He, Haili He, Li Mo, Zili You, Jinqiang Zhan. Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice. Brain, behavior, and immunity. 2023-11-01. PMID:37914097. |
here we explored in an animal model of depression whether disruption of the gut microbiome primes hippocampal microglia, thereby impairing neurogenesis and sensitizing to stress. |
2023-11-01 |
2023-11-08 |
mouse |
| Thalita Mázala-de-Oliveira, Bruna Teixeira Silva, Paula Campello-Costa, Vinicius Frias Carvalh. The Role of the Adrenal-Gut-Brain Axis on Comorbid Depressive Disorder Development in Diabetes. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892186. |
in this context, we propose here that hypercortisolism, in association with gut dysbiosis, leads to an exacerbation of hippocampal neuroinflammation, glutamatergic transmission, and neuronal apoptosis, leading to the development and aggravation of depression and to resistance to treatment of this mood disorder in diabetic patients. |
2023-10-30 |
2023-11-08 |
mouse |
| Hao Zhang, Mingqi Qiao, Dongmei Gao, Jieqiong Wang, Chunyan Sun, Ya Sun, Yang Zhang, Huayuan Liu, Zhen Zhang, Mingzhou Ga. Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus. Asian journal of psychiatry. vol 90. 2023-10-28. PMID:37898099. |
shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting gaba (a) receptors δ subunit in the hippocampus. |
2023-10-28 |
2023-11-08 |
rat |
| Artemis Zavaliangos-Petropulu, Shawn M McClintock, Shantanu H Joshi, Brandon Taraku, Noor B Al-Sharif, Randall T Espinoza, Katherine L Nar. Hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment. Frontiers in psychiatry. vol 14. 2023-10-26. PMID:37876623. |
hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
adult hippocampal neurogenesis generates functional neurons from neural progenitor cells in the hippocampal dentate gyrus (dg) to complement and repair neurons and neural circuits, thus benefiting the treatment of depression. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
however, the mechanisms of the crosstalk between microglia and adult hippocampal neurogenesis in depression are not yet fully understood. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
therefore, in this review, we first introduce recent discoveries regarding the roles of microglia and adult hippocampal neurogenesis in the etiology of depression. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |
| Hailee Hurtado, Melissa Hansen, Jordan Strack, Uku Vainik, Alexandra L Decker, Budhachandra Khundrakpam, Katherine Duncan, Amy S Finn, Donald J Mabbott, Emily C Mer. Polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents. Journal of affective disorders. 2023-10-20. PMID:37858734. |
polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents. |
2023-10-20 |
2023-11-08 |
Not clear |
| Hailee Hurtado, Melissa Hansen, Jordan Strack, Uku Vainik, Alexandra L Decker, Budhachandra Khundrakpam, Katherine Duncan, Amy S Finn, Donald J Mabbott, Emily C Mer. Polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents. Journal of affective disorders. 2023-10-20. PMID:37858734. |
depression has frequently been associated with smaller hippocampal volume. |
2023-10-20 |
2023-11-08 |
Not clear |
| Hailee Hurtado, Melissa Hansen, Jordan Strack, Uku Vainik, Alexandra L Decker, Budhachandra Khundrakpam, Katherine Duncan, Amy S Finn, Donald J Mabbott, Emily C Mer. Polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents. Journal of affective disorders. 2023-10-20. PMID:37858734. |
the goals of this study were to examine the associations among parental history of anxiety/depression, polygenic risk scores for depression (pgs-dep), and anterior and posterior hippocampal volumes in children and adolescents. |
2023-10-20 |
2023-11-08 |
Not clear |
| Yanzhi Bi, Yian Xiao, Xinyu Pan, Yuqi Zhang, Quanqi Yang, Li H. Long-term post-traumatic stress symptoms in COVID-19 survivors and its risk factors: a two-year longitudinal cohort study. Psychiatry research. vol 329. 2023-10-09. PMID:37812942. |
neuroimaging revealed increased amygdala activity in male survivors and correlations between hippocampus activity and depression symptoms as well as between right hippocampus activity and social support. |
2023-10-09 |
2023-10-15 |
Not clear |