| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Jia, Xin Zhang, Yongmei Wang, Yang Liu, Jie Dai, Liangliang Zhang, Xian Wu, Jie Zhang, Hongxi Xiang, Yanping Yang, Zhu Zeng, Yulian Che. Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice. Biological trace element research. 2023-10-06. PMID:37801218. |
in this study, we evaluated the changes in the expression levels of selenbp1 in the hippocampus of a mouse model of depression and in the serum of human patients with depression using the gene expression omnibus database. |
2023-10-06 |
2023-10-07 |
mouse |
| Yi Jia, Xin Zhang, Yongmei Wang, Yang Liu, Jie Dai, Liangliang Zhang, Xian Wu, Jie Zhang, Hongxi Xiang, Yanping Yang, Zhu Zeng, Yulian Che. Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice. Biological trace element research. 2023-10-06. PMID:37801218. |
we also investigated the effects of selenbp1 knockout (ko) on inflammation, oxidative stress, and hippocampal neurogenesis in mice with cums-induced depression. |
2023-10-06 |
2023-10-07 |
mouse |
| Yi Jia, Xin Zhang, Yongmei Wang, Yang Liu, Jie Dai, Liangliang Zhang, Xian Wu, Jie Zhang, Hongxi Xiang, Yanping Yang, Zhu Zeng, Yulian Che. Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice. Biological trace element research. 2023-10-06. PMID:37801218. |
our results revealed that selenbp1 levels was decreased in the blood of human patients with depression and in the hippocampus of mice with cums-induced depression. |
2023-10-06 |
2023-10-07 |
mouse |
| Ruiting Huang, Min Gong, Xue Tan, Jianying Shen, You Wu, Xiaoshi Cai, Suying Wang, Li Min, Lin Gong, Wenna Lian. Effects of Chaihu Shugan San on Brain Functional Network Connectivity in the Hippocampus of a Perimenopausal Depression Rat Model. Molecular neurobiology. 2023-09-26. PMID:37751044. |
effects of chaihu shugan san on brain functional network connectivity in the hippocampus of a perimenopausal depression rat model. |
2023-09-26 |
2023-10-07 |
rat |
| Ruiting Huang, Min Gong, Xue Tan, Jianying Shen, You Wu, Xiaoshi Cai, Suying Wang, Li Min, Lin Gong, Wenna Lian. Effects of Chaihu Shugan San on Brain Functional Network Connectivity in the Hippocampus of a Perimenopausal Depression Rat Model. Molecular neurobiology. 2023-09-26. PMID:37751044. |
in this study, we used chaihu shugan san (css), a traditional chinese herbal formula, as a probe to investigate the involvement of brain functional network connectivity and hippocampus energy metabolism in perimenopausal depression. |
2023-09-26 |
2023-10-07 |
rat |
| Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song, Lei Gao, Zhiping L. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. Journal of neuroinflammation. vol 20. issue 1. 2023-09-22. PMID:37735410. |
nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. |
2023-09-22 |
2023-10-07 |
mouse |
| Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song, Lei Gao, Zhiping L. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. Journal of neuroinflammation. vol 20. issue 1. 2023-09-22. PMID:37735410. |
our study aims to investigate how nuclear factor-erythroid 2 (nf-e2)-related factor 2 (nrf2) ameliorates hippocampal synaptic dysfunction and reduces brain functional connectivity (fc) associated with excessive iron in depression. |
2023-09-22 |
2023-10-07 |
mouse |
| Shuming Zhong, Pan Chen, Shunkai Lai, Yiliang Zhang, Guanmao Chen, Jiali He, Youling Pan, Guixian Tang, Ying Wang, Yanbin Ji. Hippocampal dynamic functional connectivity, HPA axis activity, and personality trait in bipolar disorder with suicidal attempt. Neuroendocrinology. 2023-09-20. PMID:37729896. |
additionally, multivariable regression analysis revealed the interaction of acth × dfc variability between the right caudal hippocampus and the left stg independently predicted mmpi-2 score (depression evaluation) in suicidal bd patients. |
2023-09-20 |
2023-10-07 |
human |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
moreover, tocilizumab could alleviate the "inflammatory storm" and impaired hippocampal synaptic plasticity in lps-challenged depression rats, inhibiting the hyperactivation of astrocyte and microglia, decreasing the peripheral and central abundance of il-6, crp, and tnf-α, and balancing the hippocampal expression levels of synaptic plasticity-associated proteins and key molecular in wnt/β-catenin signaling pathway. |
2023-09-17 |
2023-10-07 |
human |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
these results indicated a predictive role of il-6 in discriminating depression from controls, and demonstrated an antidepressant effect of tocilizumab in lps-challenged rats, targeting at the inflammatory storm and the subsequent impairments of hippocampal synaptic plasticity. |
2023-09-17 |
2023-10-07 |
human |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
in addition, depression is characterized by a decreased functioning of the serotonergic system due to changes in the activity or expression of its receptors including, most significantly, 5-ht1a, 5-ht2a, and 5-ht3 in brain regions that regulate mood, emotions, and memory, such as the prefrontal cortex, hippocampus, and amygdala. |
2023-09-15 |
2023-10-07 |
rat |
| Taylor O Phillips, Madelyn Castro, Rishi K Vas, Lorena A Ferguson, Amritha Harikumar, Stephanie L Lea. Perceived antidepressant efficacy associated with reduced negative and enhanced neutral mnemonic discrimination. Frontiers in human neuroscience. vol 17. 2023-09-13. PMID:37701502. |
mnemonic discrimination tasks have been designed to tax hippocampal pattern separation in humans and provide a powerful approach to develop a mechanistic account for cognitive dysfunction in depression. |
2023-09-13 |
2023-10-07 |
Not clear |
| Yunjian Dai, Taofeng Wei, Yuwen Huang, Yun Bei, Haoran Lin, Zexu Shen, Lingyan Yu, Mingdong Yang, Huimin Xu, Wei He, Zheng Lin, Haibin Da. Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-09-10. PMID:37690046. |
herein, we found that hdac9 was highly expressed in the hippocampus of chronic restraint stress (crs) mouse model of depression. |
2023-09-10 |
2023-10-07 |
mouse |
| Cheng Chen, Zhengxinyue Wang, Xinyu Cao, Jianjun Zh. Exploring the association between early exposure to material hardship and psychopathology through indirect effects of fronto-limbic functional connectivity during fear learning. Cerebral cortex (New York, N.Y. : 1991). 2023-09-09. PMID:37689831. |
a mediation analysis showed that material hardship was associated with depression via amygdala functional connectivity (indirect effect = 0.228, p = 0.016), and also indirectly associated with aggression and anger-hostility symptoms through hippocampal connections (aggression: indirect effect = 0.057, p = 0.001; anger-hostility: indirect effect = 0.169, p = 0.048). |
2023-09-09 |
2023-10-07 |
Not clear |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
these results demonstrate that stimulation of hippocampal microglia by intranasal lps administration can induce antidepressant effects via erk1/2-dependent synthesis of bdnf protein, providing hope for the development of new strategies for the treatment of depression. |
2023-09-07 |
2023-10-07 |
mouse |
| Brandon K Hayes, Amritha Harikumar, Lorena A Ferguson, Eva E Dicker, Bryan T Denny, Stephanie L Lea. Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms. Neurobiology of learning and memory. 2023-09-06. PMID:37673391. |
recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation - a computation that processes experiences with overlapping features as unique. |
2023-09-06 |
2023-10-07 |
Not clear |
| Wenjuan Han, Yaxin Zheng, Lan Wang, Cuixia A. Disordered gut microbiota and changes in short-chain fatty acids and inflammatory processes in stress-vulnerable mice. Journal of neuroimmunology. vol 383. 2023-09-02. PMID:37659269. |
susceptible mice to cums showed more severe symptoms of depression and anxiety, α diversity was significantly different, as well as higher expression of interleukin (il)-1β and tlr4/myd88/nf-κb inflammatory pathway components in the hippocampus. |
2023-09-02 |
2023-09-07 |
mouse |
| Rawand H Al-Dmour, Nafe M Al-Tawarah, Nesrin Mwafi, Banan A Alkhataybeh, Khalid M Khleifat, Amjad Tarawneh, Anas O M Satari, Sahem M Alkharabsheh, Laila Albustanj. Enhancement of hippocampal-dependent spatial memory by Ashwagandha ( The International journal of neuroscience. 2023-09-02. PMID:37659008. |
further, we elucidated a strong correlation between nmdar-positive cells in the hippocampus and enhancement of spatial learning induced by long-term administration of ash as well as a strong correlation between nmdar positive cells in the hippocampus and depression of spatial learning induced by long-term administration of ash and msg. |
2023-09-02 |
2023-09-07 |
rat |
| Shao-Qi Zhang, Qiao Deng, Qi Zhu, Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu, Jin-Gang He, Hong-Sheng Chen, Zhenyu Yue, Jia-Hong Lu, Fang Wang, Jian-Guo Che. Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression. Cell discovery. vol 9. issue 1. 2023-08-29. PMID:37644025. |
cell type-specific nrbf2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression. |
2023-08-29 |
2023-09-07 |
mouse |
| Liu Ruilian, Zhou Hao, Qu Honglin, Chen Yilin, Bai Qingyun, Guo Fuqiang, Wang Liang, Jiang Xiaobo, Mao Haifen. Effects of aerobic exercise on depression-like behavior and TLR4/NLRP3 pathway in hippocampus CA1 region of CUMS-depressed mice. Journal of affective disorders. 2023-08-27. PMID:37634821. |
the paper observes regulation of the expression levels of nlrp3 and tlr4 in hippocampal ca1 neurons in cums mice by aerobic exercise with constructing cums depression mouse model, in order to explore the neuroprotective mechanism of aerobic exercise on the hippocampus of depressed mice. |
2023-08-27 |
2023-09-07 |
mouse |