| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.) vol 165 issue 2023 36869551 |
in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation. |
2023-03-04 |
2023-03-06 |
mouse |
| Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pa. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. Journal of affective disorders vol issue 2023 36746244 |
after depression behavior tests, seven segments (cortex, hippocampus, striatum, hypothalamus, serum, cecum, and colon) along the gut-brain axis were collected to characterize their kp metabolism. |
2023-02-06 |
2023-03-06 |
rat |
| Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience vol 15 issue 2022 36466807 |
function of brain-derived neurotrophic factor in the hypothalamus: implications for depression pathology. |
2022-12-05 |
2023-01-30 |
Not clear |
| Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience vol 15 issue 2022 36466807 |
however, much of the symptomatology for depression is consistent with disruptions in functions of the hypothalamus including changes in weight, activity levels, responses to stress, and sociability. |
2022-12-05 |
2023-01-30 |
Not clear |
| Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience vol 15 issue 2022 36466807 |
here, we review evidence for the role of bdnf and trkb signaling in the regions of the hypothalamus and their role in these autonomic and behavioral functions associated with depression. |
2022-12-05 |
2023-01-30 |
Not clear |
| Anita E Autr. Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology. Frontiers in molecular neuroscience vol 15 issue 2022 36466807 |
understanding the role of bdnf signaling in the hypothalamus will lead to valuable insights for sex- and stress-dependent neurobiological underpinnings of depression pathology. |
2022-12-05 |
2023-01-30 |
Not clear |
| Yuan Wang, Ling Liu, Jiang-Hong Gu, Cheng-Niu Wang, Wei Guan, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Yan-Mei Chen, Jie Huang, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Bo Jian. Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. Molecular psychiatry vol issue 2022 36434056 |
salt-inducible kinase 1-creb-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. |
2022-11-26 |
2023-01-30 |
mouse |
| Bob Daripa, Scott Lucches. Unusual Presentation of COVID-19 Headache and Its Possible Pathomechanism. Cureus vol 14 issue 9 2022 36284805 |
the possible covid-19 pain pathway pathomechanism engaging interleukin (il)-1, il-6, and tumor necrosis factor (tnf) alpha aided with a cortical spreading depression disturbing the hypothalamus is also described in this study. |
2022-10-26 |
2023-01-30 |
human |
| Fu-Rong Yang, Xiao-Xu Zhu, Ming-Wang Kong, Xiao-Juan Zou, Qing-Yu Ma, Xiao-Juan Li, Jia-Xu Che. Xiaoyaosan Exerts Antidepressant-Like Effect by Regulating Autophagy Involves the Expression of GLUT4 in the Mice Hypothalamic Neurons. Frontiers in pharmacology vol 13 issue 2022 35784760 |
many studies have proven that autophagy plays a pivotal role in the development of depression and it also affects the expression of glut4 in the hypothalamus. |
2022-07-05 |
2023-01-27 |
mouse |
| Marie N N Hellem, Rachel Y Cheong, Simone Tonetto, Tua Vinther-Jensen, Rebecca K Hendel, Ida U Larsen, Troels T Nielsen, Lena E Hjermind, Asmus Vogel, Esben Budtz-J\\xc3\\xb8rgensen, \\xc3\\x85sa Peters\\xc3\\xa9n, J\\xc3\\xb8rgen E Nielse. Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. Parkinsonism & related disorders vol 99 issue 2022 35580426 |
non-motor symptoms like depression and altered social cognition are proposed to be caused by dysfunction of the hypothalamus. |
2022-05-17 |
2023-01-27 |
Not clear |
| Hatice Solak, Z Isik Solak Gormus, Raviye Ozen Koca, Canan Eroglu Gunes, Selim Kutl. Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression? Neurochemical research vol issue 2022 35080689 |
based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (cms) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. |
2022-01-26 |
2023-01-26 |
rat |
| Daniela Baptista-de-Souza, L\\xc3\\xadgia Renata Rodrigues Tavares, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souz. Behavioral, hormonal, and neural alterations induced by social contagion for pain in mice. Neuropharmacology vol 203 issue 2021 34774550 |
to amplify the knowledge about behavioral, hormonal, and neural alterations induced by cohabitation with a pair in neuropathic pain, we investigated the effects of this protocol on (i) pain (writhing, formalin, hot plate tests) and depression (sucrose splash test) responses, (ii) the serum levels of corticosterone, testosterone, and oxytocin, (iii) noradrenalin, dopamine and its metabolite (dopac and hva) levels in the amygdaloid complex and insular cortex, (iv) neuronal activation pattern (fosb labeling) in the ventral tegmental area (vta), paraventricular nucleus of the hypothalamus (pvn) and supraoptic nucleus (so). |
2021-12-03 |
2023-01-26 |
mouse |
| Xiang Li, Si-Min Qi, Yu Wang, Hui-Wu Jiang, Ya-Huan Li, Bing-Cong Zhao, Tao Zhang, Yang Sun, Xing-Zhou Gao, Song-Xiao Quan, Peng-Fei Liu, Wen-Shan Li, Ji-Hong Wu, Tu-Ya Bao, Hui-Li Jian. Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway. Anatomical record (Hoboken, N.J. : 2007) vol 304 issue 11 2021 34431619 |
the expression levels of c-jun in the hypothalamus, c-fos in the pituitary gland, and c-fos and ap-1 in the serum of cums induced rat model of depression were detected by elisa. |
2021-11-15 |
2023-01-26 |
rat |
| Tanveer Singh, Rajesh Kumar Goe. Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities. Neurochemical research vol 46 issue 6 2021 33665775 |
we should also move beyond ads, and therefore, we reviewed common pathological mechanisms such as neuroinflammation, dysregulated hypothalamus pituitary adrenal (hpa) axis, altered neurogenesis, and altered tryptophan metabolism responsible for coexistent relationship of epilepsy and depression. |
2021-10-12 |
2023-01-26 |
Not clear |
| Rongrong Li, Chiyuan Ma, Yue Xiong, Huashan Zhao, Yali Yang, Li Xue, Baobei Wang, Tianxia Xiao, Jie Chen, Xiaohua Lei, Baohua Ma, Jian Zhan. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules vol 11 issue 6 2021 34207497 |
depression affects the reproductive axis at the hypothalamus and pituitary levels, which has a significant impact on female fertility. |
2021-09-20 |
2023-01-26 |
mouse |
| Weibo Gong, Wei Liao, Chui Fang, Yanchen Liu, Hong Xie, Faping Yi, Rongzhong Huang, Lixiang Wang, Jian Zho. Analysis of Chronic Mild Stress-Induced Hypothalamic Proteome: Identification of Protein Dysregulations Associated With Vulnerability and Resiliency to Depression or Anxiety. Frontiers in molecular neuroscience vol 14 issue 2021 33737865 |
in summary, the current proteomic research on the hypothalamus provided insights into the specific and common molecular basis for the hpa dysfunction mechanisms that underlie resiliency and vulnerability to stress-induced depression or anxiety. |
2021-06-04 |
2023-01-26 |
rat |
| Wei Han, Qian Xue, Guohui Li, Jianmei Yin, Huiyong Zhang, Yunfen Zhu, Weijie Xing, Yuxia Cao, Yijun Su, Kehua Wang, Jianmin Zo. Genome-wide analysis of the role of DNA methylation in inbreeding depression of reproduction in Langshan chicken. Genomics vol 112 issue 4 2021 32057912 |
to investigate the potential dna methylation sites involved in the inbreeding depression of chicken reproduction, we carried out whole-genome bisulfite sequencing (wgbs) of hypothalamus and ovary tissues from the strongly and weakly inbred langshan chickens, respectively. |
2021-04-09 |
2023-01-26 |
chicken |
| Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirull. High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats. The European journal of neuroscience vol issue 2021 33711185 |
changes in the expression levels of inflammatory (il-1\xce\xb2, tnf-\xce\xb1, il-6) and of stress response mediators (nr3c1, fkbp5) as well as of mood and metabolic regulators (bdnf, ghs-r) were investigated in the hippocampus, prefrontal cortex and hypothalamus, brain regions involved in the pathogenesis of depression and prone to inflammation in response to stress. |
2021-03-26 |
2023-01-26 |
rat |
| Yajing Hou, Yueyun Liu, Chenyue Liu, Zhiyi Yan, Qingyu Ma, Jianbei Chen, Man Zhang, Qiuying Yan, Xiaojuan Li, Jiaxu Che. Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus. Anatomical record (Hoboken, N.J. : 2007) vol 303 issue 8 2021 32175693 |
abnormal changes in the lateral region of the hypothalamus are associated with the comorbidity of depression and physical symptoms, and how the traditional chinese formula xiaoyaosan regulates these changes may reveal aspects of the pathogenesis of depression. |
2021-03-24 |
2023-01-26 |
rat |
| Yajing Hou, Yueyun Liu, Chenyue Liu, Zhiyi Yan, Qingyu Ma, Jianbei Chen, Man Zhang, Qiuying Yan, Xiaojuan Li, Jiaxu Che. Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus. Anatomical record (Hoboken, N.J. : 2007) vol 303 issue 8 2021 32175693 |
this study aimed to establish a rat model of depression in order to examine changes in orexin a/oxr1 expression in the lateral region of the hypothalamus and the effects of xiaoyaosan. |
2021-03-24 |
2023-01-26 |
rat |