| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiong-Jun Mou, Hao Liu, Ning Lin, Xin Chen, Song-Lin Li. [Effects of Shugan Hewei Decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 15. 2019-10-21. PMID:31602893. |
[effects of shugan hewei decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats]. |
2019-10-21 |
2023-08-13 |
rat |
| Xiong-Jun Mou, Hao Liu, Ning Lin, Xin Chen, Song-Lin Li. [Effects of Shugan Hewei Decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 15. 2019-10-21. PMID:31602893. |
shugan hewei decoction whole recipe and its active substance fractions can improve the behavior of depression model rats and may exert anti-depression effects by regulating the content of neurotransmitters in the hypothalamus. |
2019-10-21 |
2023-08-13 |
rat |
| Hans-Gert Bernstein, Henrik Dobrowolny, Bernhard Bogerts, Gerburg Keilhoff, Johann Steine. The hypothalamus and neuropsychiatric disorders: psychiatry meets microscopy. Cell and tissue research. vol 375. issue 1. 2019-05-16. PMID:29767278. |
gross anatomical abnormalities (volume changes of the third ventricle, the hypothalamus, and its nuclei) and alterations at the cellular level (loss of neurons, increased or decreased expression of hypothalamic peptides such as oxytocin, vasopressin, corticotropin-releasing hormone, and other regulatory factors as well as of enzymes involved in neurotransmitter and neuropeptide metabolism) have been reported in schizophrenia and/or depression. |
2019-05-16 |
2023-08-13 |
Not clear |
| Rebecca Lipschutz, Johanna Bick, Victoria Nguyen, Maria Lee, Lin Leng, Elena Grigorenko, Richard Bucala, Linda C Mayes, Michael J Crowle. Macrophage migration inhibitory factor (MIF) gene is associated with adolescents' cortisol reactivity and anxiety. Psychoneuroendocrinology. vol 95. 2019-04-10. PMID:29870971. |
macrophage migration inhibitory factor (mif) is a pleiotropic cytokine involved in inflammatory signaling and hypothalamus pituitary adrenal (hpa) axis stress-response, and has recently been identified as a candidate biomarker for depression and anxiety risk. |
2019-04-10 |
2023-08-13 |
Not clear |
| Nazia Karsan, Eric B Gonzales, Gregory Dusso. Targeted Acid-Sensing Ion Channel Therapies for Migraine. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 2. 2019-03-13. PMID:29549622. |
their expression within areas of interest in the brain in migraine, such as the hypothalamus and pag, their demonstrated involvement in preclinical models of meningeal afferent signaling, and their role in cortical spreading depression (the electrophysiological correlate of migraine aura), has enhanced research interest into these channels as potential therapeutic targets in migraine. |
2019-03-13 |
2023-08-13 |
Not clear |
| Qing Ya. Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression. Methods in molecular biology (Clifton, N.J.). vol 1781. 2019-02-22. PMID:29705843. |
at the molecular and cellular levels, the imbalances in multiple networks including the cytokine and redox pathways, immune-kynurenine networks, hpa axis, and synaptic plasticity in the hypothalamus are the key factors in depression. |
2019-02-22 |
2023-08-13 |
Not clear |
| Zhi-Yong Xiao, Bo Wang, Wan Fu, Xin Jin, Yong You, Shao-Wen Tian, Xin Kuan. The Hippocampus is a Critical Site Mediating Antidepressant-like Activity of Apelin-13 in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29432881. |
the peptide apelin and its receptor apj are found to express in multiple brain regions, especially in the regions such as the hippocampus and hypothalamus that play important roles in stress and depression. |
2019-02-21 |
2023-08-13 |
rat |
| Sara Carmo-Silva, Cláudia Cavada. Hypothalamic Dysfunction in Obesity and Metabolic Disorders. Advances in neurobiology. vol 19. 2018-11-01. PMID:28933062. |
alterations in circadian rhythm, stress response, and fertility further contribute to aggravate the metabolic dysfunction of obesity and contribute to the development of chronic disorders such as depression and infertility.at cellular level, obesity caused by overnutrition can damage the hypothalamus promoting inflammation and impairing hypothalamic neurogenesis. |
2018-11-01 |
2023-08-13 |
Not clear |
| Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Ga. Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. Molecular bioSystems. vol 13. issue 12. 2018-07-02. PMID:29160327. |
imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by gc-ms. hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression. |
2018-07-02 |
2023-08-13 |
mouse |
| Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Ga. Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. Molecular bioSystems. vol 13. issue 12. 2018-07-02. PMID:29160327. |
herein, taking advantage of the well-established lipopolysaccharide (lps)-induced depression mouse model, we measured metabolic changes in the hypothalamus using gas chromatography-mass spectrometry (gc-ms). |
2018-07-02 |
2023-08-13 |
mouse |
| Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Ga. Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. Molecular bioSystems. vol 13. issue 12. 2018-07-02. PMID:29160327. |
to better understand the metabolic disturbances occurring in the hypothalamus of depressed mice, multivariate statistics were applied to analyse the clinical significance of differentially expressed metabolites in the hypothalamus of mice with lps-induced depression. |
2018-07-02 |
2023-08-13 |
mouse |
| Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Ga. Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. Molecular bioSystems. vol 13. issue 12. 2018-07-02. PMID:29160327. |
in our study, 27 differentially expressed metabolites were identified in the hypothalamus of mice with lps-induced depression. |
2018-07-02 |
2023-08-13 |
mouse |
| Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Ga. Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. Molecular bioSystems. vol 13. issue 12. 2018-07-02. PMID:29160327. |
these results provide new insights into the mechanisms underlying depression, which may shed some light on the role of the hypothalamus in the pathogenesis of inflammation-mediated depression. |
2018-07-02 |
2023-08-13 |
mouse |
| Xueyan Wu, Rawien Balesar, Jing Lu, Sahar Farajnia, Qiongbin Zhu, Manli Huang, Ai-Min Bao, Dick F Swaa. Increased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression. Brain structure & function. vol 222. issue 9. 2018-06-25. PMID:28608287. |
postmortem hypothalamus specimens of 13 subjects suffering from depression and of 13 well-matched controls were collected. |
2018-06-25 |
2023-08-13 |
human |
| Karim Fifel, Johanna H Meijer, Tom Deboe. Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas. Neurobiology of disease. vol 109. issue Pt A. 2018-06-25. PMID:29017795. |
we propose that these hypothalamic changes underlie the well-established relationship between sleep loss and several diseases such as metabolic disorders, stress and depression and that sufficient sleep is vital for autonomic functions controlled by the hypothalamus. |
2018-06-25 |
2023-08-13 |
rat |
| Jing Lu, Juan Zhao, Rawien Balesar, Rolf Fronczek, Qiong-Bin Zhu, Xue-Yan Wu, Shao-Hua Hu, Ai-Min Bao, Dick F Swaa. Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression. EBioMedicine. vol 18. 2018-01-17. PMID:28377228. |
we explored the hypocretin system changes in the hypothalamus and cortex in depression from male and female subjects. |
2018-01-17 |
2023-08-13 |
human |
| Juan-Li Wu, Yang He, Radovan Hrubý, Rawien Balesar, Yang-Jian Qi, Lei Guo, Zhong Ren, Qiong-Bin Zhu, Man-Li Huang, Dick F Swaab, Ai-Min Ba. Aromatase changes in depression: A postmortem and animal experimental study. Psychoneuroendocrinology. vol 77. 2017-12-07. PMID:28024269. |
we have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. |
2017-12-07 |
2023-08-13 |
human |
| Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa, Joshua G Corbi. Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. Neural development. vol 11. issue 1. 2017-09-20. PMID:27209204. |
neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as anxiety, depression or obesity. |
2017-09-20 |
2023-08-13 |
Not clear |
| Jonathon Sens, Eric Schneider, Joseph Mauch, Anna Schaffstein, Sara Mohamed, Kathryn Fasoli, Joseph Saurine, Aikaterini Britzolaki, Connor Thelen, Pothitos M Pitychouti. Lipopolysaccharide administration induces sex-dependent behavioural and serotonergic neurochemical signatures in mice. Pharmacology, biochemistry, and behavior. vol 153. 2017-08-25. PMID:28057525. |
we further mapped the brain's serotonergic and dopaminergic activity in five limbic brain regions implicated in the pathophysiology of major depression (i.e., prefrontal cortex, hippocampus, striatum, amygdala, and hypothalamus) at two critical time-points post-lps treatment; at 6h when depression of behavioural activity is maximal, and at 24h when depressive-like symptoms develop independently of obvious locomotor performance impairments associated with acute lps administration. |
2017-08-25 |
2023-08-13 |
mouse |
| Xiao-Yan Zhou, Fang Zhang, Xiao-Tong Hu, Jing Chen, Ren-Xian Tang, Kui-Yang Zheng, Yuan-Jian Son. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain research. vol 1657. 2017-08-07. PMID:28017669. |
these findings suggest that the mechanism of astaxanthin in preventing depression in diabetic mice involves the inhibition of inflammation/inflammation inhibition, thereby protecting neurons in hippocampus, amygdala and hypothalamus against hyperglycemic damage. |
2017-08-07 |
2023-08-13 |
mouse |