| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Juan Zhu, Meng-Ying Liu, Huan Li, Xiao Liu, Chen Chen, Zhou Han, Hai-Yin Wu, Xing Jing, Hai-Hui Zhou, Hoonkyo Suh, Dong-Ya Zhu, Qi-Gang Zho. The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity. PloS one. vol 9. issue 5. 2015-06-15. PMID:24831808. |
this study suggests that the glucocorticoids in the hippocampus play an important role in the development of hpa axis hyperactivity and the glucocorticoids in the hypothalamus can't induce hyperactivity of hpa axis, revealing new insights into understanding the mechanism of depression. |
2015-06-15 |
2023-08-13 |
Not clear |
| Ming Wang, Qian Chen, Mei Li, Wei Zhou, Tengfei Ma, Yun Wang, Shuling G. Alarin-induced antidepressant-like effects and their relationship with hypothalamus-pituitary-adrenal axis activity and brain derived neurotrophic factor levels in mice. Peptides. vol 56. 2015-01-09. PMID:24768903. |
similar to galanin in distribution, alarin is also expressed in the medial amygdala and hypothalamus, i.e., regions interrelated with depression. |
2015-01-09 |
2023-08-13 |
mouse |
| Rui Yang, Hongbo Zhang, Xiaoping Wu, Junle Yang, Mingyue Ma, Yanjun Gao, Hongsheng Liu, Shengbin L. Hypothalamus-anchored resting brain network changes before and after sertraline treatment in major depression. BioMed research international. vol 2014. 2014-11-21. PMID:24772438. |
after eight weeks of antidepressant treatment, patients with depression showed significantly increased connectivity between the hypothalamus and dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, insula, putamen, caudate, and claustrum. |
2014-11-21 |
2023-08-13 |
human |
| Hendrik Bielau, Ralf Brisch, Tomasz Gos, Henrik Dobrowolny, Bruno Baumann, Christian Mawrin, Peter Kreutzmann, Hans-Gert Bernstein, Bernhard Bogerts, Johann Steine. Volumetric analysis of the hypothalamus, amygdala and hippocampus in non-suicidal and suicidal mood disorder patients--a post-mortem study. CNS & neurological disorders drug targets. vol 12. issue 7. 2014-11-12. PMID:24040806. |
in recent years, the hypothalamus, amygdala and hippocampus have attracted increased interest with regard to the effects of stress on neurobiological systems in individuals with depression and suicidal behaviour. |
2014-11-12 |
2023-08-12 |
human |
| Leah M Pyter, Sarah El Mouatassim Bih, Husain Sattar, Brian J Prendergas. Peripheral tumors alter neuroinflammatory responses to lipopolysaccharide in female rats. Brain research. vol 1552. 2014-10-16. PMID:24457042. |
), and expression of mrnas involved in the pathway linking inflammation and depression (interleukin-1beta [il-1β], cd11b, iκbα, indolamine 2,3-deoxygenase [ido]) was quantified by qpcr in the hippocampus, hypothalamus, and frontal cortex, 4 or 24h post-treatment. |
2014-10-16 |
2023-08-12 |
rat |
| Xue Deng, Lu Ren, Jing Li, Jian-Duan Sun, Shen-Kang Fu, Shou-Zhang Zha. [Effect of electroacupuncture stimulation of "Ganshu" (BL 18) on locomotor, gastric mucosal and hypothalamic SP immunoactivity and hippocampal 5-HT content in rats with depression and gastric ulcer]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 2. 2014-06-17. PMID:24818496. |
to observe the effect of electroacupuncture (ea) stimulation of "ganshu" (bl18) on expression of substance p (sp) in the gastric mucosa and hypothalamus tissues and hippocampal 5-hydroxytryptamine (5-ht) content in rats with depression + gastric ulcer, so as to explore its mechanism underlying improvement of depressive gastric ulcer. |
2014-06-17 |
2023-08-13 |
rat |
| Shan-Shan Wang, Ya-Guang Wang, Hai-Ying Chen, Zhi-Ping Wu, Heng-Ge Xi. Expression of genes encoding cytokines and corticotropin releasing factor are altered by citalopram in the hypothalamus of post-stroke depression rats. Neuro endocrinology letters. vol 34. issue 8. 2014-04-01. PMID:24522018. |
expression of genes encoding cytokines and corticotropin releasing factor are altered by citalopram in the hypothalamus of post-stroke depression rats. |
2014-04-01 |
2023-08-12 |
rat |
| Shan-Shan Wang, Ya-Guang Wang, Hai-Ying Chen, Zhi-Ping Wu, Heng-Ge Xi. Expression of genes encoding cytokines and corticotropin releasing factor are altered by citalopram in the hypothalamus of post-stroke depression rats. Neuro endocrinology letters. vol 34. issue 8. 2014-04-01. PMID:24522018. |
to establish a rat model of post-stroke depression (psd), and examine expression of genes encoding corticotropin releasing factor (crf), interleukin 1 beta (il-1β), and tumor necrosis factor alpha (tnf-α) in the hypothalamus of psd rats. |
2014-04-01 |
2023-08-12 |
rat |
| Sung Chung, Hee Jeong Kim, In Seon Yoon, Hyun Ju Kim, Sun Hye Choi, Yong Sik Kim, Kyung Ho Shi. Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus. The journal of ECT. vol 29. issue 2. 2014-01-08. PMID:23519217. |
the present study was designed to observe whether ecs dynamically regulates sirt1 levels in the hippocampus and hypothalamus; both of these regions have been implicated in the pathophysiology of depression. |
2014-01-08 |
2023-08-12 |
mouse |
| Jin-Fang Ge, Cong-Cong Qi, Jiang-Ning Zho. Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats. Behavioural brain research. vol 249. 2013-10-21. PMID:23619134. |
imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats. |
2013-10-21 |
2023-08-12 |
rat |
| Szilvia Vas, Csaba Ádori, Katalin Könczöl, Zita Kátai, Dorottya Pap, Rege S Papp, György Bagdy, Miklós Palkovits, Zsuzsanna E Tót. Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats. PloS one. vol 8. issue 4. 2013-09-16. PMID:23560056. |
melanin-concentrating hormone (mch) and nesfatin-1/nucb2 (nesfatin) are strongly co - expressed in the hypothalamus and are involved both in food intake regulation and depression. |
2013-09-16 |
2023-08-12 |
rat |
| T M Iavisheva, S D Shcherbako. [Participation of morphofunctional zones in aging processes]. Advances in gerontology = Uspekhi gerontologii. vol 25. issue 4. 2013-06-28. PMID:23734504. |
the depression of cambial cell number with aging is connected with the work of another morphofunctional zone--the hypothalamus, which is the major center of vegetative regulation and initially has very high rhoa activity, which has been established in embryogenesis. |
2013-06-28 |
2023-08-12 |
Not clear |
| Xiao-hong Li, Jing-jing Li, Yue-yun Liu, Jia-xu Che. [Central neurobiological mechanism of liver depression and spleen deficiency syndrome based on chronic stress: a review]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 10. issue 1. 2012-12-06. PMID:22237267. |
the research showed that the central neurobiology mechanism of liver depression and spleen deficiency syndrome closely correlates to the hypothalamic-pituitary-adrenal axis, brain-gut axis, myriad central neurotrophic factors, neurotransmitters, neuropeptides and hormones and their receptors, involving in many encephalic regions such as the hypothalamus, hippocampus, cortex, amygdale, etc. |
2012-12-06 |
2023-08-12 |
rat |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
the social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. |
2012-11-16 |
2023-08-12 |
rat |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
but whether their influences are modified or imbalanced within the hypothalamus or dopamine system in anhedonic preclinical depression models is not yet clear. |
2012-11-16 |
2023-08-12 |
rat |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
these findings suggest that orexin and dynorphin function may be imbalanced between the hypothalamus and mesocortical dopaminergic brain regions in depression. |
2012-11-16 |
2023-08-12 |
rat |
| K A Baranova, E A Rybnikova, M O Samoilo. Antidepressant effect of hypoxic preconditioning is associated with modification of expression of transcription factor c-Fos in rat brain in response to unavoidable stress. Bulletin of experimental biology and medicine. vol 152. issue 5. 2012-11-13. PMID:22803133. |
development of post-stress depression in rats was accompanied by long-term moderate activation of the expression of transcription factor c-fos in the neocortex, hippocampus, and paraventricular nucleus of the hypothalamus. |
2012-11-13 |
2023-08-12 |
rat |
| Hideho Arit. [The neuroscience of suicide]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868884. |
corticotropin-releasing factor (crf)-immunoreactive varicose fibers were detected in the drn of suicide victims, suggesting that crf neurons in the paraventricular nucleus of the hypothalamus and 5-ht neurons in the drn may form a circuit in stress-induced depression. |
2012-10-18 |
2023-08-12 |
Not clear |
| Bombi Lee, Hye-Yeon Yun, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress. Journal of microbiology and biotechnology. vol 22. issue 3. 2012-07-16. PMID:22450800. |
previous studies have demonstrated that repeated restraint stress in rodents produces increases in depression and anxietylike behaviors and alters the expression of corticotrophinreleasing factor (crf) in the hypothalamus. |
2012-07-16 |
2023-08-12 |
rat |
| Mathieu Nollet, Philippe Gaillard, Frédéric Minier, Arnaud Tanti, Catherine Belzung, Samuel Lema. Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21530551. |
activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression. |
2012-04-17 |
2023-08-12 |
mouse |