| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-Sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua L. Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-17. PMID:36251080. |
huntingtin-associated protein 1 (hap1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mhtt), which causes huntington disease. |
2022-10-17 |
2023-08-14 |
mouse |
| Hannah S Hart, Madeline A Valentin, Stephanie Toering Peters, Susan W Holler, Hongmin Wang, Aaron F Harmon, Larry D Holle. The cytoprotective role of GM1 ganglioside in Huntington disease cells. Molecular biology reports. 2022-09-30. PMID:36180805. |
huntington disease (hd) is a neurodegenerative disease where a genetic mutation leads to excessive polyglutamine (q) repeats in the huntingtin protein. |
2022-09-30 |
2023-08-14 |
Not clear |
| Sukhbir Singh, Hema, Neelam Sharma, Monika Sachdeva, Tapan Behl, Ishrat Zahoor, Neeraj Kumar Fuloria, Mahendran Sekar, Shivkanya Fuloria, Vetriselvan Subramaniyan, Amal M Alsubayiel, Hamed Ghaleb Dailah, Tanveer Naved, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aley. Focusing the pivotal role of nanotechnology in Huntington's disease: an insight into the recent advancements. Environmental science and pollution research international. 2022-09-13. PMID:36100788. |
huntington disease has been recognized as a disorder that affects the complete body and brain in which the mutant huntingtin polyglutamine (polyq) sequence is extensively increased and gets correlated to cag trinucleotide which codes for glutamine (q). |
2022-09-13 |
2023-08-14 |
Not clear |
| Sophie Lenoir, Romane A Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R Hayden, Frédéric Saudo. Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model. Neurobiology of disease. 2022-09-08. PMID:36075537. |
huntington disease (hd) is a neurodegenerative disorder caused by polyglutamine-encoding cag repeat expansion in the huntingtin (htt) gene. |
2022-09-08 |
2023-08-14 |
mouse |
| Jessica Dawson, Fiona K Baine-Savanhu, Marc Ciosi, Alastair Maxwell, Darren G Monckton, Amanda Kraus. A probable HGG advances. vol 3. issue 4. 2022-08-08. PMID:35935919. |
a probable huntington disease (hd)is a dominantly inherited neurodegenerative disorder caused by the expansion of a polyglutamine encoding cag repeat in the huntingtin gene. |
2022-08-08 |
2023-08-14 |
Not clear |
| Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Georgina F Osborne, Edward J Smith, Samuel T Jones, Marie K Bondulich, Emily C E Danby, Jemima Phillips, Bridget A Taxy, Holly B Kordasiewicz, Gillian P Bate. Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics. Brain : a journal of neurology. 2022-07-06. PMID:35793238. |
huntington disease is caused by a cag repeat expansion in exon 1 of the huntingtin gene (htt) that is translated into a polyglutamine stretch in the huntingtin protein (htt). |
2022-07-06 |
2023-08-14 |
mouse |
| Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Che. A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT. Autophagy. 2022-05-31. PMID:35635192. |
the aggregation of mutant htt (huntingtin; mhtt) is a hallmark of huntington disease (hd). |
2022-05-31 |
2023-08-13 |
Not clear |
| Richard A Hickman, Phyllis L Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsatte. The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade. Acta neuropathologica communications. vol 10. issue 1. 2022-04-20. PMID:35440014. |
the distribution and density of huntingtin inclusions across the huntington disease neocortex: regional correlations with huntingtin repeat expansion independent of pathologic grade. |
2022-04-20 |
2023-08-13 |
human |
| Richard A Hickman, Phyllis L Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsatte. The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade. Acta neuropathologica communications. vol 10. issue 1. 2022-04-20. PMID:35440014. |
huntington disease is characterized by progressive neurodegeneration, especially of the striatum, and the presence of polyglutamine huntingtin (htt) inclusions. |
2022-04-20 |
2023-08-13 |
human |
| Arianna Novati, Huu Phuc Nguyen, Julia Schulze-Hentric. Environmental stimulation in Huntington disease patients and animal models. Neurobiology of disease. 2022-04-15. PMID:35427742. |
while huntington disease (hd) is caused solely by a polyglutamine expansion in the huntingtin gene, environmental factors can influence hd onset and progression. |
2022-04-15 |
2023-08-13 |
mouse |
| Luis Marte, Susanna Boronat, Rubén Barrios, Anna Barcons-Simon, Benedetta Bolognesi, Margarita Cabrera, José Ayté, Elena Hidalg. Expression of Huntingtin and TDP-43 Derivatives in Fission Yeast Can Cause Both Beneficial and Toxic Effects. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409310. |
many neurodegenerative disorders display protein aggregation as a hallmark, huntingtin and tdp-43 aggregates being characteristic of huntington disease and amyotrophic lateral sclerosis, respectively. |
2022-04-12 |
2023-08-13 |
human |
| E Srinivasan, Vavish Ram, R Rajasekara. A review on Huntington protein Insight into protein aggregation and therapeutic interventions. Current drug metabolism. 2022-03-23. PMID:35319359. |
huntington disease (hd) is a distressing, innate neurodegenerative disease that descends from cag repeat expansion in the huntingtin gene causing behavioral changes, motor dysfunction, and dementia in children and adults. |
2022-03-23 |
2023-08-13 |
Not clear |
| Morgan E Rook, Amber L Southwel. Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022-03-07. PMID:35254632. |
huntington disease (hd) is a fatal progressive neurodegenerative disorder caused by an inherited mutation in the huntingtin (htt) gene, which encodes mutant htt protein. |
2022-03-07 |
2023-08-13 |
human |
| Hongsun Park, Tomoyuki Yamanaka, Yumiko Toyama, Atsushi Fujita, Hiroshi Doi, Takashi Nirasawa, Shigeo Murayama, Naomichi Matsumoto, Tomomi Shimogori, Masaya Ikegawa, Matti J Haltia, Nobuyuki Nukin. Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions. Acta neuropathologica communications. vol 10. issue 1. 2022-03-05. PMID:35246273. |
in order to establish a method to directly identify the components of niis, we first analyzed the huntingtin inclusion-rich fraction obtained from the brains of huntington disease model mice. |
2022-03-05 |
2023-08-13 |
mouse |
| Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Criste. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell systems. 2022-02-12. PMID:35148841. |
dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of huntington disease. |
2022-02-12 |
2023-08-13 |
mouse |
| Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Criste. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell systems. 2022-02-12. PMID:35148841. |
huntington disease (hd) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (htt). |
2022-02-12 |
2023-08-13 |
mouse |
| Rana Soylu-Kucharz, Ali Khoshnan, Åsa Petersé. IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington disease mouse model. iScience. vol 25. issue 2. 2022-02-11. PMID:35146388. |
huntington disease (hd) is a neurodegenerative disorder caused by a cag repeat expansion in the huntingtin ( |
2022-02-11 |
2023-08-13 |
mouse |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of huntington disease mice. |
2022-02-10 |
2023-08-13 |
mouse |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
huntington disease (hd) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene encoding an elongated polyglutamine tract in the huntingtin (htt) protein. |
2022-02-10 |
2023-08-13 |
mouse |
| Uri Nimrod Ramírez-Jarquín, Manish Sharma, Wuyue Zhou, Neelam Shahani, Srinivasa Subramania. Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 5. 2022-01-28. PMID:35086928. |
the cag expansion of huntingtin (mhtt) associated with huntington disease (hd) is a ubiquitously expressed gene, yet it prominently damages the striatum and cortex, followed by widespread peripheral defects as the disease progresses. |
2022-01-28 |
2023-08-13 |
mouse |