| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordan L Schultz, Carsten Saft, Peggy C Nopoulo. Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults. Neurology. vol 96. issue 19. 2021-06-15. PMID:33692166. |
to investigate the relationships between cag repeat length in the huntingtin gene and cognitive performance in participants above and below the disease threshold for huntington disease (hd), we performed a cross-sectional analysis of the enroll-hd database. |
2021-06-15 |
2023-08-13 |
human |
| Leora Fox, Ai Yamamot. Examining aggregates through the eyes of WDFY3/Alfy. Autophagy. vol 16. issue 5. 2021-06-07. PMID:32150493. |
in this autophagic punctum, we discuss our recent findings of how the selectivity scaffold/adaptor wdfy3/alfy is required for the turnover of aggregated mutant htt (huntingtin; mhtt) in the adult brain, and how it confers resistance to huntington disease (hd)-like symptoms. |
2021-06-07 |
2023-08-13 |
mouse |
| Sandra Franco-Iborra, Ainhoa Plaza-Zabala, Marta Montpeyo, David Sebastian, Miquel Vila, Marta Martinez-Vicent. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. vol 17. issue 3. 2021-05-25. PMID:32093570. |
mutant htt (huntingtin) impairs mitophagy in a cellular model of huntington disease. |
2021-05-25 |
2023-08-13 |
Not clear |
| Xiaohong Xu, Bryan Ng, Bernice Sim, Carola I Radulescu, Nur Amirah Binte Mohammad Yusof, Wah Ing Goh, Shuping Lin, John Soon Yew Lim, Yoonjeong Cha, Rebecca Kusko, Chris Kay, Tamara Ratovitski, Christopher Ross, Michael R Hayden, Graham Wright, Mahmoud A Poulad. pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model. Cell death & disease. vol 11. issue 9. 2021-04-23. PMID:32978366. |
huntington disease (hd) is a hereditary neurodegenerative disorder caused by mutant huntingtin (mhtt). |
2021-04-23 |
2023-08-13 |
human |
| Kirby M Donnelly, Olivia R DeLorenzo, Aprem DA Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R Kopito, Margaret M Panning Pearc. Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses. eLife. vol 9. 2021-03-30. PMID:32463364. |
here, we show that mutant huntingtin (mhtt) aggregates associated with huntington disease transfer anterogradely from presynaptic to postsynaptic neurons in the adult |
2021-03-30 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Raul Banos, Christopher Yanick, Amirah E Aly, Lauren M Byrne, Ethan D Smith, Yuanyun Xie, Stephen E P Smith, Nalini Potluri, Hailey Findlay Black, Lorenzo Casal, Seunghyun Ko, Daphne Cheung, Hyeongju Kim, Ihn Sik Seong, Edward J Wild, Ji-Joon Song, Michael R Hayden, Amber L Southwel. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 4. 2021-03-26. PMID:33310753. |
mutant huntingtin is cleared from the brain via active mechanisms in huntington disease. |
2021-03-26 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Raul Banos, Christopher Yanick, Amirah E Aly, Lauren M Byrne, Ethan D Smith, Yuanyun Xie, Stephen E P Smith, Nalini Potluri, Hailey Findlay Black, Lorenzo Casal, Seunghyun Ko, Daphne Cheung, Hyeongju Kim, Ihn Sik Seong, Edward J Wild, Ji-Joon Song, Michael R Hayden, Amber L Southwel. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 4. 2021-03-26. PMID:33310753. |
huntington disease (hd) is a neurodegenerative disease caused by a cag trinucleotide repeat expansion in the huntingtin ( |
2021-03-26 |
2023-08-13 |
Not clear |
| Mehdi Eshraghi, Pabalu P Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P Ricci, Audrey Michel, Nicolai T Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramania. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nature communications. vol 12. issue 1. 2021-03-19. PMID:33674575. |
mutant huntingtin stalls ribosomes and represses protein synthesis in a cellular model of huntington disease. |
2021-03-19 |
2023-08-13 |
mouse |
| Mehdi Eshraghi, Pabalu P Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P Ricci, Audrey Michel, Nicolai T Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramania. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nature communications. vol 12. issue 1. 2021-03-19. PMID:33674575. |
the polyglutamine expansion of huntingtin (mhtt) causes huntington disease (hd) and neurodegeneration, but the mechanisms remain unclear. |
2021-03-19 |
2023-08-13 |
mouse |
| Niels Henning Skotte, Mahmoud A Pouladi, Dagmar E Ehrnhoefer, Katie Huynh, Xiaofan Qiu, Signe Marie Borch Nielsen, Troels Tolstrup Nielsen, Anne Nørremølle, Michael R Hayde. Compromised IGF signaling causes caspase-6 activation in Huntington disease. Experimental neurology. vol 332. 2021-03-09. PMID:32622701. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder caused by an expansion of a polyglutamine repeat in the huntingtin (htt) protein. |
2021-03-09 |
2023-08-13 |
mouse |
| Elisabeth A Spronck, Astrid Vallès, Margit H Lampen, Paula S Montenegro-Miranda, Sonay Keskin, Liesbeth Heijink, Melvin M Evers, Harald Petry, Sander J van Deventer, Pavlina Konstantinova, Martin de Haa. Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology. Brain sciences. vol 11. issue 2. 2021-02-27. PMID:33498212. |
huntington disease (hd) is a fatal, neurodegenerative genetic disorder with aggregation of mutant huntingtin protein (muthtt) in the brain as a key pathological mechanism. |
2021-02-27 |
2023-08-13 |
rat |
| Blair R Leavitt, Holly B Kordasiewicz, Scott A Schobe. Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks. JAMA neurology. vol 77. issue 6. 2021-02-17. PMID:32202594. |
huntington disease (hd) is caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene, htt, that results in expression of variant (mutant) huntingtin protein (htt). |
2021-02-17 |
2023-08-13 |
mouse |
| Blair R Leavitt, Holly B Kordasiewicz, Scott A Schobe. Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks. JAMA neurology. vol 77. issue 6. 2021-02-17. PMID:32202594. |
studies indexed in pubmed were searched using the mesh term huntington disease or the text words huntington or huntingtin from august 31, 1999, to august 31, 2019, with no language restrictions. |
2021-02-17 |
2023-08-13 |
mouse |
| Per Breimer, Åsa Petersén, Håkan Widne. [Recurrent psychotic symtoms over several years were caused by Huntington's disease]. Lakartidningen. vol 118. 2021-02-08. PMID:33474718. |
huntington disease (hd) is a progressive neurodegenerative disorder caused by an expanded cag repeat in the huntingtin gene. |
2021-02-08 |
2023-08-13 |
Not clear |
| Şule Altıner, Senol Ardic, Alper H Çeb. Extending the Phenotypic Spectrum of Huntington Disease: Hypothermia. Molecular syndromology. vol 11. issue 1. 2021-02-01. PMID:32256303. |
huntington disease (hd) is an autosomal dominant progressive neurodegenerative disorder associated with expanded cag repeat size in the huntingtin gene and usually presenting with movement disorder, psychiatric symptoms, and cognitive decline. |
2021-02-01 |
2023-08-13 |
Not clear |
| Havva Yalinca, Charlotte Julie Caroline Gehin, Vladimiras Oleinikovas, Hilal A Lashuel, Francesco Luigi Gervasio, Annalisa Pastor. The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus. Frontiers in molecular biosciences. vol 6. 2021-01-10. PMID:31632982. |
huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. |
2021-01-10 |
2023-08-13 |
human |
| Elisabeth Singer, Carolin Walter, Doriano Fabbro, Denise Rageot, Florent Beaufils, Matthias P Wymann, Nadine Rischert, Olaf Riess, Petra Hillmann, Huu Phuc Nguye. Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD. Neuropharmacology. vol 162. 2021-01-06. PMID:31622602. |
one of the pathological hallmarks of huntington disease (hd) is accumulation of the disease-causing mutant huntingtin (mhtt), which leads to the disruption of a variety of cellular functions, ultimately resulting in cell death. |
2021-01-06 |
2023-08-13 |
mouse |
| Osama Al-Dalahmah, Alexander A Sosunov, A Shaik, Kenneth Ofori, Yang Liu, Jean Paul Vonsattel, Istvan Adorjan, Vilas Menon, James E Goldma. Single-nucleus RNA-seq identifies Huntington disease astrocyte states. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32070434. |
huntington disease (hd) is an inherited movement disorder caused by expanded cag repeats in the huntingtin gene. |
2020-12-23 |
2023-08-13 |
Not clear |
| Mandi E Schmidt, Nicholas S Caron, Amirah E Aly, Fanny L Lemarié, Louisa Dal Cengio, Yun Ko, Nikola Lazic, Lisa Anderson, Betty Nguyen, Lynn A Raymond, Michael R Hayde. DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease. Frontiers in cellular neuroscience. vol 14. 2020-12-01. PMID:33250715. |
huntington disease (hd) is a devastating neurodegenerative disorder caused by a cag repeat expansion in the huntingtin gene. |
2020-12-01 |
2023-08-13 |
mouse |
| Andrea Gallardo-Orihuela, Irati Hervás-Corpión, Carmen Hierro-Bujalance, Daniel Sanchez-Sotano, Gema Jiménez-Gómez, Francisco Mora-López, Antonio Campos-Caro, Monica Garcia-Alloza, Luis M Valo. Transcriptional correlates of the pathological phenotype in a Huntington's disease mouse model. Scientific reports. vol 9. issue 1. 2020-11-23. PMID:31822756. |
huntington disease (hd) is a fatal neurodegenerative disorder without a cure that is caused by an aberrant expansion of cag repeats in exon 1 of the huntingtin (htt) gene. |
2020-11-23 |
2023-08-13 |
mouse |