| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manish Sharma, Srinivasa Subramania. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. The Journal of cell biology. vol 218. issue 6. 2020-04-09. PMID:31076452. |
here, we report, rhes, a brain-enriched gtpase/sumo e3-like protein, induces the biogenesis of tnt-like cellular protrusions, "rhes tunnels," through which rhes moves from cell to cell and transports huntington disease (hd) protein, the poly-q expanded mutant huntingtin (mhtt). |
2020-04-09 |
2023-08-13 |
Not clear |
| Sara Sameni, Run Zhang, Michelle A Digma. The Phasor FLIM Method Reveals a Link Between a Change in Energy Metabolism and mHtt protein spread in Healthy Mammalian Cells when Co-cultured with Huntington Diseased Cells. Methods and applications in fluorescence. 2020-04-04. PMID:32235053. |
huntington disease (hd) is a late-onset autosomal neurodegenerative disease characterized by the aggregations of mutant huntingtin proteins (mhtt). |
2020-04-04 |
2023-08-13 |
Not clear |
| Amy I Smith-Dijak, Marja D Sepers, Lynn A Raymon. Alterations in synaptic function and plasticity in Huntington disease. Journal of neurochemistry. vol 150. issue 4. 2020-03-18. PMID:31095731. |
huntington disease (hd) is an inherited neurodegenerative disorder caused by an expansion of the cag repeat region in the first exon of the huntingtin gene. |
2020-03-18 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Amber L Southwell, Cynthia C Brouwers, Louisa Dal Cengio, Yuanyun Xie, Hailey Findlay Black, Lisa M Anderson, Seunghyun Ko, Xiang Zhu, Sander J van Deventer, Melvin M Evers, Pavlina Konstantinova, Michael R Hayde. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease. Nucleic acids research. vol 48. issue 1. 2020-03-18. PMID:31745548. |
potent and sustained huntingtin lowering via aav5 encoding mirna preserves striatal volume and cognitive function in a humanized mouse model of huntington disease. |
2020-03-18 |
2023-08-13 |
mouse |
| Nicholas S Caron, Amber L Southwell, Cynthia C Brouwers, Louisa Dal Cengio, Yuanyun Xie, Hailey Findlay Black, Lisa M Anderson, Seunghyun Ko, Xiang Zhu, Sander J van Deventer, Melvin M Evers, Pavlina Konstantinova, Michael R Hayde. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease. Nucleic acids research. vol 48. issue 1. 2020-03-18. PMID:31745548. |
huntington disease (hd) is a fatal neurodegenerative disease caused by a pathogenic expansion of a cag repeat in the huntingtin (htt) gene. |
2020-03-18 |
2023-08-13 |
mouse |
| Hongsun Park, Haruko Miyazaki, Tomoyuki Yamanaka, Nobuyuki Nukin. Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice. Neuroscience research. vol 147. 2020-03-17. PMID:30391555. |
huntington disease (hd) is a neurodegenerative disorder caused by expanded cag repeats in the exon1 of huntingtin gene (htt). |
2020-03-17 |
2023-08-13 |
mouse |
| Galen E B Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen, Brett Trost, Fiona Richards, Emilia K Bijlsma, Ferdinando Squitieri, Colin J D Ross, Stephen W Scherer, Michael A Eberle, Ryan K C Yuen, Michael R Hayde. Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease. American journal of human genetics. vol 104. issue 6. 2020-03-11. PMID:31104771. |
huntington disease (hd) is caused by a cag repeat expansion in the huntingtin (htt) gene. |
2020-03-11 |
2023-08-13 |
Not clear |
| Raúl Orozco-Díaz, Angélica Sánchez-Álvarez, José Manuel Hernández-Hernández, José Tapia-Ramíre. The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease. PloS one. vol 14. issue 7. 2020-03-10. PMID:31361762. |
discovering mechanisms to reduce the cellular levels of mutant huntingtin and rest provide promising strategies for treating huntington disease. |
2020-03-10 |
2023-08-13 |
Not clear |
| Arianna Novati, Thomas Hentrich, Zinah Wassouf, Jonasz J Weber, Libo Yu-Taeger, Nicole Déglon, Huu Phuc Nguyen, Julia M Schulze-Hentric. Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29643462. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (htt) gene which results in progressive neurodegeneration in the striatum, cortex, and eventually most brain areas. |
2019-10-07 |
2023-08-13 |
mouse |
| D D O Martin, C Kay, J A Collins, Y T Nguyen, R A Slama, M R Hayde. A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29802276. |
a human huntingtin snp alters post-translational modification and pathogenic proteolysis of the protein causing huntington disease. |
2019-10-07 |
2023-08-13 |
human |
| D D O Martin, C Kay, J A Collins, Y T Nguyen, R A Slama, M R Hayde. A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29802276. |
huntington disease (hd) is a dominantly inherited neurodegenerative disorder caused by an expanded cag trinucleotide repeat in the huntingtin (htt) gene. |
2019-10-07 |
2023-08-13 |
human |
| Jun Wu, Daniel Ryskamp, Lutz Birnbaumer, Ilya Bezprozvann. Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease. Journal of Huntington's disease. vol 7. issue 1. 2019-10-02. PMID:29480205. |
huntington disease (hd) is a dominantly inherited neurodegenerative disorder caused by a cag repeat expansion in the huntingtin gene. |
2019-10-02 |
2023-08-13 |
mouse |
| Kenneth W Drombosky, Sascha Rode, Ravi Kodali, Tija C Jacob, Michael J Palladino, Ronald Wetze. Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease. Neurobiology of disease. vol 120. 2019-09-06. PMID:30171891. |
in huntington disease (hd), an expanded polyglutamine (polyq > 37) sequence within huntingtin (htt) exon1 leads to enhanced disease risk. |
2019-09-06 |
2023-08-13 |
rat |
| Ida Höijer, Yu-Chih Tsai, Tyson A Clark, Paul Kotturi, Niklas Dahl, Eva-Lena Stattin, Marie-Louise Bondeson, Lars Feuk, Ulf Gyllensten, Adam Ameu. Detailed analysis of HTT repeat elements in human blood using targeted amplification-free long-read sequencing. Human mutation. vol 39. issue 9. 2019-07-26. PMID:29932473. |
here, we used an amplification-free protocol for targeted enrichment utilizing the crispr/cas9 system (no-amp targeted sequencing) in combination with single molecule, real-time (smrt) sequencing for studying repeat elements in the huntingtin (htt) gene, where an expanded cag repeat is causative for huntington disease. |
2019-07-26 |
2023-08-13 |
human |
| Elisabeth Singer, Carolin Walter, Jonasz J Weber, Ann-Christin Krahl, Ulrike A Mau-Holzmann, Nadine Rischert, Olaf Riess, Laura E Clemensson, Huu P Nguye. Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease. Scientific reports. vol 7. issue 1. 2019-07-10. PMID:29203806. |
huntington disease is a fatal neurodegenerative disorder caused by a cag repeat expansion in the gene encoding the huntingtin protein. |
2019-07-10 |
2023-08-13 |
mouse |
| Elisabeth Singer, Carolin Walter, Jonasz J Weber, Ann-Christin Krahl, Ulrike A Mau-Holzmann, Nadine Rischert, Olaf Riess, Laura E Clemensson, Huu P Nguye. Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease. Scientific reports. vol 7. issue 1. 2019-07-10. PMID:29203806. |
a well-known and commonly used model to study molecular aspects of huntington disease are the striatum-derived sthdh cell lines generated from wild type and huntingtin knock-in mouse embryos. |
2019-07-10 |
2023-08-13 |
mouse |
| Xiaoli Sun, Yuhua Fu, Yuyin Pan, Boxun L. Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy. Autophagy. vol 13. issue 12. 2019-07-05. PMID:28976800. |
protein misfolding is the common theme for neurodegenerative disorders including huntington disease (hd), which is mainly caused by cytotoxicity of the mutant htt (huntingtin) protein (mhtt). |
2019-07-05 |
2023-08-13 |
mouse |
| Willeke M C van Roon-Mom, Raymund A C Roos, Susanne T de Bo. Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients. Nucleic acid therapeutics. vol 28. issue 2. 2019-07-05. PMID:29620999. |
dose-dependent lowering of mutant huntingtin using antisense oligonucleotides in huntington disease patients. |
2019-07-05 |
2023-08-13 |
Not clear |
| Willeke M C van Roon-Mom, Raymund A C Roos, Susanne T de Bo. Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients. Nucleic acid therapeutics. vol 28. issue 2. 2019-07-05. PMID:29620999. |
on december 11 of 2017, ionis pharmaceuticals published a press release announcing dose-dependent reductions of mutant huntingtin protein in their httrx phase 1/2a study in huntington disease (hd) patients. |
2019-07-05 |
2023-08-13 |
Not clear |
| Mandi E Schmidt, Caodu Buren, James P Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A Raymond, Michael R Hayde. Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease. BMC biology. vol 16. issue 1. 2019-05-13. PMID:29945611. |
huntington disease (hd) is a fatal neurodegenerative disorder caused by a cag expansion in the huntingtin (htt) gene, leading to selective and progressive neuronal death predominantly in the striatum. |
2019-05-13 |
2023-08-13 |
mouse |