| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily Machiela, Ritika Jeloka, Nicholas S Caron, Shagun Mehta, Mandi E Schmidt, Helen J E Baddeley, Colton M Tom, Nalini Polturi, Yuanyun Xie, Virginia B Mattis, Michael R Hayden, Amber L Southwel. The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192449. |
huntington disease (hd) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin ( |
2020-11-17 |
2023-08-13 |
mouse |
| Mingjue Zhao, Felicia Siew Hong Cheah, Arnold Sia Chye Tan, Mulias Lian, Gui Ping Phang, Anupriya Agarwal, Samuel S Chon. Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping. Scientific reports. vol 9. issue 1. 2020-11-04. PMID:31712634. |
huntington disease (hd) is a lethal neurodegenerative disorder caused by expansion of a cag repeat within the huntingtin (htt) gene. |
2020-11-04 |
2023-08-13 |
Not clear |
| Yu-Hsien Lin, Houda Ouns Maaroufi, Emad Ibrahim, Lucie Kucerova, Michal Zurove. Expression of Human Mutant Huntingtin Protein in Frontiers in immunology. vol 10. 2020-10-29. PMID:31681295. |
expression of human mutant huntingtin protein in the pathogenic effect of mutant htt (mhtt) which causes huntington disease (hd) are not restricted to nervous system. |
2020-10-29 |
2023-08-13 |
human |
| Qiong Liu, Siying Cheng, Huiming Yang, Louyin Zhu, Yongcheng Pan, Liang Jing, Beisha Tang, Shihua Li, Xiao-Jiang L. Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 33. 2020-10-06. PMID:32747555. |
huntington disease (hd) is an ideal model for investigating selective neurodegeneration, as expanded polyq repeats in the ubiquitously expressed huntingtin (htt) cause the preferential neurodegeneration in the striatum of the hd patient brains. |
2020-10-06 |
2023-08-13 |
mouse |
| Dong-Kyu Kim, Kyu-Won Cho, Woo Jung Ahn, Dayana Perez-Acuña, Hyunsu Jeong, He-Jin Lee, Seung-Jae Le. Cell-to-cell Transmission of Polyglutamine Aggregates in Experimental neurobiology. vol 26. issue 6. 2020-10-01. PMID:29302199. |
cell-to-cell transmission of polyglutamine aggregates in huntington disease (hd) is an inherited neurodegenerative disorder characterized by motor and cognitive dysfunction caused by expansion of polyglutamine (polyq) repeat in exon 1 of huntingtin (htt). |
2020-10-01 |
2023-08-13 |
Not clear |
| Anne-Christine Plank, Fabio Canneva, Kerstin A Raber, Yvonne K Urbach, Julia Dobner, Maja Puchades, Jan G Bjaalie, Clarissa Gillmann, Tobias Bäuerle, Olaf Riess, Hoa H P Nguyen, Stephan von Hörste. Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAG Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29422836. |
early alterations in operant performance and prominent huntingtin aggregation in a congenic f344 rat line of the classical cag the transgenic rat model of huntington disease expressing a fragment of mutant htt (tghd rat) has been thoroughly characterized and reproduces hallmark symptoms of human adult-onset hd. |
2020-10-01 |
2023-08-13 |
human |
| Leonardo Guzman-Martinez, Ricardo B Maccioni, Víctor Andrade, Leonardo Patricio Navarrete, María Gabriela Pastor, Nicolas Ramos-Escoba. Neuroinflammation as a Common Feature of Neurodegenerative Disorders. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31572186. |
this is a characteristic of tau protein in alzheimer's disease and several tauopathies associated with tau unfolding, α-synuclein in parkinson's disease, and huntingtin in huntington disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sonay Keskin, Cynthia C Brouwers, Marina Sogorb-Gonzalez, Raygene Martier, Josse A Depla, Astrid Vallès, Sander J van Deventer, Pavlina Konstantinova, Melvin M Ever. AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes. Molecular therapy. Methods & clinical development. vol 15. 2020-10-01. PMID:31737741. |
huntington disease (hd) is a fatal neurodegenerative genetic disorder, thought to reflect a toxic gain of function in huntingtin (htt) protein. |
2020-10-01 |
2023-08-13 |
Not clear |
| Diogo Ferreira, Berta Carvalho, Ana P Neto, Joaquina Silva, Ana M Póvoa, Alberto Barros, Filipa Carvalh. Preimplantation genetic testing for Huntington disease: the perspective of one Portuguese center. Porto biomedical journal. vol 4. issue 5. 2020-10-01. PMID:31893246. |
huntington disease (hd) is an autosomal dominant late-onset neurodegenerative disease caused by an unstable cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin ( |
2020-10-01 |
2023-08-13 |
Not clear |
| David M Smit. Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases? Journal of experimental neuroscience. vol 12. 2020-09-30. PMID:30147359. |
prominent species that accumulate early and play fundamental roles in disease pathogenesis are amyloid β (aβ) and tau in alzheimer disease, α-synuclein (α-syn) in parkinson disease, and polyq-expanded huntingtin (htt) in huntington disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wojciech J Szlachcic, Kalina Wiatr, Marta Trzeciak, Marek Figlerowicz, Maciej Figie. The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:28848389. |
the generation of mouse and human huntington disease ips cells suitable for huntington disease (hd) is an incurable neurodegenerative disorder caused by expansion of cag repeats in huntingtin (htt) gene, resulting in expanded polyglutamine tract in htt protein. |
2020-09-29 |
2023-08-13 |
mouse |
| Maxmore Chaibva, Xiang Gao, Pranav Jain, Warren A Campbell, Shelli L Frey, Justin Legleite. Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes. ACS omega. vol 3. issue 1. 2020-09-29. PMID:29399649. |
huntington disease (hd) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyq) tract near the n-terminus of the huntingtin (htt) protein. |
2020-09-29 |
2023-08-13 |
Not clear |
| Elisabeth A Spronck, Cynthia C Brouwers, Astrid Vallès, Martin de Haan, Harald Petry, Sander J van Deventer, Pavlina Konstantinova, Melvin M Ever. AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models. Molecular therapy. Methods & clinical development. vol 13. 2020-09-29. PMID:30984798. |
aav5-mihtt gene therapy demonstrates sustained huntingtin lowering and functional improvement in huntington disease mouse models. |
2020-09-29 |
2023-08-13 |
mouse |
| Silvia Rea, David Della-Morte, Francesca Pacifici, Barbara Capuani, Donatella Pastore, Andrea Coppola, Roberto Arriga, Aikaterini Andreadi, Giulia Donadel, Nicola Di Daniele, Alfonso Bellia, Davide Laur. Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32547392. |
a pathological association between an autosomal dominant neurological disorder caused by brain accumulation in mutated huntingtin (mhtt), known as huntington disease (hd), and dm, has been reported. |
2020-09-28 |
2023-08-13 |
mouse |
| Christine M Stahl, Andrew Feigi. Medical, Surgical, and Genetic Treatment of Huntington Disease. Neurologic clinics. vol 38. issue 2. 2020-09-21. PMID:32279715. |
huntington disease, a neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, is caused by a cag trinucleotide repeat expansion in the huntingtin gene on chromosome 4. |
2020-09-21 |
2023-08-13 |
Not clear |
| Manish Sharma, Sumitha Rajendrarao, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Srinivasa Subramania. Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 27. 2020-09-08. PMID:32581130. |
huntington disease (hd) is caused by an expansion mutation of the n-terminal polyglutamine of huntingtin (mhtt). |
2020-09-08 |
2023-08-13 |
Not clear |
| S Binny Priya, M Michael Gromih. Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30672003. |
huntington disease is a neurodegenerative disorder caused by the expansion of polyglutamine (polyq) at the n-terminal of the huntingtin exon 1 protein. |
2020-08-05 |
2023-08-13 |
Not clear |
| Marina R von Essen, Marie N N Hellem, Tua Vinther-Jensen, Cecilie Ammitzbøll, Rikke H Hansen, Lena E Hjermind, Troels T Nielsen, Jørgen E Nielsen, Finn Sellebjer. Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease. Annals of neurology. vol 87. issue 2. 2020-05-18. PMID:31725947. |
huntington disease (hd) is an autosomal dominantly inherited neurodegenerative disorder caused by a cag repeat expansion in the huntingtin (htt) gene. |
2020-05-18 |
2023-08-13 |
Not clear |
| Yin Xu, Sheng Zhang, Hui Zhen. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. vol 15. issue 4. 2020-05-11. PMID:30290707. |
abbreviations: aav: adeno-associated virus; ad: alzheimer disease; alp: autophagy-lysosomal pathway; als: amyotrophic lateral sclerosis; calcoco2/ndp52: calcium binding and coiled-coil domain 2; ftd: frontotemporal dementias; hd: huntington disease; htt: huntingtin; lir: lc3-interacting region; nbr1: autophagy cargo receptor; nfe2l2/nrf2: nuclear factor, erythroid derived 2, like 2; nfts: neurofibrillary tangles; mapt: microtubule associated protein tau; optn: optineurin; p-mapt: hyperphosphorylated mapt; pfa: paraformaldehyde; tardbp/tdp-43: tar dna binding protein; tax1bp1 tax1: binding protein 1; thios: thioflavin-s; uba: ubiquitin-associated. |
2020-05-11 |
2023-08-13 |
mouse |
| Åsa Petersén, Patrick Weyd. The psychopharmacology of Huntington disease. Handbook of clinical neurology. vol 165. 2020-04-17. PMID:31727211. |
huntington disease (hd) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repeat in the huntingtin gene. |
2020-04-17 |
2023-08-13 |
Not clear |