| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Vela, María Adelaida García-Gimeno, Ana Sanchis, José Bono-Yagüe, José Cumella, Laura Lagartera, Concepción Pérez, Eva-María Priego, Angela Campos, Pascual Sanz, Rafael P Vázquez-Manrique, Ana Castr. Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease. ACS chemical neuroscience. 2021-12-28. PMID:34962383. |
aggregation of mutant huntingtin, because of an expanded polyglutamine track, underlies the cause of neurodegeneration in huntington disease (hd). |
2021-12-28 |
2023-08-13 |
mouse |
| Douglas R Langbeh. Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease. American journal of human genetics. 2021-12-23. PMID:34942093. |
it is well known that the length of the cag trinucleotide expansion of the huntingtin gene is associated with many aspects of huntington disease progression. |
2021-12-23 |
2023-08-13 |
human |
| Bhagyashree S Joshi, Sameh A Youssef, Reinier Bron, Alain de Bruin, Harm H Kampinga, Inge S Zuhor. DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in iScience. vol 24. issue 11. 2021-11-11. PMID:34755099. |
dnajb6b-enriched small extracellular vesicles decrease polyglutamine aggregation in huntington disease (hd) is a devastating neurodegenerative disorder characterized by aggregation of huntingtin (htt) protein containing expanded polyglutamine (polyq) tracts. |
2021-11-11 |
2023-08-13 |
Not clear |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
huntington disease (hd) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the cag expansion mutation in the huntingtin gene (htt) is in the range of full penetrance. |
2021-11-11 |
2023-08-13 |
Not clear |
| Sanaz Gabery, Jing Eugene Kwa, Rachel Y Cheong, Barbara Baldo, Costanza Ferrari Bardile, Brendan Tan, Catriona McLean, Nellie Georgiou-Karistianis, Govinda R Poudel, Glenda Halliday, Mahmoud A Pouladi, Åsa Petersé. Early white matter pathology in the fornix of the limbic system in Huntington disease. Acta neuropathologica. vol 142. issue 5. 2021-11-08. PMID:34448021. |
huntington disease (hd) is a fatal neurodegenerative disorder caused by an expanded cag repeat in the huntingtin (htt) gene. |
2021-11-08 |
2023-08-13 |
Not clear |
| R A Hickman, P L Faust, M K Rosenblum, K Marder, M F Mehler, J P Vonsatte. Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains. Acta neuropathologica. vol 141. issue 3. 2021-11-05. PMID:33517535. |
neuropathologic hallmarks of huntington disease (hd) include the progressive neurodegeneration of the striatum and the presence of huntingtin (htt) aggregates that result from abnormal polyq expansion of the htt gene. |
2021-11-05 |
2023-08-13 |
human |
| Fanny L Lemarié, Nicholas S Caron, Shaun S Sanders, Mandi E Schmidt, Yen T N Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A Pouladi, Dale D O Martin, Michael R Hayde. Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity. Neurobiology of disease. vol 158. 2021-10-14. PMID:34390831. |
huntington disease (hd) is a neurodegenerative disorder caused by a cag expansion in the htt gene that codes for an elongated polyglutamine tract in the huntingtin (htt) protein. |
2021-10-14 |
2023-08-13 |
mouse |
| Liang Jing, Siying Cheng, Yongcheng Pan, Qiong Liu, Weili Yang, Shihua Li, Xiao-Jiang L. Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34250577. |
accumulation of endogenous mutant huntingtin in astrocytes exacerbates neuropathology of huntington disease in mice. |
2021-10-08 |
2023-08-13 |
mouse |
| Nicholas S Caron, Christine Anderson, Hailey Findlay Black, Shaun S Sanders, Fanny L Lemarié, Crystal N Doty, Michael R Hayde. Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting. Journal of Huntington's disease. vol 10. issue 3. 2021-10-06. PMID:34092649. |
therapeutics that lower mutant huntingtin (mhtt) have shown promise in preclinical studies and are in clinical development for the treatment of huntington disease (hd). |
2021-10-06 |
2023-08-13 |
Not clear |
| X Zhao, A Chen, Z Wang, Xiao-Han Xu, Y Ta. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021-09-26. PMID:34564830. |
huntington disease (hd) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (htt). |
2021-09-26 |
2023-08-13 |
Not clear |
| Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P Bates, Daniel Aeschlimann, Joan S Steffan, Stephan von Hörste. Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models. International journal of molecular sciences. vol 22. issue 16. 2021-09-20. PMID:34445621. |
transglutaminase 6 is colocalized and interacts with mutant huntingtin in huntington disease rodent animal models. |
2021-09-20 |
2023-08-13 |
mouse |
| Jo B Henningsen, Rana Soylu-Kucharz, Maria Björkqvist, Åsa Petersé. Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. Heliyon. vol 7. issue 8. 2021-08-31. PMID:34458633. |
huntington disease (hd) is a fatal neurodegenerative movement disorder caused by an expanded cag repeat in the huntingtin gene (htt). |
2021-08-31 |
2023-08-13 |
mouse |
| Jesús G Galaz-Montoya, Sarah H Shahmoradian, Koning Shen, Judith Frydman, Wah Chi. Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34239038. |
huntington disease (hd) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyq) tract in the mutant huntingtin (mhtt) protein. |
2021-08-16 |
2023-08-13 |
Not clear |
| Saurabh Gupta, Arzoo Khan, Sukriti Vishwas, Monica Gulati, Thakur Gurjeet Singh, Kamal Dua, Sachin Kumar Singh, Agnieszka Najda, Amany A Sayed, Rafa Almeer, Mohamed M Abdel-Dai. Demethyleneberberine: A possible treatment for Huntington's disease. Medical hypotheses. vol 153. 2021-08-09. PMID:34229236. |
huntington disease (hd) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (cag) trinucleotides and mutated huntingtin (mhtt). |
2021-08-09 |
2023-08-13 |
Not clear |
| Dazhang Bai, Peng Yin, Yiran Zhang, Fengwei Sun, Laiqiang Chen, Li Lin, Sen Yan, Shihua Li, Xiao-Jiang L. Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Human molecular genetics. vol 30. issue 16. 2021-08-04. PMID:33949657. |
our previous work has established a huntingtin knock-in (ki) pig model that displays striatal neuronal loss, allowing us to examine if somatic cag expansion in striatum accounts for the preferential neurodegeneration in huntington disease (hd). |
2021-08-04 |
2023-08-13 |
mouse |
| Adam S Ravalia, James Lau, Jessica C Barron, Stephanie L M Purchase, Amber L Southwell, Michael R Hayden, Firoozeh Nafar, Matthew P Parson. Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice. Neurobiology of disease. vol 152. 2021-07-30. PMID:33556538. |
in huntington disease (hd), a cag repeat expansion in the gene encoding the huntingtin protein results in a presymptomatic stage that typically spans multiple decades and is followed by striking degeneration of striatal tissue and the progression of debilitating motor symptoms. |
2021-07-30 |
2023-08-13 |
mouse |
| Rachel Y Cheong, Simone Tonetto, Stephan von Hörsten, Åsa Petersé. Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32590293. |
neuropsychiatric disturbances with altered social cognition, depression and anxiety are among the most debilitating early features in the fatal neurodegenerative disorder huntington disease (hd) which is caused by an expanded cag repeat in the huntingtin gene. |
2021-07-21 |
2023-08-13 |
mouse |
| Barbara J Bailus, Stephen M Scheeler, Jesse Simons, Maria A Sanchez, Kizito-Tshitoko Tshilenge, Jordi Creus-Muncunill, Swati Naphade, Alejandro Lopez-Ramirez, Ningzhe Zhang, Kuruwitage Lakshika Madushani, Stanislav Moroz, Ashley Loureiro, Katherine H Schreiber, Felix Hausch, Brian K Kennedy, Michelle E Ehrlich, Lisa M Ellerb. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 2021-07-11. PMID:34024231. |
current disease-modifying therapies for huntington disease (hd) focus on lowering mutant htt (huntingtin; mhtt) levels, and the immunosuppressant drug rapamycin is an intriguing therapeutic for aging and neurological disorders. |
2021-07-11 |
2023-08-13 |
mouse |
| Sarah J Tabrizi, Michael D Flower, Christopher A Ross, Edward J Wil. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32796930. |
huntington disease (hd) is a neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt) and involves a complex web of pathogenic mechanisms. |
2021-06-24 |
2023-08-13 |
human |
| Chia-Lung Chuang, Fabio Demonti. Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis. Ageing research reviews. vol 69. 2021-06-24. PMID:33979693. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (htt) gene, which leads to a toxic, aggregation-prone, mutant htt-polyq protein. |
2021-06-24 |
2023-08-13 |
Not clear |