| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruheng Wei, Lijuan Song, Zhuyue Miao, Kexin Liu, Guangyuan Han, Haifei Zhang, Dong Ma, Jianjun Huang, Hao Tian, Baoguo Xiao, Cungen M. Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R. Cells. vol 11. issue 23. 2022-12-11. PMID:36496986. |
in the process of ischemic stroke (is), cellular macroautophagy/autophagy and apoptosis play a vital role in neuroprotection against it. |
2022-12-11 |
2023-08-14 |
Not clear |
| Chao-Chao Yu, Le-Bin Liu, Shi-Yuan Chen, Xiao-Fei Wang, Li Wang, Yan-Jun D. Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence. Aging and disease. vol 13. issue 6. 2022-12-05. PMID:36465168. |
the underlying pathophysiology of ischemic stroke is highly complicated and correlates with various pathological processes, including neuroinflammation, oxidative stress injury, altered cell apoptosis and autophagy, excitotoxicity, and acidosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Weizhuo Lu, Jiyue We. H Metabolic brain disease. 2022-12-05. PMID:36469178. |
in the pathological process of ischemic stroke, the up-regulation of ras homolog gene family, member a (rhoa) and its downstream effector, ras homolog gene family (rho)-associated coiled coil-containing kinase (rock), contribute to the neuroinflammation, blood-brain barrier (bbb) dysfunction, neuronal apoptosis, axon growth inhibition and astrogliosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Nana Tan, Wenqiang Xin, Min Huang, Yuling Ma. Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells. Frontiers in neurology. vol 13. 2022-11-25. PMID:36425795. |
moreover, a notion will be given to mscs participating in multiple pathological processes, such as increasing cell survival angiogenesis and suppressing cell apoptosis and autophagy in several phases of ischemic stroke, consequently promoting neurological function recovery. |
2022-11-25 |
2023-08-14 |
Not clear |
| Xiao-Fei Jin, Shan Wang, Min Shen, Xin Wen, Xin-Rui Han, Jun-Chang Wu, Gao-Zhuo Tang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. Retraction notice to "Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways" [Brain Res. Bull. 134 (2017) 236-245]. Brain research bulletin. vol 192. 2022-11-07. PMID:36343567. |
retraction notice to "effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the pi3k/akt and nrf2/are signaling pathways" [brain res. |
2022-11-07 |
2023-08-14 |
rat |
| Shan-Shan Zhang, Man Liu, Dong-Ni Liu, Yu-Fu Shang, Guan-Hua Du, Yue-Hua Wan. Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293548. |
network pharmacology analysis and experimental validation of kaempferol in the treatment of ischemic stroke by inhibiting apoptosis and regulating neuroinflammation involving neutrophils. |
2022-10-27 |
2023-08-14 |
rat |
| Shan-Shan Zhang, Man Liu, Dong-Ni Liu, Yu-Fu Shang, Guan-Hua Du, Yue-Hua Wan. Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293548. |
first, network pharmacology analysis identified the biological process of kaempferol, suggesting that kaempferol may partly help in treating ischemic stroke by regulating apoptosis and inflammatory response. |
2022-10-27 |
2023-08-14 |
rat |
| Shan-Shan Zhang, Man Liu, Dong-Ni Liu, Yu-Fu Shang, Guan-Hua Du, Yue-Hua Wan. Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293548. |
then, we evaluated the efficacy of kaempferol in the acute stage of ischemic stroke and elucidated its effects and possible mechanisms on cell apoptosis and neuroinflammation involved by neutrophils. |
2022-10-27 |
2023-08-14 |
rat |
| Qiushi Li, Xuying Liu, Ruixian Xing, Rubo Su. TMED10 inhibits mitochondrial damage and protects neurons in ischemic stroke via the JNK signaling pathway. Experimental animals. 2022-10-16. PMID:36244749. |
collectively, this study reveals that tmed10 inhibits mitochondrial damage, and protects neurons from apoptosis in mcao-induced ischemic stroke and cognitive impairment via blocking the jnk pathway. |
2022-10-16 |
2023-08-14 |
mouse |
| Yi-Hsin Wang, Jiuan-Miaw Liao, Ke-Min Chen, Hsing-Hui Su, Pei-Hsun Liu, Yi-Hung Chen, Yuang-Seng Tsuei, Chin-Feng Tsai, Shiang-Suo Huan. Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke. Neuropharmacology. 2022-10-12. PMID:36223864. |
our evidence indicates that post-stroke treatment with lumbrokinase protects against ischemic stroke, thereby regulating er stress through the collective inhibitory effect of the ire1 signaling pathways to decrease apoptosis, autophagy, and inflammatory responses. |
2022-10-12 |
2023-08-14 |
mouse |
| Zhao Zheng, Fei Hou, Guodong He, Fengfeng Jiang, Xiang Bao, Minfeng Ton. Carvedilol reduces the Neuronal apoptosis after ischemic stroke by modulating ATF3 expression in vitro. Developmental neuroscience. 2022-10-11. PMID:36219954. |
carvedilol reduces the neuronal apoptosis after ischemic stroke by modulating atf3 expression in vitro. |
2022-10-11 |
2023-08-14 |
Not clear |
| Yong Mo, Weilin Xu, Kaijing Fu, Hainan Chen, Jing Wen, Qianrong Huang, Fangzhou Guo, Ligen Mo, Jun Ya. The dual function of microglial polarization and its treatment targets in ischemic stroke. Frontiers in neurology. vol 13. 2022-10-10. PMID:36212660. |
microglial/macrophage activation is important in reducing neuronal apoptosis, enhancing neurogenesis, and promoting functional recovery after ischemic stroke. |
2022-10-10 |
2023-08-14 |
Not clear |
| Lei Li, Jing-Jing Song, Meng-Xue Zhang, Hui-Wen Zhang, Hai-Yan Zhu, Wei Guo, Cai-Long Pan, Xue Liu, Lu Xu, Zhi-Yuan Zhan. Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. Acta pharmacologica Sinica. 2022-10-10. PMID:36216897. |
oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting ripk3-mediated mitophagy. |
2022-10-10 |
2023-08-14 |
mouse |
| Weiping Chen, Yangbo Zhang, Min Yin, Zhijuan Cheng, Dandan Li, Xin Luo, Xu Liu, Jianglong T. Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3. Brain research. 2022-10-08. PMID:36208650. |
circular rna circprdx3 mediates neuronal survival apoptosis in ischemic stroke by targeting mir-641 and npr3. |
2022-10-08 |
2023-08-14 |
Not clear |
| Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Pen. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164862. |
current studies have shown that c. tinctorius can prevent and treat ischemic stroke by reducing inflammation, oxidative stress, and endoplasmic reticulum stress, inhibiting neuronal apoptosis and platelet aggregation, as well as increasing blood flow. |
2022-09-27 |
2023-08-14 |
Not clear |
| Lijuan Shu, Chunfu D. PHLDA1 promotes sevoflurane-induced pyroptosis of neuronal cells in developing rats through TRAF6-mediated activation of Rac1. Neurotoxicology. 2022-09-26. PMID:36155068. |
pleckstrin homology-like domain, family a, member 1 (phlda1) was involved in neuronal apoptosis, oxidative stress and inflammation during ischemic stroke. |
2022-09-26 |
2023-08-14 |
rat |
| Dong-Hee Choi, In-Ae Choi, Jongmin Le. The Role of DNA Methylation in Stroke Recovery. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142283. |
in this review, we summarize the role of dna methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of dna methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. |
2022-09-23 |
2023-08-14 |
Not clear |
| Cheng-Tien Wu, Ting-Hua Yang, Man-Chih Chen, Siao-Syun Guan, Chang-Mu Chen, Shing-Hwa Li. Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules (Basel, Switzerland). vol 27. issue 18. 2022-09-23. PMID:36144517. |
therapeutic effect of icaritin on cerebral ischemia-reperfusion-induced senescence and apoptosis in an acute ischemic stroke mouse model. |
2022-09-23 |
2023-08-14 |
mouse |
| Zhongzhou Su, Yingze Ye, Chengen Shen, Sheng Qiu, Yao Sun, Siping Hu, Xiaoxing Xiong, Yuntao Li, Liqin Li, Hongfa Wan. Pathophysiology of Ischemic Stroke: Noncoding RNA Role in Oxidative Stress. Oxidative medicine and cellular longevity. vol 2022. 2022-09-22. PMID:36132228. |
the pathophysiological processes underlying ischemic stroke include oxidative stress, the toxicity of excitatory amino acids, ion disorder, enhanced apoptosis, and inflammation. |
2022-09-22 |
2023-08-14 |
Not clear |
| Yubao Ding, Yue Lang, Hui Zhang, Yu Li, Xiao Liu, Minjie L. Candesartan Reduces Neuronal Apoptosis Caused by Ischemic Stroke via Regulating the FFAR1/ITGA4 Pathway. Mediators of inflammation. vol 2022. 2022-09-19. PMID:36117589. |
candesartan reduces neuronal apoptosis caused by ischemic stroke via regulating the ffar1/itga4 pathway. |
2022-09-19 |
2023-08-14 |
Not clear |