| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M do Nascimento, E M de Lima, G A P Boëchat, S D S Meyrelles, N S Bissoli, D Lenz, D C Endringer, T U de Andrad. Testosterone induces apoptosis in cardiomyocytes by increasing proapoptotic signaling involving tumor necrosis factor-α and renin angiotensin system. Human & experimental toxicology. vol 34. issue 11. 2016-08-01. PMID:25673179. |
the aim of this study was to assess whether apoptosis and the activation of caspase-3 (casp-3) induced by testosterone in high concentrations involves increments in tumor necrosis factor-α (tnf-α) concentrations and angiotensin-converting enzyme (ace) activity in cardiomyocytes (h9c2) cell cultures. |
2016-08-01 |
2023-08-13 |
Not clear |
| Yong Zha, Ping Gan, Qin Liu, Jing Ta. Relationship between polymorphism of angiotensin-converting enzyme gene insertion/deletion and risk of hepatocellular carcinoma in a Chinese Dai population. Journal of the renin-angiotensin-aldosterone system : JRAAS. vol 16. issue 3. 2016-06-13. PMID:25208933. |
the angiotensin-converting enzyme gene (ace) is directly involved in the process of cancer cell proliferation, differentiation, apoptosis and angiogenesis. |
2016-06-13 |
2023-08-13 |
Not clear |
| Jenq-Sheng Chang, Hsiang-Ping Kuo, Ke Liang B Chang, Zwe-Ling Kon. Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata. PloS one. vol 10. issue 9. 2016-05-18. PMID:26327534. |
in this study, ace polysaccharides were nano-encapsulated in chitosan-silica and silica (expressed as ace/cs and ace/s, respectively) to evaluate the apoptosis effect on a hepatoma cell line (hep g2). |
2016-05-18 |
2023-08-13 |
Not clear |
| Jenq-Sheng Chang, Hsiang-Ping Kuo, Ke Liang B Chang, Zwe-Ling Kon. Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata. PloS one. vol 10. issue 9. 2016-05-18. PMID:26327534. |
unsurprisingly, ace/cs induced a similar apoptosis mechanism at a lower dosage (ace polysaccharides = 13.2 μg/ml) than those of ace/s (ace polysaccharides = 21.2 μg/ml) and ace polysaccharides (25 μg/ml). |
2016-05-18 |
2023-08-13 |
Not clear |
| Xiaomiao Zhang, Fengying Gao, Qian Li, Zhixia Dong, Bo Sun, Lili Hou, Zhuozhe Li, Zhenwei Li. MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin. Experimental lung research. vol 41. issue 1. 2015-10-13. PMID:25419634. |
mscs with ace ii gene affect apoptosis pathway of acute lung injury induced by bleomycin. |
2015-10-13 |
2023-08-13 |
Not clear |
| Chu-I Lee, Chih-Chung Wu, Shu-Ling Hsieh, Chun-Lin Lee, Yueh-Ping Chang, Chih-Chuan Chang, Yi-Zhen Wang, Jyh-Jye Wan. Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata. Food & function. vol 5. issue 12. 2015-07-17. PMID:25317925. |
ace induced apoptosis in bxpc-3 cells through a mitochondria-dependent pathway by triggering an appropriate balance of bax/bcl-2, cytochrome c release, activation of caspase-9 and -3, and poly(adp-ribose) polymerase cleavage. |
2015-07-17 |
2023-08-13 |
human |
| Chu-I Lee, Chih-Chung Wu, Shu-Ling Hsieh, Chun-Lin Lee, Yueh-Ping Chang, Chih-Chuan Chang, Yi-Zhen Wang, Jyh-Jye Wan. Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata. Food & function. vol 5. issue 12. 2015-07-17. PMID:25317925. |
ace shows great therapeutic potential due to its cytotoxic effects against bxpc-3 cells which include inhibiting cell migration and inducing mitochondria-mediated apoptosis. |
2015-07-17 |
2023-08-13 |
human |
| Wei-Guo Wan, Xue-Jun Jiang, Xiao-Yan Li, Cui Zhang, Xin Yi, Shan Ren, Xian-Zheng Zhan. Enhanced cardioprotective effects mediated by plasmid containing the short-hairpin RNA of angiotensin converting enzyme with a biodegradable hydrogel after myocardial infarction. Journal of biomedical materials research. Part A. vol 102. issue 10. 2015-05-12. PMID:24222385. |
moreover, it was shown that direct intramyocardial injection of ace-shrna plasmid-loaded hydrogel significantly decreased the expression of local ace expression, inhibited cell apoptosis, reduced infarct size, and improved cardiac function compared with the injection of either alone 30 days after mi in rats. |
2015-05-12 |
2023-08-12 |
rat |
| Seref Alpsoy, Mehmet Kanter, Cevat Aktas, Mustafa Erboga, Aydın Akyuz, Dursun Cayan Akkoyun, Mustafa Ora. Protective effects of onion extract on cadmium-induced oxidative stress, histological damage, and apoptosis in rat heart. Biological trace element research. vol 159. issue 1-3. 2015-01-26. PMID:24736979. |
furthermore, our data indicate a significant reduction of apoptosis in the cardiomyocytes of the cd group treated with ace therapy. |
2015-01-26 |
2023-08-13 |
rat |
| Seref Alpsoy, Mehmet Kanter, Cevat Aktas, Mustafa Erboga, Aydın Akyuz, Dursun Cayan Akkoyun, Mustafa Ora. Protective effects of onion extract on cadmium-induced oxidative stress, histological damage, and apoptosis in rat heart. Biological trace element research. vol 159. issue 1-3. 2015-01-26. PMID:24736979. |
our study showed that ace therapy reduced cd-induced oxidative stress and apoptosis, possibly through its antioxidant and anti-apoptotic activity. |
2015-01-26 |
2023-08-13 |
rat |
| Nikola Radović, Gorana Aralica, Danica Galesić Ljubanović, Vjekoslav Jelec, Mladen Konte. Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats. Collegium antropologicum. vol 38. issue 2. 2014-09-15. PMID:25144992. |
in this study, the effect of ace inhibitors and at1 receptor antagonists on tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy after uuo in rats was investigated. |
2014-09-15 |
2023-08-13 |
rat |
| Nikola Radović, Gorana Aralica, Danica Galesić Ljubanović, Vjekoslav Jelec, Mladen Konte. Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats. Collegium antropologicum. vol 38. issue 2. 2014-09-15. PMID:25144992. |
ace inhibitors and at1 receptor antagonists could not decrease the extent of renal cells apoptosis and interstitial fibrosis after uuo. |
2014-09-15 |
2023-08-13 |
rat |
| Weiguo Wan, Xuejun Jiang, Xiaoyan Li, Cui Zhang, Xin Y. Silencing of angiotensin‑converting enzyme by RNA interference prevents H9c2 cardiomyocytes from apoptosis induced by anoxia/reoxygenation through regulation of the intracellular renin-angiotensin system. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126381. |
the objective of this study was to determine whether the apoptosis in h9c2 cardiomyocytes following anoxia/reoxygenation (a/r) would be improved by the silencing of intracellular ace by rna interference (rnai). |
2014-05-27 |
2023-08-12 |
Not clear |
| Weiguo Wan, Xuejun Jiang, Xiaoyan Li, Cui Zhang, Xin Y. Silencing of angiotensin‑converting enzyme by RNA interference prevents H9c2 cardiomyocytes from apoptosis induced by anoxia/reoxygenation through regulation of the intracellular renin-angiotensin system. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126381. |
the results suggest that the gene silencing of intracellular ace holds great potential in the treatment of cardiomyocyte apoptosis following i/r injury through the regulation of the intracellular renin‑angiotensin system, thereby regulating the intrinsic pathway of apoptosis. |
2014-05-27 |
2023-08-12 |
Not clear |
| Martina Monti, Erika Terzuoli, Marina Ziche, Lucia Morbidell. The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis. Pharmacological research. vol 76. 2014-04-16. PMID:23965518. |
the sulphydryl containing ace inhibitor zofenoprilat protects coronary endothelium from doxorubicin-induced apoptosis. |
2014-04-16 |
2023-08-12 |
Not clear |
| James J Dinicolantonio, Carl J Lavie, James H O'Keef. Not all angiotensin-converting enzyme inhibitors are equal: focus on ramipril and perindopril. Postgraduate medicine. vol 125. issue 4. 2013-10-21. PMID:23933903. |
among the ace inhibitor class, the agent perindopril, in particular, has pleiotropic effects that are not equally shared by other ace inhibitors, including bradykinin site selectivity and subsequent enhancement of nitric oxide and inhibition of endothelial cell apoptosis. |
2013-10-21 |
2023-08-12 |
Not clear |
| Seref Alpsoy, Ramazan Uygur, Cevat Aktas, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya, Asuman Gedikbas. The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells. Journal of applied toxicology : JAT. vol 33. issue 5. 2013-09-25. PMID:21989851. |
the aim of this study was to investigate the effects of onion (allium cepa) extracts (ace) on doxorubicin (dox)-induced apoptosis in aortic endothelial cells. |
2013-09-25 |
2023-08-12 |
rat |
| Seref Alpsoy, Ramazan Uygur, Cevat Aktas, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya, Asuman Gedikbas. The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells. Journal of applied toxicology : JAT. vol 33. issue 5. 2013-09-25. PMID:21989851. |
to date, no such studies have been performed on antiapoptotic potential of ace on dox-induced apoptosis in aortic endothelial cells. |
2013-09-25 |
2023-08-12 |
rat |
| Seref Alpsoy, Ramazan Uygur, Cevat Aktas, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya, Asuman Gedikbas. The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells. Journal of applied toxicology : JAT. vol 33. issue 5. 2013-09-25. PMID:21989851. |
our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dutp nick end-labeling in aortic endothelial cells of the dox-treated group with ace therapy. |
2013-09-25 |
2023-08-12 |
rat |
| Seref Alpsoy, Ramazan Uygur, Cevat Aktas, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya, Asuman Gedikbas. The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells. Journal of applied toxicology : JAT. vol 33. issue 5. 2013-09-25. PMID:21989851. |
data from our study show that prevention of endothelial cell apoptosis by ace may contribute to the restoration of aortic endothelial dysfunction that is associated with dox treatment. |
2013-09-25 |
2023-08-12 |
rat |