| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shant Der Sarkissian, Bun-Seng Tea, Rhian M Touyz, Denis deBlois, Taben M Hal. Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension : JASH. vol 7. issue 2. 2013-09-19. PMID:23414835. |
we previously reported that the at1 receptor antagonist valsartan and the angiotensin converting enzyme (ace) inhibitor enalapril decrease dna synthesis and stimulate apoptosis in interstitial fibroblasts and epicardial mesothelial cells during regression of ventricular hypertrophy in spontaneously hypertensive rats (shr). |
2013-09-19 |
2023-08-12 |
rat |
| Shant Der Sarkissian, Bun-Seng Tea, Rhian M Touyz, Denis deBlois, Taben M Hal. Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension : JASH. vol 7. issue 2. 2013-09-19. PMID:23414835. |
these results demonstrate that at1 and at2 receptors act in a coordinated yet cell-specific manner to regulate cell growth and apoptosis in the left ventricle of shr during at1 receptor blockade but not ace inhibition. |
2013-09-19 |
2023-08-12 |
rat |
| Seref Alpsoy, Cevat Aktas, Ramazan Uygur, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya, Asuman Gedikbas. Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats. Journal of applied toxicology : JAT. vol 33. issue 3. 2013-07-02. PMID:21996788. |
our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dutp nick end-labeling in cardiomyocytes of the dox-treated group with ace therapy. |
2013-07-02 |
2023-08-12 |
rat |
| Wensheng Wang, Weidong Xiao, Lihua Sun, Chaojun Zhang, Guoqing Chen, Hua Yan. Inhibition of ACE activity contributes to the intestinal structural compensation in a massive intestinal resection rat model. Pediatric surgery international. vol 28. issue 5. 2012-08-13. PMID:22441330. |
angiotensin-converting enzyme (ace) has been shown to regulate ecs apoptosis. |
2012-08-13 |
2023-08-12 |
rat |
| R Domitrovi. The molecular basis for the pharmacological activity of anthocyans. Current medicinal chemistry. vol 18. issue 29. 2012-02-27. PMID:21864288. |
the molecular basis for anthocyans pharmacological activity includes the regulation of plethora of mechanisms mainly involved in: (1) suppression of the inflammatory response through targeting the phospholipase a2 and pi3k/akt and nf-κb pathways, (2) protection from cardiovascular disease by exerting (i) antihypertensive and endothelium-protective activity through targeting the akt/enos and ace pathways (ii) antiatherogenic activity through targeting nf-κb mediated vcam and icam expression, (3) growth/differentiation control and tumor suppression by exerting (i) anticancerogenic activity through targeting the egf and hgf signaling pathways (ii) tumor anti-invasive activity through targeting the vegf signaling pathway and ecm degrading enzymes (iii) cell cycle arrest and induction of apoptosis through the jnk/p38 mapk mediated caspase activation (iv) modulation of chemotherapeutic efficacy by affecting resistance to anticancer drugs, (4) reduction of diabetes incidence through modulation of insulin sensitivity and glucose utilization, (5) neuroprotection through amelioration of oxidative stress and aβ deposition, and (6) hepatoprotective activity through interference with tnf-α and tgf-β in the liver. |
2012-02-27 |
2023-08-12 |
Not clear |
| Sung Phil Kim, Mi Young Kang, Yong Hee Choi, Jae Ho Kim, Seok Hyun Nam, Mendel Friedma. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food & function. vol 2. issue 6. 2012-01-24. PMID:21779573. |
in the present study, we evaluated hot water (hwe), microwaved 50% ethanol (mwe), acidic (ace), and alkaline (ake) extracts of the fruitbody (sporocarp) of hericium erinaceus (yamabushitake, lion's mane) mushrooms for their ability to induce apoptosis (programmed cell death) in u937 human monocytic leukemia cells. |
2012-01-24 |
2023-08-12 |
human |
| Elisa Cangiano, Jlenia Marchesini, Gianluca Campo, Gloria Francolini, Cinzia Fortini, Giacomo Carrà, Matteo Miccoli, Claudio Ceconi, Luigi Tavazzi, Roberto Ferrar. ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 11. issue 3. 2011-09-16. PMID:21619382. |
ace inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. |
2011-09-16 |
2023-08-12 |
Not clear |
| Bruno Fabris, Riccardo Candido, Monica Bortoletto, Barbara Toffoli, Stella Bernardi, Marco Stebel, Moreno Bardelli, Lorena Zentilin, Mauro Giacca, Renzo Carrett. Stimulation of cardiac apoptosis in ovariectomized hypertensive rats: potential role of the renin-angiotensin system. Journal of hypertension. vol 29. issue 2. 2011-05-04. PMID:21107282. |
to investigate whether the loss of the natural inhibition of the ras by estrogen may be linked to an increase of cardiac apoptosis, we studied 17β-estradiol (e2) and/or angiotensin-converting enzyme (ace) inhibitor treatment effects on cardiomyocyte survival in ovariectomized spontaneously hypertensive rats (shrs). |
2011-05-04 |
2023-08-12 |
rat |
| Roberto Ferrari, Gabriele Guardigli, Claudio Cecon. Secondary prevention of CAD with ACE inhibitors: a struggle between life and death of the endothelium. Cardiovascular drugs and therapy. vol 24. issue 4. 2011-03-08. PMID:20577898. |
in cad, chronic overexpression of tissue ace disrupts the angiotensin ii/bradykinin balance with a net result of endothelial dysfunction, mainly due to an increased rate of apoptosis. |
2011-03-08 |
2023-08-12 |
Not clear |
| Roberto Ferrari, Gabriele Guardigli, Claudio Cecon. Secondary prevention of CAD with ACE inhibitors: a struggle between life and death of the endothelium. Cardiovascular drugs and therapy. vol 24. issue 4. 2011-03-08. PMID:20577898. |
by restoring the bradykinin/angiotensin ii balance, ace inhibition reduces the rate of endothelial apoptosis and experimental results suggest that ace inhibition can also improve the production and mobilization of endothelial progenitor cells from bone marrow. |
2011-03-08 |
2023-08-12 |
Not clear |
| Jorge Correia-Pinto, Tiago Henriques-Coelho, Roberto Roncon-Albuquerque, André P Lourenço, Gustavo Melo-Rocha, Francisco Vasques-Nóvoa, Thierry C Gillebert, Adelino F Leite-Moreir. Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension. Basic research in cardiology. vol 104. issue 5. 2009-12-04. PMID:19288153. |
mhc-isoform switch, ace upregulation and cardiomyocyte apoptosis were present in both mct groups. |
2009-12-04 |
2023-08-12 |
rat |
| Jorge Correia-Pinto, Tiago Henriques-Coelho, Roberto Roncon-Albuquerque, André P Lourenço, Gustavo Melo-Rocha, Francisco Vasques-Nóvoa, Thierry C Gillebert, Adelino F Leite-Moreir. Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension. Basic research in cardiology. vol 104. issue 5. 2009-12-04. PMID:19288153. |
diastolic dysfunction, however, could be elicited at earlier stages in response to hemodynamic stress, when only lv molecular changes, such as mhc isoform switch, ace upregulation, and myocardial apoptosis were present. |
2009-12-04 |
2023-08-12 |
rat |
| H L Sun, L Sun, Y Y Li, M M Shao, X Y Cheng, N Ge, J D Lu, S M L. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 117. issue 7. 2009-10-01. PMID:19301230. |
the effects of ace inhibitor on the endoplasmic reticulum stress and apoptosis were also assessed. |
2009-10-01 |
2023-08-12 |
rat |
| Roberto Ferrari, Kim Fo. Insight into the mode of action of ACE inhibition in coronary artery disease: the ultimate 'EUROPA' story. Drugs. vol 69. issue 3. 2009-06-01. PMID:19275271. |
ace inhibitors reduce production of angiotensin ii, which prevents vasoconstriction, reduces adhesion molecules and growth factors, decreases oxidative stress and prevents apoptosis. |
2009-06-01 |
2023-08-12 |
Not clear |
| Roberto Ferrari, Kim Fo. Insight into the mode of action of ACE inhibition in coronary artery disease: the ultimate 'EUROPA' story. Drugs. vol 69. issue 3. 2009-06-01. PMID:19275271. |
accumulating preclinical evidence for the absence of a class effect for ace inhibitors includes differences in terms of effect on enos and rate of endothelial apoptosis. |
2009-06-01 |
2023-08-12 |
Not clear |
| Hiroyuki Koga, Hua Yang, Emir Q Haxhija, Daniel H Teitelbau. The role of angiotensin II type 1a receptor on intestinal epithelial cells following small bowel resection in a mouse model. Pediatric surgery international. vol 24. issue 12. 2009-03-12. PMID:18989682. |
we have previously shown that inhibition of angiotensin converting enzyme (ace) significantly reduced intestinal epithelial cell (ec) apoptosis and improved morphometric intestinal adaptation in a mouse model of massive small-bowel resection (sbr). |
2009-03-12 |
2023-08-12 |
mouse |
| Matem Tunçdemir, Melek Oztur. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. Journal of molecular histology. vol 39. issue 6. 2009-02-03. PMID:18949565. |
the effects of ace inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. |
2009-02-03 |
2023-08-12 |
human |
| Emir Q Haxhija, Hua Yang, Ariel U Spencer, Hiroyuki Koga, Xiaoyi Sun, Daniel H Teitelbau. Modulation of mouse intestinal epithelial cell turnover in the absence of angiotensin converting enzyme. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 1. 2008-09-09. PMID:18483182. |
angiotensin converting enzyme (ace) has been shown to be involved in regulation of apoptosis in nonintestinal tissues. |
2008-09-09 |
2023-08-12 |
mouse |
| Emir Q Haxhija, Hua Yang, Ariel U Spencer, Hiroyuki Koga, Xiaoyi Sun, Daniel H Teitelbau. Modulation of mouse intestinal epithelial cell turnover in the absence of angiotensin converting enzyme. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 1. 2008-09-09. PMID:18483182. |
in conclusion, ace appears to have an important role in the modulation of intestinal ec apoptosis and proliferation and suggests that the presence of ace in the intestinal epithelium has a critical role in guiding epithelial cell adaptive response. |
2008-09-09 |
2023-08-12 |
mouse |
| S Colie, C Pecher, J P Girolami, N Blae. Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype. International immunopharmacology. vol 8. issue 2. 2008-04-03. PMID:18182232. |
there is evidence for a clinical benefit of ace inhibitors or at1 antagonists in cardiovascular diseases with deleterious smooth muscle cells (smc) apoptosis. |
2008-04-03 |
2023-08-12 |
Not clear |