| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B E Wildhaber, H Yang, E Q Haxhija, A U Spencer, D H Teitelbau. Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215678. |
because ace has been shown to promote alveolar ec apoptosis, we examined if iel-derived ace plays a role in intestinal ec apoptosis. |
2008-03-25 |
2023-08-12 |
Not clear |
| R M Wösten-van Asperen, R Lutter, J J Haitsma, M P Merkus, J B van Woensel, C M van der Loos, S Florquin, B Lachmann, A P Bo. ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin. The European respiratory journal. vol 31. issue 2. 2008-03-13. PMID:17959639. |
the authors assessed whether ace and, if so, ang ii and/or bradykinin are implicated in inflammation and apoptosis by mechanical ventilation. |
2008-03-13 |
2023-08-12 |
rat |
| R M Wösten-van Asperen, R Lutter, J J Haitsma, M P Merkus, J B van Woensel, C M van der Loos, S Florquin, B Lachmann, A P Bo. ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin. The European respiratory journal. vol 31. issue 2. 2008-03-13. PMID:17959639. |
blocking ace activity by captopril attenuated inflammation and apoptosis in the latter group. |
2008-03-13 |
2023-08-12 |
rat |
| C Ceconi, G Francolini, D Bastianon, G L Gitti, L Comini, R Ferrar. Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovascular drugs and therapy. vol 21. issue 6. 2008-02-15. PMID:18004652. |
angiotensin-converting enzyme (ace) inhibition corrects the endothelial dysfunction observed in coronary artery disease, and this could be the consequence of a reduction in the rate of endothelial apoptosis. |
2008-02-15 |
2023-08-12 |
Not clear |
| C Ceconi, G Francolini, D Bastianon, G L Gitti, L Comini, R Ferrar. Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovascular drugs and therapy. vol 21. issue 6. 2008-02-15. PMID:18004652. |
the aim of this study was to investigate the effect of different ace inhibitors on endothelial apoptosis. |
2008-02-15 |
2023-08-12 |
Not clear |
| Stefan Hammerschmidt, Hartmut Kuhn, Christian Gessner, Hans-Jurgen Seyfarth, Hubert Wirt. Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling. American journal of respiratory cell and molecular biology. vol 37. issue 6. 2007-12-06. PMID:17630321. |
previously, it was demonstrated in an in vitro model that stretch-induced atii cell apoptosis was prevented by angiotensin-converting enzyme (ace) inhibitors. |
2007-12-06 |
2023-08-12 |
rat |
| Stefan Hammerschmidt, Hartmut Kuhn, Christian Gessner, Hans-Jurgen Seyfarth, Hubert Wirt. Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling. American journal of respiratory cell and molecular biology. vol 37. issue 6. 2007-12-06. PMID:17630321. |
this study investigates the mechanism by which ace inhibitors prevent stretch-induced apoptosis and elucidates the role of bradykinin as an endogenous anti-apoptotic factor. |
2007-12-06 |
2023-08-12 |
rat |
| Stefan Hammerschmidt, Hartmut Kuhn, Christian Gessner, Hans-Jurgen Seyfarth, Hubert Wirt. Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling. American journal of respiratory cell and molecular biology. vol 37. issue 6. 2007-12-06. PMID:17630321. |
the angiotensin ii receptor antagonist saralasin did not prevent stretch-induced apoptosis, whereas ace inhibitors did. |
2007-12-06 |
2023-08-12 |
rat |
| Ariel U Spencer, Hua Yang, Emir Q Haxhija, Barbara E Wildhaber, Joel K Greenson, Daniel H Teitelbau. Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition. Digestive diseases and sciences. vol 52. issue 4. 2007-05-24. PMID:17342403. |
recently, angiotensin converting enzyme (ace) has been shown to promote apoptosis. |
2007-05-24 |
2023-08-12 |
mouse |
| Ariel U Spencer, Hua Yang, Emir Q Haxhija, Barbara E Wildhaber, Joel K Greenson, Daniel H Teitelbau. Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition. Digestive diseases and sciences. vol 52. issue 4. 2007-05-24. PMID:17342403. |
in addition, pharmacologic ace inhibition (ace-i) both prevents apoptosis and reduces tnf-alpha expression in vitro. |
2007-05-24 |
2023-08-12 |
mouse |
| Wei Yu, Masahiro Akishita, Hang Xi, Kumiko Nagai, Noriko Sudoh, Hiroshi Hasegawa, Koichi Kozaki, Kenji Tob. Angiotensin converting enzyme inhibitor attenuates oxidative stress-induced endothelial cell apoptosis via p38 MAP kinase inhibition. Clinica chimica acta; international journal of clinical chemistry. vol 364. issue 1-2. 2006-04-19. PMID:16150432. |
the effects of angiotensin converting enzyme (ace) inhibitors on oxidative stress-induced apoptosis of endothelial cells and the intracellular signaling were investigated. |
2006-04-19 |
2023-08-12 |
Not clear |
| Anita S Gálvez, Jenny L Fiedler, María Paz Ocaranza, Jorge E Jalil, Sergio Lavandero, Guillermo Díaz-Aray. Perindopril regulates beta-agonist-induced cardiac apoptosis. Journal of cardiovascular pharmacology. vol 46. issue 3. 2006-01-19. PMID:16116328. |
the effect of short-term beta-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (lv) angiotensin i-converting enzyme (ace) activity and its association with the development of cardiac apoptosis was investigated. |
2006-01-19 |
2023-08-12 |
Not clear |
| Karin A M Jandeleit-Dahm, Christos Tikellis, Christopher M Reid, Colin I Johnston, Mark E Coope. Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. Journal of hypertension. vol 23. issue 3. 2005-07-21. PMID:15716683. |
thus, ace inhibitors and arbs may act by attenuating the deleterious effect of angiotensin ii on vasoconstriction, fibrosis, inflammation, apoptosis and beta-cell death in the pancreas, thereby protecting a critical beta-cell mass essential for insulin production. |
2005-07-21 |
2023-08-12 |
Not clear |
| Mark E Coope. The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications. American journal of hypertension. vol 17. issue 11 Pt 2. 2005-01-24. PMID:15539106. |
in the diabetic rat model (zucker diabetic fatty rats), pancreatic islets exhibit an increased intraislet expression of ace and at(1) as well as increased intraislet fibrosis, apoptosis, and oxidative stress. |
2005-01-24 |
2023-08-12 |
rat |
| Hidehiko Ono, Mayumi Saitoh, Yuko Ono, Toshihiko Ishimitu, Hiroaki Matsuok. Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats. Journal of hypertension. vol 22. issue 7. 2005-01-05. PMID:15201556. |
this study was designed to investigate whether chronic angiotensin-converting enzyme (ace) inhibition prevents hypertensive glomerular injury and inhibits increases in the mrna levels and immunohistological expression of the apoptosis inducer caspase-3, and transforming growth factor (tgf)-beta 1 during prolonged nitric oxide synthase (nos) inhibition with n-nitro-l-arginine methyl ester (l-name) in spontaneously hypertensive rats (shr). |
2005-01-05 |
2023-08-12 |
rat |
| Nathalie Lapointe, James N Tsoporis, Thomas G Parker, Charles Blais, Albert Adam, Dominique Rouleau, Graham Slaughter, Robert Clément, Christian E Deschepper, Jean L Roulea. Comparative effects of a vasopeptidase inhibitor vs. an angiotensin converting enzyme inhibitor on cardiomyocyte apoptosis in rats with heart failure. Molecular and cellular biochemistry. vol 254. issue 1-2. 2004-08-04. PMID:14674703. |
the vpi omapatrilat, with its combination of nep and ace inhibition, suppresses cardiomyocyte apoptosis post-mi and in neonatal cultured rat cardiomyocytes more than the acei captopril, but this does not result in significant hemodynamic or morphologic differences between omapatrilat and captopril. |
2004-08-04 |
2023-08-12 |
rat |
| Robert J Boucek, Ann Steele, Ann Miracle, James Atkinso. Effects of angiotensin-converting enzyme inhibitor on delayed-onset doxorubicin-induced cardiotoxicity. Cardiovascular toxicology. vol 3. issue 4. 2004-07-22. PMID:14734829. |
because angiotensin ii has been implicated in the progression of other cardiomyopathies, this investigation was undertaken to determine whether treatment with an angiotensinconverting enzyme (ace) inhibitor, lisinopril, reduces the time-dependent effects of doxorubicin on cardiac gene expression and myocellular apoptosis. |
2004-07-22 |
2023-08-12 |
Not clear |
| Xiaopeng Li, Heather Rayford, Ruijie Shu, Jiaju Zhuang, Bruce D Uha. Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 1. 2004-07-08. PMID:14977632. |
given the documented role of cathepsin d (catd) in apoptosis of other cell types, we hypothesized that catd might be the aec enzyme responsible for the conversion of angiotensinogen into ang i, the substrate for ace. |
2004-07-08 |
2023-08-12 |
rat |
| Xiaopeng Li, Heather Rayford, Ruijie Shu, Jiaju Zhuang, Bruce D Uha. Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 1. 2004-07-08. PMID:14977632. |
a purified fragment of angiotensinogen (f1-14) containing the catd and ace cleavage sites, when applied to unchallenged aec in vitro, yielded mature ang ii peptide and induced apoptosis. |
2004-07-08 |
2023-08-12 |
rat |
| Qin M Chen, Victoria C T. Apoptosis and heart failure: mechanisms and therapeutic implications. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 2. issue 1. 2004-04-14. PMID:14727998. |
eliminating these inducers reduces apoptosis and reverses the loss of contractile function in many cases, indicating the feasibility of the pharmacological application of antioxidants, nitric oxide synthetase inhibitors, ace inhibitors, angiotensin ii receptor antagonists and adrenergic receptor antagonists. |
2004-04-14 |
2023-08-12 |
Not clear |