| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juliane Stehle, Jörn Weisner, Leanne Eichhorn, Daniel Rauh, Malte Dresche. Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-02-16. PMID:36795969. |
the serine/threonine kinase akt1 is part of the pi3k/akt pathway and plays a key role in the regulation of various cellular processes such as cell growth, proliferation, and apoptosis. |
2023-02-16 |
2023-08-14 |
Not clear |
| Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Sun Sik Bae, Soo Bong Le. Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition. Experimental cell research. 2023-02-11. PMID:36773738. |
akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition. |
2023-02-11 |
2023-08-14 |
Not clear |
| Haiqiong Chen, Miaoqing Liu, Qiyao Li, Pingjiang Zhou, Jie Huang, Qiqi Zhu, Zhongrong Li, Ren-Shan G. Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPK phosphorylation. Environmental toxicology. 2023-01-30. PMID:36715143. |
in conclusion, in utero exposure to dpep disrupts adrenocortical function of the adult male offspring by (1) increasing ampk phosphorylation and decreasing akt1 phosphorylation and sirt1 levels, (2) reducing adrenocorticotropic hormone levels, and (3) possibly inducing oxidative stress and apoptosis. |
2023-01-30 |
2023-08-14 |
rat |
| Lakshmi Kanth Kotarkonda, Subhashini Bharathala, Tej Prakash Sinha, Kapil Dev Soni, Richa Aggarwal, Arul Selvi, D N Rao, Ashok Sharma, Sanjeev Bho. ALTERATION OF AKT1-GSK3Β SIGNALING PATHWAY IN TRAUMA HEMORRHAGIC SHOCK PATIENTS. Shock (Augusta, Ga.). vol 58. issue 6. 2022-12-22. PMID:36548639. |
the akt (protein kinase b) isoform, akt1, and glycogen synthase kinase 3β (akt1-gsk3β) signaling pathway controls cell survival and apoptosis. |
2022-12-22 |
2023-08-14 |
Not clear |
| Lei Zhao, Tony Hsiao, Connor Stonesifer, Jay Daniels, Tiffany J Garcia-Saleem, Jaehyuk Choi, Larisa Geskin, Alain H Rook, Gary S Woo. The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in Cutaneous T-Cell Lymphoma Can Be Reproduced by ΔNp73 Depletion. The Journal of investigative dermatology. vol 142. issue 12. 2022-11-23. PMID:35787399. |
at 96 hours when apoptosis was extensive, a majority of ctcl lines showed ≥2-fold suppression of t-cell survival factors (e.g., akt1, bcl2 antiapoptotic factors, birc5, cd40, cd70, gadd45a, prkca, tnfrsf1b, Δnp73) and ≥2-fold upregulation of proapoptotic factors and tumor suppressors (e.g., atm, bak, bim, multiple caspases, fhit, hic1, mgmt, nod1) (p < 0.05). |
2022-11-23 |
2023-12-10 |
Not clear |
| Jiuting Tan, Chunpu Li, Lijue Ren, Xiaohui Zhu, Fei Hua, Yuming F. miR-451a suppresses papillary thyroid cancer cell proliferation and invasion and facilitates apoptosis through targeting DCBLD2 and AKT1. Molecular and cellular probes. 2022-10-17. PMID:36252912. |
mir-451a suppresses papillary thyroid cancer cell proliferation and invasion and facilitates apoptosis through targeting dcbld2 and akt1. |
2022-10-17 |
2023-08-14 |
Not clear |
| Jiuting Tan, Chunpu Li, Lijue Ren, Xiaohui Zhu, Fei Hua, Yuming F. miR-451a suppresses papillary thyroid cancer cell proliferation and invasion and facilitates apoptosis through targeting DCBLD2 and AKT1. Molecular and cellular probes. 2022-10-17. PMID:36252912. |
the data suggested that mir-451a attenuated the proliferation, invasion and promoted apoptosis in ptc cells via inhibiting dcbld2 and akt1. |
2022-10-17 |
2023-08-14 |
Not clear |
| James Wachir. Morphological Alterations of CAD Cells Overexpressing AKT1. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. vol 26. issue Suppl 2. 2022-10-14. PMID:36237516. |
further, expression of exogenous akt1 in these cell lines led to morphological changes reminiscent of apoptosis. |
2022-10-14 |
2023-08-14 |
Not clear |
| Silvia Codenotti, Daniela Zizioli, Luca Mignani, Sara Rezzola, Giovanna Tabellini, Silvia Parolini, Arianna Giacomini, Michela Asperti, Maura Poli, Delia Mandracchia, Marika Vezzoli, Simona Bernardi, Domenico Russo, Stefania Mitola, Eugenio Monti, Luca Triggiani, Davide Tomasini, Stefano Gastaldello, Matteo Cassandri, Rossella Rota, Francesco Marampon, Alessandro Fanzan. Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors. Cells. vol 11. issue 18. 2022-09-23. PMID:36139434. |
furthermore, we found that pronounced akt1 signaling increased the susceptibility to cell apoptosis after treatments with 2-deoxy-d-glucose (2-dg) and lovastatin, enzymatic inhibitors of hexokinase, and 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase (hmgcr), especially in combination with radiotherapy and doxorubicin. |
2022-09-23 |
2023-08-14 |
human |
| Xiao-Wei Wang, Ci-An Zhang, Min Y. Study on the Mechanism of Xiaotan Sanjie Recipe in the Treatment of Colon Cancer Based on Network Pharmacology. BioMed research international. vol 2022. 2022-08-29. PMID:36033553. |
the key targets included akt1 and tp53, and go functional analysis mainly related to ubiquitination and apoptosis, etc. |
2022-08-29 |
2023-08-14 |
Not clear |
| Huimin Li, Yunhan Zhao, Qiuzi Shen, Honggang L. Multiple circRNAs regulated by QKI5 conjointly spongemiR-214-3p to antagonize Bisphenol A-inducedspermatocyte toxicity. Acta biochimica et biophysica Sinica. 2022-08-12. PMID:35959880. |
here by cck-8 assay, apoptosis assay, qrt-pcr and western blot analysis, we further discover that circrnas (represented by circdcbld2, circmapk1 and circtbcld20) can cooperatively sponge mir-214-3p and then up-regulate akt1 in ameliorating bpa-induced reproductive toxicity. |
2022-08-12 |
2023-08-14 |
Not clear |
| Qinyao Wei, Huiqing Xue, Congjiao Sun, Juan Li, Haorong He, Felix Kwame Amevor, Bo Tan, Menggen Ma, Kai Tian, Zhichao Zhang, Yao Zhang, Hua He, Lu Xia, Qing Zhu, Huadong Yin, Can Cu. Gga-miR-146b-3p promotes apoptosis and attenuate autophagy by targeting AKT1 in chicken granulosa cells. Theriogenology. vol 190. 2022-08-11. PMID:35952473. |
gga-mir-146b-3p promotes apoptosis and attenuate autophagy by targeting akt1 in chicken granulosa cells. |
2022-08-11 |
2023-08-14 |
chicken |
| Qinyao Wei, Huiqing Xue, Congjiao Sun, Juan Li, Haorong He, Felix Kwame Amevor, Bo Tan, Menggen Ma, Kai Tian, Zhichao Zhang, Yao Zhang, Hua He, Lu Xia, Qing Zhu, Huadong Yin, Can Cu. Gga-miR-146b-3p promotes apoptosis and attenuate autophagy by targeting AKT1 in chicken granulosa cells. Theriogenology. vol 190. 2022-08-11. PMID:35952473. |
moreover, knockout of akt1 decelerated proliferation and autophagy while accelerating the apoptosis of gc. |
2022-08-11 |
2023-08-14 |
chicken |
| Qinyao Wei, Huiqing Xue, Congjiao Sun, Juan Li, Haorong He, Felix Kwame Amevor, Bo Tan, Menggen Ma, Kai Tian, Zhichao Zhang, Yao Zhang, Hua He, Lu Xia, Qing Zhu, Huadong Yin, Can Cu. Gga-miR-146b-3p promotes apoptosis and attenuate autophagy by targeting AKT1 in chicken granulosa cells. Theriogenology. vol 190. 2022-08-11. PMID:35952473. |
in summary, our results demonstrated that gga-mir-146b-3p repressed the proliferation and autophagy of chicken gc while up-regulating apoptosis by targeting akt1 through the pi3k/akt signaling pathway. |
2022-08-11 |
2023-08-14 |
chicken |
| Xiaoqin Ma, Chenxia Hao, Meixiang Yu, Zhaokang Zhang, Jingjing Huang, Wanhua Yan. Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-05-26. PMID:35615688. |
this study revealed that que could protect against podocyte injury in dn through the following mechanisms: downregulating inflammatory cytokine of tnf, reducing vegf-induced vascular permeability, inhibiting apoptosis by stimulating akt1 phosphorylation, and suppressing the age-induced oxidative stress via the age-rage signaling pathway. |
2022-05-26 |
2023-08-13 |
rat |
| Tushar Dnyaneshwar Desai, Yao-Tseng Wen, Jayasimha Rayalu Daddam, Felice Cheng, Chia-Ching Chen, Chien-Lin Pan, Keh-Liang Lin, Rong-Kung Tsa. Long term therapeutic effects of icariin-loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP-β/G-CSF/noncanonical NF-κB axis. Bioengineering & translational medicine. vol 7. issue 2. 2022-05-23. PMID:35600664. |
activation of noncanonical nf-κb signaling pathway promoted the m2 microglia/macrophage polarization and akt1 activation, which prevented neuroinflammation and rgc apoptosis after on infarct. |
2022-05-23 |
2023-08-13 |
rat |
| Yan Luo, Liwei Liu, Jihua Zhao, Yue Jiao, Meiyu Zhang, Guangli Xu, Yumao Jian. PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An in Vitro and in Vivo Study. Biological & pharmaceutical bulletin. vol 45. issue 5. 2022-05-01. PMID:35491166. |
the results illustrated that sin suppressed sk-hep-1 hcc cells' proliferation, enhanced the collapse of potential of the mitochondrial membrane, triggered cell apoptosis, down-regulated pi3k p85α, akt1, bcl-2, pro-caspase 9, pro-caspase 3 expressions, and up-regulated cleaved caspase 9 and cleaved caspase 3 expressions in vitro and in vivo. |
2022-05-01 |
2023-08-13 |
mouse |
| Wei Huang, Guo Li, Xiang-Hong He, He-Ping Li, Qian Zhao, Dong-Ai Li, Hong-Ping Zhu, Yue-Hua Zhang, Gu Zha. Design, synthesis, and biological evaluation of tetrahydro-αcarbolines as Akt1 inhibitors that inhibit colorectal cancer cells proliferation. ChemMedChem. 2022-03-31. PMID:35355421. |
in vitro kinase inhibitory abilities and cytotoxicity assays revealed that compound 3af was the most potent akt1 inhibitor, and mechanistic study indicated that compound 3af suppressed the proliferation of colorectal cancer cells via inducing apoptosis and autophagy. |
2022-03-31 |
2023-08-13 |
Not clear |
| Dandan Zheng, Yongming Zhou, Yong Liu, Lihai Ma, Lingzhan Men. Molecular Mechanism Investigation on Monomer Kaempferol of the Traditional Medicine Dingqing Tablet in Promoting Apoptosis of Acute Myeloid Leukemia HL-60 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-07. PMID:35251215. |
the combination of kaempferol and akt1 was verified using an immunoprecipitation (ip) experiment and the effects of kaempferol on hl-60 cell apoptosis by western blot (wb) and qpcr. |
2022-03-07 |
2023-08-13 |
Not clear |
| Dandan Zheng, Yongming Zhou, Yong Liu, Lihai Ma, Lingzhan Men. Molecular Mechanism Investigation on Monomer Kaempferol of the Traditional Medicine Dingqing Tablet in Promoting Apoptosis of Acute Myeloid Leukemia HL-60 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-07. PMID:35251215. |
ip assay results testified that kaempferol could bind to akt1, thereby reducing the level of p-akt and promoting hl-60 cell apoptosis. |
2022-03-07 |
2023-08-13 |
Not clear |