| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Il Young Kim, Yeon Kyeong Park, Sang Heon Song, Eun Young Seong, Dong Won Lee, Sun Sik Bae, Soo Bong Le. Akt1 is involved in tubular apoptosis and inflammatory response during renal ischemia-reperfusion injury. Molecular biology reports. vol 47. issue 12. 2021-05-19. PMID:33247386. |
akt1 is involved in tubular apoptosis and inflammatory response during renal ischemia-reperfusion injury. |
2021-05-19 |
2023-08-13 |
mouse |
| Yemei Yang, Shengfang Ma, Zi Ye, Xianyi Zho. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-10. PMID:31535400. |
our study aimed to study the effects of mcm7 silencing on cm cell autophagy and apoptosis by modulating the akt threonine kinase 1 (akt1)/mechanistic target of rapamycin kinase (mtor) signaling pathway. |
2021-05-10 |
2023-08-13 |
Not clear |
| Yemei Yang, Shengfang Ma, Zi Ye, Xianyi Zho. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-10. PMID:31535400. |
to further investigate the regulatory mechanisms of mcm7 in cm progress, the expression of mcm7, akt1, mtor, cyclin d1, as well as autophagy and apoptosis relative factors, such as lc3b, sod2, dj-1, p62, bcl-2, bax, and caspase-3 in melanoma cells was determined. |
2021-05-10 |
2023-08-13 |
Not clear |
| Cai-Feng Li, Feng-Rong Zhang, Na Zhu, Jian-Zhi Cui, Shi-Huan Tang, Zhi-Yong L. [Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 4. 2021-03-02. PMID:33645091. |
jinweitai capsules may exert an effect in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis by acting on akt1, egfr, ptpn11 and other targets in 15 signal pathways relating to cell inflammation and immunity, cell proliferation and apoptosis, helicobacter pylori infection, and gastrointestinal tract. |
2021-03-02 |
2023-08-13 |
Not clear |
| Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. vol 9. issue 5. 2021-02-25. PMID:32438621. |
next, we analyzed the role of pi3k p85α, p85β, p110α, p110β, akt1, and akt2 proteins on tnbc cell cycle progression and apoptosis induction. |
2021-02-25 |
2023-08-13 |
Not clear |
| Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. vol 9. issue 5. 2021-02-25. PMID:32438621. |
akt1 and p110α knockdown diminished cyclin d1 expression and induced apoptosis. |
2021-02-25 |
2023-08-13 |
Not clear |
| Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. vol 9. issue 5. 2021-02-25. PMID:32438621. |
silencing akt1 promoted synergistic apoptosis induction during radiotherapy and further reduced survival after radiation. |
2021-02-25 |
2023-08-13 |
Not clear |
| Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. vol 9. issue 5. 2021-02-25. PMID:32438621. |
treatment with the akt inhibitor, mk-2206 48 h after radiotherapy decreased akt1 levels and potentiated radiation-induced apoptosis. |
2021-02-25 |
2023-08-13 |
Not clear |
| McShane McKenna, Nileeka Balasuriya, Shanshan Zhong, Shawn Shun-Cheng Li, Patrick O'Donoghu. Phospho-Form Specific Substrates of Protein Kinase B (AKT1). Frontiers in bioengineering and biotechnology. vol 8. 2021-02-23. PMID:33614606. |
akt1 is well-known for phosphorylating proteins that regulate cell survival and apoptosis, however, the full catalog of akt1 substrates remains unknown. |
2021-02-23 |
2023-08-13 |
human |
| Wang-Qiang Chen, Cai-Fei Ding, Jia Yu, Chen-Ye Wang, Ling-Yi Wan, Hui-Min Hu, Jian-Xiong M. Wuzi Yanzong Pill-Based on Network Pharmacology and Frontiers in pharmacology. vol 11. 2021-01-05. PMID:33390971. |
the results showed that wzyzp treatment improved rat sperm quality and attenuated serum hormone levels, reversed histopathological damage of the testis, reduced cell apoptosis in testis tissues, and ameliorated the expression of the predicted hub targets (tp53, tnf-α, akt1, nfκb, and iκba) and the apoptosis related proteins (bcl-xl, bcl-2, bax, caspase 3, and caspase 9). |
2021-01-05 |
2023-08-13 |
human |
| Kai Zhang, Chuanxin Liu, Tiange Yang, Xinxin Li, Longyin Wei, Dongling Chen, Jiali Zhou, Yihui Yin, Xinyu Yu, Fei L. Systematically explore the potential hepatotoxic material basis and molecular mechanism of Radix Aconiti Lateralis based on the concept of toxicological evidence chain (TEC). Ecotoxicology and environmental safety. vol 205. 2020-10-23. PMID:32971455. |
it was found that 22 potential toxic components screened can affect th17 cell differentiation, jak-stat signaling pathway, glutathione metabolism, and other related pathways by regulating akt1, il2, f2, gsr, egfr and other related targets, which induces oxidative stress, metabolic disorders, cell apoptosis, immune response, and excessive release of inflammatory factors, eventually inducing liver damage in rats. |
2020-10-23 |
2023-08-13 |
rat |
| Priya Mahajan, Bhumika Wadhwa, Manas Ranjan Barik, Fayaz Malik, Amit Nargotr. Combining ligand- and structure-based in silico methods for the identification of natural product-based inhibitors of Akt1. Molecular diversity. vol 24. issue 1. 2020-10-13. PMID:30798436. |
herein, in silico structure- and ligand-based approaches have been applied to screen in-house iiim natural product repository for akt1 (serine/threonine protein kinases) which is a well-known therapeutic target for cancer due to its overexpression and preventing the cells from undergoing apoptosis. |
2020-10-13 |
2023-08-13 |
Not clear |
| Juwen C DuBois, Alex K Ray, Ross C Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan, Bridget Shafit-Zagard. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Frontiers in immunology. vol 10. 2020-10-13. PMID:31404142. |
while the isoforms akt1 and akt2 are involved in apoptosis and insulin signaling, respectively, the role for akt3 remains uncertain. |
2020-10-13 |
2023-08-13 |
mouse |
| Fa-Xiu Chen, Ning Du, Jian Hu, Fang Ning, Xun Mei, Qiang Li, Le Pen. Intramuscular accumulation of pentadecanoic acid activates AKT1 to phosphorylate NCOR1 and triggers FOXM1-mediated apoptosis in the pathogenesis of sarcopenia. American journal of translational research. vol 12. issue 9. 2020-10-13. PMID:33042406. |
intramuscular accumulation of pentadecanoic acid activates akt1 to phosphorylate ncor1 and triggers foxm1-mediated apoptosis in the pathogenesis of sarcopenia. |
2020-10-13 |
2023-08-13 |
human |
| Xinmin Zhao, Xianghua Wu, Huijie Wang, Hui Yu, Jialei Wan. USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling. Molecular carcinogenesis. vol 59. issue 8. 2020-10-06. PMID:32511815. |
usp53 regulates cell apoptosis and glycolysis through the akt1 pathway. |
2020-10-06 |
2023-08-13 |
human |
| Juan Liu, Lina Quan, Chunhui Zhang, Aichun Liu, Dongxia Tong, Jinghua Wan. Over-activated PD-1/PD-L1 axis facilitates the chemoresistance of diffuse large B-cell lymphoma cells to the CHOP regimen. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435074. |
in chop-treated pd-l1 knockdown cells, the increased apoptosis was markedly inhibited by the overexpression of constitutively active akt1. |
2020-10-01 |
2023-08-13 |
human |
| Xingyu Zhao, Tiejun Wang, Bo Cai, Xiaoning Wang, Wei Feng, Yu Han, Dongsong Li, Shuqiang Li, Jianguo Li. MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105831. |
microrna-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting akt1. |
2020-10-01 |
2023-08-13 |
human |
| Xingyu Zhao, Tiejun Wang, Bo Cai, Xiaoning Wang, Wei Feng, Yu Han, Dongsong Li, Shuqiang Li, Jianguo Li. MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105831. |
transfection of a mir-495 mimic into rat primary chondrocytes, human chondrocytes (hc) and sw1353 chondrosarcoma cells inhibited akt1 expression, proliferation and scratch wound closure and induced apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Xingyu Zhao, Tiejun Wang, Bo Cai, Xiaoning Wang, Wei Feng, Yu Han, Dongsong Li, Shuqiang Li, Jianguo Li. MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105831. |
akt1 overexpression amplified p-s6 and p-mtor levels as well as abolished mir-495 mimic-induced apoptosis and inhibition of proliferation. |
2020-10-01 |
2023-08-13 |
human |
| Xin Deng, Laijun Song, Wen Zhao, Ying Wei, Xin-Bin Gu. HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311840. |
hax-1 protects glioblastoma cells from apoptosis through the akt1 pathway. |
2020-09-30 |
2023-08-13 |
Not clear |