| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dandan Zheng, Yongming Zhou, Yong Liu, Lihai Ma, Lingzhan Men. Molecular Mechanism Investigation on Monomer Kaempferol of the Traditional Medicine Dingqing Tablet in Promoting Apoptosis of Acute Myeloid Leukemia HL-60 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-07. PMID:35251215. |
the monomer kaempferol of dingqing tablet could promote apoptosis of hl-60 cells, and the mechanism might correlate with the combination of kaempferol and akt1, reducing the level of p-akt and promoting the expression of the apoptotic signaling pathway. |
2022-03-07 |
2023-08-13 |
Not clear |
| Ya-Li Wu, Xiao-Yan Wang, Hui Zhang, Yu-Long Chen, Ming-Liang Zhang, Xiao-Fei Chen, Lu Niu, Wei-Xia Li, Jin-Fa Tan. [Study on alleviating effect of Glycyrrhizae Radix et Rhizoma on Psoraleae Fructus-induced liver injury based on network pharmacology and cell experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 1. 2022-02-18. PMID:35178925. |
the predicted core targets were proto-oncogene tyrosine-protein kinase(src), phosphatidylinositol 4,5-bisphosphate 3-kinase subunit alpha(pik3 ca), rac-alpha serine/threonine-protein kinase(akt1), etc, with pi3 k-akt signaling pathway, mapk signaling pathway, apoptosis, toll-like receptor signaling pathway, and nf-κb signaling pathway mainly involved. |
2022-02-18 |
2023-08-13 |
Not clear |
| Yan Liang, Ruo-Lan Sun, Fu-Yan Liu, Tian-Tian Liu, Han-Qing Guan, De-Cai Tan. [Anti-colorectal cancer mechanism of Astragali Radix-Curcumae Rhizoma-Paridis Rhizoma based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178961. |
as revealed by network pharmacology, ar-cr-pr contained nine core components, such as quercetin, curcumin, and β-ecdysone, and the key targets included protein kinase b(akt1), mitogen-activated protein kinase 3(mapk3), mapk1, and epithelial growth factor receptor(egfr), which was indicated that the anti-crc effect of ar-cr-pr was presumedly achieved by regulating tumor cell proliferation, apoptosis, migration, and angiogenesis through pi3 k-akt, mapk and other signaling pathways. |
2022-02-18 |
2023-08-13 |
mouse |
| Mengyuan Niu, Bin Zhang, Li Li, Zhonglan Su, Wenyuan Pu, Chen Zhao, Lulu Wei, Panpan Lian, Renwei Lu, Ranran Wang, Junaid Wazir, Qian Gao, Shiyu Song, Hongwei Wan. Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Through AKT1/ERK Pathway in Lung Cancer. Frontiers in pharmacology. vol 12. 2022-01-31. PMID:35095481. |
in both human and mouse lung cancer cell lines, knocking down hsp90aa1 promoted cell apoptosis through the inhibition of the pro-survival effect of akt1 by decreasing the phosphorylation of itself and its downstream factors of mtor and bad, as well as downregulating mcl1, bcl-xl, and survivin. |
2022-01-31 |
2023-08-13 |
mouse |
| Xuan Wang, Renhong Huang, Zhouyi Lu, Zheng Wang, Xiaofeng Chen, Dayu Huan. Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis. Cancer science. 2022-01-29. PMID:35092121. |
silencing stk16 expression inhibited cell proliferation and promoted apoptosis via the akt1 pathway. |
2022-01-29 |
2023-08-13 |
mouse |
| V N Mal'tseva, M V Goltyaev, S V Novoselov, E G Varlamov. [Effects of Sodium Selenite and Dithiothreitol on Expression of Endoplasmic Reticulum Selenoproteins and Apoptosis Markers in MSF7 Breast Adenocarcinoma Cells]. Molekuliarnaia biologiia. vol 56. issue 1. 2022-01-27. PMID:35082262. |
when the ss concentration was increased to 0.1 μm, an increase in expression was observed for key er stress genes and apoptosis markers, including chop, gadd34, puma, bim, atf4, sxbp, uxbp, akt1, bax, and bak. |
2022-01-27 |
2023-08-13 |
Not clear |
| Song Na, Li Ying, Cheng Jun, Xiong Ya, Zhang Suifeng, He Yuxi, Wang Jing, Lai Zonglang, Yang Xiaojun, Wu Yu. Study on the molecular mechanism of nightshade in the treatment of colon cancer. Bioengineered. vol 13. issue 1. 2022-01-11. PMID:35012428. |
based on the network diagram of 'traditional chinese medicine - component - target - disease' and kegg analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including pik3r1, pik3ca, akt1, and akt2. |
2022-01-11 |
2023-08-13 |
mouse |
| Jeremy Johnson, Zeta Chow, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Role of AMPK and Akt in triple negative breast cancer lung colonization. Neoplasia (New York, N.Y.). vol 23. issue 4. 2021-11-16. PMID:33839456. |
transient silencing of akt1 or akt2 dramatically decreased metastatic colonization of lungs by inducing apoptosis or inhibiting invasion, respectively. |
2021-11-16 |
2023-08-13 |
Not clear |
| Mei Yang, Hui Liu, Guo-Ping Qiu, Fei Ga. Silencing Akt1 enhances the resistance of prostate cancer cells to starvation and inhibits starvation-induced lung metastasis through epithelial-mesenchymal transition in prostate cancer. Medical oncology (Northwood, London, England). vol 39. issue 1. 2021-11-11. PMID:34761338. |
silencing akt1 slowed down the decrease of cell number and increase of apoptosis caused by nst. |
2021-11-11 |
2023-08-13 |
Not clear |
| Jiahui Zhao, Qiankun Li, Bingfu Feng, Dechao Wei, Yili Han, Mingchuan Li, Yongxing Wang, Yong Luo, Yongguang Jian. MicroRNA‑149 inhibits cancer cell malignant phenotype by regulating Akt1 in C4‑2 CRPC cell line. Oncology reports. vol 46. issue 6. 2021-11-05. PMID:34698359. |
knockdown of akt1 by short hairpin rna increased apoptosis, reduced proliferation, and restrained migration and invasion in crpc cells, with the effect of ar inhibition. |
2021-11-05 |
2023-08-13 |
Not clear |
| Teng Wang, Chun-Yi Lyu, Yue-Hua Jiang, Xue-Yan Dong, Yan Wang, Zong-Hong Li, Jin-Xin Wang, Rui-Rong X. A drug-biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Molecular diversity. vol 25. issue 4. 2021-10-28. PMID:32676746. |
the results suggest that luteolin and quercetin are the main active components of sbd against adverse-risk aml, and affected drug resistance, apoptosis, immune regulation and angiogenesis through the core targets akt1, mapk1, il6, egfr, src, vegfa and tp53. |
2021-10-28 |
2023-08-13 |
Not clear |
| Yi-Xin Wang, Peng Liu, Tong Li, Xing-Hua Qin, Qiang-Sun Zhen. [Active components and action mechanism of Shenmai Injection in treatment of atrial fibrillation based on network pharmacology and molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 17. 2021-09-29. PMID:34581057. |
homoisoflavonoids of ophiopogon japonicus are its important active components, which target akt1 to regulate metabolism, inflammation, and apoptosis in af treatment. |
2021-09-29 |
2023-08-13 |
Not clear |
| María-Aránzazu Martínez, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, Jose-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Arturo Anadón, Cesar Peteiro, Susana Rubiño, María Horto. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 156. 2021-09-14. PMID:34348126. |
moreover, g. baccata extract caused up-regulation of gstm2, nrf2, and akt1 gene expressions, as well as g. baccata extract reduced significantly bax, bnip3, apaf1, erk1, jnk1, mapk1, p38, p53, nfκb1, tnfα, il-6, il-1β and ho-1 gene expressions related to apoptosis, proinflammation and oxidative stress induced by tert-booh. |
2021-09-14 |
2023-08-13 |
Not clear |
| Tingting Wang, Zhenchuan Liu, Yunlang She, Jiajun Deng, Yifan Zhong, Mengmeng Zhao, Shenghui Li, Dong Xie, Xiwen Sun, Xuefei Hu, Chang Che. A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. Cancer letters. vol 520. 2021-09-13. PMID:34389432. |
importantly, this novel isoform competes with ask1 for binding to akt1, therefore antagonizing akt1-induced ask1 phosphorylation and inactivation, leading to the activation of ask1-induced apoptosis and alleviating gefitinib resistance. |
2021-09-13 |
2023-08-13 |
Not clear |
| Han Yang, Jun Zhao, Mengjing Zhao, Lihao Zhao, Li-Na Zhou, Yuxia Duan, Gang L. GDC-0349 inhibits non-small cell lung cancer cell growth. Cell death & disease. vol 11. issue 11. 2021-09-07. PMID:33154352. |
furthermore, restoring akt-mtor activation by a constitutively-active akt1 only partially attenuated gdc-0349-induced a549 cell apoptosis, indicating the existence of akt-mtor-independent mechanisms. |
2021-09-07 |
2023-08-13 |
mouse |
| G A Puzanov, V N Senchenk. [SCP Phosphatases and Oncogenesis]. Molekuliarnaia biologiia. vol 55. issue 4. 2021-08-27. PMID:34432772. |
in addition, the substrates of scp phosphatases include smad transcription modulators; akt1 protein kinase, which regulates the cell cycle, apoptosis, and angiogenesis; the twist1 and c-myc transcription factors; ras family proteins, which are involved in signaling pathways regulating the cell growth and apoptosis; cdca3, which is associated with cell division; the cyclin-dependent kinase inhibitor p21; and the promyelocytic leukemia protein (pml), which is involved in regulation of the tumor suppressors p53, pten, and mtor. |
2021-08-27 |
2023-08-13 |
Not clear |
| Andrew J McGovern, George E Barret. Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-08-10. PMID:34058440. |
following protein-protein functional analysis, the top connected proteins were related to kinase activity (mapk1/14/3, akt1 pik3r1), apoptosis (tp53, casp3), growth factors (egfr), estrogen signalling (esr1) and inflammation (il6, tnf), with il6 as an important signalling hub belonging to the top go categories. |
2021-08-10 |
2023-08-13 |
Not clear |
| Fatemeh Gheidari, Ehsan Arefian, Fatemeh Jamshidi Adegani, Mohammad Reza Kalhori, Ehsan Seyedjafari, Mahboubeh Kabiri, Ladan Teimoori-Toolabi, Masoud Soleiman. miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway. European journal of pharmacology. vol 906. 2021-07-16. PMID:34153339. |
mir-424 induces apoptosis in glioblastoma cells and targets akt1 and raf1 oncogenes from the erbb signaling pathway. |
2021-07-16 |
2023-08-13 |
Not clear |
| Yuxia Qu, Chenning Zhang, Runhua Liu, Hao Wu, Yu Sun, Na Zhang, Ciren Nima, Quzeng Danpei, Shuofeng Zhang, Yikun Su. Rapid characterization the chemical constituents of Bergenia purpurascens and explore potential mechanism in treating osteoarthritis by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry combined with network pharmacology. Journal of separation science. vol 43. issue 16. 2021-05-31. PMID:32496008. |
through the analysis of network pharmacology, several potential candidate targets and pathways were initially predicted, including akt1, mapk1, and mapk3, as well as the apoptosis, estrogen, and mapk signaling pathways. |
2021-05-31 |
2023-08-13 |
Not clear |
| Muhammad Safdar, Sana Zaheer, Rozhgar A Khailany, Sadaf Parvez, Muhammad Naveed, Piplu Bhuiyan, Mehmet Ozaslan, Rebaz Moatasam, Mustafa S Al-Attar, Musarrat Abbas Khan, Yasmeen Junej. The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis. Cell biochemistry and biophysics. vol 78. issue 4. 2021-05-19. PMID:32951155. |
besides, mir-371b-5p targets many apoptosis-related genes (hip1, triap1, gskip, nin, dap, caap1, xiap, tmbim1, tmbim4, tnfrsf10a, rad21, akt1, bag1, bag4) even though it had no apoptosis correlated interaction demonstrated formerly. |
2021-05-19 |
2023-08-13 |
human |