| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Chen, Jun Liang, Shihai Liu, Shanai Song, Wenxuan Guo, Fangzhen She. Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725418. |
molecular mechanisms and the influences of different regulation the expression of akt1 on hcc cell growth, proliferation were determined by western blotting, mtt and colony formation assays, cell cycle and apoptosis were investigated by flow cytometry. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hong Yu, Jianying Sun, Shaochang Jiang, Ying X. MicroRNA-490-3p regulates cell proliferation and apoptosis in gastric cancer via direct targeting of AKT1. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30680010. |
microrna-490-3p regulates cell proliferation and apoptosis in gastric cancer via direct targeting of akt1. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xin Deng, Laijun Song, Wen Zhao, Ying Wei, Xin-Bin Gu. Corrigendum: HAX-1 Protects Glioblastoma Cells From Apoptosis Through the Akt1 Pathway. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:30766479. |
corrigendum: hax-1 protects glioblastoma cells from apoptosis through the akt1 pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shoumei Zhang, Li Shuai, Dong Wang, Tingting Huang, Shengsheng Yang, Mingyong Miao, Fang Liu, Jiajun X. Pim-1 Protects Retinal Ganglion Cells by Enhancing Their Regenerative Ability Following Optic Nerve Crush. Experimental neurobiology. vol 29. issue 3. 2020-09-28. PMID:32624507. |
in addition, it enhanced the intrinsic regeneration capacity of rgcs after onc by activating stat3, akt1 and akt2 pathways, and inhibiting the mitochondrial apoptosis pathways. |
2020-09-28 |
2023-08-13 |
rat |
| Swati Jain, Alkesh Jan. Renal Tubular Cells from Hibernating Squirrels are Protected against Cisplatin Induced Apoptosis. International journal of nephrology. vol 2020. 2020-09-28. PMID:32832155. |
squirrel rtecs deficient in akt1 and xiap had increased apoptosis and cleaved caspase-3 when treated with cisplatin. |
2020-09-28 |
2023-08-13 |
mouse |
| Po Hu, Hui Li, Xiaoxuan Yu, Xiao Liu, Xiangyuan Wang, Yingjie Qing, Zhanyu Wang, Hongzheng Wang, Mengyuan Zhu, Jingyan Xu, Renxiang Tan, Qinglong Guo, Hui Hu. GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis. Free radical biology & medicine. vol 145. 2020-09-02. PMID:31560953. |
here, we found that gl-v9, a newly synthesized flavonoid compound, had a potent to inhibit the activation of akt1 and induce the cell apoptosis in t-cell malignancies including cell lines and primary lymphoblastic leukemia. |
2020-09-02 |
2023-08-13 |
Not clear |
| Guanghui Ren, Xiaoyan Hao, Shuyi Yang, Jun Chen, Guobin Qiu, Kok Pian Ang, Mohd Islahuddin Mohd Tamri. 10H-3,6-Diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of MCF-7 breast cancer cells via inhibition of AKT1 pathways. Journal of biochemical and molecular toxicology. 2020-07-03. PMID:32619082. |
10h-3,6-diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of mcf-7 breast cancer cells via inhibition of akt1 pathways. |
2020-07-03 |
2023-08-13 |
Not clear |
| Shuo Lu, Lingling Chen, Li Tan. Upregulation of AKT1 and downregulation of AKT3 caused by dysregulation of microRNAs contributes to pathogenesis of hemangioma by promoting proliferation of endothelial cells. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31074018. |
and mir-15a, akt3 sirna and anti-mir-205 evidently induced viability, and mir-205, akt1 sirna, and anti-mir-15a obviously promoted apoptosis of cells. |
2020-06-01 |
2023-08-13 |
Not clear |
| Li Zhou, Ming Li, Xinyou Yu, Feng Gao, Wei L. Repression of Hexokinases II-Mediated Glycolysis Contributes to Piperlongumine-Induced Tumor Suppression in Non-Small Cell Lung Cancer Cells. International journal of biological sciences. vol 15. issue 4. 2020-02-03. PMID:30906213. |
moreover, our results revealed that piperlongumine down-regulated the akt signaling, exogenous overexpression of constitutively activated akt1 in hcc827 and h1975 cells significantly rescued piperlongumine-induced glycolysis suppression and apoptosis. |
2020-02-03 |
2023-08-13 |
mouse |
| Shibnath Ghatak, Suniti Misra, Ricardo A Moreno-Rodrigue, Vincent C Hascall, Gustavo W Leone, Roger R Markwal. Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization. Biochimica et biophysica acta. General subjects. vol 1863. issue 5. 2019-12-03. PMID:30742951. |
further, the pn-pak1-induced akt1 protects cells from apoptosis through suppression of transcriptional activation of forkhead-transcription-factor (fkhr). |
2019-12-03 |
2023-08-13 |
Not clear |
| Anna Kovalchuk, Yaroslav Ilnytskyy, Rafal Woycicki, Rocio Rodriguez-Juarez, Gerlinde A S Metz, Olga Kovalchu. Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain. Oncotarget. vol 9. issue 11. 2019-11-20. PMID:29515791. |
furthermore, there were changes in proliferation and apoptosis proteins bcl2 and akt1, the proteins associated with dna methylation, dnmt1 and mecp2. |
2019-11-20 |
2023-08-13 |
Not clear |
| M Arias-Álvarez, R M García-García, J López-Tello, P G Rebollar, A Gutiérrez-Adán, P L Lorenz. α-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during in vitro maturation and enhances the developmental competence of rabbit oocytes. Reproduction, fertility, and development. vol 30. issue 12. 2019-09-30. PMID:29966585. |
the present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µm) during ivm on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (sod2), glutathione peroxidase 1 (gpx1), catalase (cat)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (tp53), caspase 3, apoptosis-related cysteine protease (casp3)), cell cycle progression (cellular cycle v-akt murine thymoma viral oncogene homologue 1 (akt1)), cumulus expansion (gap junction protein, alpha 1, 43 kda (gja1) and prostaglandin-endoperoxide synthase 2 (prostaglandin g/h synthase and cyclo-oxygenase) (ptgs2)) and metabolism (glucose-6-phosphate dehydrogenase (g6pd)). |
2019-09-30 |
2023-08-13 |
rabbit |
| Maedeh Vakili Saatloo, Amir Ala Aghbali, Maryam Koohsoltani, Ahmad Yari Khosroushah. Akt1 and Jak1 siRNA based silencing effects on the proliferation and apoptosis in head and neck squamous cell carcinoma. Gene. vol 714. 2019-08-20. PMID:31348981. |
akt1 and jak1 sirna based silencing effects on the proliferation and apoptosis in head and neck squamous cell carcinoma. |
2019-08-20 |
2023-08-13 |
Not clear |
| Maedeh Vakili Saatloo, Amir Ala Aghbali, Maryam Koohsoltani, Ahmad Yari Khosroushah. Akt1 and Jak1 siRNA based silencing effects on the proliferation and apoptosis in head and neck squamous cell carcinoma. Gene. vol 714. 2019-08-20. PMID:31348981. |
based on akt1 and jak1 key roles in apoptosis and proliferation of many cancers, the aim of this study was to find a new gene therapy strategy by silencing of these main anti-apoptotic genes for hnscc treatment. |
2019-08-20 |
2023-08-13 |
Not clear |
| Maedeh Vakili Saatloo, Amir Ala Aghbali, Maryam Koohsoltani, Ahmad Yari Khosroushah. Akt1 and Jak1 siRNA based silencing effects on the proliferation and apoptosis in head and neck squamous cell carcinoma. Gene. vol 714. 2019-08-20. PMID:31348981. |
knocking down akt1 and jak1 genes using sirnas could increase levels of apoptosis and reduce proliferation rate in hnscc indicating the powerful effects of these genes sirnas with or without chemotherapeutic agents in hnscc treatment. |
2019-08-20 |
2023-08-13 |
Not clear |
| Bruno Martinucci, Brenda de Carvalho Minatel, Maira Smaniotto Cucielo, Mariana Medeiros, Ivan José Vechetti-Junior, Sérgio Luis Felisbino, Flávia Karina Delell. Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29961211. |
when fn was the predominant matrix element, such as in blood plasma, pca tumor cells increased their expression of genes related to an invasive behavior and resistance to apoptosis, including cdh2, itga5, akt1, and bcl2. |
2019-03-08 |
2023-08-13 |
Not clear |
| Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Gu. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387805. |
furthermore, knockdown of akt1 and akt2 inhibited cell proliferation and colony growth, by attenuating cell cycle progression and increasing apoptosis in colon cancer cells, effects that were similar to those caused by resveratrol treatment. |
2019-03-05 |
2023-08-13 |
Not clear |
| Bangdang Chen, Xiaocui Chen, Cheng Liu, Jihong Li, Fen Liu, Ying Huan. Co-expression of Akt1 and Wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-28. PMID:30243083. |
co-expression of akt1 and wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. |
2019-02-28 |
2023-08-13 |
Not clear |
| Bangdang Chen, Xiaocui Chen, Cheng Liu, Jihong Li, Fen Liu, Ying Huan. Co-expression of Akt1 and Wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-28. PMID:30243083. |
notably, co-expression of akt1 and wnt11 increased cell survival and reduced cell apoptosis of mscs under hypoxia/reoxygenation (h/r) treatment; however, these effects were blocked by wnt11 neutralizing antibodies or akt1 inhibitor. |
2019-02-28 |
2023-08-13 |
Not clear |
| Bangdang Chen, Xiaocui Chen, Cheng Liu, Jihong Li, Fen Liu, Ying Huan. Co-expression of Akt1 and Wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-28. PMID:30243083. |
overall, our results showed that mscs, co-expressing akt1 and wnt11, showed greater survival and cardiac differentiation under h/r conditions and effectively ameliorated h/r-induced cardiomyocyte apoptosis in vitro. |
2019-02-28 |
2023-08-13 |
Not clear |