| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hang Zhao, Yating Ma, Leifang Zhan. Low-molecular-mass hyaluronan induces pulmonary inflammation by up-regulation of Mcl-1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway. Immunology. vol 155. issue 3. 2019-02-05. PMID:29975419. |
our results indicate that pharmacological inhibition of pi3k or genetic deletion of akt1 enhances neutrophil apoptosis, attenuates neutrophil influx into the lungs of mice and diminishes the expression of pro-inflammatory factors such as interleukin-6, keratinocyte cell-derived chemokine and pro-matrix metalloproteinase-9 in bronchoalveolar lavage fluid after intratracheal administration of lmmha. |
2019-02-05 |
2023-08-13 |
mouse |
| Lingxin Meng, Zhu Fuhao, Zhou Xiaoming, Zheng Yuxiu, Ding Zhaojun, Li Bingcheng, Xu Meiling, Sun Shuya. Survivin is critically involved in VEGFR2 signaling-mediated esophageal cancer cell survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30086460. |
the inhibition of vegfr2 signaling with the xl184 treatment downregulated the phosphorylation of akt1 and mdm2, and then, increased the activation of caspase 3/7, resulting in the reduction of cell viability and the apoptosis of huvecs. |
2019-01-22 |
2023-08-13 |
Not clear |
| Andrés López-Cortés, Paola E Leone, Byron Freire-Paspuel, Nathaly Arcos-Villacís, Patricia Guevara-Ramírez, Felipe Rosales, César Paz-Y-Miñ. Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population. BioMed research international. vol 2018. 2019-01-07. PMID:30065942. |
activated akt1 phosphorylates downstream substrates regulating cell growth, metabolism, apoptosis, angiogenesis, and drug responses. |
2019-01-07 |
2023-08-13 |
Not clear |
| Chunyan Luo, Fan Wang, Xiang Ren, Tie Ke, Chengqi Xu, Bo Tang, Subo Qin, Yufeng Yao, Qiuyun Chen, Qing Kenneth Wan. Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28341552. |
knockdown of adtrp expression by sirna promoted oxidized-ldl-mediated monocyte adhesion to ecs and transendothelial migration of monocytes, inhibited ec proliferation and migration, and increased apoptosis, which was reversed by expression of constitutively active akt1 and mia3/tango1 overexpression, while the over-expression of adtrp in ecs blunted these processes. |
2018-11-26 |
2023-08-13 |
Not clear |
| Rui-Lian Xu, Wan He, Jun Tang, Wei Guo, Peng Zhuang, Chang-Qing Wang, Wei-Ming Fu, Jin-Fang Zhan. Primate-specific miRNA-637 inhibited tumorigenesis in human pancreatic ductal adenocarcinoma cells by suppressing Akt1 expression. Experimental cell research. vol 363. issue 2. 2018-11-13. PMID:29366808. |
our data confirmed that akt1 was a novel target for mir-637, and its knockdown also induced cell growth inhibition and apoptosis in pdac cells. |
2018-11-13 |
2023-08-13 |
human |
| Xin-Bin Guo, Xin Deng, Ying We. Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation. Stem cells (Dayton, Ohio). vol 36. issue 3. 2018-11-05. PMID:29139175. |
in conclusion, this novel study suggests that hax-1 could facilitate the akt1 pathway through hsp90, which led to a decline in the levels of p53, and finally promoted the proliferation and inhibited the apoptosis of epcs. |
2018-11-05 |
2023-08-13 |
Not clear |
| Elif Sinem Iplik, Baris Ertugrul, Gonca Candan, Saim Pamuk, Levent Aydemir, Mehmet Celik, Murat Ulusan, Arzu Ergen, Bedia Cakmakogl. ROS related enzyme levels and its association to molecular signaling pathway in the development of head and neck cancer. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 7. 2018-11-05. PMID:29974842. |
determination of the apoptosis genes expression levels (mtch1, akt1, caspase3, caspase9, bcl2, mdm2, mtor) were determined by rt-pcr techniques and the same patients' sample used for ros associated oxidant-antioxidant system by using mpo, nqo1, sod2 enzyme levels using elisa method. |
2018-11-05 |
2023-08-13 |
Not clear |
| Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wan. Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. Scientific reports. vol 7. 2018-10-24. PMID:28139737. |
histone h4 expression is cooperatively maintained by ikkβ and akt1 which attenuates cisplatin-induced apoptosis through the dna-pk/rip1/iaps signaling cascade. |
2018-10-24 |
2023-08-13 |
Not clear |
| Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wan. Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. Scientific reports. vol 7. 2018-10-24. PMID:28139737. |
extended from our previous studies showing that concurrent blockage of the nf-κb and akt signaling pathways sensitizes lung cancer cells to cisplatin-induced apoptosis, we for the first time found that knockdown of akt1 and the nf-κb-activating kinase ikkβ cooperatively downregulated histone h4 expression, which increased cisplatin-induced apoptosis in lung cancer cells. |
2018-10-24 |
2023-08-13 |
Not clear |
| Zhengang Tao, Xia Meng, Yan-Qi Han, Ming-Ming Xue, Shifei Wu, Ping Wu, Ying Yuan, Qiang Zhu, Tie-Jun Zhang, Catherine C L Won. Therapeutic Mechanistic Studies of ShuFengJieDu Capsule in an Acute Lung Injury Animal Model Using Quantitative Proteomics Technology. Journal of proteome research. vol 16. issue 11. 2018-08-01. PMID:28880561. |
gain- and loss-of-function analyses following lentivirus-akt1 or lentivirus-si-akt1 infection in macrophages also indicated that akt1 was essential for the development of ali due to its ability to regulate oxidative stress, apoptosis, or inflammatory responses. |
2018-08-01 |
2023-08-13 |
rat |
| M Arias-Álvarez, R M García-García, J López-Tello, P G Rebollar, A Gutiérrez-Adán, P L Lorenz. In vivo and in vitro maturation of rabbit oocytes differently affects the gene expression profile, mitochondrial distribution, apoptosis and early embryo development. Reproduction, fertility, and development. vol 29. issue 9. 2018-07-23. PMID:27678473. |
in addition, there were differences in gene expression after in vivo maturation versus ivm in both oocytes and ccs for genes related to cell cycle regulation and apoptosis (v-akt murine thymoma viral oncogene homologue 1 (akt1), tumour protein 53 (tp53), caspase 3, apoptosis-related cysteine protease (casp3)), oxidative response (superoxide dismutase 2, mitochondrial (sod2)) and metabolism (glucose-6-phosphate dehydrogenase (g6pd), glyceraldehyde-3-phosphate dehydrogenase (gapdh)). |
2018-07-23 |
2023-08-13 |
rabbit |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
an akt1 overexpression plasmid was used to demonstrate the role of akt in h9c2 cells apoptosis. |
2018-06-08 |
2023-08-13 |
Not clear |
| Vinod Tiwari, Mohammad Zahid Kamran, Atul Ranjan, Hemlata Nimesh, Manish Singh, Vibha Tando. Akt1/NFκB signaling pathway activation by a small molecule DMA confers radioprotection to intestinal epithelium in xenograft model. Free radical biology & medicine. vol 108. 2018-04-09. PMID:28435051. |
abrogation of akt1 and nfκb genes resulted in no radioprotection by dma and enhanced apoptosis against radiation. |
2018-04-09 |
2023-08-13 |
mouse |
| Wei-Wei Dai, Li-Bo Wang, Guo-Qin Jin, Hong-Jin Wu, Jie Zhang, Cheng-Long Wang, Yuan-Ji Wei, Joon-Ho Lee, Yu-An Evan Lay, Wei Ya. Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro. Planta medica. vol 83. issue 11. 2017-12-05. PMID:28388784. |
the expression levels of osteoblast growth and differentiation factors (runt-related transcription factor 2, osteogenic protein-1, and alkaline phosphatase), apoptosis-related genes (transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8), and akt1 and phospho-akt (thr308) were then assessed via alkaline phosphatase staining, acridine orange-propidium iodide staining, annexin v/pi apoptosis assay, real-time rt-pcr, and western blot analyses. |
2017-12-05 |
2023-08-13 |
mouse |
| Han Xu, Fengjuan Lin, Ziliang Wang, Lina Yang, Jiao Meng, Zhouluo Ou, Zhimin Shao, Genhong Di, Gong Yan. CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. Cancer letters. vol 412. 2017-12-05. PMID:28964785. |
further study suggested that akt1 and cyclooxygenase-2 (cox2; ptgs2) might mediate the cxcr2 signaling to inversely control the breast cancer metastasis and chemoresistance through the regulation of emt, apoptosis, and senescence. |
2017-12-05 |
2023-08-13 |
Not clear |
| Wanjun Liu, Tao Wang, Xingwei He, Xintian Liu, Bei Wang, Yujian Liu, Zhuxi Li, Rong Tan, Chen Ding, Hongjie Wang, Hesong Zen. CYP2J2 Overexpression Increases EETs and Protects Against HFD-Induced Atherosclerosis in ApoE-/- Mice. Journal of cardiovascular pharmacology. vol 67. issue 6. 2017-09-11. PMID:26859195. |
the aim of the present study was to investigate how cytochrome p450 (cyp)2j2-derived epoxyeicosatrienoic acids (eets) regulate the akt1 and foxo1 and bim pathway and protect against endothelial apoptosis in the development and progression of atherosclerosis. |
2017-09-11 |
2023-08-13 |
mouse |
| Fangzhen Jiang, Kai Jin, Shenyu Huang, Qi Bao, Zheren Shao, Xueqing Hu, Juan Y. Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells. PloS one. vol 11. issue 9. 2017-08-02. PMID:27631768. |
on the other hand, pp1 shrna knockdown or exogenous expression of constitutively activate akt1 (ca-akt1) restored akt-mtor activation and significantly attenuated liposomal c6-mediated cytotoxicity and apoptosis in melanoma cells. |
2017-08-02 |
2023-08-13 |
mouse |
| Hangjun Gong, Yu Cao, Gang Han, Yun Zhang, Qing You, Yidong Wang, Yamin Pa. p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. International journal of oncology. vol 50. issue 5. 2017-07-20. PMID:28339062. |
moreover, inhibition on mir-374b relieved the suppressed akt1 protein, and reduced cell apoptosis induced by blm. |
2017-07-20 |
2023-08-13 |
Not clear |
| Ye Cheng, Gang Zhao, Siwen Zhang, Fares Nigim, Guangtong Zhou, Zhiyun Yu, Yang Song, Yong Chen, Yunqian L. AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin. PloS one. vol 11. issue 12. 2017-06-29. PMID:27907160. |
here we report that as1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of bcl-2 and akt1 in human glioma cells. |
2017-06-29 |
2023-08-13 |
mouse |
| Da-Shi Qi, Jin-Hao Tao, Lian-Qin Zhang, Man Li, Mei Wang, Rui Qu, Shi-Chun Zhang, Pei Liu, Fuming Liu, Jian-Cheng Miu, Jing-Yi Ma, Xin-Yu Mei, Fayong Zhan. Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1. Brain research. vol 1653. 2017-06-26. PMID:27769787. |
additionally, akt1 phosphorylation levels were evidently up-regulated (p<0.05), while the activation of jnk3, which is an important contributor to i/r-induced neuron apoptosis, was reduced by ctl after i/r (p<0.05), and caspase-3 levels were also decreased by ctl treatment. |
2017-06-26 |
2023-08-13 |
rat |