| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Afifiyan, B Tillman, B A French, M Masouminia, S Samadzadeh, S W Frenc. Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies. Experimental and molecular pathology. vol 102. issue 1. 2017-06-01. PMID:28089901. |
akt1 is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. |
2017-06-01 |
2023-08-13 |
Not clear |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
aspalathin was able to modulate key regulators associated with lipid metabolism (adipoq, apob, cd36, cpt1, pparγ, srebf1/2, scd1 and vldlr), insulin resistance (igf1, akt1, pde3 and map2k1), inflammation (il3, il6, jak2, lepr, socs3, and tnf13) and apoptosis (bcl2 and chuk). |
2017-05-09 |
2023-08-13 |
Not clear |
| Sara Häggblad Sahlberg, Anja C Mortensen, Jakob Haglöf, Mikael K R Engskog, Torbjörn Arvidsson, Curt Pettersson, Bengt Glimelius, Bo Stenerlöw, Marika Nesto. Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. International journal of oncology. vol 50. issue 1. 2017-04-04. PMID:27878243. |
in conclusion, downregulation of genes in the cell adhesion, extracellular matrix and notch-pathways and upregulation of apoptosis and metastasis inhibitory genes in the p53-pathway, confirm that the knockout of both akt1 and akt2 will attenuate metastasis and tumor cell growth. |
2017-04-04 |
2023-08-13 |
Not clear |
| Xiaojuan Wang, Pei Wang, Yan Zhu, Zhi Zhang, Jinqian Zhang, Hongwei Wan. MicroRNA-520a attenuates proliferation of Raji cells through inhibition of AKT1/NF-κB and PERK/eIF2α signaling pathway. Oncology reports. vol 36. issue 3. 2017-03-17. PMID:27461820. |
our data indicated that the mimics of mir‑520a inhibited growth, proliferation of raji cells and promoted its apoptosis, which was related to downregulation of akt1, nf‑κb and er stress response mediated by perk/eif2α pathway. |
2017-03-17 |
2023-08-13 |
human |
| Jingjing Zhao, Xue Zeng, Ping Song, Xiaohong Wu, Hongbo Sh. AKT1 as the PageRank hub gene is associated with melanoma and its functional annotation is highly related to the estrogen signaling pathway that may regulate the growth of melanoma. Oncology reports. vol 36. issue 4. 2017-03-03. PMID:27573172. |
our studies highlighted the top differentially expressed gene akt1 and its correlation with the estrogen signaling and rap1 signaling pathways to alter the proliferation and apoptosis of melanoma cells. |
2017-03-03 |
2023-08-13 |
Not clear |
| Rizma Khan, Nadir Naveed Siddiqui, Ahtesham Ul Haq, M Ataur Rahma. Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26242269. |
the later included the interacting partner of hspb27, i.e., mitogen-activated protein kinase-3 and 5 (mapk3 and 5), ubiquitin c (ubc), v-akt murine thymoma viral oncogene homolog 1 (akt1), mitogen-activated protein kinase 14 (mapk14), and tumor protein p53 (tp53), which bestowed with critical capabilities, namely, apoptosis, cell cycling, stress activation, tumor suppression, cell survival, angiogenesis, proliferation, and stress resistance. |
2017-02-06 |
2023-08-13 |
human |
| Xi Yang, Yaping Zhang, Hong Liu, Zenghua Li. Cancerous Inhibitor of PP2A Silencing Inhibits Proliferation and Promotes Apoptosis in Human Multiple Myeloma Cells. BioMed research international. vol 2016. 2017-02-01. PMID:27144172. |
cip2a knockdown inhibited proliferation and induced apoptosis in rpmi-8226 and nci-h929 cells and decreased the phosphorylation of phosphoinositide 3-kinase (pi3k) p85, akt1, and mammalian target of rapamycin (mtor) without affecting total protein levels. |
2017-02-01 |
2023-08-13 |
human |
| X Gai, K Tu, C Li, Z Lu, L R Roberts, X Zhen. Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma. Cell death & disease. vol 6. 2016-09-29. PMID:25855960. |
we previously reported that pcaf upregulates cell apoptosis by inactivating serine/threonine protein kinase 1 (akt1) signaling and consequently inhibits hepatocellular carcinoma (hcc) cell growth. |
2016-09-29 |
2023-08-13 |
Not clear |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation. In vivo (Athens, Greece). vol 29. issue 6. 2016-08-29. PMID:26546525. |
our previous studies showed that oligonucleotide-treated lncap prostate cancer cells compensate for diminished expression of b-cell chronic lymphocytic leukemia/lymphoma 2 (bcl2), an apoptosis inhibitor, by suppressing the expression of caspase-3 (an apoptosis promoter) while enhancing that of serine/threonine protein kinase (akt1) (another apoptosis inhibitor). |
2016-08-29 |
2023-08-13 |
Not clear |
| Dong Qian, Kailin Chen, Haixia Deng, Huilan Rao, Huiqiang Huang, Yiji Liao, Xiaofei Sun, Suying Lu, Zhiyong Yuan, Dan Xie, Qingqing Ca. MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 21. issue 21. 2016-08-19. PMID:26100275. |
microrna-374b suppresses proliferation and promotes apoptosis in t-cell lymphoblastic lymphoma by repressing akt1 and wnt-16. |
2016-08-19 |
2023-08-13 |
Not clear |
| Jennifer L Larson-Casey, Jessy S Deshane, Alan J Ryan, Victor J Thannickal, A Brent Carte. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity. vol 44. issue 3. 2016-08-15. PMID:26921108. |
macrophage akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis. |
2016-08-15 |
2023-08-13 |
mouse |
| Jennifer L Larson-Casey, Jessy S Deshane, Alan J Ryan, Victor J Thannickal, A Brent Carte. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity. vol 44. issue 3. 2016-08-15. PMID:26921108. |
importantly, conditional akt1(-/-)lyz2-cre mice and park2(-/-) mice had increased macrophage apoptosis and were protected from pulmonary fibrosis. |
2016-08-15 |
2023-08-13 |
mouse |
| Bethany A Kerr, Xiaoxia Z West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M Cull, Timothy W Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V Petrova, Ralf H Adams, Nissim Hay, Sathyamangla V Naga Prasad, Tatiana V Byzov. Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Nature communications. vol 7. 2016-07-27. PMID:26971877. |
inducible endothelial-specific akt1 deletion in adult global akt2ko mice triggers progressive vsmc apoptosis. |
2016-07-27 |
2023-08-13 |
mouse |
| Manman Huang, Defeng Pan, Yinping Du, Hong Zhu, Lin Zhang, Tongda Xu, Yuanyuan Luo, Dongye L. Na(+)/Ca(2+) exchanger 1 (NCX-1) mediates the anti-apoptotic effect of Akt1 in neonatal rat cardiomyocytes during ischemia/reperfusion. American journal of translational research. vol 8. issue 3. 2016-05-17. PMID:27186265. |
cardiomyocyte vitality was determined using mtt, and the apoptosis was determined by tunel to verify the anti-apoptotic role of akt1. |
2016-05-17 |
2023-08-13 |
rat |
| Manman Huang, Defeng Pan, Yinping Du, Hong Zhu, Lin Zhang, Tongda Xu, Yuanyuan Luo, Dongye L. Na(+)/Ca(2+) exchanger 1 (NCX-1) mediates the anti-apoptotic effect of Akt1 in neonatal rat cardiomyocytes during ischemia/reperfusion. American journal of translational research. vol 8. issue 3. 2016-05-17. PMID:27186265. |
as a result, transfected akt1 (a group) showed increased myocardial cell viability and reduced apoptosis, with increase in akt1 expression and decrease in ncx1 expression. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
the activity of caspase 3 (casp3) and level changes of several apoptosis factors including b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), phosphatase and tensin homolog (pten) and v-akt murine thymoma viral oncogene homolog 1 (akt1) were detected. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
it also caused the corresponding changes in casp3 activity and other apoptosis factors, with cleaved casp3, bax and pten inhibited and bcl2 and phosphorylated akt1 promoted, while mir-22 antagomir had the opposite effects. |
2016-05-17 |
2023-08-13 |
rat |
| Sheng-Yuan Liu, He-Dan Zhao, Jin-Long Wang, Tong Huang, Hua-Wei Tian, Li-Fen Yao, Hua Tao, Zhong-Wei Chen, Chang-Yi Wang, Si-Tong Sheng, Hua Li, Bin Zhao, Ke-Shen L. Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer's Disease in a Chinese Han Population with Type 2 Diabetes. CNS neuroscience & therapeutics. vol 21. issue 8. 2016-04-19. PMID:26178916. |
alzheimer's disease (ad) is a multifactor disease that has been reported to have a close association with type 2 diabetes (t2d) where the v-akt murine thymoma viral oncogene homolog 1 (akt1) plays an important role in the protein synthesis pathways and cell apoptosis processes. |
2016-04-19 |
2023-08-13 |
Not clear |
| Xiaoli Zhang, Haiyu Zhang, Qing Gao, Shufang Ji, Lujun Bing, Jing Ha. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reproductive biomedicine online. vol 30. issue 5. 2016-02-08. PMID:25773528. |
tdt (terminal deoxynucleotidyl transferase)-mediated dudp nick-end labelling assay was carried out to detect the oocyte apoptosis; immunocytochemical staining and quantitative real time-polymerase chain reaction detected the expression of c-kit and forkhead box o3a (foxo3a); western blot was performed to detect the expression of sohlh2, c-kit, saerine/threonine kinases (akt1) and foxo3a. |
2016-02-08 |
2023-08-13 |
mouse |
| Xiaoli Zhang, Haiyu Zhang, Qing Gao, Shufang Ji, Lujun Bing, Jing Ha. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reproductive biomedicine online. vol 30. issue 5. 2016-02-08. PMID:25773528. |
the results showed that sohlh2 inhibited oocyte apoptosis and upregulated c-kit expression; sohlh2 decreased the endonuclear foxo3a via the upregulation of phosphorylated akt1 (p-akt1) and phosphorylated foxo3a (p-foxo3a) but not total akt1 (t-akt1) or total foxo3a (t-foxo3a); sohlh2 increased p-akt1 but not t-akt1; the pi3k (phosphotidylinsitol-3-kinase) inhibitor ly294002 ameliorated the role of sohlh2 on phosphorylation of akt1 and foxo3a. |
2016-02-08 |
2023-08-13 |
mouse |